{"id":"https://openalex.org/W1966732899","doi":"https://doi.org/10.1002/jcph.407","title":"Beyond peptides and mAbs\u2014current status and future perspectives for biotherapeutics with novel constructs","display_name":"Beyond peptides and mAbs\u2014current status and future perspectives for biotherapeutics with novel constructs","publication_year":2015,"publication_date":"2015-02-23","ids":{"openalex":"https://openalex.org/W1966732899","doi":"https://doi.org/10.1002/jcph.407","mag":"1966732899","pmid":"https://pubmed.ncbi.nlm.nih.gov/25707963","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4340091"},"language":"en","primary_location":{"id":"doi:10.1002/jcph.407","doi":"https://doi.org/10.1002/jcph.407","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcph.407","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4340091","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027034093","display_name":"Dalal S. Aldeghaither","orcid":"https://orcid.org/0000-0003-1891-6394","observed_orcids":["https://orcid.org/0000-0003-1891-6394"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dalal AlDeghaither","raw_affiliation_strings":["Georgetown Lombardi Comprehensive Cancer Center Department of Oncology Georgetown University Medical Center Washington DC USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown Lombardi Comprehensive Cancer Center Department of Oncology Georgetown University Medical Center Washington DC USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024146796","display_name":"Brandon George Smaglo","orcid":"https://orcid.org/0000-0002-8814-8004","observed_orcids":["https://orcid.org/0000-0002-8814-8004"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon G. Smaglo","raw_affiliation_strings":["Medstar Georgetown University Hospital Department of Medicine, Division of Hematology/Oncology Washington DC USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medstar Georgetown University Hospital Department of Medicine, Division of Hematology/Oncology Washington DC USA","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045107557","display_name":"Louis M. Weiner","orcid":"https://orcid.org/0000-0001-5192-0710","observed_orcids":["https://orcid.org/0000-0001-5192-0710"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Louis M. Weiner","raw_affiliation_strings":["Georgetown Lombardi Comprehensive Cancer Center Department of Oncology Georgetown University Medical Center Washington DC USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown Lombardi Comprehensive Cancer Center Department of Oncology Georgetown University Medical Center Washington DC USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045107557"],"corresponding_institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.893,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.62466667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"55","issue":"S3","first_page":"S4","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9760000109672546},{"id":"https://openalex.org/keywords/therapeutic-peptides","display_name":"peptide therapeutics","score":0.8460000157356262},{"id":"https://openalex.org/keywords/antibody-engineering","display_name":"antibody engineering","score":0.5460000038146973},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5830000042915344},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6909999847412109},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.4009999930858612},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.4860000014305115},{"id":"https://openalex.org/keywords/imaging-probes","display_name":"imaging agents","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6664438247680664},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.47325995564460754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45984920859336853},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4497520625591278},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42954668402671814},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.36406874656677246},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35186830163002014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2231294810771942},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1730271279811859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15449729561805725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.099315345287323}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jcph.407","doi":"https://doi.org/10.1002/jcph.407","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcph.407","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:25707963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25707963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4340091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4340091","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Clin Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4340091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4340091","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Clin Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1334669072","display_name":null,"funder_award_id":"CA 50633","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3591767037","display_name":null,"funder_award_id":"CA51880","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4824609705","display_name":"ENGINEERED ANTIBREAST CANCER SINGLE CHAIN FV IMMUNOTOXIN","funder_award_id":"U01CA051880","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6078543242","display_name":"Antibody-Targeted Cancer Immunotherapy","funder_award_id":"R01CA050633","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000862544","display_name":"Georgetown University Lombardi Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA051008","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":214,"referenced_works":["https://openalex.org/W21149459","https://openalex.org/W76525280","https://openalex.org/W98712137","https://openalex.org/W113695330","https://openalex.org/W201357455","https://openalex.org/W1521321020","https://openalex.org/W1529809181","https://openalex.org/W1537791451","https://openalex.org/W1556136319","https://openalex.org/W1580407891","https://openalex.org/W1716395694","https://openalex.org/W1821781403","https://openalex.org/W1914082619","https://openalex.org/W1917936346","https://openalex.org/W1937551881","https://openalex.org/W1937564833","https://openalex.org/W1939186328","https://openalex.org/W1965205681","https://openalex.org/W1966122087","https://openalex.org/W1969548871","https://openalex.org/W1969595441","https://openalex.org/W1971724092","https://openalex.org/W1972729210","https://openalex.org/W1972848082","https://openalex.org/W1973450171","https://openalex.org/W1976148354","https://openalex.org/W1977273255","https://openalex.org/W1979839074","https://openalex.org/W1984007340","https://openalex.org/W1984342356","https://openalex.org/W1985102822","https://openalex.org/W1986216391","https://openalex.org/W1986445948","https://openalex.org/W1986994125","https://openalex.org/W1988377672","https://openalex.org/W1989971414","https://openalex.org/W1990030711","https://openalex.org/W1993421446","https://openalex.org/W1993838164","https://openalex.org/W1995278782","https://openalex.org/W1996144185","https://openalex.org/W1997634164","https://openalex.org/W1998162097","https://openalex.org/W2000000541","https://openalex.org/W2000436105","https://openalex.org/W2001363722","https://openalex.org/W2001850157","https://openalex.org/W2004964129","https://openalex.org/W2005393061","https://openalex.org/W2008635725","https://openalex.org/W2008925833","https://openalex.org/W2011695495","https://openalex.org/W2011912935","https://openalex.org/W2012328380","https://openalex.org/W2012875979","https://openalex.org/W2017665745","https://openalex.org/W2018249770","https://openalex.org/W2018478612","https://openalex.org/W2023848476","https://openalex.org/W2024298562","https://openalex.org/W2024890197","https://openalex.org/W2025478673","https://openalex.org/W2027269306","https://openalex.org/W2030424522","https://openalex.org/W2030522563","https://openalex.org/W2031193073","https://openalex.org/W2033079214","https://openalex.org/W2033660436","https://openalex.org/W2038720675","https://openalex.org/W2038809664","https://openalex.org/W2040935952","https://openalex.org/W2041197793","https://openalex.org/W2043944189","https://openalex.org/W2043970203","https://openalex.org/W2044567178","https://openalex.org/W2044676804","https://openalex.org/W2050105922","https://openalex.org/W2050279724","https://openalex.org/W2050949125","https://openalex.org/W2051240173","https://openalex.org/W2051363346","https://openalex.org/W2052143929","https://openalex.org/W2056358717","https://openalex.org/W2056405796","https://openalex.org/W2057064048","https://openalex.org/W2058015212","https://openalex.org/W2059165960","https://openalex.org/W2060963594","https://openalex.org/W2061641422","https://openalex.org/W2062692422","https://openalex.org/W2062756251","https://openalex.org/W2064252188","https://openalex.org/W2065620086","https://openalex.org/W2065654184","https://openalex.org/W2065849320","https://openalex.org/W2066671159","https://openalex.org/W2067005226","https://openalex.org/W2071843728","https://openalex.org/W2074348188","https://openalex.org/W2076207455","https://openalex.org/W2076859770","https://openalex.org/W2077158310","https://openalex.org/W2078863172","https://openalex.org/W2081399278","https://openalex.org/W2083483697","https://openalex.org/W2086421438","https://openalex.org/W2086766201","https://openalex.org/W2086889737","https://openalex.org/W2087094217","https://openalex.org/W2087480443","https://openalex.org/W2087829760","https://openalex.org/W2089282467","https://openalex.org/W2090383712","https://openalex.org/W2092499431","https://openalex.org/W2093783077","https://openalex.org/W2095615236","https://openalex.org/W2095783131","https://openalex.org/W2097121246","https://openalex.org/W2097203662","https://openalex.org/W2097478805","https://openalex.org/W2099145932","https://openalex.org/W2099395323","https://openalex.org/W2099973504","https://openalex.org/W2100283328","https://openalex.org/W2100439220","https://openalex.org/W2102095362","https://openalex.org/W2102505853","https://openalex.org/W2106215754","https://openalex.org/W2106787323","https://openalex.org/W2107990794","https://openalex.org/W2111116820","https://openalex.org/W2111497685","https://openalex.org/W2112845420","https://openalex.org/W2113790964","https://openalex.org/W2113818241","https://openalex.org/W2113873088","https://openalex.org/W2114063509","https://openalex.org/W2114282952","https://openalex.org/W2115735904","https://openalex.org/W2117099303","https://openalex.org/W2118994799","https://openalex.org/W2120043042","https://openalex.org/W2120291439","https://openalex.org/W2120661754","https://openalex.org/W2121357123","https://openalex.org/W2121427407","https://openalex.org/W2123023182","https://openalex.org/W2123462156","https://openalex.org/W2124016062","https://openalex.org/W2124472420","https://openalex.org/W2124575836","https://openalex.org/W2125781036","https://openalex.org/W2128273976","https://openalex.org/W2128964123","https://openalex.org/W2129515878","https://openalex.org/W2130255732","https://openalex.org/W2131082981","https://openalex.org/W2132353981","https://openalex.org/W2132545630","https://openalex.org/W2132562995","https://openalex.org/W2134758761","https://openalex.org/W2136032819","https://openalex.org/W2139709150","https://openalex.org/W2139714860","https://openalex.org/W2139891818","https://openalex.org/W2139983745","https://openalex.org/W2140758955","https://openalex.org/W2143562636","https://openalex.org/W2144425748","https://openalex.org/W2145453495","https://openalex.org/W2147581636","https://openalex.org/W2148177811","https://openalex.org/W2149908785","https://openalex.org/W2150648608","https://openalex.org/W2150678612","https://openalex.org/W2151730005","https://openalex.org/W2151813007","https://openalex.org/W2152390135","https://openalex.org/W2153297361","https://openalex.org/W2153400235","https://openalex.org/W2153847455","https://openalex.org/W2154373485","https://openalex.org/W2154559615","https://openalex.org/W2155256323","https://openalex.org/W2156671071","https://openalex.org/W2159819161","https://openalex.org/W2159931806","https://openalex.org/W2159967578","https://openalex.org/W2162872121","https://openalex.org/W2163657830","https://openalex.org/W2165011173","https://openalex.org/W2165437317","https://openalex.org/W2168340462","https://openalex.org/W2168750246","https://openalex.org/W2169578616","https://openalex.org/W2169610187","https://openalex.org/W2171293165","https://openalex.org/W2182412535","https://openalex.org/W2225363868","https://openalex.org/W2246437856","https://openalex.org/W2247406157","https://openalex.org/W2256690185","https://openalex.org/W2293532321","https://openalex.org/W2318605753","https://openalex.org/W2329968121","https://openalex.org/W2331193224","https://openalex.org/W2413791977","https://openalex.org/W2546853358","https://openalex.org/W2560283468","https://openalex.org/W2560367415","https://openalex.org/W2994508484","https://openalex.org/W4211051615","https://openalex.org/W4237637069","https://openalex.org/W4301806686"],"related_works":["https://openalex.org/W1991160477","https://openalex.org/W4311524477","https://openalex.org/W55390518","https://openalex.org/W3013160292","https://openalex.org/W2065300548","https://openalex.org/W3135522636","https://openalex.org/W7172261139","https://openalex.org/W2920967947","https://openalex.org/W4387115981","https://openalex.org/W7166497520"],"abstract_inverted_index":{"Biotherapeutics":[0],"are":[1,19],"attractive":[2],"anti-cancer":[3],"agents":[4],"due":[5],"to":[6,14,29,60,80,82],"their":[7],"high":[8],"specificity":[9],"and":[10,45,63,72,87,102,104],"limited":[11],"toxicity":[12],"compared":[13],"conventional":[15],"small":[16],"molecules.":[17],"Antibodies":[18],"widely":[20],"used":[21],"in":[22,42],"cancer":[23],"therapy,":[24],"either":[25],"directly":[26],"or":[27],"conjugated":[28],"a":[30,106],"cytotoxic":[31],"payload.":[32],"Peptide":[33],"therapies,":[34],"though":[35],"not":[36],"as":[37],"prevalent,":[38],"have":[39,58,75],"been":[40],"utilized":[41],"hormonal":[43],"therapy":[44],"imaging.":[46],"The":[47],"limitations":[48],"associated":[49],"with":[50],"unmodified":[51],"forms":[52],"of":[53,56,65,99,111],"both":[54],"types":[55],"biotherapeutics":[57,112],"led":[59],"the":[61,77,96,109],"design":[62],"development":[64],"novel":[66,114],"structures,":[67],"which":[68],"incorporate":[69],"key":[70],"features":[71],"structures":[73],"that":[74],"improved":[76],"molecules'":[78],"abilities":[79],"bind":[81],"tumor":[83],"targets,":[84],"avoid":[85],"degradation,":[86],"exhibit":[88],"favorable":[89],"pharmacokinetics.":[90],"In":[91],"this":[92],"review,":[93],"we":[94],"highlight":[95],"current":[97],"status":[98],"monoclonal":[100],"antibodies":[101],"peptides,":[103],"provide":[105],"perspective":[107],"on":[108],"future":[110],"using":[113],"constructs.":[115]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}