{"id":"https://openalex.org/W1966889718","doi":"https://doi.org/10.1016/s1074-7613(00)80678-0","title":"Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development","display_name":"Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W1966889718","doi":"https://doi.org/10.1016/s1074-7613(00)80678-0","mag":"1966889718","pmid":"https://pubmed.ncbi.nlm.nih.gov/8624804"},"language":"en","primary_location":{"id":"doi:10.1016/s1074-7613(00)80678-0","doi":"https://doi.org/10.1016/s1074-7613(00)80678-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80678-0","pdf_url":"http://www.cell.com/article/S1074761300806780/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1074761300806780/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024758407","display_name":"Dirk L\u00f6ffert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Dirk L\u00f6ffert","raw_affiliation_strings":["Institute for Genetics, University of Cologne, Federal Republic of Germany","Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetics, University of Cologne, Federal Republic of Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany,","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062880957","display_name":"Andreas Ehlich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Ehlich","raw_affiliation_strings":["Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043324387","display_name":"Werner M\u00fcller","orcid":"https://orcid.org/0000-0002-1297-9725","observed_orcids":["https://orcid.org/0000-0002-1297-9725"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Werner M\u00fcller","raw_affiliation_strings":["Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012958604","display_name":"Klaus Rajewsky","orcid":"https://orcid.org/0000-0002-6633-6370","observed_orcids":["https://orcid.org/0000-0002-6633-6370"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Rajewsky","raw_affiliation_strings":["Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024758407"],"corresponding_institution_ids":["https://openalex.org/I180923762"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":7.1224,"has_fulltext":false,"cited_by_count":177,"citation_normalized_percentile":{"value":0.97606365,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"2","first_page":"133","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surrogate-light-chain","display_name":"surrogate light chain","score":0.8640000224113464},{"id":"https://openalex.org/keywords/allelic-exclusion","display_name":"allelic exclusion","score":0.9309999942779541},{"id":"https://openalex.org/keywords/immunoglobulin-heavy-chain","display_name":"immunoglobulin heavy chain","score":0.906000018119812},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.7609999775886536},{"id":"https://openalex.org/keywords/pre-b-cell-receptor","display_name":"pre-B cell receptor","score":0.847000002861023},{"id":"https://openalex.org/keywords/mu-chain","display_name":"mu chain","score":0.6000000238418579},{"id":"https://openalex.org/keywords/single-cell-pcr","display_name":"single-cell PCR","score":0.6480000019073486},{"id":"https://openalex.org/keywords/b-cell-lineage","display_name":"B-cell lineage","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C2778794311","wikidata":"https://www.wikidata.org/wiki/Q2348651","display_name":"Allelic exclusion","level":5,"score":0.9670482277870178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7715916633605957},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.7116027474403381},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6296314001083374},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.6164786219596863},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5872722268104553},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5630888938903809},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5507459044456482},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.5125164985656738},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.23310229182243347},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.23231199383735657},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23191532492637634},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2008858621120453},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0968216061592102}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015322","descriptor_name":"Gene Rearrangement, B-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054444","descriptor_name":"Immunoglobulin Light Chains, Surrogate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s1074-7613(00)80678-0","doi":"https://doi.org/10.1016/s1074-7613(00)80678-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80678-0","pdf_url":"http://www.cell.com/article/S1074761300806780/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},{"id":"pmid:8624804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8624804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/54e7ad27-bb74-4bd4-8fe2-c2cc2c19f48f","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/54e7ad27-bb74-4bd4-8fe2-c2cc2c19f48f","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"L\u00f6ffert, D, Ehlich, A, M\u00fcller, W & Rajewsky, K 1996, 'Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development', Immunity, vol. 4, no. 2, pp. 133-144. https://doi.org/10.1016/S1074-7613(00)80678-0","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3146225454","doi":null,"is_oa":false,"landing_page_url":"https://www.escholar.manchester.ac.uk/uk-ac-man-scw:1c6736","pdf_url":null,"source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Immunity","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/s1074-7613(00)80678-0","doi":"https://doi.org/10.1016/s1074-7613(00)80678-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80678-0","pdf_url":"http://www.cell.com/article/S1074761300806780/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1966889718.pdf"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W108329363","https://openalex.org/W111997425","https://openalex.org/W116950724","https://openalex.org/W1484092314","https://openalex.org/W1488045575","https://openalex.org/W1488506859","https://openalex.org/W1747312855","https://openalex.org/W1969499881","https://openalex.org/W1971025314","https://openalex.org/W1972263794","https://openalex.org/W1973717772","https://openalex.org/W1974596630","https://openalex.org/W1978854851","https://openalex.org/W1978878058","https://openalex.org/W1980889239","https://openalex.org/W1983284948","https://openalex.org/W1983763219","https://openalex.org/W1987541812","https://openalex.org/W1987754228","https://openalex.org/W1988141224","https://openalex.org/W1988671772","https://openalex.org/W1992214487","https://openalex.org/W1996967283","https://openalex.org/W1997764118","https://openalex.org/W1998276486","https://openalex.org/W2000568454","https://openalex.org/W2000647388","https://openalex.org/W2006098333","https://openalex.org/W2008710038","https://openalex.org/W2010776654","https://openalex.org/W2012621186","https://openalex.org/W2013929398","https://openalex.org/W2014957077","https://openalex.org/W2015838204","https://openalex.org/W2016898005","https://openalex.org/W2017985531","https://openalex.org/W2019513091","https://openalex.org/W2020349828","https://openalex.org/W2029436495","https://openalex.org/W2029844299","https://openalex.org/W2032348735","https://openalex.org/W2034909664","https://openalex.org/W2036859226","https://openalex.org/W2039140653","https://openalex.org/W2041217108","https://openalex.org/W2045417932","https://openalex.org/W2048240423","https://openalex.org/W2053200644","https://openalex.org/W2064421628","https://openalex.org/W2065313347","https://openalex.org/W2065549899","https://openalex.org/W2068012172","https://openalex.org/W2069501059","https://openalex.org/W2070818143","https://openalex.org/W2072415380","https://openalex.org/W2074497477","https://openalex.org/W2075174748","https://openalex.org/W2079725260","https://openalex.org/W2088423732","https://openalex.org/W2088653018","https://openalex.org/W2090080879","https://openalex.org/W2096982215","https://openalex.org/W2098977954","https://openalex.org/W2103405744","https://openalex.org/W2107263866","https://openalex.org/W2107357655","https://openalex.org/W2108082319","https://openalex.org/W2119604051","https://openalex.org/W2127534803","https://openalex.org/W2142132827","https://openalex.org/W2143319884","https://openalex.org/W2150066505","https://openalex.org/W2164422628","https://openalex.org/W2168142439","https://openalex.org/W2337738842","https://openalex.org/W2578150941","https://openalex.org/W4237023209","https://openalex.org/W4251435659","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2071532361","https://openalex.org/W1892803210","https://openalex.org/W1968500624","https://openalex.org/W2082818240","https://openalex.org/W7074174982","https://openalex.org/W4250843468","https://openalex.org/W2073263247","https://openalex.org/W1590151734","https://openalex.org/W2025818718","https://openalex.org/W1571635080"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
