{"id":"https://openalex.org/W1966477091","doi":"https://doi.org/10.1210/endo-125-1-13","title":"Platelet-Derived Growth Factor Enhances Deoxyribonucleic Acid and Collagen Synthesis in Osteoblast-Enriched Cultures from Fetal Rat Parietal Bone*","display_name":"Platelet-Derived Growth Factor Enhances Deoxyribonucleic Acid and Collagen Synthesis in Osteoblast-Enriched Cultures from Fetal Rat Parietal Bone*","publication_year":1989,"publication_date":"1989-07-01","ids":{"openalex":"https://openalex.org/W1966477091","doi":"https://doi.org/10.1210/endo-125-1-13","mag":"1966477091","pmid":"https://pubmed.ncbi.nlm.nih.gov/2737139"},"language":"en","primary_location":{"id":"doi:10.1210/endo-125-1-13","doi":"https://doi.org/10.1210/endo-125-1-13","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-125-1-13","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108509520","display_name":"Thomas L. McCarthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127810","display_name":"Saint Francis Hospital & Medical Center","ror":"https://ror.org/03h2ajh11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210127810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"THOMAS L. MCCARTHY","raw_affiliation_strings":["Department of Medicine (Endocrine Section), Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Endocrine Section), Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105","institution_ids":["https://openalex.org/I4210127810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004430702","display_name":"ERNESTO M. CANALIS","orcid":"https://orcid.org/0000-0002-9154-952X","observed_orcids":["https://orcid.org/0000-0002-9154-952X"]},"institutions":[{"id":"https://openalex.org/I4210127810","display_name":"Saint Francis Hospital & Medical Center","ror":"https://ror.org/03h2ajh11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210127810"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ERNESTO CANALIS","raw_affiliation_strings":["Department of Medicine (Endocrine Section) and Research Laboratory, Saint Francis Hospital and Medical CenterHartford, Connecticut 06105the University of Connecticut Health CenterFarmington, Connecticut 06032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Endocrine Section) and Research Laboratory, Saint Francis Hospital and Medical CenterHartford, Connecticut 06105the University of Connecticut Health CenterFarmington, Connecticut 06032","institution_ids":["https://openalex.org/I4210127810","https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.2416,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.89240646,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"125","issue":"1","first_page":"13","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":1.0},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9340000152587891},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/growth-factor-receptors","display_name":"growth factor receptors","score":0.6460000276565552},{"id":"https://openalex.org/keywords/mitogenic-response","display_name":"mitogen response","score":0.6740000247955322},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9549999833106995},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.7260000109672546},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.9760000109672546},{"id":"https://openalex.org/keywords/osteoblast-precursors","display_name":"osteoblast precursors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.7277859449386597},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.715839684009552},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6959002017974854},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.6750321984291077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6482893824577332},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6130623817443848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5312471389770508},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47718799114227295},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.469044029712677},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.46123552322387695},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.42541080713272095},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3482127785682678},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28429746627807617},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24162113666534424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23604145646095276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10959160327911377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010294","descriptor_name":"Parietal Bone","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010294","descriptor_name":"Parietal Bone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-125-1-13","doi":"https://doi.org/10.1210/endo-125-1-13","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-125-1-13","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:2737139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2737139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1104295822","display_name":null,"funder_award_id":"AR-39201","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5524095835","display_name":null,"funder_award_id":"AR 21707","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1573798987","https://openalex.org/W1703816965","https://openalex.org/W1954010972","https://openalex.org/W1967709376","https://openalex.org/W1969921590","https://openalex.org/W2009496517","https://openalex.org/W2013581100","https://openalex.org/W2039281296","https://openalex.org/W2040470809","https://openalex.org/W2041671903","https://openalex.org/W2045835452","https://openalex.org/W2046733107","https://openalex.org/W2050183943","https://openalex.org/W2056557043","https://openalex.org/W2062510144","https://openalex.org/W2070594843","https://openalex.org/W2076658299","https://openalex.org/W2089938893","https://openalex.org/W2093101342","https://openalex.org/W2102945947","https://openalex.org/W2127001303","https://openalex.org/W2143367539"],"related_works":["https://openalex.org/W2133940180","https://openalex.org/W3022490367","https://openalex.org/W1969921590","https://openalex.org/W1992105186","https://openalex.org/W2095016531","https://openalex.org/W2173917538","https://openalex.org/W2067712761","https://openalex.org/W2153845487","https://openalex.org/W2031507914","https://openalex.org/W2020457061"],"abstract_inverted_index":{"Platelet-derived":[0],"growth":[1,89],"factor":[2,90],"(PDGF)":[3],"or":[4,222,234],"closely":[5],"related":[6],"proteins":[7],"are":[8,14],"found":[9,143],"in":[10,79,106,144,231],"bone":[11,145,217,232],"matrix":[12,209],"and":[13,56,102,113,150,173,182,208,215,219],"produced":[15],"by":[16,47,63,109,212],"cultured":[17],"osteosarcoma":[18],"cells.":[19],"In":[20],"serum-deprived":[21],"osteoblast-enriched":[22],"(ob)":[23],"cultures":[24,81,108,134,147,160,186],"from":[25,135],"fetal":[26,136],"rat":[27,70,137],"bone,":[28,138],"recombinant":[29],"human":[30],"PDGF":[31,59,78,92,127,153,203,224],"(composed":[32],"of":[33,44,54,77,87,100,126,165,170,179],"a":[34,162,168,188],"B":[35],"chain":[36],"homodimer)":[37],"at":[38,93,155,192],"0.1-3":[39],"nM":[40,58,95,172],"enhanced":[41,97],"the":[42,74,98],"rate":[43],"DNA":[45,119],"synthesis":[46,105,120,211],"2-":[48],"to":[49,65,111,132,158,184],"8-fold":[50],"within":[51],"24":[52],"h":[53],"treatment,":[55],"0.3-3":[57],"increased":[60],"cell":[61,146],"number":[62],"1.3-":[64],"1.6-fold.":[66],"Unlike":[67],"results":[68],"with":[69,85,167],"kidney":[71],"fibroblast":[72],"cultures,":[73],"mitogenic":[75],"effect":[76],"ob":[80,107,133,159,185],"was":[82,121],"not":[83,129],"synergistic":[84],"that":[86,202,220],"insulin-like":[88],"I.":[91],"0.3-10":[94],"also":[96],"rates":[99],"collagen":[101],"noncollagen":[103],"protein":[104,210],"1.5-":[110],"4.0-fold,":[112],"these":[114],"increases":[115,141],"were":[116,142],"blocked":[117],"when":[118],"prevented.":[122],"The":[123,197],"stimulatory":[124],"effects":[125],"did":[128],"appear":[130],"specific":[131],"since":[139],"similar":[140],"containing":[148],"fibroblasts":[149],"osteoblast":[151],"precursors.":[152],"binding":[154],"4":[156],"C":[157],"indicated":[161],"single":[163,189],"class":[164],"receptors":[166],"Kd":[169],"0.16":[171],"approximately":[174,193],"60,000":[175],"sites/cell.":[176],"Polyacrylamide":[177],"gel":[178],"125I-PDGF":[180],"bound":[181],"cross-linked":[183],"revealed":[187],"radioactive":[190],"band":[191],"180,000-190,000":[194],"mol":[195],"wt.":[196],"present":[198],"studies,":[199],"therefore,":[200],"indicate":[201],"can":[204],"directly":[205],"increase":[206],"replication":[207],"both":[213],"differentiated":[214],"undifferentiated":[216],"cells,":[218],"bone-":[221],"platelet-derived":[223],"may":[225],"have":[226],"an":[227],"important":[228],"anabolic":[229],"role":[230],"remodeling":[233],"fracture":[235],"repair.":[236]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
