{"id":"https://openalex.org/W1966534811","doi":"https://doi.org/10.1016/s0021-5198(19)31601-4","title":"THE EFFECT OF CLONIXIN AND BETAMETHASONE ON ADJUVANT-INDUCED ARTHRITIS AND EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RATS","display_name":"THE EFFECT OF CLONIXIN AND BETAMETHASONE ON ADJUVANT-INDUCED ARTHRITIS AND EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RATS","publication_year":1972,"publication_date":"1972-01-01","ids":{"openalex":"https://openalex.org/W1966534811","doi":"https://doi.org/10.1016/s0021-5198(19)31601-4","mag":"1966534811","pmid":"https://pubmed.ncbi.nlm.nih.gov/4541481"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-5198(19)31601-4","doi":"https://doi.org/10.1016/s0021-5198(19)31601-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)31601-4","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/s0021-5198(19)31601-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089048167","display_name":"Arthur S. Watnick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arthur S. WATNICK","raw_affiliation_strings":["Department of Physiology, Biological Research, Schering Corporation, Bloomfield, New Jersey 07003, U.S.A","Department of Physiology, Biological Research, Schering Corporation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biological Research, Schering Corporation, Bloomfield, New Jersey 07003, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology, Biological Research, Schering Corporation","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035589085","display_name":"Crawford Sabin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Crawford SABIN","raw_affiliation_strings":["Department of Physiology, Biological Research, Schering Corporation, Bloomfield, New Jersey 07003, U.S.A","Department of Physiology, Biological Research, Schering Corporation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Biological Research, Schering Corporation, Bloomfield, New Jersey 07003, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology, Biological Research, Schering Corporation","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6653,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.70920585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"22","issue":"6","first_page":"741","last_page":"742"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.5663999915122986,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.5663999915122986,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.09120000153779984,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/betamethasone","display_name":"betamethasone","score":0.9850000143051147},{"id":"https://openalex.org/keywords/adjuvant-induced-arthritis","display_name":"adjuvant-induced arthritis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.7630000114440918},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.8809999823570251},{"id":"https://openalex.org/keywords/paw-edema","display_name":"paw edema","score":0.6430000066757202},{"id":"https://openalex.org/keywords/hind-limb-paralysis","display_name":"hindlimb paralysis","score":0.7049999833106995},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.8294661045074463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6932194828987122},{"id":"https://openalex.org/C2781162121","wikidata":"https://www.wikidata.org/wiki/Q416132","display_name":"Betamethasone","level":2,"score":0.6892032623291016},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5802602767944336},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4585975408554077},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37784820795059204},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3453536033630371},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.0919598639011383}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001623","descriptor_name":"Betamethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001623","descriptor_name":"Betamethasone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001799","descriptor_name":"Blood Sedimentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005620","descriptor_name":"Freund's Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009539","descriptor_name":"Nicotinic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009539","descriptor_name":"Nicotinic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010243","descriptor_name":"Paralysis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014052","descriptor_name":"Toluidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0021-5198(19)31601-4","doi":"https://doi.org/10.1016/s0021-5198(19)31601-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)31601-4","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"doi:10.1254/jjp.22.741","doi":"https://doi.org/10.1254/jjp.22.741","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.22.741","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:4541481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4541481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of pharmacology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0021-5198(19)31601-4","doi":"https://doi.org/10.1016/s0021-5198(19)31601-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-5198(19)31601-4","pdf_url":null,"source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2021856785","https://openalex.org/W2325951213","https://openalex.org/W2328518159","https://openalex.org/W2552479556","https://openalex.org/W4206389007","https://openalex.org/W4247631194","https://openalex.org/W4298750405","https://openalex.org/W4313374357"],"related_works":["https://openalex.org/W2328518159","https://openalex.org/W369171862","https://openalex.org/W2406749753","https://openalex.org/W2417199325","https://openalex.org/W2279311558","https://openalex.org/W1943551362","https://openalex.org/W2010587126","https://openalex.org/W1988123874","https://openalex.org/W2152348983","https://openalex.org/W2066928493"],"abstract_inverted_index":{"The":[0],"adjuvant":[1],"arthritic":[2],"rat":[3,9],"(AAR)":[4],"and":[5,81,95],"experimental":[6],"allergic":[7],"encephalomyelitic":[8],"(EAE)":[10],"are":[11,62,87,97],"models":[12],"for":[13],"studying":[14],"inflammatory":[15],"reactions":[16],"triggered":[17],"by":[18,37],"immunologic":[19],"processes":[20],"(1\u20133).":[21],"In":[22,45],"the":[23,25,39,42,46,48,51,68,73,90,100],"AAR":[24,91],"disease":[26],"manifests":[27],"itself":[28],"in":[29,56,89,99],"a":[30],"systemic":[31],"inflammation":[32,49],"which":[33,54],"can":[34],"be":[35],"evaluated":[36],"measuring":[38],"swelling":[40],"of":[41,75],"hind":[43,57],"paws.":[44],"EAE":[47,101],"encompasses":[50],"myelin":[52],"sheath":[53],"results":[55],"limb":[58],"paralysis.":[59],"Although":[60],"there":[61],"similarities":[63],"between":[64],"these":[65],"two":[66],"models,":[67],"response":[69],"varies":[70],"according":[71],"to":[72],"classes":[74],"drugs.":[76],"Anti-inflammatory":[77],"drugs,":[78],"both":[79],"steroidal":[80],"nonsteroidal":[82],"as":[83,85],"well":[84],"immunosuppressants":[86,96],"active":[88,98],"while":[92],"only":[93],"steroids":[94],"(4,5).":[102]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}