{"id":"https://openalex.org/W1966545614","doi":"https://doi.org/10.3109/08923979109019717","title":"Anticryptococcal Activity of Amphotericin B-Stimulated Macrophages","display_name":"Anticryptococcal Activity of Amphotericin B-Stimulated Macrophages","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W1966545614","doi":"https://doi.org/10.3109/08923979109019717","mag":"1966545614","pmid":"https://pubmed.ncbi.nlm.nih.gov/1774432"},"language":"en","primary_location":{"id":"doi:10.3109/08923979109019717","doi":"https://doi.org/10.3109/08923979109019717","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08923979109019717","pdf_url":null,"source":{"id":"https://openalex.org/S16829457","display_name":"Immunopharmacology and Immunotoxicology","issn_l":"0892-3973","issn":["0892-3973","1532-2513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and Immunotoxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034080284","display_name":"Jaber Aslanzadeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Aslanzadeh","raw_affiliation_strings":["Department of Medicine, Jewish Hospital, St. Louis","Departments of Medicine, Jewish Hospital 216 S, Kings highway, St Louis, 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Jewish Hospital, St. Louis","institution_ids":[]},{"raw_affiliation_string":"Departments of Medicine, Jewish Hospital 216 S, Kings highway, St Louis, 63110","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002147689","display_name":"J S Mormol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. S. Mormol","raw_affiliation_strings":["Departments of Medicine, Jewish Hospital 216 S, Kings highway, St Louis, 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Jewish Hospital 216 S, Kings highway, St Louis, 63110","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"J. R. Little","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135078","display_name":"Washington University Medical Center","ror":"https://ror.org/036c27j91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135078"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. R. Little","raw_affiliation_strings":["Departments of Medicine, Jewish Hospital 216 S, Kings highway, St Louis, 63110; Departments of Medicine at the Jewish HospitalMolecular Microbiology, Washington University Medical Center; 216 S, Kings highway, St Louis, 63110","216 S, Kings highway, St Louis, 63110","Departments of Medicine at the Jewish HospitalMolecular Microbiology, Washington University Medical Center","Departments of Medicine, Jewish Hospital 216 S, Kings highway, St Louis, 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Jewish Hospital 216 S, Kings highway, St Louis, 63110; Departments of Medicine at the Jewish HospitalMolecular Microbiology, Washington University Medical Center; 216 S, Kings highway, St Louis, 63110","institution_ids":["https://openalex.org/I4210135078"]},{"raw_affiliation_string":"216 S, Kings highway, St Louis, 63110","institution_ids":[]},{"raw_affiliation_string":"Departments of Medicine at the Jewish HospitalMolecular Microbiology, Washington University Medical Center","institution_ids":["https://openalex.org/I4210135078"]},{"raw_affiliation_string":"Departments of Medicine, Jewish Hospital 216 S, Kings highway, St Louis, 63110","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3569,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.58546671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"13","issue":"4","first_page":"465","last_page":"483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.996999979019165},{"id":"https://openalex.org/keywords/amphotericin-b-methyl-ester","display_name":"amphotericin B methyl ester","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cryptococcosis","display_name":"cryptococcosis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cryptococcus-neoformans","display_name":"Cryptococcus neoformans","score":0.9879999756813049},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8899999856948853},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/immunoadjuvant","display_name":"immunoadjuvant","score":0.8759999871253967},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/culture-supernatant","display_name":"culture supernatant","score":0.7599999904632568},{"id":"https://openalex.org/keywords/photoinactivation","display_name":"photoinactivation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/antifungal-synergy","display_name":"antifungal synergy","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.7468134760856628},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6492670178413391},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.5777822136878967},{"id":"https://openalex.org/C2781264782","wikidata":"https://www.wikidata.org/wiki/Q901656","display_name":"Immunostimulant","level":3,"score":0.5462561845779419},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5115659832954407},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.49555766582489014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4719618558883667},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46830594539642334},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.44871076941490173},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3665972948074341},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3514595627784729},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3219059705734253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1632491648197174}],"mesh":[{"descriptor_ui":"D000666","descriptor_name":"Amphotericin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003455","descriptor_name":"Cryptococcus neoformans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003455","descriptor_name":"Cryptococcus neoformans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08923979109019717","doi":"https://doi.org/10.3109/08923979109019717","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08923979109019717","pdf_url":null,"source":{"id":"https://openalex.org/S16829457","display_name":"Immunopharmacology and Immunotoxicology","issn_l":"0892-3973","issn":["0892-3973","1532-2513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and Immunotoxicology","raw_type":"journal-article"},{"id":"pmid:1774432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1774432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and immunotoxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9483000040054321,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2646274291","display_name":"H. CAPSULATUM INTERACTIONS WITH MURINE MACROPHAGES","funder_award_id":"R01AI027466","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2864877848","display_name":null,"funder_award_id":"AI-27466","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2966729015","display_name":null,"funder_award_id":"AI 07015","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4782938316","display_name":"FUNGAL DISEASES","funder_award_id":"T32AI007015","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G577894010","display_name":"DEVEL OF ADDITIONAL DRUGS FOR TREATMENT OF CANDIDIASIS","funder_award_id":"n01ai072640-007","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G600115381","display_name":null,"funder_award_id":"AI72640","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W36639497","https://openalex.org/W1520576798","https://openalex.org/W1543156176","https://openalex.org/W1564583356","https://openalex.org/W1567581543","https://openalex.org/W1572407579","https://openalex.org/W1573093393","https://openalex.org/W1623539801","https://openalex.org/W1766468848","https://openalex.org/W1833207062","https://openalex.org/W1860530067","https://openalex.org/W1869450659","https://openalex.org/W1983613734","https://openalex.org/W1988416772","https://openalex.org/W1988514341","https://openalex.org/W2014912702","https://openalex.org/W2017347652","https://openalex.org/W2017359321","https://openalex.org/W2019385731","https://openalex.org/W2045974069","https://openalex.org/W2061999034","https://openalex.org/W2074076719","https://openalex.org/W2088403804","https://openalex.org/W2110276970","https://openalex.org/W2111793848","https://openalex.org/W2121421405","https://openalex.org/W2126110999","https://openalex.org/W2129047172","https://openalex.org/W2137383202","https://openalex.org/W2145408997","https://openalex.org/W2158440928","https://openalex.org/W2181179425","https://openalex.org/W2287986098","https://openalex.org/W2314302729","https://openalex.org/W2330271675","https://openalex.org/W2467821685"],"related_works":["https://openalex.org/W1988416772","https://openalex.org/W2152420278","https://openalex.org/W2133677080","https://openalex.org/W2074076719","https://openalex.org/W2015423070","https://openalex.org/W2007038405","https://openalex.org/W2168747059","https://openalex.org/W2471806293","https://openalex.org/W7095087882","https://openalex.org/W2120832349"],"abstract_inverted_index":{"Amphotericin":[0],"B":[1],"(AmB)":[2],"and":[3,18,34,73],"its":[4],"methyl":[5],"ester":[6],"derivative":[7],"(AME)":[8],"are":[9],"immunoadjuvants":[10],"with":[11,31,35],"macrophage":[12,46,59],"stimulating":[13],"properties.":[14],"Cultures":[15],"containing":[16],"AmB":[17,43],"murine":[19],"peritoneal":[20],"macrophages":[21,33],"showed":[22],"synergistic":[23],"anticryptococcal":[24],"activity.":[25,57],"The":[26],"antifungal":[27,56],"activity":[28,75],"was":[29,76],"associated":[30],"AmB-stimulated":[32,58],"their":[36],"culture":[37,47,60],"supernatants.":[38],"Photoinactivation":[39],"of":[40,55,65],"the":[41,45,53,63,74],"residual":[42],"in":[44,52,68],"supernatant":[48],"did":[49],"not":[50,85],"result":[51],"loss":[54],"supernatants":[61],"inhibited":[62],"growth":[64],"C.":[66,89],"neoformans":[67],"a":[69],"dose":[70],"responsive":[71],"manner":[72],"destroyed":[77],"by":[78],"incubation":[79],"at":[80,86],"100":[81],"degrees":[82,88],"C":[83],"but":[84],"60":[87]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
