{"id":"https://openalex.org/W1966822425","doi":"https://doi.org/10.1371/journal.pone.0001654","title":"The Gammaherpesvirus m2 Protein Manipulates the Fyn/Vav Pathway through a Multidocking Mechanism of Assembly","display_name":"The Gammaherpesvirus m2 Protein Manipulates the Fyn/Vav Pathway through a Multidocking Mechanism of Assembly","publication_year":2008,"publication_date":"2008-02-26","ids":{"openalex":"https://openalex.org/W1966822425","doi":"https://doi.org/10.1371/journal.pone.0001654","mag":"1966822425","pmid":"https://pubmed.ncbi.nlm.nih.gov/18301737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2244710"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0001654","doi":"https://doi.org/10.1371/journal.pone.0001654","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001654","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001654&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001654&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035550387","display_name":"Marta Pires de Miranda","orcid":"https://orcid.org/0000-0003-3733-4963","observed_orcids":["https://orcid.org/0000-0003-3733-4963"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Marta Pires de Miranda","raw_affiliation_strings":["Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal","Instituto Gulbenkian de Ci\u00eancia Oeiras Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]},{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia Oeiras Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080219817","display_name":"Marta Alenquer","orcid":"https://orcid.org/0000-0003-3062-1222","observed_orcids":["https://orcid.org/0000-0003-3062-1222"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Marta Alenquer","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026466065","display_name":"Sofia Marques","orcid":"https://orcid.org/0000-0003-1467-1529","observed_orcids":["https://orcid.org/0000-0003-1467-1529"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sofia Marques","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069057650","display_name":"L\u00e9nia Rodrigues","orcid":"https://orcid.org/0000-0003-4233-6170","observed_orcids":["https://orcid.org/0000-0003-4233-6170"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"L\u00e9nia Rodrigues","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055200016","display_name":"Filipa B. Lopes","orcid":"https://orcid.org/0000-0002-9338-4060","observed_orcids":["https://orcid.org/0000-0002-9338-4060"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Filipa Lopes","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078879898","display_name":"Xos\u00e9 R. Bustelo","orcid":"https://orcid.org/0000-0001-9398-6072","observed_orcids":["https://orcid.org/0000-0001-9398-6072"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210138819","display_name":"Centro de Investigaci\u00f3n del C\u00e1ncer","ror":"https://ror.org/04rxrdv16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210138819"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Xos\u00e9 R. Bustelo","raw_affiliation_strings":["Centro de Investigaci\u00f3n del C\u00e1ncer and Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, Consejo Superior de Investigaciones Cient\u00edficas (CSIC), University of Salamanca, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n del C\u00e1ncer and Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, Consejo Superior de Investigaciones Cient\u00edficas (CSIC), University of Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210138819"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080329523","display_name":"J. Pedro Simas","orcid":"https://orcid.org/0000-0001-6982-9253","observed_orcids":["https://orcid.org/0000-0001-6982-9253"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"J. Pedro Simas","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078879898","https://openalex.org/A5080329523"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I141596103","https://openalex.org/I184999862","https://openalex.org/I4210138819","https://openalex.org/I4392738257","https://openalex.org/I48057805"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.2097,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.87357967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":"2","first_page":"e1654","last_page":"e1654"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.6557999849319458,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.12600000202655792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.045899998396635056,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/murine-gammaherpesvirus-68","display_name":"murine gammaherpesvirus 68","score":0.9760000109672546},{"id":"https://openalex.org/keywords/m2-protein","display_name":"M2 protein","score":0.8450000286102295},{"id":"https://openalex.org/keywords/vav1","display_name":"Vav1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/fyn","display_name":"Fyn","score":0.9399999976158142},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/proline-rich-region","display_name":"proline-rich region","score":0.9049999713897705},{"id":"https://openalex.org/keywords/viral-latency","display_name":"viral latency","score":0.5479999780654907},{"id":"https://openalex.org/keywords/latent-infection","display_name":"latent infection","score":0.5580000281333923},{"id":"https://openalex.org/keywords/protein-complex-assembly","display_name":"protein complex formation","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C37686147","wikidata":"https://www.wikidata.org/wiki/Q423628","display_name":"FYN","level":4,"score":0.7959349155426025},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.731323778629303},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6059834957122803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6045450568199158},{"id":"https://openalex.org/C175818844","wikidata":"https://www.wikidata.org/wiki/Q2463389","display_name":"LYN","level":4,"score":0.5272354483604431},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5262200832366943},{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.523993194103241},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.48830199241638184},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4545227587223053},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.4408698081970215},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.41802510619163513},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.2936728596687317},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2712094783782959}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018142","descriptor_name":"Gammaherpesvirinae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051076","descriptor_name":"Proto-Oncogene Proteins c-fyn","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051567","descriptor_name":"Proto-Oncogene Proteins c-vav","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0001654","doi":"https://doi.org/10.1371/journal.pone.0001654","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001654","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001654&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2244710","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2244710","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:18301737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18301737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.283.4501","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.283.4501","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2e/ec/PLoS_ONE_2008_Feb_27_3(2)_e1654.tar.gz","raw_type":"text"},{"id":"pmh:oai:digital.csic.es:10261/5148","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/5148","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:6ecf4672375146b3bf991e6e9b244325","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6ecf4672375146b3bf991e6e9b244325","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 3, Iss 2, p e1654 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0001654","doi":"https://doi.org/10.1371/journal.pone.0001654","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0001654","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001654&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3170664214","display_name":null,"funder_award_id":"RD06/0020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4885864782","display_name":null,"funder_award_id":"RD06/0020","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5110498454","display_name":null,"funder_award_id":"SAF2006-01789","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5932924763","display_name":null,"funder_award_id":"RD06/0020","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7025610956","display_name":null,"funder_award_id":"5R01-CA73735-11","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7220831584","display_name":"Role of Vav family proteins in cell signaling and cancer","funder_award_id":"R01CA073735","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1966822425.pdf","grobid_xml":"https://content.openalex.org/works/W1966822425.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W50615129","https://openalex.org/W190337313","https://openalex.org/W1493816460","https://openalex.org/W1977248955","https://openalex.org/W1979435019","https://openalex.org/W1982665299","https://openalex.org/W1987658986","https://openalex.org/W1993807543","https://openalex.org/W1997346264","https://openalex.org/W2006182367","https://openalex.org/W2013592169","https://openalex.org/W2014408171","https://openalex.org/W2022659649","https://openalex.org/W2024431713","https://openalex.org/W2030277142","https://openalex.org/W2040839183","https://openalex.org/W2044356299","https://openalex.org/W2050064956","https://openalex.org/W2053479489","https://openalex.org/W2059726693","https://openalex.org/W2063575573","https://openalex.org/W2066784330","https://openalex.org/W2067530904","https://openalex.org/W2079053367","https://openalex.org/W2080542109","https://openalex.org/W2081920416","https://openalex.org/W2106873084","https://openalex.org/W2107478965","https://openalex.org/W2111656409","https://openalex.org/W2119246911","https://openalex.org/W2122652506","https://openalex.org/W2124055032","https://openalex.org/W2125690438","https://openalex.org/W2133559415","https://openalex.org/W2137833823","https://openalex.org/W2138823387","https://openalex.org/W2138842966","https://openalex.org/W2146573379","https://openalex.org/W2150214528","https://openalex.org/W2154106784","https://openalex.org/W2155051286","https://openalex.org/W2168635603","https://openalex.org/W2170170334","https://openalex.org/W2170913623","https://openalex.org/W2171176190","https://openalex.org/W2171432125","https://openalex.org/W2171811057","https://openalex.org/W2188464094","https://openalex.org/W4205204633","https://openalex.org/W6669785307"],"related_works":["https://openalex.org/W1975139790","https://openalex.org/W2154106784","https://openalex.org/W1974967315","https://openalex.org/W2152487631","https://openalex.org/W7100913540","https://openalex.org/W7100722726","https://openalex.org/W6996996361","https://openalex.org/W2276581492","https://openalex.org/W1977031868","https://openalex.org/W2157244708"],"abstract_inverted_index":{"To":[0],"establish":[1],"latent":[2],"infections":[3],"in":[4,9,108,114,151,162,197,243],"B-cells,":[5],"gammaherpesviruses":[6],"express":[7],"proteins":[8,88,150],"the":[10,14,24,39,43,57,73,83,120,129,143,158,165,179,183,198,204,217,230,235,249,253],"infected":[11],"B-cells":[12,163],"of":[13,23,45,59,70,86,122,132,146,160,168,181,206,208,220,252],"host":[15,254],"that":[16,37,56,82,119,157,177,203,229],"spuriously":[17],"activate":[18],"signalling":[19,149],"pathways":[20],"located":[21],"downstream":[22],"B-cell":[25],"receptor.":[26],"One":[27],"such":[28],"protein":[29],"is":[30,214],"M2,":[31],"a":[32,66,90,137,174,244],"murine":[33,221],"gammaherpesvirus":[34],"68-encoded":[35],"molecule":[36],"activates":[38],"Vav1/Rac1":[40],"pathway":[41],"via":[42],"formation":[44,58],"trimolecular":[46],"complexes":[47],"with":[48,194],"Scr":[49],"family":[50],"members.":[51],"Previous":[52],"reports":[53],"have":[54],"shown":[55],"this":[60],"heteromolecular":[61],"complex":[62],"involves":[63],"interactions":[64],"between":[65],"proline":[67,187,239],"rich":[68,188,240],"region":[69,189,241],"M2":[71,161,184,211,231,238],"and":[72,75,99,111,135,170,186,234],"Vav1":[74,134,169],"Fyn":[76,107],"SH3":[77],"domains.":[78],"Here,":[79],"we":[80,201],"show":[81,202],"optimal":[84,144],"association":[85,145],"these":[87,147,209,226],"requires":[89,178],"second":[91],"structural":[92],"motif":[93,233],"encompassing":[94],"two":[95,148,210],"tyrosine":[96,166],"residues":[97,102],"(Tyr120":[98],"129).":[100],"These":[101],"are":[103],"inducibly":[104],"phosphorylated":[105,113],"by":[106],"non-hematopoietic":[109],"cells":[110],"constitutively":[112],"B-cells.":[115],"We":[116],"also":[117],"demonstrate":[118],"phosphorylation":[121,167],"Tyr120":[123],"creates":[124],"specific":[125],"docking":[126,212],"sites":[127],"for":[128,142,216],"SH2":[130],"domains":[131],"both":[133,182],"Fyn,":[136],"condition":[138],"sine":[139],"qua":[140],"non":[141],"vivo.":[152],"Interestingly,":[153],"signaling":[154,172,250],"experiments":[155],"indicate":[156,228],"expression":[159],"promotes":[164],"additional":[171],"proteins,":[173],"biological":[175],"process":[176],"integrity":[180,205],"phosphotyrosine":[185,232],"motifs.":[190],"By":[191],"infecting":[192],"mice":[193],"viruses":[195],"mutated":[196],"m2":[199],"locus,":[200],"each":[207],"motifs":[213],"essential":[215],"early":[218],"steps":[219],"gammaherpesvirus-68":[222],"latency.":[223],"Taken":[224],"together,":[225],"results":[227],"previously":[236],"described":[237],"work":[242],"concerted":[245],"manner":[246],"to":[247],"manipulate":[248],"machinery":[251],"B-cell.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}