{"id":"https://openalex.org/W1966396183","doi":"https://doi.org/10.1016/j.mad.2005.06.007","title":"Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: Effect of alternate-day fasting","display_name":"Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: Effect of alternate-day fasting","publication_year":2005,"publication_date":"2005-08-27","ids":{"openalex":"https://openalex.org/W1966396183","doi":"https://doi.org/10.1016/j.mad.2005.06.007","mag":"1966396183","pmid":"https://pubmed.ncbi.nlm.nih.gov/16126250"},"language":"en","primary_location":{"id":"doi:10.1016/j.mad.2005.06.007","doi":"https://doi.org/10.1016/j.mad.2005.06.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mad.2005.06.007","pdf_url":null,"source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Olivier Descamps","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281311","display_name":"P\u00f4le de recherche et d'enseignement sup\u00e9rieur Universit\u00e9 de Grenoble","ror":"https://ror.org/04668v621","country_code":"FR","type":"education","lineage":["https://openalex.org/I4392738279","https://openalex.org/I4405281311","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Descamps","raw_affiliation_strings":["Laboratoire de Nutrition, Vieillissement, Maladies Cardio-vasculaires, Facult\u00e9 de Pharmacie, Universit\u00e9 de Grenoble, Domaine de la Merci, 38706 la Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Nutrition, Vieillissement, Maladies Cardio-vasculaires, Facult\u00e9 de Pharmacie, Universit\u00e9 de Grenoble, Domaine de la Merci, 38706 la Tronche, France","institution_ids":["https://openalex.org/I4405281311","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088443575","display_name":"J Riondel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281311","display_name":"P\u00f4le de recherche et d'enseignement sup\u00e9rieur Universit\u00e9 de Grenoble","ror":"https://ror.org/04668v621","country_code":"FR","type":"education","lineage":["https://openalex.org/I4392738279","https://openalex.org/I4405281311","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jacqueline Riondel","raw_affiliation_strings":["Laboratoire de Nutrition, Vieillissement, Maladies Cardio-vasculaires, Facult\u00e9 de Pharmacie, Universit\u00e9 de Grenoble, Domaine de la Merci, 38706 la Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Nutrition, Vieillissement, Maladies Cardio-vasculaires, Facult\u00e9 de Pharmacie, Universit\u00e9 de Grenoble, Domaine de la Merci, 38706 la Tronche, France","institution_ids":["https://openalex.org/I4405281311","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108407947","display_name":"V\u00e9ronique Ducros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Ducros","raw_affiliation_strings":["D\u00e9partement de Biologie Int\u00e9gr\u00e9e, H\u00f4pital Universitaire de Grenoble, 38043 la Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Biologie Int\u00e9gr\u00e9e, H\u00f4pital Universitaire de Grenoble, 38043 la Tronche, France","institution_ids":["https://openalex.org/I2800555055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107361769","display_name":"Anne\u2010Marie Roussel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281311","display_name":"P\u00f4le de recherche et d'enseignement sup\u00e9rieur Universit\u00e9 de Grenoble","ror":"https://ror.org/04668v621","country_code":"FR","type":"education","lineage":["https://openalex.org/I4392738279","https://openalex.org/I4405281311","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne-Marie Roussel","raw_affiliation_strings":["Laboratoire de Nutrition, Vieillissement, Maladies Cardio-vasculaires, Facult\u00e9 de Pharmacie, Universit\u00e9 de Grenoble, Domaine de la Merci, 38706 la Tronche, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Nutrition, Vieillissement, Maladies Cardio-vasculaires, Facult\u00e9 de Pharmacie, Universit\u00e9 de Grenoble, Domaine de la Merci, 38706 la Tronche, France","institution_ids":["https://openalex.org/I4405281311","https://openalex.org/I899635006"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088443575"],"corresponding_institution_ids":["https://openalex.org/I4405281311","https://openalex.org/I899635006"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.998,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.84415406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"126","issue":"11","first_page":"1185","last_page":"1191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternate-day-fasting","display_name":"alternate-day fasting","score":0.9909999966621399},{"id":"https://openalex.org/keywords/intermittent-fasting","display_name":"intermittent fasting","score":0.9169999957084656},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mitochondrial-ros-production","display_name":"mitochondrial ROS production","score":0.7139999866485596},{"id":"https://openalex.org/keywords/of1-mice","display_name":"OF1 mice","score":0.8190000057220459},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7279999852180481},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8579999804496765},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6010000109672546},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7099999785423279},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.625}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7405989170074463},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7102015614509583},{"id":"https://openalex.org/C2778707264","wikidata":"https://www.wikidata.org/wiki/Q1332886","display_name":"Calorie restriction","level":2,"score":0.6039035320281982},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5756902694702148},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5600858330726624},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5489691495895386},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4805222451686859},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.46371105313301086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4293457269668579},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3968324065208435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3934997320175171},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1773512363433838},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mad.2005.06.007","doi":"https://doi.org/10.1016/j.mad.2005.06.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mad.2005.06.007","pdf_url":null,"source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},{"id":"pmid:16126250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16126250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of ageing and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W2386647","https://openalex.org/W51799544","https://openalex.org/W163605352","https://openalex.org/W284644654","https://openalex.org/W1498636565","https://openalex.org/W1533333278","https://openalex.org/W1541649582","https://openalex.org/W1607663818","https://openalex.org/W1650754258","https://openalex.org/W1759706356","https://openalex.org/W1782830164","https://openalex.org/W1862557020","https://openalex.org/W1925793145","https://openalex.org/W1974008725","https://openalex.org/W1974817453","https://openalex.org/W1982647833","https://openalex.org/W2001562153","https://openalex.org/W2023677185","https://openalex.org/W2026710722","https://openalex.org/W2027262563","https://openalex.org/W2028103779","https://openalex.org/W2033258839","https://openalex.org/W2034606681","https://openalex.org/W2042137835","https://openalex.org/W2046831727","https://openalex.org/W2055512409","https://openalex.org/W2056626274","https://openalex.org/W2063186064","https://openalex.org/W2068405110","https://openalex.org/W2068862678","https://openalex.org/W2087725694","https://openalex.org/W2089939834","https://openalex.org/W2092134362","https://openalex.org/W2101861123","https://openalex.org/W2113007696","https://openalex.org/W2113279188","https://openalex.org/W2128635872","https://openalex.org/W2136725886","https://openalex.org/W2166100609","https://openalex.org/W2171667805","https://openalex.org/W2340324006","https://openalex.org/W2409556958","https://openalex.org/W2891046586","https://openalex.org/W6606638420","https://openalex.org/W6684346299"],"related_works":["https://openalex.org/W7045425311","https://openalex.org/W2062490224","https://openalex.org/W2089814579","https://openalex.org/W2045187441","https://openalex.org/W2012028285","https://openalex.org/W1997225393","https://openalex.org/W3043591034","https://openalex.org/W2027395393","https://openalex.org/W2086971627","https://openalex.org/W2026194773"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}