{"id":"https://openalex.org/W1966628133","doi":"https://doi.org/10.1158/1538-7445.am2011-4634","title":"Abstract 4634: Association between reproductive factors and urinary estrogen metabolites in premenopausal women","display_name":"Abstract 4634: Association between reproductive factors and urinary estrogen metabolites in premenopausal women","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W1966628133","doi":"https://doi.org/10.1158/1538-7445.am2011-4634","mag":"1966628133"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-4634","doi":"https://doi.org/10.1158/1538-7445.am2011-4634","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-4634","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059302865","display_name":"Ren\u00e9e T. Fortner","orcid":"https://orcid.org/0000-0002-1426-8505","observed_orcids":["https://orcid.org/0000-0002-1426-8505"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rene\u0301e Turzanski Fortner","raw_affiliation_strings":["1Harvard University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Harvard University, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014551852","display_name":"A. Heather Eliassen","orcid":"https://orcid.org/0000-0002-3961-6609","observed_orcids":["https://orcid.org/0000-0002-3961-6609"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Heather Eliassen","raw_affiliation_strings":["1Harvard University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Harvard University, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109159770","display_name":"Xia Xu","orcid":"https://orcid.org/0000-0002-7806-291X","observed_orcids":["https://orcid.org/0000-0002-7806-291X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xia Xu","raw_affiliation_strings":["2SAIC-Frederick, Inc, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2SAIC-Frederick, Inc, Frederick, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023179121","display_name":"Catherine Schairer","orcid":"https://orcid.org/0000-0001-7671-4972","observed_orcids":["https://orcid.org/0000-0001-7671-4972"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Schairer","raw_affiliation_strings":["3National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019010663","display_name":"Timothy D. Veenstra","orcid":"https://orcid.org/0000-0003-2941-0225","observed_orcids":["https://orcid.org/0000-0003-2941-0225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy D. Veenstra","raw_affiliation_strings":["2SAIC-Frederick, Inc, Frederick, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2SAIC-Frederick, Inc, Frederick, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053374075","display_name":"Regina G. Ziegler","orcid":"https://orcid.org/0000-0002-5100-9852","observed_orcids":["https://orcid.org/0000-0002-5100-9852"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Regina G. Ziegler","raw_affiliation_strings":["3National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008373933","display_name":"Susan E. Hankinson","orcid":"https://orcid.org/0000-0001-9155-3767","observed_orcids":["https://orcid.org/0000-0001-9155-3767"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan E. Hankinson","raw_affiliation_strings":["1Harvard University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Harvard University, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"4634","last_page":"4634"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reproductive-factors","display_name":"reproductive factors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/urinary-estrogen-metabolites","display_name":"urinary estrogen metabolites","score":0.9919999837875366},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.8240000009536743},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.9750000238418579},{"id":"https://openalex.org/keywords/menstrual-cycle-length","display_name":"menstrual cycle length","score":0.8529999852180481},{"id":"https://openalex.org/keywords/menstrual-cycle-pattern","display_name":"menstrual cycle pattern","score":0.925000011920929},{"id":"https://openalex.org/keywords/age-at-menarche","display_name":"age at menarche","score":0.9279999732971191},{"id":"https://openalex.org/keywords/parity","display_name":"parity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/age-at-first-birth","display_name":"age at first birth","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oral-contraceptives","display_name":"oral contraceptives","score":0.9430000185966492},{"id":"https://openalex.org/keywords/breastfeeding","display_name":"breastfeeding","score":0.9959999918937683},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.7950000166893005},{"id":"https://openalex.org/keywords/estrone","display_name":"estrone","score":0.949999988079071},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.734000027179718},{"id":"https://openalex.org/keywords/nurses-health-study-ii","display_name":"Nurses' Health Study II","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7069951295852661},{"id":"https://openalex.org/C2779058012","wikidata":"https://www.wikidata.org/wiki/Q83864","display_name":"Menstrual cycle","level":3,"score":0.662857174873352},{"id":"https://openalex.org/C4258228","wikidata":"https://www.wikidata.org/wiki/Q492514","display_name":"Menarche","level":2,"score":0.592587411403656},{"id":"https://openalex.org/C143228043","wikidata":"https://www.wikidata.org/wiki/Q2363481","display_name":"Luteal phase","level":3,"score":0.5390446186065674},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.5368125438690186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5013620853424072},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4783841371536255},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.47180095314979553},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45368021726608276},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4015507698059082},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39159542322158813},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2633880376815796},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2475728988647461}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-4634","doi":"https://doi.org/10.1158/1538-7445.am2011-4634","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-4634","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2153495192","https://openalex.org/W7098626538","https://openalex.org/W2317877909","https://openalex.org/W2140529599","https://openalex.org/W7099364525","https://openalex.org/W2065964048","https://openalex.org/W2158551759","https://openalex.org/W2112813818","https://openalex.org/W3215188608","https://openalex.org/W2163151567"],"abstract_inverted_index":{"Abstract":[0],"Little":[1],"is":[2,28,40],"known":[3,41],"about":[4,42],"relationships":[5],"among":[6],"reproductive":[7,127,358],"factors,":[8],"individual":[9,52],"estrogens/estrogen":[10],"metabolites":[11],"(EM)":[12],"and":[13,25,33,62,92,104,151,164,167,170,176,194,196,226,261,273,301,305,334,365,390,392],"patterns":[14,366],"of":[15,45,51,85,100,114,216,256,354,367,377,384,412,417],"estrogen":[16,24,46,368,401],"metabolism.":[17,47],"While":[18],"the":[19,43,83,119,243,281,320,327,355,373,413,418],"positive":[20],"association":[21],"between":[22,269,357],"circulating":[23],"breast":[26,60,362],"cancer":[27,363],"established":[29],"in":[30,35,78,111,361],"postmenopausal":[31],"women":[32,117,203,208],"suggested":[34],"premenopausal":[36,116,385],"women,":[37,386],"relatively":[38],"little":[39],"role":[44],"The":[48,266],"hypothesized":[49],"effects":[50],"EM":[53,110,136,154,218,224,264,299,323,344],"vary,":[54],"with":[55,106,147,204,209,253,295,342,400],"some":[56],"thought":[57,64],"to":[58,65,202,240,284,324],"stimulate":[59],"proliferation":[61],"others":[63],"be":[66],"mutagenic.":[67],"These":[68,347],"hypotheses,":[69],"derived":[70],"from":[71,235,278,317],"experimental":[72],"research,":[73],"have":[74],"been":[75],"minimally":[76],"explored":[77],"epidemiologic":[79],"studies.":[80],"We":[81],"examined":[82],"associations":[84,187,356],"age":[86,95,197,289,312,335,393],"at":[87,96,198,290,313,336,394],"menarche,":[88],"menstrual":[89,191,206,248,387],"cycle":[90,192,249,388],"length":[91,195,250,389],"pattern,":[93],"parity,":[94],"first":[97,199,291,314,395],"birth,":[98],"use":[99],"oral":[101],"contraceptives":[102],"(OC)":[103],"breastfeeding":[105],"luteal":[107,375],"phase":[108],"urinary":[109,214,343,374],"a":[112,140,227,381],"sample":[113,383],"603":[115],"within":[118],"Nurses\u2019":[120],"Health":[121],"Study":[122],"II":[123],"(NHSII).":[124],"Data":[125],"on":[126],"factors":[128,359],"were":[129,137,155,179,188,338],"collected":[130],"prospectively":[131],"through":[132],"biennial":[133],"questionnaires.":[134],"Fifteen":[135],"quantified":[138],"using":[139,181],"high-performance":[141],"liquid":[142],"chromatography-tandem":[143],"mass":[144],"spectrometry":[145],"method":[146],"high":[148],"sensitivity,":[149],"specificity":[150],"reproducibility.":[152],"Creatinine-adjusted":[153],"evaluated":[156],"individually,":[157],"by":[158,171,372],"metabolic":[159,345],"pathway":[160,172,223,263,283,298,322],"(e.g.,":[161],"2-,":[162],"4-,":[163],"16-hydroxylation;":[165],"catechols":[166],"methylated":[168],"catechols)":[169],"ratios.":[173,308],"Geometric":[174],"means":[175],"p":[177],"values":[178],"calculated":[180],"multivariable":[182],"generalized":[183],"linear":[184],"models.":[185],"Significant":[186],"found":[189],"for":[190,237,242,280,286,311,319,326,421],"pattern":[193,391],"birth.":[200],"Relative":[201],"regular":[205],"cycles,":[207],"irregular":[210],"cycles":[211,272,276],"had":[212],"lower":[213,296],"levels":[215,255,376],"total":[217,238],"(p=0.01),":[219],"estradiol":[220,259],"(p=0.03),":[221],"16-hydroxylation":[222,262,282,297,321],"(p<0.01)":[225],"higher":[228,254,302],"4/16":[229,244],"hydroxylation":[230,245],"ratio":[231],"(p=0.02).":[232],"Differences":[233],"ranged":[234,277,316],"22.1%":[236],"EMs":[239],"70.5%":[241],"ratio.":[246,329],"Longer":[247],"was":[251,293],"associated":[252,294,341,399],"estrone":[257],"(p=0.02),":[258],"(p=0.01)":[260,307],"(p=0.03).":[265],"percent":[267],"difference":[268,310],"<26":[270],"day":[271,275],"\u226532":[274],"23.9%":[279],"26.9%":[285],"estrone.":[287],"Higher":[288],"birth":[292,315,396],"(p=0.03)":[300],"2/16-hydroxylation":[303],"(p=0.02)":[304],"4/16-hydroxylation":[306,328],"Percent":[309],"15.1%":[318],"59.7%":[325],"Breastfeeding,":[330],"OC":[331],"use,":[332],"parity":[333],"menarche":[337],"not":[339],"significantly":[340,398],"pathways.":[346],"data":[348],"provide":[349],"an":[350],"important":[351,360],"initial":[352],"evaluation":[353],"etiology":[364],"metabolism,":[369],"as":[370],"measured":[371],"15":[378],"EM.":[379],"In":[380],"large":[382],"are":[397],"metabolism":[402],"profiles.":[403],"Citation":[404],"Format:":[405],"{Authors}.":[406],"{Abstract":[407],"title}":[408],"[abstract].":[409],"In:":[410],"Proceedings":[411],"102nd":[414],"Annual":[415],"Meeting":[416],"American":[419],"Association":[420],"Cancer":[422,432],"Research;":[423],"2011":[424],"Apr":[425],"2-6;":[426],"Orlando,":[427],"FL.":[428],"Philadelphia":[429],"(PA):":[430],"AACR;":[431],"Res":[433],"2011;71(8":[434],"Suppl):Abstract":[435],"nr":[436],"4634.":[437],"doi:10.1158/1538-7445.AM2011-4634":[438]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}
