{"id":"https://openalex.org/W1966401331","doi":"https://doi.org/10.1016/j.molbrainres.2004.09.018","title":"Proteomic analysis of phosphotyrosyl proteins in morphine-dependent rat brains","display_name":"Proteomic analysis of phosphotyrosyl proteins in morphine-dependent rat brains","publication_year":2004,"publication_date":"2004-11-04","ids":{"openalex":"https://openalex.org/W1966401331","doi":"https://doi.org/10.1016/j.molbrainres.2004.09.018","mag":"1966401331","pmid":"https://pubmed.ncbi.nlm.nih.gov/15661365"},"language":"en","primary_location":{"id":"doi:10.1016/j.molbrainres.2004.09.018","doi":"https://doi.org/10.1016/j.molbrainres.2004.09.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molbrainres.2004.09.018","pdf_url":null,"source":{"id":"https://openalex.org/S158036907","display_name":"Molecular Brain Research","issn_l":"0169-328X","issn":["0169-328X","1872-6941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038034421","display_name":"Seong\u2010Youl Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seong-Youl Kim","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008064677","display_name":"Nuannoi Chudapongse","orcid":"https://orcid.org/0000-0003-4843-3799","observed_orcids":["https://orcid.org/0000-0003-4843-3799"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nuannoi Chudapongse","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104062852","display_name":"Sangmin Lee","orcid":"https://orcid.org/0000-0002-2321-1922","observed_orcids":["https://orcid.org/0000-0002-2321-1922"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sang-Min Lee","raw_affiliation_strings":["Department of Neurology, University of Tennessee Health Sciences Center, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Tennessee Health Sciences Center, Memphis, TN, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052118118","display_name":"Michael C. Levin","orcid":"https://orcid.org/0000-0002-3880-9193","observed_orcids":["https://orcid.org/0000-0002-3880-9193"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Levin","raw_affiliation_strings":["Department of Neurology, University of Tennessee Health Sciences Center, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Tennessee Health Sciences Center, Memphis, TN, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087799443","display_name":"Jae\u2010Taek Oh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jae-Taek Oh","raw_affiliation_strings":["Department of Immunology, Mogam Biotechnology Research Institute, Yongin, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mogam Biotechnology Research Institute, Yongin, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073210917","display_name":"Hae\u2010Joon Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hae-Joon Park","raw_affiliation_strings":["Department of Immunology, Mogam Biotechnology Research Institute, Yongin, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mogam Biotechnology Research Institute, Yongin, South Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109947739","display_name":"Ing Kang Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ing K. Ho","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA","institution_ids":["https://openalex.org/I29606459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109947739"],"corresponding_institution_ids":["https://openalex.org/I29606459"],"apc_list":null,"apc_paid":null,"fwci":3.2432,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.92938294,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"133","issue":"1","first_page":"58","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.3488999903202057,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.3488999903202057,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.25589999556541443,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.1826999932527542,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphine-dependence","display_name":"morphine dependence","score":0.9990000128746033},{"id":"https://openalex.org/keywords/morphine-tolerance","display_name":"morphine tolerance","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.9459999799728394},{"id":"https://openalex.org/keywords/chronic-morphine-treatment","display_name":"chronic morphine administration","score":0.7829999923706055},{"id":"https://openalex.org/keywords/neural-adaptation","display_name":"neural adaptation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.527999997138977},{"id":"https://openalex.org/keywords/brain-protein-expression","display_name":"brain protein expression","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.8129841089248657},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6990379691123962},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5468577146530151},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.5355987548828125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48808324337005615},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.46468213200569153},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.44115686416625977},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4244233965873718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40815144777297974},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3835506737232208},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25655287504196167},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22205039858818054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17763593792915344},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005625","descriptor_name":"Frontal Lobe","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005625","descriptor_name":"Frontal Lobe","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009021","descriptor_name":"Morphine Dependence","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019000","descriptor_name":"Phosphotyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.molbrainres.2004.09.018","doi":"https://doi.org/10.1016/j.molbrainres.2004.09.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molbrainres.2004.09.018","pdf_url":null,"source":{"id":"https://openalex.org/S158036907","display_name":"Molecular Brain Research","issn_l":"0169-328X","issn":["0169-328X","1872-6941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Brain Research","raw_type":"journal-article"},{"id":"pmid:15661365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15661365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research. Molecular brain research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1969669575","display_name":null,"funder_award_id":"DA-05828","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W131404291","https://openalex.org/W249845531","https://openalex.org/W273152011","https://openalex.org/W602250854","https://openalex.org/W1523806406","https://openalex.org/W1585650753","https://openalex.org/W1607902351","https://openalex.org/W1964865761","https://openalex.org/W1965473846","https://openalex.org/W1966501840","https://openalex.org/W1970807381","https://openalex.org/W1977046816","https://openalex.org/W1980656906","https://openalex.org/W1981522273","https://openalex.org/W1988640316","https://openalex.org/W1992497040","https://openalex.org/W1995227276","https://openalex.org/W1996016459","https://openalex.org/W1996566732","https://openalex.org/W1997458078","https://openalex.org/W2002399698","https://openalex.org/W2008439876","https://openalex.org/W2015160022","https://openalex.org/W2015732856","https://openalex.org/W2017663673","https://openalex.org/W2021979138","https://openalex.org/W2023079553","https://openalex.org/W2023680518","https://openalex.org/W2026890435","https://openalex.org/W2028508345","https://openalex.org/W2030611695","https://openalex.org/W2031649346","https://openalex.org/W2037617868","https://openalex.org/W2040404554","https://openalex.org/W2047578735","https://openalex.org/W2056422807","https://openalex.org/W2060735102","https://openalex.org/W2061588957","https://openalex.org/W2071998745","https://openalex.org/W2075000499","https://openalex.org/W2080182715","https://openalex.org/W2082220840","https://openalex.org/W2090473934","https://openalex.org/W2093385852","https://openalex.org/W2112293254","https://openalex.org/W2126375190","https://openalex.org/W2160112211","https://openalex.org/W2163815564","https://openalex.org/W2170807563","https://openalex.org/W2172734677","https://openalex.org/W2259357557","https://openalex.org/W2328048826","https://openalex.org/W2396134661","https://openalex.org/W2424818956","https://openalex.org/W4247772244"],"related_works":["https://openalex.org/W1710482752","https://openalex.org/W322922107","https://openalex.org/W2076753069","https://openalex.org/W2388247121","https://openalex.org/W2083579602","https://openalex.org/W2091541579","https://openalex.org/W4408566667","https://openalex.org/W2070793335","https://openalex.org/W7100394906","https://openalex.org/W2386620560"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}