{"id":"https://openalex.org/W1966972737","doi":"https://doi.org/10.1055/s-2008-1034896","title":"Un deficit endog\u00e8ne en monoxide d'azote est un facteur aggravant lors d'une occlusion veineuse r\u00e9tinienne","display_name":"Un deficit endog\u00e8ne en monoxide d'azote est un facteur aggravant lors d'une occlusion veineuse r\u00e9tinienne","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W1966972737","doi":"https://doi.org/10.1055/s-2008-1034896","mag":"1966972737","pmid":"https://pubmed.ncbi.nlm.nih.gov/9677569"},"language":"fr","primary_location":{"id":"doi:10.1055/s-2008-1034896","doi":"https://doi.org/10.1055/s-2008-1034896","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2008-1034896","pdf_url":null,"source":{"id":"https://openalex.org/S61378919","display_name":"Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde","issn_l":"0023-2165","issn":["0023-2165","0344-6360","1439-3999"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028345280","display_name":"Guy Donati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Donati","raw_affiliation_strings":["Clinique d'Ophtalmologie, Dpt. Neurosciences cliniques, Gen\u00e8ve"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinique d'Ophtalmologie, Dpt. Neurosciences cliniques, Gen\u00e8ve","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113547227","display_name":"Constantin J. Pournaras","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. J. Pournaras","raw_affiliation_strings":["Clinique d'Ophtalmologie. Dpt. Neurosciences cliniques, HUG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinique d'Ophtalmologie. Dpt. Neurosciences cliniques, HUG","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109867498","display_name":"Marcos Tsacopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Tsacopoulos","raw_affiliation_strings":["Clinique d'Ophtalmologie. Dpt. Neurosciences cliniques, HUG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinique d'Ophtalmologie. Dpt. Neurosciences cliniques, HUG","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.09221065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"212","issue":"05","first_page":"324","last_page":"325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.05590000003576279,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-vein-occlusion","display_name":"retinal vein occlusion","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7129999995231628},{"id":"https://openalex.org/keywords/arteriolar-vasoconstriction","display_name":"arteriolar constriction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/systemic-hypoxia","display_name":"systemic hypoxia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/retinal-ischemia","display_name":"retinal ischemia","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2779482390","wikidata":"https://www.wikidata.org/wiki/Q501908","display_name":"Arteriole","level":3,"score":0.9289394617080688},{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.8445868492126465},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.6813904047012329},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6103602647781372},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.577346682548523},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5227649211883545},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.5000460147857666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4395589232444763},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4248027205467224},{"id":"https://openalex.org/C2778672379","wikidata":"https://www.wikidata.org/wiki/Q388209","display_name":"Venule","level":3,"score":0.422313392162323},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4198572337627411},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.4170449376106262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39482972025871277},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3812450170516968},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.24512189626693726},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.2180768847465515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14788812398910522},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012161","descriptor_name":"Retinal Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012170","descriptor_name":"Retinal Vein Occlusion","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013556","descriptor_name":"Swine, Miniature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2008-1034896","doi":"https://doi.org/10.1055/s-2008-1034896","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2008-1034896","pdf_url":null,"source":{"id":"https://openalex.org/S61378919","display_name":"Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde","issn_l":"0023-2165","issn":["0023-2165","0344-6360","1439-3999"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde","raw_type":"journal-article"},{"id":"pmid:9677569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9677569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Monatsblatter fur Augenheilkunde","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W116547692","https://openalex.org/W2424967765","https://openalex.org/W28950945","https://openalex.org/W2051858051","https://openalex.org/W140562995","https://openalex.org/W2740411997","https://openalex.org/W2033743083","https://openalex.org/W2075127136","https://openalex.org/W2280197148","https://openalex.org/W2189464221"],"abstract_inverted_index":{"PURPOSE:":[0],"Following":[1],"retinal":[2,95],"branch":[3],"vein":[4],"occlusion":[5],"(b.v.o.),":[6],"the":[7,10,27,43,48,56,70,77,139,142,145,194,200,214,225],"arteriole":[8,143,161,182],"crossing":[9],"occluded":[11],"territories":[12,31],"is":[13,24],"often":[14],"constricted.":[15],"This":[16],"constriction":[17,173],"persists":[18],"up":[19],"to":[20,90,98,213],"several":[21],"weeks":[22],"and":[23,75,115,131,205,219,222],"correlated":[25,89],"with":[26],"development":[28,215],"of":[29,32,39,50,85,108,141,202,216],"extended":[30],"non-perfused":[33],"capillaries.":[34],"We":[35],"present":[36],"here":[37],"results":[38,187],"an":[40,66,160,181,197,206],"investigation":[41],"supporting":[42],"hypothesis":[44],"that":[45,189],"decrease":[46,127,137],"in":[47,69,128,138,144,193,199,210,224],"production":[49],"nitric":[51],"oxide":[52],"(NO)":[53],"accounts":[54],"for":[55,150],"observed":[57,175],"arteriolar":[58,86,96,172,207],"constriction.":[59],"METHODS:":[60],"Preretinal":[61],"[NO]":[62,92,130],"was":[63,101,123,174,178],"measured":[64],"using":[65],"NO":[67,100,204],"microprobe":[68],"anesthethized":[71],"miniature":[72],"pigs,":[73],"before":[74],"within":[76],"first":[78],"4":[79,153],"hours":[80,119,154],"following":[81],"experimental":[82,190],"b.v.o.":[83,116,121,156,184,191],"Modifications":[84],"diameter":[87,140],"were":[88],"preretinal":[91,105,129],"changes.":[93],"The":[94],"sensitivity":[97],"constitutive":[99,203],"checked":[102],"by":[103,164],"performing":[104],"puff":[106],"injections":[107],"nitro-1-arginine":[109],"(L-NA)":[110],"after":[111,120,155,183],"both":[112],"systemic":[113,165],"hypoxia":[114,166,218],"RESULTS:":[117],"Two":[118],"there":[122],"73.7":[124],"+/-":[125,135],"4%":[126],"a":[132,168],"simultaneous":[133],"25.4":[134],"3.4%":[136],"affected":[146,195],"territory.":[147],"Both":[148],"persisted":[149],"at":[151],"least":[152],"Puffing":[157],"L-NA":[158],"over":[159],"previously":[162],"dilated":[163],"induced":[167,192],"vasoconstriction.":[169],"However":[170],"no":[171],"when":[176],"puffing":[177],"performed":[179],"on":[180],"CONCLUSIONS:":[185],"These":[186],"show":[188],"retina":[196],"impairment":[198],"release":[201],"constriction,":[208],"which":[209],"turn,":[211],"contribute":[212],"tissue":[217],"neuronal":[220],"swelling":[221],"death":[223],"inner":[226],"retina.":[227]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}