{"id":"https://openalex.org/W1966949468","doi":"https://doi.org/10.1016/j.ddstr.2014.04.001","title":"Synaptic function as a preclinical and experimental medicine readout for disease-modifying therapy in Alzheimer's Disease","display_name":"Synaptic function as a preclinical and experimental medicine readout for disease-modifying therapy in Alzheimer's Disease","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1966949468","doi":"https://doi.org/10.1016/j.ddstr.2014.04.001","mag":"1966949468"},"language":"en","primary_location":{"id":"doi:10.1016/j.ddstr.2014.04.001","doi":"https://doi.org/10.1016/j.ddstr.2014.04.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ddstr.2014.04.001","pdf_url":null,"source":{"id":"https://openalex.org/S96412912","display_name":"Drug Discovery Today Therapeutic Strategies","issn_l":"1740-6773","issn":["1740-6773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today: Therapeutic Strategies","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060056784","display_name":"Bai Lu","orcid":"https://orcid.org/0000-0001-5418-9759","observed_orcids":["https://orcid.org/0000-0001-5418-9759"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bai Lu","raw_affiliation_strings":["Tsinghua University School of Medicine, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsinghua University School of Medicine, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071509150","display_name":"Guhan Nagappan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137016","display_name":"GlaxoSmithKline (China)","ror":"https://ror.org/03jrn4k58","country_code":"CN","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210137016"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guhan Nagappan","raw_affiliation_strings":["GlaxoSmithKline, R&D China, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, R&D China, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210137016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018958936","display_name":"Pradeep J. Nathan","orcid":"https://orcid.org/0000-0003-0943-5329","observed_orcids":["https://orcid.org/0000-0003-0943-5329"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]},{"id":"https://openalex.org/I85722119","display_name":"UCB Pharma (Belgium)","ror":"https://ror.org/01n029866","country_code":"BE","type":"company","lineage":["https://openalex.org/I85722119"]}],"countries":["AU","BE","GB"],"is_corresponding":false,"raw_author_name":"Pradeep J. Nathan","raw_affiliation_strings":["Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK","New Medicines, UCB Pharma, Brussels, Belgium","School of Psychology and Psychiatry, Monash University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"New Medicines, UCB Pharma, Brussels, Belgium","institution_ids":["https://openalex.org/I85722119"]},{"raw_affiliation_string":"School of Psychology and Psychiatry, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108088008","display_name":"Olivier Blin","orcid":"https://orcid.org/0000-0003-0142-0931","observed_orcids":["https://orcid.org/0000-0003-0142-0931"]},"institutions":[{"id":"https://openalex.org/I4210087487","display_name":"Assistance Publique H\u00f4pitaux de Marseille","ror":"https://ror.org/002cp4060","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Blin","raw_affiliation_strings":["Head Clinical Pharmacology & Pharmacovigilance at University Hospital Marseille"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head Clinical Pharmacology & Pharmacovigilance at University Hospital Marseille","institution_ids":["https://openalex.org/I4210087487"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5060056784"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.06041803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"2","first_page":"e99","last_page":"e104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.875},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/preclinical-models","display_name":"preclinical models","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6439999938011169},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.8268314599990845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6033910512924194},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.576520562171936},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4995903968811035},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.46175193786621094},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4507744312286377},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.23257288336753845},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.23041832447052002},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15033775568008423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08728834986686707},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ddstr.2014.04.001","doi":"https://doi.org/10.1016/j.ddstr.2014.04.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ddstr.2014.04.001","pdf_url":null,"source":{"id":"https://openalex.org/S96412912","display_name":"Drug Discovery Today Therapeutic Strategies","issn_l":"1740-6773","issn":["1740-6773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today: Therapeutic Strategies","raw_type":"journal-article"},{"id":"mag:2489432000","doi":null,"is_oa":false,"landing_page_url":"http://arrow.monash.edu.au/vital/access/manager/Repository/monash:146233","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W186149320","https://openalex.org/W1541126883","https://openalex.org/W1584834830","https://openalex.org/W1654885769","https://openalex.org/W1694922823","https://openalex.org/W1962254068","https://openalex.org/W1967464880","https://openalex.org/W1967931162","https://openalex.org/W1974594322","https://openalex.org/W1977022762","https://openalex.org/W1979426401","https://openalex.org/W1979631864","https://openalex.org/W1983493842","https://openalex.org/W1983603079","https://openalex.org/W1993657223","https://openalex.org/W2000112233","https://openalex.org/W2003131754","https://openalex.org/W2007572953","https://openalex.org/W2008767130","https://openalex.org/W2009173112","https://openalex.org/W2009576287","https://openalex.org/W2011502145","https://openalex.org/W2013553668","https://openalex.org/W2015933608","https://openalex.org/W2016061869","https://openalex.org/W2017533501","https://openalex.org/W2020486984","https://openalex.org/W2040956654","https://openalex.org/W2042466570","https://openalex.org/W2043838674","https://openalex.org/W2049041989","https://openalex.org/W2053488262","https://openalex.org/W2054182314","https://openalex.org/W2056389198","https://openalex.org/W2056678372","https://openalex.org/W2057929164","https://openalex.org/W2058298068","https://openalex.org/W2059143861","https://openalex.org/W2060739883","https://openalex.org/W2063498363","https://openalex.org/W2068883870","https://openalex.org/W2073795431","https://openalex.org/W2076304606","https://openalex.org/W2076664767","https://openalex.org/W2079749054","https://openalex.org/W2079890482","https://openalex.org/W2083579475","https://openalex.org/W2083752135","https://openalex.org/W2083920471","https://openalex.org/W2089351762","https://openalex.org/W2094166526","https://openalex.org/W2095128332","https://openalex.org/W2102366043","https://openalex.org/W2103270219","https://openalex.org/W2108898741","https://openalex.org/W2109334244","https://openalex.org/W2110101223","https://openalex.org/W2117415070","https://openalex.org/W2119525425","https://openalex.org/W2125757815","https://openalex.org/W2126650951","https://openalex.org/W2129617026","https://openalex.org/W2131897453","https://openalex.org/W2134180298","https://openalex.org/W2136435696","https://openalex.org/W2138991775","https://openalex.org/W2147435466","https://openalex.org/W2152644978","https://openalex.org/W2154861477","https://openalex.org/W2156326104","https://openalex.org/W2157064933","https://openalex.org/W2166866921","https://openalex.org/W2171250577","https://openalex.org/W2172297511"],"related_works":["https://openalex.org/W4224222666","https://openalex.org/W2901147556","https://openalex.org/W7204604322","https://openalex.org/W3011252852","https://openalex.org/W2963100704","https://openalex.org/W2073673356","https://openalex.org/W1990729227","https://openalex.org/W2914138894","https://openalex.org/W4402097598","https://openalex.org/W3025202897"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}