{"id":"https://openalex.org/W1966962897","doi":"https://doi.org/10.1038/nmat2444","title":"Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA","display_name":"Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA","publication_year":2009,"publication_date":"2009-04-29","ids":{"openalex":"https://openalex.org/W1966962897","doi":"https://doi.org/10.1038/nmat2444","mag":"1966962897","pmid":"https://pubmed.ncbi.nlm.nih.gov/19404239","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693358"},"language":"en","primary_location":{"id":"doi:10.1038/nmat2444","doi":"https://doi.org/10.1038/nmat2444","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nmat2444","pdf_url":null,"source":{"id":"https://openalex.org/S103895331","display_name":"Nature Materials","issn_l":"1476-1122","issn":["1476-1122","1476-4660"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693358","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046773398","display_name":"Kim A. Woodrow","orcid":"https://orcid.org/0000-0002-9508-8804","observed_orcids":["https://orcid.org/0000-0002-9508-8804"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim A. Woodrow","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075525812","display_name":"Yen Cu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yen Cu","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043081740","display_name":"Carmen Jane Booth","orcid":"https://orcid.org/0000-0002-2153-738X","observed_orcids":["https://orcid.org/0000-0002-2153-738X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen J. Booth","raw_affiliation_strings":["Section of Comparative Medicine, Yale University, New Haven, Connecticut 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Comparative Medicine, Yale University, New Haven, Connecticut 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055921008","display_name":"Jennifer K. Saucier-Sawyer","orcid":"https://orcid.org/0000-0003-2620-1014","observed_orcids":["https://orcid.org/0000-0003-2620-1014"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer K. Saucier-Sawyer","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051548978","display_name":"Monica J. Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica J. Wood","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. Mark Saltzman","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012106344"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":14.9992,"has_fulltext":false,"cited_by_count":437,"citation_normalized_percentile":{"value":0.99543503,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"8","issue":"6","first_page":"526","last_page":"533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.8339999914169312},{"id":"https://openalex.org/keywords/biodegradable-polymeric-nanoparticles","display_name":"biodegradable polymer nanoparticles","score":0.9129999876022339},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.8820000290870667},{"id":"https://openalex.org/keywords/vaginal-mucosa","display_name":"vaginal mucosa","score":0.9570000171661377},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.5419999957084656},{"id":"https://openalex.org/keywords/female-reproductive-tract","display_name":"female reproductive tract","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.9198708534240723},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.8528121113777161},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6994985938072205},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5598329901695251},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5303830504417419},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48191526532173157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37701526284217834},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3499339818954468},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34895771741867065},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33432644605636597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2876501679420471},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22083055973052979},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10180088877677917}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014621","descriptor_name":"Vagina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/nmat2444","doi":"https://doi.org/10.1038/nmat2444","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nmat2444","pdf_url":null,"source":{"id":"https://openalex.org/S103895331","display_name":"Nature Materials","issn_l":"1476-1122","issn":["1476-1122","1476-4660"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Materials","raw_type":"journal-article"},{"id":"pmid:19404239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19404239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature materials","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2693358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693358","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Mater","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2693358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2693358","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Mater","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4336169015","display_name":null,"funder_award_id":"T32-HL007950-08","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6368652804","display_name":"Cellular and molecular transport in mucus","funder_award_id":"R01EB000487","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G724664186","display_name":null,"funder_award_id":"R01-EB0000487-18","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000893099","display_name":"Vascular Training Grant","funder_award_id":"T32HL007950","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1485302340","https://openalex.org/W1520349470","https://openalex.org/W1552589960","https://openalex.org/W1581476272","https://openalex.org/W1963852477","https://openalex.org/W1964146045","https://openalex.org/W1965583953","https://openalex.org/W1977237283","https://openalex.org/W1981508315","https://openalex.org/W1985786449","https://openalex.org/W1989407131","https://openalex.org/W1989753758","https://openalex.org/W1994978160","https://openalex.org/W1999253394","https://openalex.org/W2000136129","https://openalex.org/W2000772086","https://openalex.org/W2002629577","https://openalex.org/W2014760202","https://openalex.org/W2019631541","https://openalex.org/W2022132405","https://openalex.org/W2029561253","https://openalex.org/W2030621748","https://openalex.org/W2032888813","https://openalex.org/W2041934694","https://openalex.org/W2046851174","https://openalex.org/W2047165821","https://openalex.org/W2047584537","https://openalex.org/W2052312685","https://openalex.org/W2059262359","https://openalex.org/W2060056553","https://openalex.org/W2077998713","https://openalex.org/W2079793032","https://openalex.org/W2084851425","https://openalex.org/W2086731246","https://openalex.org/W2091211551","https://openalex.org/W2095151181","https://openalex.org/W2097700181","https://openalex.org/W2099956255","https://openalex.org/W2100206933","https://openalex.org/W2102002215","https://openalex.org/W2111598262","https://openalex.org/W2117698690","https://openalex.org/W2127078930","https://openalex.org/W2127409621","https://openalex.org/W2144023036","https://openalex.org/W2155737863","https://openalex.org/W2159477638","https://openalex.org/W2167806590","https://openalex.org/W2314642321","https://openalex.org/W2329331033"],"related_works":["https://openalex.org/W2396433906","https://openalex.org/W4214675288","https://openalex.org/W2054786837","https://openalex.org/W2024353213","https://openalex.org/W2090085157","https://openalex.org/W99195578","https://openalex.org/W2057900479","https://openalex.org/W3045591679","https://openalex.org/W2055371352","https://openalex.org/W2042609130"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":39},{"year":2013,"cited_by_count":45},{"year":2012,"cited_by_count":36}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
