{"id":"https://openalex.org/W1966646293","doi":"https://doi.org/10.2174/13816128113199990064","title":"Molecular Characterization of the Hetero-Assembly of \u03b2-Amyloid Peptide with Islet Amyloid Polypeptide","display_name":"Molecular Characterization of the Hetero-Assembly of \u03b2-Amyloid Peptide with Islet Amyloid Polypeptide","publication_year":2014,"publication_date":"2014-03-08","ids":{"openalex":"https://openalex.org/W1966646293","doi":"https://doi.org/10.2174/13816128113199990064","mag":"1966646293","pmid":"https://pubmed.ncbi.nlm.nih.gov/23713771"},"language":"en","primary_location":{"id":"doi:10.2174/13816128113199990064","doi":"https://doi.org/10.2174/13816128113199990064","is_oa":false,"landing_page_url":"https://doi.org/10.2174/13816128113199990064","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017146367","display_name":"Limei Yan","orcid":"https://orcid.org/0000-0003-2212-3864","observed_orcids":["https://orcid.org/0000-0003-2212-3864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Mei Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044242493","display_name":"Aleksandra Velkova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aleksandra Velkova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032494718","display_name":"Aphrodite Kapurniotu","orcid":"https://orcid.org/0000-0001-6124-7232","observed_orcids":["https://orcid.org/0000-0001-6124-7232"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Aphrodite Kapurniotu","raw_affiliation_strings":["Division of Peptide Biochemistry, Technische Universitat Munchen, Emil-Erlenmeyer-Forum 5, D- 85354 Freising, Germany. akapurniotu@wzw.tum.de","Division of Peptide Biochemistry, Technische Universitat Munchen, Emil-Erlenmeyer-Forum 5, D- 85354 Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Peptide Biochemistry, Technische Universitat Munchen, Emil-Erlenmeyer-Forum 5, D- 85354 Freising, Germany. akapurniotu@wzw.tum.de","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Division of Peptide Biochemistry, Technische Universitat Munchen, Emil-Erlenmeyer-Forum 5, D- 85354 Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5905,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.79363029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"20","issue":"8","first_page":"1182","last_page":"1191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8560000061988831},{"id":"https://openalex.org/keywords/amylin","display_name":"amylin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amyloidogenesis","display_name":"amyloidogenesis","score":0.796999990940094},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6850000023841858},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.6620000004768372},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amyloid-seeding","display_name":"amyloid seeding","score":0.5879999995231628},{"id":"https://openalex.org/keywords/peptide-self-assembly","display_name":"peptide self-assembly","score":0.6240000128746033},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.7507535219192505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7291567921638489},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.7096512913703918},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6913048028945923},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.6492190361022949},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6464896202087402},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5258270502090454},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5133430361747742},{"id":"https://openalex.org/C2780705028","wikidata":"https://www.wikidata.org/wiki/Q424643","display_name":"Amylin","level":4,"score":0.49535027146339417},{"id":"https://openalex.org/C2909607560","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid disease","level":5,"score":0.44470441341400146},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4440491199493408},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3524239957332611},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.33238619565963745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1570921242237091},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.14425763487815857},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.11667168140411377},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08198434114456177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07878804206848145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06010580062866211},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05728042125701904},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/13816128113199990064","doi":"https://doi.org/10.2174/13816128113199990064","is_oa":false,"landing_page_url":"https://doi.org/10.2174/13816128113199990064","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:23713771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23713771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4221041619","https://openalex.org/W2913130019","https://openalex.org/W3202889766","https://openalex.org/W4401972684","https://openalex.org/W4229456350","https://openalex.org/W2415975637","https://openalex.org/W4404961439","https://openalex.org/W2625093790","https://openalex.org/W1969345397","https://openalex.org/W2749937517"],"abstract_inverted_index":{"Increasing":[0],"amounts":[1],"of":[2,33,40,47,59,78,97,183,188,200,235],"evidence":[3,164],"suggest":[4],"that":[5,106,165],"Alzheimer's":[6],"disease":[7],"(AD)":[8],"and":[9,35,49,81,89,101,112,120,131,145,168,178,203,212,221,229,237],"type":[10],"2":[11],"diabetes":[12],"(T2D)":[13],"are":[14,115,172],"linked":[15],"to":[16,66,117,140,174,209,216,224,232],"each":[17],"other.":[18],"We":[19,104],"have":[20],"recently":[21],"identified":[22],"in":[23,44,122,126,148,190],"vitro":[24],"a":[25,73,79,149,180,196,217],"high":[26],"affinity":[27],"interaction":[28,55],"between":[29],"\u03b2-amyloid":[30],"peptide":[31],"(A\u03b2)":[32],"AD":[34,236],"islet":[36],"amyloid":[37],"polypeptide":[38],"(IAPP)":[39],"T2D":[41],"which":[42],"results":[43,194],"the":[45,94,184,201,233],"formation":[46],"non-fibrillar":[48,130,167],"non-cytotoxic":[50],"A\u03b2-IAPP":[51,54,123,133,170],"hetero-oligomers.":[52],"The":[53],"delays":[56],"cytotoxic":[57,113,146,226],"self-association":[58,227],"both":[60],"polypeptides":[61],"albeit":[62],"it":[63],"is":[64],"unable":[65],"block":[67],"it.":[68],"In":[69],"this":[70,191],"context,":[71],"IAPP-GI,":[72],"soluble":[74],"conformationally":[75],"constrained":[76],"mimic":[77],"non-amyloidogenic":[80],"non-toxic":[82,132,169],"IAPP":[83,100,110,156,189,204,222],"conformer,":[84],"completely":[85],"blocks":[86],"A\u03b2":[87,98,108,154,202,220],"amyloidogenesis":[88,119],"cytotoxicity.":[90],"Here":[91],"we":[92],"studied":[93],"hetero-association":[95,223],"pathways":[96,228],"with":[99,102],"IAPP-GI.":[103],"found":[105,139],"preformed":[107],"or":[109,155],"fibrils":[111],"assemblies":[114,147],"able":[116,173],"seed":[118],"cytotoxicity":[121],"but":[124,134],"not":[125,135],"A\u03b2-IAPP-GI":[127,136],"solutions.":[128],"Initially":[129],"hetero-oligomers":[137,171],"were":[138],"further":[141],"aggregate":[142],"into":[143,176],"hetero-fibrils":[144,177],"process":[150],"strongly":[151],"enhanced":[152],"under":[153],"self-assembly":[157],"promoting":[158],"conditions.":[159],"Importantly,":[160],"our":[161],"studies":[162],"provided":[163],"initially":[166],"misfold":[175],"indicated":[179],"crucial":[181],"role":[182],"strong":[185],"amyloidogenic":[186],"character":[187],"process.":[192],"These":[193],"uncover":[195],"novel":[197],"molecular":[198],"property":[199],"sequences,":[205],"i.e.":[206],"their":[207,225],"ability":[208],"form":[210],"hetero-fibrils,":[211],"offer":[213],"mechanistic":[214],"support":[215],"model":[218],"linking":[219],"thus":[230],"likely":[231],"pathogenesis":[234],"T2D.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
