{"id":"https://openalex.org/W1966366355","doi":"https://doi.org/10.1101/gr.10.8.1241","title":"A Quantitative Evaluation of SAGE","display_name":"A Quantitative Evaluation of SAGE","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W1966366355","doi":"https://doi.org/10.1101/gr.10.8.1241","mag":"1966366355","pmid":"https://pubmed.ncbi.nlm.nih.gov/10958642"},"language":"en","primary_location":{"id":"doi:10.1101/gr.10.8.1241","doi":"https://doi.org/10.1101/gr.10.8.1241","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.10.8.1241","pdf_url":"https://genome.cshlp.org/content/10/8/1241.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://genome.cshlp.org/content/10/8/1241.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109071190","display_name":"Jes Stollberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jes Stollberg","raw_affiliation_strings":["Pacific Biomedical Research Center, University of Hawai'i at Manoa, Honolulu, Hawaii 96822, USA. jesse@pbrc.hawaii.edu","Pacific Biomedical Research Center, University of Hawai'i at Manoa, Honolulu, Hawaii 96822"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Biomedical Research Center, University of Hawai'i at Manoa, Honolulu, Hawaii 96822, USA. jesse@pbrc.hawaii.edu","institution_ids":["https://openalex.org/I117965899"]},{"raw_affiliation_string":"Pacific Biomedical Research Center, University of Hawai'i at Manoa, Honolulu, Hawaii 96822","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029606941","display_name":"Johann Urschitz","orcid":"https://orcid.org/0000-0002-8894-5716","observed_orcids":["https://orcid.org/0000-0002-8894-5716"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johann Urschitz","raw_affiliation_strings":["Pacific Biomedical Research Center, University of Hawai'i at Manoa, Honolulu, Hawaii 96822"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Biomedical Research Center, University of Hawai'i at Manoa, Honolulu, Hawaii 96822","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056895680","display_name":"Zsolt Urb\u00e1n","orcid":"https://orcid.org/0000-0003-3890-1843","observed_orcids":["https://orcid.org/0000-0003-3890-1843"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zsolt Urban","raw_affiliation_strings":["Pacific Biomedical Research Center, University of Hawai'i at Manoa, Honolulu, Hawaii 96822"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Biomedical Research Center, University of Hawai'i at Manoa, Honolulu, Hawaii 96822","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110148851","display_name":"Charles D. Boyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles D. Boyd","raw_affiliation_strings":["Pacific Biomedical Research Center, University of Hawai'i at Manoa, Honolulu, Hawaii 96822"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Biomedical Research Center, University of Hawai'i at Manoa, Honolulu, Hawaii 96822","institution_ids":["https://openalex.org/I117965899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I117965899"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"8","first_page":"1241","last_page":"1248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.353300005197525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serial-analysis-of-gene-expression","display_name":"serial analysis of gene expression","score":0.9449999928474426},{"id":"https://openalex.org/keywords/sage","display_name":"sage","score":0.5540000200271606},{"id":"https://openalex.org/keywords/gene-expression-quantification","display_name":"gene expression quantification","score":0.6880000233650208},{"id":"https://openalex.org/keywords/sampling-bias","display_name":"sampling bias","score":0.5479999780654907},{"id":"https://openalex.org/keywords/sequencing-errors","display_name":"sequencing errors","score":0.800000011920929},{"id":"https://openalex.org/keywords/gene-number-estimation","display_name":"gene number estimation","score":0.878000020980835},{"id":"https://openalex.org/keywords/maximum-likelihood-estimation","display_name":"maximum likelihood estimation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/poly-a-rna","display_name":"polyadenylated RNA","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8173702955245972},{"id":"https://openalex.org/C20032557","wikidata":"https://www.wikidata.org/wiki/Q286721","display_name":"Serial analysis of gene expression","level":5,"score":0.6111413240432739},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5316166281700134},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5306103825569153},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.519934356212616},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49262863397598267},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.49241340160369873},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.48142072558403015},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.47679829597473145},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4440241754055023},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3690083920955658},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.30571919679641724},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15459635853767395},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016324","descriptor_name":"Sequence Tagged Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016324","descriptor_name":"Sequence Tagged Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016324","descriptor_name":"Sequence Tagged Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1101/gr.10.8.1241","doi":"https://doi.org/10.1101/gr.10.8.1241","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.10.8.1241","pdf_url":"https://genome.cshlp.org/content/10/8/1241.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},{"id":"pmid:10958642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10958642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome research","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:310928","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/310928","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/gr.10.8.1241","doi":"https://doi.org/10.1101/gr.10.8.1241","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.10.8.1241","pdf_url":"https://genome.cshlp.org/content/10/8/1241.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3355429260","display_name":"Bioscience Research Infrastructure Development for Grant Enhancement and Success","funder_award_id":"G12RR003061","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7428940574","display_name":"Ultrastructural Organization of Developing Acetylcholine    Receptor Aggregates","funder_award_id":"9724035","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1966366355.pdf","grobid_xml":"https://content.openalex.org/works/W1966366355.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W119342848","https://openalex.org/W1768187423","https://openalex.org/W1970156673","https://openalex.org/W1978368163","https://openalex.org/W1978895831","https://openalex.org/W1981397830","https://openalex.org/W1984575633","https://openalex.org/W1995346924","https://openalex.org/W2000334423","https://openalex.org/W2010888033","https://openalex.org/W2016799976","https://openalex.org/W2027600997","https://openalex.org/W2030958510","https://openalex.org/W2040231043","https://openalex.org/W2041902006","https://openalex.org/W2087150039","https://openalex.org/W2111618336","https://openalex.org/W2131379448","https://openalex.org/W2133636765","https://openalex.org/W2151238743","https://openalex.org/W2170120409","https://openalex.org/W2170121771","https://openalex.org/W2272723439","https://openalex.org/W2323995323","https://openalex.org/W2798455746","https://openalex.org/W4213265720","https://openalex.org/W4213387068","https://openalex.org/W4249877820","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1982027298","https://openalex.org/W1974145978","https://openalex.org/W2771731734","https://openalex.org/W1974120932","https://openalex.org/W2017157146","https://openalex.org/W2145590305","https://openalex.org/W2070248259","https://openalex.org/W2052655934","https://openalex.org/W2071038281","https://openalex.org/W104645380"],"abstract_inverted_index":{"Serial":[0],"Analysis":[1],"of":[2,14,22,42,71,82,84,87,93,135,145,150,154],"Gene":[3],"Expression":[4],"(SAGE)":[5],"is":[6,33,100,173,181,188],"an":[7],"innovative":[8],"technique":[9],"that":[10,53,175,183],"offers":[11],"the":[12,17,40,50,57,85,90,101,151,165,168,191],"potential":[13],"cataloging":[15],"both":[16],"identity":[18],"and":[19,69,89,127,138],"relative":[20],"frequencies":[21,141],"mRNA":[23,43],"transcripts":[24],"in":[25,49,56,177,193],"a":[26,34,105,129,143,184],"given":[27,106,142,185],"poly(A(+))":[28],"RNA":[29],"preparation.":[30],"Although":[31],"it":[32,180],"very":[35],"effective":[36],"approach":[37],"for":[38,131],"determining":[39],"expression":[41,156],"populations,":[44],"there":[45],"are":[46,54,61,157],"significant":[47],"biases":[48,124],"observed":[51],"results":[52],"inherent":[55],"experimental":[58,146],"process.":[59],"These":[60,148],"caused":[62],"by":[63],"sampling":[64],"error,":[65,67],"sequencing":[66],"nonuniqueness,":[68],"nonrandomness":[70],"tag":[72,107,186],"sequences.":[73],"The":[74,118],"quantitative":[75],"information":[76],"desired":[77],"from":[78,160,167],"SAGE":[79],"experiments":[80],"consists":[81],"estimates":[83,149],"number":[86,137],"genes":[88],"frequency":[91],"distribution":[92],"transcript":[94,139],"copy":[95,140],"numbers.":[96],"Of":[97],"additional":[98],"concern":[99],"extent":[102],"to":[103,112,115],"which":[104],"sequence":[108,187],"can":[109],"be":[110,113,198],"assumed":[111],"unique":[114,189],"its":[116],"gene.":[117],"present":[119],"study":[120],"takes":[121],"these":[122],"mathematical":[123],"into":[125],"account":[126],"presents":[128],"basis":[130],"maximum":[132],"likelihood":[133],"estimation":[134],"gene":[136],"set":[144],"results.":[147],"true":[152],"state":[153],"genomic":[155],"markedly":[158],"different":[159],"those":[161],"based":[162],"directly":[163],"on":[164],"observations":[166],"underlying":[169],"experiments.":[170],"It":[171],"also":[172],"shown":[174],"while":[176],"many":[178],"cases":[179],"probable":[182],"within":[190],"genome,":[192],"larger":[194],"genomes":[195],"this":[196],"cannot":[197],"safely":[199],"assumed.":[200]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}