{"id":"https://openalex.org/W1966762655","doi":"https://doi.org/10.1109/emb.2007.907090","title":"Circadian Rhythm Regulations of the Cardiovascular System in Rats and Mice","display_name":"Circadian Rhythm Regulations of the Cardiovascular System in Rats and Mice","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W1966762655","doi":"https://doi.org/10.1109/emb.2007.907090","mag":"1966762655","pmid":"https://pubmed.ncbi.nlm.nih.gov/18189084"},"language":"en","primary_location":{"id":"doi:10.1109/emb.2007.907090","doi":"https://doi.org/10.1109/emb.2007.907090","is_oa":false,"landing_page_url":"https://doi.org/10.1109/emb.2007.907090","pdf_url":null,"source":{"id":"https://openalex.org/S20334542","display_name":"IEEE Engineering in Medicine and Biology Magazine","issn_l":"0739-5175","issn":["0739-5175","1937-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310322504","host_organization_name":"IEEE Engineering in Medicine and Biology Society","host_organization_lineage":["https://openalex.org/P4310322504","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Engineering in Medicine and Biology Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Engineering in Medicine and Biology Magazine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111802303","display_name":"Bj\u00f6rn Lemmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"B. Lemmer","raw_affiliation_strings":["Institute of Pharmacology and Toxicology, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany. bjoern.lemmer@pharmtox.uni-heidelberg.de","Inst. of Pharmacology & Toxicology, Ruprecht-Karls-Univ. of Heidelberg, Mannheim"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany. bjoern.lemmer@pharmtox.uni-heidelberg.de","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Inst. of Pharmacology & Toxicology, Ruprecht-Karls-Univ. of Heidelberg, Mannheim","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111802303"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":0.0689,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.04804805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"6","first_page":"30","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cardiovascular-system","display_name":"cardiovascular system","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7350000143051147},{"id":"https://openalex.org/keywords/rat-strains","display_name":"rat strains","score":0.6399999856948853},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5830000042915344},{"id":"https://openalex.org/keywords/jet-lag","display_name":"jet lag","score":0.6570000052452087},{"id":"https://openalex.org/keywords/light-dark-cycle","display_name":"light-dark cycle","score":0.8730000257492065},{"id":"https://openalex.org/keywords/free-running-conditions","display_name":"free-running conditions","score":0.6610000133514404},{"id":"https://openalex.org/keywords/biological-clock","display_name":"biological clock","score":0.8410000205039978},{"id":"https://openalex.org/keywords/radio-telemetry","display_name":"radio telemetry","score":0.6959999799728394},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8519617319107056},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.6398353576660156},{"id":"https://openalex.org/C2779027399","wikidata":"https://www.wikidata.org/wiki/Q204170","display_name":"Darkness","level":2,"score":0.6288393139839172},{"id":"https://openalex.org/C187765855","wikidata":"https://www.wikidata.org/wiki/Q506874","display_name":"Chronobiology","level":3,"score":0.5640243887901306},{"id":"https://openalex.org/C84302363","wikidata":"https://www.wikidata.org/wiki/Q16154683","display_name":"Biological clock","level":3,"score":0.5090855956077576},{"id":"https://openalex.org/C68387754","wikidata":"https://www.wikidata.org/wiki/Q7271585","display_name":"Schedule","level":2,"score":0.46859636902809143},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.4332219064235687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42343616485595703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3835040032863617},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3623815178871155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3454849421977997},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32360780239105225},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23958683013916016},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002320","descriptor_name":"Cardiovascular Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/emb.2007.907090","doi":"https://doi.org/10.1109/emb.2007.907090","is_oa":false,"landing_page_url":"https://doi.org/10.1109/emb.2007.907090","pdf_url":null,"source":{"id":"https://openalex.org/S20334542","display_name":"IEEE Engineering in Medicine and Biology Magazine","issn_l":"0739-5175","issn":["0739-5175","1937-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310322504","host_organization_name":"IEEE Engineering in Medicine and Biology Society","host_organization_lineage":["https://openalex.org/P4310322504","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Engineering in Medicine and Biology Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Engineering in Medicine and Biology Magazine","raw_type":"journal-article"},{"id":"pmid:18189084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18189084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society","raw_type":"Journal Article"},{"id":"mag:2182598681","doi":null,"is_oa":false,"landing_page_url":"http://ieeexplore.ieee.org/iel5/51/4385552/04385567.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1969653160","https://openalex.org/W1970355769","https://openalex.org/W1984638957","https://openalex.org/W1988315801","https://openalex.org/W2015139164","https://openalex.org/W2019439326","https://openalex.org/W2032549492","https://openalex.org/W2036444715","https://openalex.org/W2051574299","https://openalex.org/W2054777075","https://openalex.org/W2057522076","https://openalex.org/W2060242667","https://openalex.org/W2065558735","https://openalex.org/W2070445081","https://openalex.org/W2082089814","https://openalex.org/W2083696373","https://openalex.org/W2086089337","https://openalex.org/W2102669031","https://openalex.org/W2104725749","https://openalex.org/W2117126455","https://openalex.org/W2126539610","https://openalex.org/W2151468131","https://openalex.org/W2155923518","https://openalex.org/W2163914191","https://openalex.org/W2169796892","https://openalex.org/W2196751099","https://openalex.org/W2221064703","https://openalex.org/W6688688606"],"related_works":["https://openalex.org/W2099250836","https://openalex.org/W2735045551","https://openalex.org/W2799068806","https://openalex.org/W3196422446","https://openalex.org/W2086089337","https://openalex.org/W4387543026","https://openalex.org/W4378648997","https://openalex.org/W2076822143","https://openalex.org/W2026863851","https://openalex.org/W2015171684"],"abstract_inverted_index":{"The":[0,86],"objective":[1],"of":[2,14,20,27,46,56,78,88,108,128],"this":[3],"paper":[4],"is":[5],"to":[6,95,134],"get":[7],"more":[8],"insight":[9],"into":[10],"the":[11,15,54,57,79,106,113,126,136],"circadian":[12],"regulation":[13],"cardiovascular":[16,98],"system,":[17],"various":[18,97],"strains":[19],"rats":[21,60],"were":[22,34,63],"studied":[23],"as":[24,72,74],"animal":[25],"models":[26],"human":[28],"primary":[29],"and":[30,61,123],"secondary":[31],"hypertension.":[32],"Experiments":[33],"performed":[35],"under":[36,41,65],"highly":[37],"controlled":[38],"environmental":[39],"conditions":[40,67,114],"a":[42,76,83],"light:dark":[43],"(LD)":[44],"schedule":[45],"12":[47,49],"h":[48],"min.":[50],"To":[51],"test":[52],"for":[53],"contribution":[55],"biological":[58],"clock(s),":[59],"mice":[62],"monitored":[64],"free-run":[66],"in":[68,100,115],"total":[69],"darkness":[70],"(DD)":[71],"well":[73],"after":[75],"shift":[77],"LD":[80,118],"cycle":[81],"simulating":[82],"westward":[84],"jet-lag.":[85],"availability":[87],"implantable":[89],"radiotelemetric":[90],"devices":[91],"made":[92],"it":[93],"possible":[94],"study":[96,125],"functions":[99],"freely":[101],"moving,":[102],"unrestrained":[103],"animals.":[104],"With":[105],"use":[107],"radiotelemetry,":[109],"one":[110],"can":[111],"simulate":[112],"rodents":[116],"(changing":[117],"conditions,":[119],"inducing":[120],"light":[121],"shifts)":[122],"finally":[124],"effects":[127],"drugs,":[129],"which":[130],"might":[131],"be":[132],"helpful":[133],"ameliorate":[135],"symptoms.":[137]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}