{"id":"https://openalex.org/W1966512682","doi":"https://doi.org/10.1210/jcem.84.10.6064","title":"Sex-Dependent Association of a Genetic Polymorphism of Cholesteryl Ester Transfer Protein with High-Density Lipoprotein Cholesterol and Macrovascular Pathology in Type II Diabetic Patients","display_name":"Sex-Dependent Association of a Genetic Polymorphism of Cholesteryl Ester Transfer Protein with High-Density Lipoprotein Cholesterol and Macrovascular Pathology in Type II Diabetic Patients","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W1966512682","doi":"https://doi.org/10.1210/jcem.84.10.6064","mag":"1966512682","pmid":"https://pubmed.ncbi.nlm.nih.gov/10523010"},"language":"en","primary_location":{"id":"doi:10.1210/jcem.84.10.6064","doi":"https://doi.org/10.1210/jcem.84.10.6064","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.84.10.6064","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053986460","display_name":"A. Durlach","orcid":"https://orcid.org/0000-0002-3330-3505","observed_orcids":["https://orcid.org/0000-0002-3330-3505"]},"institutions":[{"id":"https://openalex.org/I4210105796","display_name":"Centre Hospitalier Universitaire de Reims","ror":"https://ror.org/01jbb3w63","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105796"]},{"id":"https://openalex.org/I4210165259","display_name":"H\u00f4pital Maison Blanche","ror":"https://ror.org/054bptx32","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210165259"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Durlach","raw_affiliation_strings":["Institut Pol Bouin, H\u00f4pital Maison Blanche, Centre Hospitalo-Universitaire, Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pol Bouin, H\u00f4pital Maison Blanche, Centre Hospitalo-Universitaire, Reims, France","institution_ids":["https://openalex.org/I4210105796","https://openalex.org/I4210165259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090697381","display_name":"Christine Clavel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105796","display_name":"Centre Hospitalier Universitaire de Reims","ror":"https://ror.org/01jbb3w63","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105796"]},{"id":"https://openalex.org/I4210165259","display_name":"H\u00f4pital Maison Blanche","ror":"https://ror.org/054bptx32","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210165259"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Clavel","raw_affiliation_strings":["Institut Pol Bouin (A.D., C.C.), Ho\u0302pital Maison Blanche, Centre Hospitalo-Universitaire, 51092 Reims"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pol Bouin (A.D., C.C.), Ho\u0302pital Maison Blanche, Centre Hospitalo-Universitaire, 51092 Reims","institution_ids":["https://openalex.org/I4210105796","https://openalex.org/I4210165259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085124235","display_name":"Anik Girard-Globa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210105635","display_name":"H\u00f4pital de l'Antiquaille","ror":"https://ror.org/01e2q0308","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105635"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anik Girard-Globa","raw_affiliation_strings":["Laboratoire de Me\u0301tabolisme des Lipides (A.G.-G.), Ho\u0302pital de l\u2019Antiquaille and CNRS UPRESA 5014, 69005 Lyon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Me\u0301tabolisme des Lipides (A.G.-G.), Ho\u0302pital de l\u2019Antiquaille and CNRS UPRESA 5014, 69005 Lyon","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210105635"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038185169","display_name":"Vincent Durlach","orcid":"https://orcid.org/0000-0003-1159-3051","observed_orcids":["https://orcid.org/0000-0003-1159-3051"]},"institutions":[{"id":"https://openalex.org/I4210105796","display_name":"Centre Hospitalier Universitaire de Reims","ror":"https://ror.org/01jbb3w63","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210105796"]},{"id":"https://openalex.org/I4210126712","display_name":"H\u00f4pital Robert-Debr\u00e9","ror":"https://ror.org/02dcqy320","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210126712"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Durlach","raw_affiliation_strings":["Service d\u2019Endocrinologie (V.D.), Maladies Me\u0301tabolique et de Me\u0301decine Interne, Ho\u0302pital Robert Debre\u0301, Centre Hospitalo-Universitaire, 51092 Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019Endocrinologie (V.D.), Maladies Me\u0301tabolique et de Me\u0301decine Interne, Ho\u0302pital Robert Debre\u0301, Centre Hospitalo-Universitaire, 51092 Reims, France","institution_ids":["https://openalex.org/I4210105796","https://openalex.org/I4210126712"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.0679,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.84735812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"84","issue":"10","first_page":"3656","last_page":"3659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.4293999969959259,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.4293999969959259,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.30660000443458557,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.09260000288486481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesteryl-ester-transfer-protein","display_name":"cholesteryl ester transfer protein","score":0.9419999718666077},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8659999966621399},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9300000071525574},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9229999780654907},{"id":"https://openalex.org/keywords/macrovascular-complications","display_name":"macrovascular complications","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7599999904632568},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.6859999895095825},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7870000004768372},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8859999775886536},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8475808501243591},{"id":"https://openalex.org/C45505151","wikidata":"https://www.wikidata.org/wiki/Q424706","display_name":"Cholesterylester transfer protein","level":4,"score":0.8307505249977112},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8221384286880493},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.5570755004882812},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5441554188728333},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4541248679161072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42917072772979736},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4231211543083191},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.3666772246360779},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32943934202194214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12667477130889893},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11454510688781738}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053480","descriptor_name":"Cholesterol Ester Transfer Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jcem.84.10.6064","doi":"https://doi.org/10.1210/jcem.84.10.6064","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.84.10.6064","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jc.84.10.3656","doi":"https://doi.org/10.1210/jc.84.10.3656","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.84.10.3656","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:10523010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10523010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W97614133","https://openalex.org/W1510710298","https://openalex.org/W1935892027","https://openalex.org/W1976861453","https://openalex.org/W1983330637","https://openalex.org/W1990166738","https://openalex.org/W1990824749","https://openalex.org/W1994322898","https://openalex.org/W2017480132","https://openalex.org/W2027767763","https://openalex.org/W2030156979","https://openalex.org/W2036261949","https://openalex.org/W2047070188","https://openalex.org/W2047331986","https://openalex.org/W2058420421","https://openalex.org/W2067359667","https://openalex.org/W2087570978","https://openalex.org/W2087809394","https://openalex.org/W2093130255","https://openalex.org/W2100500261","https://openalex.org/W2104661418","https://openalex.org/W2108274402","https://openalex.org/W2114689977","https://openalex.org/W2115930787","https://openalex.org/W2134428736","https://openalex.org/W2152477761","https://openalex.org/W2162116693","https://openalex.org/W2189418532","https://openalex.org/W2339428433"],"related_works":["https://openalex.org/W2108223367","https://openalex.org/W1967419648","https://openalex.org/W2371038852","https://openalex.org/W1993471663","https://openalex.org/W2423971157","https://openalex.org/W1964727898","https://openalex.org/W1984211327","https://openalex.org/W2561466489","https://openalex.org/W2993381343","https://openalex.org/W2059168832"],"abstract_inverted_index":{"Cholesterol":[0],"ester":[1],"transfer":[2],"protein":[3],"(CETP)":[4],"is":[5],"a":[6,21,34,48,150,167,173,202],"key":[7],"regulating":[8],"factor":[9],"of":[10,16,36,52,105,153,177,214],"lipid":[11,26,107],"metabolism,":[12],"and":[13,57,91,100,117,122,162,172],"the":[14,25,65,69,74,103,132,212],"polymorphism":[15,67,198],"its":[17],"gene":[18],"may":[19,209],"be":[20],"candidate":[22],"for":[23,160],"modulating":[24,203],"parameters":[27,108],"in":[28,129,181,185,192,205,217],"type":[29,38,193,218],"2":[30,39,194,219],"diabetic":[31,40,195,220],"subjects.":[32],"In":[33],"group":[35],"406":[37],"patients":[41],"aged":[42],"59.5":[43],"+/-":[44,54,61,137,142],"10.8":[45],"y,":[46],"with":[47,73,131,149],"body":[49],"mass":[50],"index":[51],"28.9":[53],"5.3":[55],"kg/m2":[56],"HbA1c":[58],"=":[59],"8.2":[60],"1.9%,":[62],"we":[63],"studied":[64],"B":[66],"at":[68],"CETP":[70],"locus":[71],"detectable":[72],"restriction":[75],"enzyme":[76],"TaqI.":[77],"Patients":[78],"were":[79],"separated":[80],"into":[81],"groups,":[82],"231":[83],"males":[84,206],"(78":[85],"B1B1,":[86,95],"108":[87],"B1B2,":[88,97],"45":[89],"B2B2)":[90],"175":[92],"females":[93],"(48":[94],"94":[96],"33":[98],"B2B2),":[99],"compared":[101],"on":[102],"basis":[104],"their":[106,120],"(total":[109],"cholesterol,":[110],"triglycerides,":[111],"high-density":[112],"lipoprotein-cholesterol":[113],"(HDL-C),":[114],"ApoA1":[115],"ApoB,":[116],"low-density":[118],"lipoprotein-cholesterol),":[119],"micro":[121],"macrovascular":[123,215],"complications.":[124],"HDL-C":[125,169],"was":[126],"significantly":[127],"higher":[128,168],"man":[130],"B2B2":[133],"genotype":[134],"(respectively,":[135],"1.31":[136],"0.44":[138],"mmol/L":[139],"vs.":[140,158,189],"1.13":[141],"0.32":[143],"mmol/L,":[144],"P":[145],"<":[146],"0.05),":[147],"together":[148],"lower":[151],"incidence":[152,176],"coronary":[154,178],"heart":[155,179],"disease":[156,180],"(9":[157],"25%":[159],"B1B1":[161],"B1B2":[163],"together).":[164],"Women":[165],"displayed":[166],"than":[170],"men":[171],"equally":[174],"high":[175],"B2":[182],"homozygotes":[183],"as":[184],"other":[186],"genotypes":[187],"(26":[188],"27%).":[190],"Thus,":[191],"patients,":[196],"Taq1b":[197],"seems":[199],"to":[200,211],"exert":[201],"role":[204],"only.":[207],"This":[208],"contribute":[210],"loss":[213],"protection":[216],"females.":[221]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
