{"id":"https://openalex.org/W1966434299","doi":"https://doi.org/10.1016/0090-6980(90)90111-8","title":"Identification of a prostacyclin receptor coupled to the adenylate cyclase system via a stimulatory GTP-binding protein in mouse mastocytoma P-815 cells","display_name":"Identification of a prostacyclin receptor coupled to the adenylate cyclase system via a stimulatory GTP-binding protein in mouse mastocytoma P-815 cells","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W1966434299","doi":"https://doi.org/10.1016/0090-6980(90)90111-8","mag":"1966434299","pmid":"https://pubmed.ncbi.nlm.nih.gov/1701557"},"language":"en","primary_location":{"id":"doi:10.1016/0090-6980(90)90111-8","doi":"https://doi.org/10.1016/0090-6980(90)90111-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0090-6980(90)90111-8","pdf_url":null,"source":{"id":"https://openalex.org/S161580142","display_name":"Prostaglandins","issn_l":"0090-6980","issn":["0090-6980","1878-416X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027301316","display_name":"Hitoshi Hashimoto","orcid":"https://orcid.org/0000-0001-6548-4016","observed_orcids":["https://orcid.org/0000-0001-6548-4016"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Hashimoto","raw_affiliation_strings":["Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089629096","display_name":"Masahiko Negishi","orcid":"https://orcid.org/0000-0002-2076-8928","observed_orcids":["https://orcid.org/0000-0002-2076-8928"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Negishi","raw_affiliation_strings":["Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036189941","display_name":"Atsushi Ichikawa","orcid":"https://orcid.org/0009-0000-2175-2963","observed_orcids":["https://orcid.org/0009-0000-2175-2963"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A. Ichikawa","raw_affiliation_strings":["Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":null,"apc_paid":null,"fwci":2.2805,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.88397225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"40","issue":"5","first_page":"491","last_page":"505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8159000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8159000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.08009999990463257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostacyclin-receptor","display_name":"prostacyclin receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/iloprost","display_name":"iloprost","score":0.9589999914169312},{"id":"https://openalex.org/keywords/adenylyl-cyclase-activation","display_name":"adenylate cyclase activation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/guanine-nucleotides","display_name":"guanine nucleotides","score":0.8420000076293945},{"id":"https://openalex.org/keywords/receptor-coupling","display_name":"receptor coupling","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.8232738971710205},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.8153012990951538},{"id":"https://openalex.org/C2781103887","wikidata":"https://www.wikidata.org/wiki/Q20817139","display_name":"Iloprost","level":3,"score":0.7517367601394653},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.6989320516586304},{"id":"https://openalex.org/C2778930412","wikidata":"https://www.wikidata.org/wiki/Q6785569","display_name":"Mastocytoma","level":3,"score":0.6053354740142822},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5564506649971008},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.5556928515434265},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.5407270789146423},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.487984836101532},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4637513756752014},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45601537823677063},{"id":"https://openalex.org/C187250156","wikidata":"https://www.wikidata.org/wiki/Q2902610","display_name":"Cooperative binding","level":3,"score":0.4542085528373718},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.42805689573287964},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41623806953430176},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3257337510585785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3116164803504944},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14775103330612183},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09117624163627625}],"mesh":[{"descriptor_ui":"D000227","descriptor_name":"Adenine Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006150","descriptor_name":"Guanine Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012515","descriptor_name":"Mast-Cell Sarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0090-6980(90)90111-8","doi":"https://doi.org/10.1016/0090-6980(90)90111-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0090-6980(90)90111-8","pdf_url":null,"source":{"id":"https://openalex.org/S161580142","display_name":"Prostaglandins","issn_l":"0090-6980","issn":["0090-6980","1878-416X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins","raw_type":"journal-article"},{"id":"pmid:1701557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1701557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.4300000071525574}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W171519394","https://openalex.org/W1484354452","https://openalex.org/W1511421814","https://openalex.org/W1775749144","https://openalex.org/W1967885105","https://openalex.org/W1990177063","https://openalex.org/W2010291027","https://openalex.org/W2010751083","https://openalex.org/W2010903919","https://openalex.org/W2021403302","https://openalex.org/W2029134608","https://openalex.org/W2056133258","https://openalex.org/W2076991479","https://openalex.org/W2080875376","https://openalex.org/W2088995904","https://openalex.org/W2179266416","https://openalex.org/W2304916517","https://openalex.org/W2407327631","https://openalex.org/W2737500826","https://openalex.org/W6697920749"],"related_works":["https://openalex.org/W2325243264","https://openalex.org/W2052697779","https://openalex.org/W2005934241","https://openalex.org/W1969744521","https://openalex.org/W2063029621","https://openalex.org/W1541868958","https://openalex.org/W1555809376","https://openalex.org/W2088223176","https://openalex.org/W1982159886","https://openalex.org/W2078608614"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
