{"id":"https://openalex.org/W1966360281","doi":"https://doi.org/10.1021/ja807963e","title":"Galactose Oxidase as a Model for Reactivity at a Copper Superoxide Center","display_name":"Galactose Oxidase as a Model for Reactivity at a Copper Superoxide Center","publication_year":2009,"publication_date":"2009-03-16","ids":{"openalex":"https://openalex.org/W1966360281","doi":"https://doi.org/10.1021/ja807963e","mag":"1966360281","pmid":"https://pubmed.ncbi.nlm.nih.gov/19290629","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2683747"},"language":"en","primary_location":{"id":"doi:10.1021/ja807963e","doi":"https://doi.org/10.1021/ja807963e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja807963e","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2683747","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075065508","display_name":"Kristi J. Humphreys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristi J. Humphreys","raw_affiliation_strings":["Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, California 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021486550","display_name":"Liviu M. Mirica","orcid":"https://orcid.org/0000-0003-0584-9508","observed_orcids":["https://orcid.org/0000-0003-0584-9508"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liviu M. Mirica","raw_affiliation_strings":["Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, California 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364898","display_name":"Yi Wang","orcid":"https://orcid.org/0000-0001-9866-2376","observed_orcids":["https://orcid.org/0000-0001-9866-2376"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Wang","raw_affiliation_strings":["Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, California 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066409965","display_name":"Judith Pollock Klinman","orcid":"https://orcid.org/0000-0001-5734-2843","observed_orcids":["https://orcid.org/0000-0001-5734-2843"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Judith P. Klinman","raw_affiliation_strings":["Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, California 94720","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066409965"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.6124,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.96358233,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"131","issue":"13","first_page":"4657","last_page":"4663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11989","display_name":"Oxidative Organic Chemistry Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galactose-oxidase","display_name":"galactose oxidase","score":1.0},{"id":"https://openalex.org/keywords/ping-pong-mechanism","display_name":"ping-pong mechanism","score":0.765999972820282},{"id":"https://openalex.org/keywords/hydrogen-atom-transfer","display_name":"hydrogen atom transfer","score":0.7599999904632568},{"id":"https://openalex.org/keywords/deuterium-isotope-effect","display_name":"deuterium isotope effect","score":0.7289999723434448},{"id":"https://openalex.org/keywords/oxygen-18-isotope-effect","display_name":"oxygen-18 isotope effect","score":0.9449999928474426},{"id":"https://openalex.org/keywords/rate-limiting-step","display_name":"rate-determining step","score":0.7269999980926514},{"id":"https://openalex.org/keywords/dopamine-beta-monooxygenase","display_name":"dopamine beta-monooxygenase","score":0.7770000100135803},{"id":"https://openalex.org/keywords/peptidylglycine-alpha-hydroxylating-monooxygenase","display_name":"peptidylglycine alpha-hydroxylating monooxygenase","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9327034950256348},{"id":"https://openalex.org/C69928629","wikidata":"https://www.wikidata.org/wiki/Q1386472","display_name":"Kinetic isotope effect","level":3,"score":0.8908059597015381},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.8220412731170654},{"id":"https://openalex.org/C2777438722","wikidata":"https://www.wikidata.org/wiki/Q2782385","display_name":"Galactose oxidase","level":3,"score":0.6609962582588196},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5629427433013916},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.539618968963623},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.5251935720443726},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3423883318901062},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.29028505086898804},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2658892273902893},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.18702900409698486},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.165122389793396},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005670","descriptor_name":"Fusarium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005692","descriptor_name":"Galactose Oxidase","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005692","descriptor_name":"Galactose Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010103","descriptor_name":"Oxygen Isotopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ja807963e","doi":"https://doi.org/10.1021/ja807963e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja807963e","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:19290629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19290629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2683747","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2683747","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2683747","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2683747","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.6700000166893005}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1510506287","display_name":"The Role of Self-Processing in Galactose Oxidase","funder_award_id":"F32GM065010","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1775130492","display_name":null,"funder_award_id":"GM 025765","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1883151623","display_name":"DOPAMINE MONOOXYGENASE--MOLECULAR MECHANISMS","funder_award_id":"R37GM025765","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7939786905","display_name":"Toward a Comprehensive Model for Enzyme Catalysis","funder_award_id":"R01GM025765","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W62248180","https://openalex.org/W67911643","https://openalex.org/W171746247","https://openalex.org/W645019570","https://openalex.org/W1154354013","https://openalex.org/W1549955084","https://openalex.org/W1593863412","https://openalex.org/W1965923596","https://openalex.org/W1969726382","https://openalex.org/W1970713347","https://openalex.org/W1972040015","https://openalex.org/W1978245227","https://openalex.org/W1981664420","https://openalex.org/W1981940760","https://openalex.org/W1987047628","https://openalex.org/W2000483193","https://openalex.org/W2011656574","https://openalex.org/W2011748332","https://openalex.org/W2013410957","https://openalex.org/W2013787274","https://openalex.org/W2021305630","https://openalex.org/W2022216240","https://openalex.org/W2032423031","https://openalex.org/W2034065968","https://openalex.org/W2034844831","https://openalex.org/W2046944490","https://openalex.org/W2047238808","https://openalex.org/W2064927965","https://openalex.org/W2075216133","https://openalex.org/W2077617823","https://openalex.org/W2084044263","https://openalex.org/W2087534166","https://openalex.org/W2091843869","https://openalex.org/W2092529814","https://openalex.org/W2094709506","https://openalex.org/W2095915788","https://openalex.org/W2103133292","https://openalex.org/W2129774902","https://openalex.org/W2132886032","https://openalex.org/W2197791599","https://openalex.org/W2205801025"],"related_works":["https://openalex.org/W2084044263","https://openalex.org/W2011748332","https://openalex.org/W2280343189","https://openalex.org/W2124098792","https://openalex.org/W87891219","https://openalex.org/W120074038","https://openalex.org/W2005087274","https://openalex.org/W1521325148","https://openalex.org/W1576888179","https://openalex.org/W2079093854"],"abstract_inverted_index":{"The":[0,29,52,86,164,195],"mononuclear":[1],"copper":[2],"enzyme,":[3],"galactose":[4,253],"oxidase,":[5],"has":[6],"been":[7],"investigated":[8],"under":[9],"steady-state":[10],"conditions":[11],"via":[12],"O(2)-consumption":[13],"assays":[14],"using":[15],"1-O-methyl-alpha-D-galactopyranoside":[16],"as":[17,184,186,212],"the":[18,26,33,39,60,64,110,137,146,173,178,213,216,231,236,241,247],"sugar":[19],"substrate":[20,42,101,200,219,239],"to":[21,55,83,145,155],"produce":[22],"an":[23],"aldehyde":[24],"at":[25,74],"C-6":[27],"position.":[28],"rate-determining":[30,161],"step":[31,234],"of":[32,41,92,105,118,127,139,190,197,215,238,243,252],"oxidative":[34,87,250],"half-reaction":[35,88],"was":[36,107,120],"probed":[37],"through":[38],"measurement":[40],"and":[43,46,78,199,249],"solvent":[44,141,198,206],"deuterium":[45,102,201,207,220],"O-18":[47,124,166],"isotope":[48,103,125,142,167,202,221],"effects":[49,126,168,203],"on":[50,122,223],"k(cat)/K(m)(O(2)).":[51,123,163,224],"reaction":[53],"conforms":[54],"a":[56,90,113,156,188],"ping-pong":[57],"mechanism":[58],"with":[59,129,136],"kinetic":[61],"parameters":[62],"for":[63,109,162,172,192],"reductive":[65,248],"half,":[66],"k(cat)/K(m)(S)":[67],"=":[68,94],"8.3":[69],"x":[70,96],"10(3)":[71],"M(-1)":[72,98],"s(-1)":[73],"10":[75],"degrees":[76],"C":[77],"pH":[79],"7.0,":[80],"comparing":[81],"favorably":[82],"literature":[84],"values.":[85],"yielded":[89],"value":[91,117],"k(cat)/K(m)(O(2))":[93],"2.5":[95],"10(6)":[97],"s(-1).":[99],"A":[100],"effect":[104,222],"32":[106],"measured":[108,165],"k(cat)/K(m)(S),":[111],"while":[112],"smaller,":[114],"but":[115],"significant":[116],"1.6-1.9":[119],"observed":[121],"1.0185":[128],"either":[130],"protiated":[131],"or":[132],"deuterated":[133],"sugar,":[134],"together":[135],"absence":[138],"any":[140],"effect,":[143],"lead":[144],"conclusion":[147],"that":[148],"hydrogen":[149,232],"atom":[150],"transfer":[151,233],"from":[152,235],"reduced":[153,210,244],"cofactor":[154,245],"Cu(II)-superoxo":[157],"intermediate":[158],"is":[159],"fully":[160],"provide":[169],"corroborative":[170],"evidence":[171],"reactive":[174],"superoxo":[175],"species":[176],"in":[177,230],"dopamine":[179],"beta-monooxygenase/peptidylglycine":[180],"alpha-hydroxylating":[181],"monooxygenase":[182],"family,":[183],"well":[185],"providing":[187],"frame":[189],"reference":[191],"copper-superoxo":[193],"reactivity.":[194],"combination":[196],"rules":[204],"out":[205],"exchange":[208],"into":[209],"enzyme":[211],"origin":[214],"relatively":[217],"small":[218],"These":[225],"data":[226],"indicate":[227],"fundamental":[228],"differences":[229],"carbon":[237],"vs":[240],"oxygen":[242],"during":[246],"half-reactions":[251],"oxidase.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
