{"id":"https://openalex.org/W1966464512","doi":"https://doi.org/10.1021/nl0516714","title":"Protein Crystals as Scanned Probes for Recognition Atomic Force Microscopy","display_name":"Protein Crystals as Scanned Probes for Recognition Atomic Force Microscopy","publication_year":2005,"publication_date":"2005-10-28","ids":{"openalex":"https://openalex.org/W1966464512","doi":"https://doi.org/10.1021/nl0516714","mag":"1966464512","pmid":"https://pubmed.ncbi.nlm.nih.gov/16351189"},"language":"en","primary_location":{"id":"doi:10.1021/nl0516714","doi":"https://doi.org/10.1021/nl0516714","is_oa":false,"landing_page_url":"https://doi.org/10.1021/nl0516714","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052682451","display_name":"Nissanka S. Wickremasinghe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nissanka S. Wickremasinghe","raw_affiliation_strings":["Department of Physics & Astronomy and Department of Chemistry, 6100 Main Street, Rice University, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics & Astronomy and Department of Chemistry, 6100 Main Street, Rice University, Houston, Texas","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053800875","display_name":"Jason H. Hafner","orcid":"https://orcid.org/0000-0002-6943-4232","observed_orcids":["https://orcid.org/0000-0002-6943-4232"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason H. Hafner","raw_affiliation_strings":["Department of Physics & Astronomy and Department of Chemistry, 6100 Main Street, Rice University, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics & Astronomy and Department of Chemistry, 6100 Main Street, Rice University, Houston, Texas","institution_ids":["https://openalex.org/I74775410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053800875"],"corresponding_institution_ids":["https://openalex.org/I74775410"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.4082,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.56827738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"5","issue":"12","first_page":"2418","last_page":"2421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12224","display_name":"Nanofabrication and Lithography Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12012","display_name":"Diatoms and Algae Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.6940000057220459},{"id":"https://openalex.org/keywords/glutaraldehyde-crosslinking","display_name":"glutaraldehyde crosslinking","score":0.9470000267028809},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.7009999752044678},{"id":"https://openalex.org/keywords/force-spectroscopy","display_name":"force spectroscopy","score":0.7269999980926514},{"id":"https://openalex.org/keywords/molecular-recognition","display_name":"molecular recognition","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.9217730760574341},{"id":"https://openalex.org/C153064111","wikidata":"https://www.wikidata.org/wiki/Q1281033","display_name":"Protein crystallization","level":3,"score":0.7600351572036743},{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.558563768863678},{"id":"https://openalex.org/C2781285689","wikidata":"https://www.wikidata.org/wiki/Q21921428","display_name":"Crystal (programming language)","level":2,"score":0.5440281629562378},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5284733176231384},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5146580338478088},{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.5038699507713318},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.431626558303833},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.42873668670654297},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.400486022233963},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.08220836520195007},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.08124476671218872},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06337675452232361},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015336","descriptor_name":"Molecular Probe Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/nl0516714","doi":"https://doi.org/10.1021/nl0516714","is_oa":false,"landing_page_url":"https://doi.org/10.1021/nl0516714","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},{"id":"pmid:16351189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16351189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1540175722","https://openalex.org/W1967869473","https://openalex.org/W1971728546","https://openalex.org/W1979405707","https://openalex.org/W1985900564","https://openalex.org/W1990720548","https://openalex.org/W1998606245","https://openalex.org/W2000382485","https://openalex.org/W2007558391","https://openalex.org/W2009885482","https://openalex.org/W2016449660","https://openalex.org/W2028069233","https://openalex.org/W2030593791","https://openalex.org/W2032641879","https://openalex.org/W2037651584","https://openalex.org/W2041977189","https://openalex.org/W2045328900","https://openalex.org/W2046160392","https://openalex.org/W2052320715","https://openalex.org/W2072932270","https://openalex.org/W2078861590","https://openalex.org/W2080167650","https://openalex.org/W2085586282","https://openalex.org/W2089154372","https://openalex.org/W2093211551","https://openalex.org/W2095939377","https://openalex.org/W2099942500","https://openalex.org/W2108220590","https://openalex.org/W2111937104","https://openalex.org/W2125150584","https://openalex.org/W2134819724","https://openalex.org/W2141222810","https://openalex.org/W2142018003","https://openalex.org/W2142081846","https://openalex.org/W2160165626","https://openalex.org/W2171413845"],"related_works":["https://openalex.org/W2568631092","https://openalex.org/W2331509819","https://openalex.org/W1971238758","https://openalex.org/W2164114487","https://openalex.org/W2063744829","https://openalex.org/W2052904419","https://openalex.org/W2068931358","https://openalex.org/W2314024209","https://openalex.org/W2080014512","https://openalex.org/W2022289923"],"abstract_inverted_index":{"Lysozyme":[0],"crystal":[1,24,46,69],"growth":[2],"has":[3],"been":[4],"localized":[5],"at":[6],"the":[7,44],"tip":[8],"of":[9,38],"a":[10,33],"conventional":[11,39],"silicon":[12],"nitride":[13],"cantilever":[14],"through":[15],"seeded":[16],"nucleation.":[17],"After":[18],"cross-linking":[19],"with":[20,32,51,62],"glutaraldehyde,":[21],"lysozyme":[22,45,68],"protein":[23],"tips":[25,47,70],"image":[26],"gold":[27],"nanoparticles":[28],"and":[29,48],"grating":[30],"standards":[31],"resolution":[34],"comparable":[35],"to":[36],"that":[37,57,67],"tips.":[40],"Force":[41],"spectra":[42],"between":[43],"surfaces":[49],"covered":[50],"antilysozyme":[52],"reveal":[53],"an":[54],"adhesion":[55],"force":[56],"drops":[58],"significantly":[59],"upon":[60],"blocking":[61],"free":[63],"lysozyme,":[64],"thus":[65],"confirming":[66],"can":[71],"detect":[72],"molecular":[73],"recognition":[74],"interactions.":[75]},"counts_by_year":[{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}