{"id":"https://openalex.org/W1966454841","doi":"https://doi.org/10.1074/jbc.m110054200","title":"Role of Neutrophil NADPH Oxidase in the Mechanism of Tumor Necrosis Factor-\u03b1-induced NF-\u03baB Activation and Intercellular Adhesion Molecule-1 Expression in Endothelial Cells","display_name":"Role of Neutrophil NADPH Oxidase in the Mechanism of Tumor Necrosis Factor-\u03b1-induced NF-\u03baB Activation and Intercellular Adhesion Molecule-1 Expression in Endothelial Cells","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W1966454841","doi":"https://doi.org/10.1074/jbc.m110054200","mag":"1966454841","pmid":"https://pubmed.ncbi.nlm.nih.gov/11729200"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110054200","doi":"https://doi.org/10.1074/jbc.m110054200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110054200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m110054200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103098465","display_name":"Jie Fan","orcid":"https://orcid.org/0000-0002-0090-2704","observed_orcids":["https://orcid.org/0000-0002-0090-2704"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie Fan","raw_affiliation_strings":["Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA. jiefan@uic.edu","From the Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA. jiefan@uic.edu","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"From the Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021969845","display_name":"Randall S. Frey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall S. Frey","raw_affiliation_strings":["Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612","From the Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"From the Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039008833","display_name":"Arshad Rahman","orcid":"https://orcid.org/0000-0002-5621-0512","observed_orcids":["https://orcid.org/0000-0002-5621-0512"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arshad Rahman","raw_affiliation_strings":["Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612","From the Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"From the Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011756238","display_name":"Asrar B. Malik","orcid":"https://orcid.org/0000-0002-8205-7128","observed_orcids":["https://orcid.org/0000-0002-8205-7128"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asrar B. Malik","raw_affiliation_strings":["Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612","From the Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"From the Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103098465"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.4784,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.93045822,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"277","issue":"5","first_page":"3404","last_page":"3411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.7470999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.7470999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.22789999842643738,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-nadph-oxidase","display_name":"neutrophil NADPH oxidase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/icam-1-expression","display_name":"ICAM-1 expression","score":0.9259999990463257},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nik","display_name":"NIK","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ikappabalpha-degradation","display_name":"I\u03baB\u03b1 degradation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.6759999990463257},{"id":"https://openalex.org/keywords/oxidant-signaling","display_name":"oxidant signaling","score":0.8569999933242798},{"id":"https://openalex.org/keywords/neutrophil-endothelial-cell-adhesion","display_name":"neutrophil-endothelial cell adhesion","score":0.843999981880188},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2781252958","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NAD(P)H oxidase","level":4,"score":0.7033514976501465},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6810733079910278},{"id":"https://openalex.org/C2909375385","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Intercellular Adhesion Molecule-1","level":3,"score":0.6709166169166565},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.651502788066864},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.6168607473373413},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5087736248970032},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.5022099018096924},{"id":"https://openalex.org/C185946421","wikidata":"https://www.wikidata.org/wiki/Q3146527","display_name":"ICAM-1","level":3,"score":0.4944143295288086},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.4666445553302765},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4439457654953003},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4432090222835541},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43298494815826416},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.42951396107673645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41422903537750244},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4125634431838989},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39431118965148926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27546459436416626},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2638115882873535},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.24634864926338196},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2044576108455658},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12275832891464233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011652","descriptor_name":"Pulmonary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m110054200","doi":"https://doi.org/10.1074/jbc.m110054200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110054200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11729200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11729200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110054200","doi":"https://doi.org/10.1074/jbc.m110054200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110054200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3409084629","display_name":"Restoration of Lung Vascular Barrier Integrity","funder_award_id":"P01HL060678","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G381287158","display_name":null,"funder_award_id":"HL 27016","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000892340","display_name":"Programming of PMN host-defense function during transendothelial migration","funder_award_id":"R01HL045638","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000917165","display_name":"Training Program in Lung Biology and Pathobiology","funder_award_id":"T32HL007829","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W105279024","https://openalex.org/W141774154","https://openalex.org/W161883251","https://openalex.org/W313760318","https://openalex.org/W1445343524","https://openalex.org/W1501442799","https://openalex.org/W1586099293","https://openalex.org/W1590514634","https://openalex.org/W1881147845","https://openalex.org/W1899509990","https://openalex.org/W1913125369","https://openalex.org/W1921874305","https://openalex.org/W1969760191","https://openalex.org/W1970935798","https://openalex.org/W1973328612","https://openalex.org/W1973632534","https://openalex.org/W1981883990","https://openalex.org/W2003081532","https://openalex.org/W2007040484","https://openalex.org/W2017247643","https://openalex.org/W2023359747","https://openalex.org/W2023481170","https://openalex.org/W2025128734","https://openalex.org/W2032514624","https://openalex.org/W2065257477","https://openalex.org/W2066868766","https://openalex.org/W2067680656","https://openalex.org/W2068605567","https://openalex.org/W2072608243","https://openalex.org/W2074011532","https://openalex.org/W2085049920","https://openalex.org/W2089394364","https://openalex.org/W2093830420","https://openalex.org/W2101216734","https://openalex.org/W2108235369","https://openalex.org/W2111357975","https://openalex.org/W2134812217","https://openalex.org/W2151892297","https://openalex.org/W2155917817","https://openalex.org/W2197083763","https://openalex.org/W2204123985","https://openalex.org/W4295677776"],"related_works":["https://openalex.org/W2149611550","https://openalex.org/W2105959408","https://openalex.org/W2045560460","https://openalex.org/W2150926180","https://openalex.org/W2057330297","https://openalex.org/W2113284547","https://openalex.org/W2034096687","https://openalex.org/W2069126947","https://openalex.org/W3186530034","https://openalex.org/W1946768698"],"abstract_inverted_index":{"In":[0,59],"this":[1],"study,":[2],"we":[3],"explored":[4],"a":[5],"novel":[6],"function":[7],"of":[8,17,42,74,94,102,122,184,201,220],"polymorphonuclear":[9],"neutrophils":[10],"(PMN)":[11],"NAD(P)H":[12,43,124,178,187,213],"oxidase":[13,44,125,179,188,214],"in":[14,30,36,48,72,87,116,126,154,167,189,204,227],"the":[15,39,108,120,131,176,185,211],"mechanism":[16],"tumor":[18],"necrosis":[19],"factor-alpha":[20],"(TNFalpha)-induced":[21],"NF-kappaB":[22,64,85,111,161,222],"activation":[23,65,86,112,162,223],"and":[24,66,97,113,163,224],"intercellular":[25],"adhesion":[26,200],"molecule-1":[27],"(ICAM-1)":[28],"expression":[29,68,115,166,226],"endothelial":[31,53,168,193,228],"cells.":[32,229],"Studies":[33],"were":[34,69,133,152],"made":[35],"mice":[37,76,89,142],"lacking":[38],"p47(phox)":[40],"subunit":[41],"as":[45,47,77],"well":[46],"cultured":[49],"mouse":[50],"lung":[51],"vascular":[52],"cells":[54,169],"(MLVEC)":[55],"from":[56,140,147],"these":[57,128],"mice.":[58,82,149],"response":[60],"to":[61,92,172],"TNFalpha":[62],"challenge,":[63],"ICAM-1":[67,114,165,225],"significantly":[70],"attenuated":[71,84],"lungs":[73],"p47(phox)(-/-)":[75,88,148,202],"compared":[78],"with":[79,137,145,157],"wild-type":[80],"(WT)":[81],"The":[83,181],"was":[90,195],"secondary":[91,171],"inhibition":[93],"NIK":[95],"activity":[96],"subsequent":[98],"IkappaBalpha":[99],"degradation.":[100],"Induction":[101],"neutropenia":[103],"using":[104],"anti-PMN":[105],"serum":[106],"prevented":[107],"initial":[109],"TNFalpha-induced":[110,191,221],"WT":[117,141],"mice,":[118],"indicating":[119],"involvement":[121],"PMN":[123,138,146,177,186,203,212],"signaling":[127,209],"responses.":[129],"Moreover,":[130],"responses":[132],"restored":[134],"upon":[135],"repletion":[136],"obtained":[139],"but":[143],"not":[144],"These":[150],"findings":[151],"recapitulated":[153],"MLVEC":[155],"co-cultured":[156],"PMN,":[158],"suggesting":[159],"that":[160],"resultant":[164],"occurred":[170],"oxidants":[173],"generated":[174],"by":[175,197,210],"complex.":[180],"functional":[182],"relevance":[183],"mediating":[190],"ICAM-1-dependent":[192],"adhesivity":[194],"evident":[196],"markedly":[198],"reduced":[199],"co-culture":[205],"experiments.":[206],"Thus,":[207],"oxidant":[208],"complex":[215],"is":[216],"an":[217],"important":[218],"determinant":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
