{"id":"https://openalex.org/W1967008598","doi":"https://doi.org/10.1097/mol.0b013e3282f2b24a","title":"Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance","display_name":"Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W1967008598","doi":"https://doi.org/10.1097/mol.0b013e3282f2b24a","mag":"1967008598","pmid":"https://pubmed.ncbi.nlm.nih.gov/18196982","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4151171"},"language":"en","primary_location":{"id":"doi:10.1097/mol.0b013e3282f2b24a","doi":"https://doi.org/10.1097/mol.0b013e3282f2b24a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mol.0b013e3282f2b24a","pdf_url":null,"source":{"id":"https://openalex.org/S203964698","display_name":"Current Opinion in Lipidology","issn_l":"0957-9672","issn":["0957-9672","1473-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Lipidology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4151171/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056635157","display_name":"Kimber L. Stanhope","orcid":"https://orcid.org/0000-0002-2474-0914","observed_orcids":["https://orcid.org/0000-0002-2474-0914"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimber L Stanhope","raw_affiliation_strings":["Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA","Department of Molecular Biosciences, School of Veterinary Medicine, USA","Department of Nutrition, University of California, Davis, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Molecular Biosciences, School of Veterinary Medicine, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, University of California, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034829692","display_name":"Peter Joseph Havel","orcid":"https://orcid.org/0000-0003-3652-8301","observed_orcids":["https://orcid.org/0000-0003-3652-8301"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter J Havel","raw_affiliation_strings":["Department of Molecular Biosciences, School of Veterinary Medicine, USA","Department of Nutrition, University of California, Davis, California, USA","to Peter J. Havel, DVM, PhD, Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA Tel: +1 530 752 6553; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","to Peter J. Havel, DVM, PhD, Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA Tel: +1 530 752 6553"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, School of Veterinary Medicine, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, University of California, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"to Peter J. Havel, DVM, PhD, Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA Tel: +1 530 752 6553; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to Peter J. Havel, DVM, PhD, Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA Tel: +1 530 752 6553","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034829692"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":2.4033,"has_fulltext":true,"cited_by_count":275,"citation_normalized_percentile":{"value":0.92032967,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"19","issue":"1","first_page":"16","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fructose-intake","display_name":"fructose consumption","score":0.9100000262260437},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.7879999876022339},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/postprandial-hypertriglyceridemia","display_name":"postprandial hypertriglyceridemia","score":0.972000002861023},{"id":"https://openalex.org/keywords/hepatic-triglyceride-accumulation","display_name":"hepatic triglyceride accumulation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.6790000200271606},{"id":"https://openalex.org/keywords/hepatic-insulin-resistance","display_name":"hepatic insulin resistance","score":0.8679999709129333},{"id":"https://openalex.org/keywords/vldl-production","display_name":"VLDL production","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hepatic-lipogenesis","display_name":"hepatic lipogenesis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/high-fructose-diet","display_name":"high-fructose diet","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8676644563674927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7589272260665894},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7530938982963562},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.7025249004364014},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.6232136487960815},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.5775181651115417},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.5585536956787109},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.5499672889709473},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5126232504844666},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.44630002975463867},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.4112709164619446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3933902680873871},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.3838862478733063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37661507725715637},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.22803860902786255},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.22456154227256775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16483443975448608},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013549","descriptor_name":"Sweetening Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050152","descriptor_name":"Intra-Abdominal Fat","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050152","descriptor_name":"Intra-Abdominal Fat","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1097/mol.0b013e3282f2b24a","doi":"https://doi.org/10.1097/mol.0b013e3282f2b24a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mol.0b013e3282f2b24a","pdf_url":null,"source":{"id":"https://openalex.org/S203964698","display_name":"Current Opinion in Lipidology","issn_l":"0957-9672","issn":["0957-9672","1473-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Lipidology","raw_type":"journal-article"},{"id":"pmid:18196982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18196982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in lipidology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4151171","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4151171/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Lipidol","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8pm1x1cj","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8pm1x1cj","pdf_url":"https://escholarship.org/content/qt8pm1x1cj/qt8pm1x1cj.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Opinion in Lipidology, vol 19, iss 1","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt8pm1x1cj","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8pm1x1cj","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current opinion in lipidology, vol 19, iss 1","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4151171","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4151171/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Lipidol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1476214619","display_name":null,"funder_award_id":"K12 HD051958","funder_id":"https://openalex.org/F4320337381","funder_display_name":"Office of Research on Women's Health"},{"id":"https://openalex.org/G223716007","display_name":null,"funder_award_id":"HL 075675","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2261235861","display_name":"Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resis","funder_award_id":"R01HL091333","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G239344607","display_name":"Dietary Fructose: Hormones & TG/Lipoprotein Metabolism","funder_award_id":"R01HL075675","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2544491570","display_name":"Effects of fish oil and alpha lipoic on the progression of insulin resistance","funder_award_id":"R21AT003645","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G2825446468","display_name":"Stress, socioeconomic status, and obesity","funder_award_id":"142691","funder_id":"https://openalex.org/F4320333677","funder_display_name":"Office of the President, University of California"},{"id":"https://openalex.org/G4142340636","display_name":"UC Davis Clinical and Translational Science Center","funder_award_id":"UL1RR024146","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5631601847","display_name":"Prevention of Diabetes with Nutritional Supplements","funder_award_id":"R21AT002993","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G5935579002","display_name":"Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia","funder_award_id":"R01HL107256","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G619771439","display_name":null,"funder_award_id":"HL-107256","funder_id":"https://openalex.org/F4320333677","funder_display_name":"Office of the President, University of California"},{"id":"https://openalex.org/G6529246799","display_name":"Effects of Chromium on Progression of Insulin Resistance","funder_award_id":"R21AT002599","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G7645327000","display_name":"Building Interdisciplinary Research Careers in Women's Health at UC Davis","funder_award_id":"K12HD051958","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8156748866","display_name":null,"funder_award_id":"HL-091333","funder_id":"https://openalex.org/F4320333677","funder_display_name":"Office of the President, University of California"}],"funders":[{"id":"https://openalex.org/F4320306096","display_name":"Office of Dietary Supplements","ror":"https://ror.org/01wtjyf13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333677","display_name":"Office of the President, University of California","ror":"https://ror.org/00dmfq477"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337381","display_name":"Office of Research on Women's Health","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967008598.pdf","grobid_xml":"https://content.openalex.org/works/W1967008598.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W62692173","https://openalex.org/W1884946913","https://openalex.org/W1886727246","https://openalex.org/W1943668942","https://openalex.org/W1968426538","https://openalex.org/W1972138027","https://openalex.org/W1980167330","https://openalex.org/W1981460885","https://openalex.org/W1982488301","https://openalex.org/W1983548385","https://openalex.org/W1983831019","https://openalex.org/W1984084795","https://openalex.org/W1985592156","https://openalex.org/W1985655319","https://openalex.org/W1988319483","https://openalex.org/W1999971397","https://openalex.org/W2003380115","https://openalex.org/W2005564177","https://openalex.org/W2007954901","https://openalex.org/W2009013500","https://openalex.org/W2009192384","https://openalex.org/W2010895111","https://openalex.org/W2012295774","https://openalex.org/W2012407931","https://openalex.org/W2020925755","https://openalex.org/W2022008301","https://openalex.org/W2023828584","https://openalex.org/W2024636512","https://openalex.org/W2025976180","https://openalex.org/W2026241394","https://openalex.org/W2028232702","https://openalex.org/W2032779971","https://openalex.org/W2033630237","https://openalex.org/W2034280561","https://openalex.org/W2035146994","https://openalex.org/W2039250890","https://openalex.org/W2039543531","https://openalex.org/W2041165301","https://openalex.org/W2046666469","https://openalex.org/W2047730892","https://openalex.org/W2049881486","https://openalex.org/W2056030232","https://openalex.org/W2058709828","https://openalex.org/W2067324334","https://openalex.org/W2069382585","https://openalex.org/W2072476641","https://openalex.org/W2075521286","https://openalex.org/W2077829695","https://openalex.org/W2079731322","https://openalex.org/W2084887776","https://openalex.org/W2085021339","https://openalex.org/W2085645589","https://openalex.org/W2087011218","https://openalex.org/W2088407989","https://openalex.org/W2090444153","https://openalex.org/W2092441434","https://openalex.org/W2093824918","https://openalex.org/W2095677526","https://openalex.org/W2102767551","https://openalex.org/W2105641300","https://openalex.org/W2106967145","https://openalex.org/W2108462699","https://openalex.org/W2108916652","https://openalex.org/W2109519875","https://openalex.org/W2112031005","https://openalex.org/W2112375566","https://openalex.org/W2114416343","https://openalex.org/W2114420424","https://openalex.org/W2117763395","https://openalex.org/W2120385990","https://openalex.org/W2122616232","https://openalex.org/W2123521914","https://openalex.org/W2126194898","https://openalex.org/W2126420509","https://openalex.org/W2127032568","https://openalex.org/W2130011755","https://openalex.org/W2130850001","https://openalex.org/W2132477505","https://openalex.org/W2133545915","https://openalex.org/W2133711136","https://openalex.org/W2136149489","https://openalex.org/W2136629006","https://openalex.org/W2138705025","https://openalex.org/W2140699761","https://openalex.org/W2145030059","https://openalex.org/W2146458296","https://openalex.org/W2146544786","https://openalex.org/W2149433053","https://openalex.org/W2150126813","https://openalex.org/W2151400756","https://openalex.org/W2153962063","https://openalex.org/W2156690149","https://openalex.org/W2161914374","https://openalex.org/W2162627097","https://openalex.org/W2165047605","https://openalex.org/W2165912352","https://openalex.org/W2167351040","https://openalex.org/W2167792970","https://openalex.org/W2168519267","https://openalex.org/W2169582126","https://openalex.org/W2175211158","https://openalex.org/W2396522650","https://openalex.org/W2401035175","https://openalex.org/W2415140035","https://openalex.org/W2475316864","https://openalex.org/W2615637571","https://openalex.org/W2887019261","https://openalex.org/W4239068820","https://openalex.org/W4252021281","https://openalex.org/W4256206092"],"related_works":["https://openalex.org/W1521042725","https://openalex.org/W2146966453","https://openalex.org/W2090420589","https://openalex.org/W2120175329","https://openalex.org/W2901447021","https://openalex.org/W2128373884","https://openalex.org/W1489727928","https://openalex.org/W2608887124","https://openalex.org/W2098947106","https://openalex.org/W2969993959"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Based":[3],"on":[4],"interim":[5],"results":[6,46],"from":[7,77],"an":[8],"ongoing":[9],"study,":[10],"we":[11,54],"have":[12],"reported":[13],"that":[14,141,170],"consumption":[15,64,79,195],"of":[16,28,30,50,59,110,148,190,193,202,207],"a":[17,22,48,166],"high-fructose":[18],"diet,":[19,24],"but":[20],"not":[21],"high-glucose":[23],"promotes":[25],"the":[26,31,51,107,115,191,200],"development":[27,206],"three":[29],"pathological":[32],"characteristics":[33],"associated":[34],"with":[35,127],"metabolic":[36,68,74,208],"syndrome:":[37],"visceral":[38,86,149],"adiposity,":[39],"dyslipidemia,":[40],"and":[41,47,101,124,151,180,187],"insulin":[42,103,118,145,182],"resistance.":[43,183],"From":[44],"these":[45],"review":[49],"current":[52],"literature,":[53],"present":[55],"two":[56],"potential":[57],"sequences":[58],"events":[60,203],"by":[61,105],"which":[62,83],"fructose":[63,78,142,162,194],"may":[65,84,163,196],"contribute":[66],"to":[67,92,114,135,172,198,205],"syndrome.":[69,209],"RECENT":[70],"FINDINGS:":[71],"The":[72],"earliest":[73],"perturbation":[75],"resulting":[76],"is":[80,122,138],"postprandial":[81],"hypertriglyceridemia,":[82],"increase":[85,132],"adipose":[87],"deposition.":[88],"Visceral":[89],"adiposity":[90,150],"contributes":[91],"hepatic":[93,102,144,160,181],"triglyceride":[94,173],"accumulation,":[95,174],"novel":[96,175],"protein":[97,176],"kinase":[98,177],"C":[99,178],"activation,":[100,179],"resistance":[104,146],"increasing":[106],"portal":[108],"delivery":[109,134],"free":[111,129,152],"fatty":[112,130,153],"acids":[113],"liver.":[116],"With":[117],"resistance,":[119],"VLDL":[120],"production":[121],"upregulated":[123],"this,":[125],"along":[126],"systemic":[128],"acids,":[131],"lipid":[133,168],"muscle.":[136],"It":[137],"also":[139],"possible":[140],"initiates":[143],"independently":[147],"acid":[154],"delivery.":[155],"By":[156],"providing":[157],"substrate":[158],"for":[159],"lipogenesis,":[161],"result":[164],"in":[165],"direct":[167],"overload":[169],"leads":[171],"SUMMARY:":[184],"Our":[185],"investigation":[186],"future":[188],"studies":[189],"effects":[192],"help":[197],"clarify":[199],"sequence":[201],"leading":[204]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}