{"id":"https://openalex.org/W1966355308","doi":"https://doi.org/10.1089/hum.2007.153","title":"Internal Radiotherapy of Liver Cancer with Rat Hepatocarcinoma-Intestine-Pancreas Gene as a Liver Tumor-Specific Promoter","display_name":"Internal Radiotherapy of Liver Cancer with Rat Hepatocarcinoma-Intestine-Pancreas Gene as a Liver Tumor-Specific Promoter","publication_year":2008,"publication_date":"2008-07-07","ids":{"openalex":"https://openalex.org/W1966355308","doi":"https://doi.org/10.1089/hum.2007.153","mag":"1966355308","pmid":"https://pubmed.ncbi.nlm.nih.gov/18759560"},"language":"en","primary_location":{"id":"doi:10.1089/hum.2007.153","doi":"https://doi.org/10.1089/hum.2007.153","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2007.153","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003086764","display_name":"Julie Herv\u00e9","orcid":"https://orcid.org/0000-0001-9735-5518","observed_orcids":["https://orcid.org/0000-0001-9735-5518"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"JULIE HERVE","raw_affiliation_strings":["INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070118413","display_name":"Ant\u00f3nio S\u00e1 Cunha","orcid":"https://orcid.org/0000-0003-4015-5368","observed_orcids":["https://orcid.org/0000-0003-4015-5368"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"ANTONIO SA CUNHA","raw_affiliation_strings":["INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":null,"display_name":"BINGKAI LIU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"BINGKAI LIU","raw_affiliation_strings":["INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024747879","display_name":"Yannick Valogne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"YANNICK VALOGNE","raw_affiliation_strings":["INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":null,"display_name":"MICHELE LONGUET","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"MICHELE LONGUET","raw_affiliation_strings":["INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","Mission des Affaires Europ\u00e9ennes, Minist\u00e8re de la Recherche, 75231 Paris Cedex 05, France","Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Mission des Affaires Europ\u00e9ennes, Minist\u00e8re de la Recherche, 75231 Paris Cedex 05, France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112030932","display_name":"Rapha\u00ebl Boisgard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"RAPHAEL BOISGARD","raw_affiliation_strings":["CEA, Service Hospitalier Fr\u00e9d\u00e9ric Joliot, Laboratoire d' Imagerie Mol\u00e9culaire Exp\u00e9rimentale, F-91400 Orsay, France","INSERM U803, Orsay F-91400, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA, Service Hospitalier Fr\u00e9d\u00e9ric Joliot, Laboratoire d' Imagerie Mol\u00e9culaire Exp\u00e9rimentale, F-91400 Orsay, France","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"INSERM U803, Orsay F-91400, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015532057","display_name":"Olivier Br\u00e9gerie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"OLIVIER BREGERIE","raw_affiliation_strings":["INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113549855","display_name":"J. Roux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"JEROME ROUX","raw_affiliation_strings":["Laboratoire H\u00e9modynamique, Interaction Fibrose et Invasivit\u00e9 Tumorale H\u00e9patique, Universit\u00e9 d' Angers, UPRES EA 3859, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire H\u00e9modynamique, Interaction Fibrose et Invasivit\u00e9 Tumorale H\u00e9patique, Universit\u00e9 d' Angers, UPRES EA 3859, France","institution_ids":["https://openalex.org/I49451733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015829616","display_name":"Catherine Guettier","orcid":"https://orcid.org/0000-0003-0791-5505","observed_orcids":["https://orcid.org/0000-0003-0791-5505"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"CATHERINE GUETTIER","raw_affiliation_strings":["INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047468439","display_name":"Paul Cal\u00e8s","orcid":"https://orcid.org/0000-0003-4866-5274","observed_orcids":["https://orcid.org/0000-0003-4866-5274"]},"institutions":[{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"PAUL CALES","raw_affiliation_strings":["Laboratoire H\u00e9modynamique, Interaction Fibrose et Invasivit\u00e9 Tumorale H\u00e9patique, Universit\u00e9 d' Angers, UPRES EA 3859, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire H\u00e9modynamique, Interaction Fibrose et Invasivit\u00e9 Tumorale H\u00e9patique, Universit\u00e9 d' Angers, UPRES EA 3859, France","institution_ids":["https://openalex.org/I49451733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078236467","display_name":"Bertrand Tavitian","orcid":"https://orcid.org/0000-0002-5349-8194","observed_orcids":["https://orcid.org/0000-0002-5349-8194"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"BERTRAND TAVITIAN","raw_affiliation_strings":["CEA, Service Hospitalier Fr\u00e9d\u00e9ric Joliot, Laboratoire d' Imagerie Mol\u00e9culaire Exp\u00e9rimentale, F-91400 Orsay, France","INSERM U803, Orsay F-91400, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA, Service Hospitalier Fr\u00e9d\u00e9ric Joliot, Laboratoire d' Imagerie Mol\u00e9culaire Exp\u00e9rimentale, F-91400 Orsay, France","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"INSERM U803, Orsay F-91400, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059508363","display_name":"Didier Samuel","orcid":"https://orcid.org/0000-0001-9481-3616","observed_orcids":["https://orcid.org/0000-0001-9481-3616"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"DIDIER SAMUEL","raw_affiliation_strings":["INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003436735","display_name":"J\u00e9r\u00f4me Clerc","orcid":"https://orcid.org/0000-0002-9089-3628","observed_orcids":["https://orcid.org/0000-0002-9089-3628"]},"institutions":[{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"JEROME CLERC","raw_affiliation_strings":["D\u00e9partement de M\u00e9decine Nucl\u00e9aire, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Cochin, Paris F-75014, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de M\u00e9decine Nucl\u00e9aire, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Cochin, Paris F-75014, France","institution_ids":["https://openalex.org/I4210092774","https://openalex.org/I4210097159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103002558","display_name":"Christian Br\u00e9chot","orcid":"https://orcid.org/0000-0002-2353-9362","observed_orcids":["https://orcid.org/0000-0002-2353-9362"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"CHRISTIAN BRECHOT","raw_affiliation_strings":["INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004876604","display_name":"Jamila Faivre","orcid":"https://orcid.org/0000-0002-1846-9224","observed_orcids":["https://orcid.org/0000-0002-1846-9224"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"JAMILA FAIVRE","raw_affiliation_strings":["INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U785, Centre H\u00e9patobiliaire, Villejuif F-94800, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine, Villejuif F-94800, France","institution_ids":["https://openalex.org/I102197404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2374,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.86091595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"0","issue":"9","first_page":"081015093227032","last_page":"081015093227032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.6615999937057495,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.6615999937057495,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.22290000319480896,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-specific-promoters","display_name":"tumor-specific promoters","score":0.6949999928474426},{"id":"https://openalex.org/keywords/sodium-iodide-symporter","display_name":"sodium iodide symporter","score":0.8659999966621399},{"id":"https://openalex.org/keywords/brachytherapy","display_name":"brachytherapy","score":0.7179999947547913},{"id":"https://openalex.org/keywords/iodine-131","display_name":"iodine-131","score":0.9200000166893005},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.9200000166893005},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.611470103263855},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4845220446586609},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.46260273456573486},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4557501971721649},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44426384568214417},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4273010492324829},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4137251079082489},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4064452648162842},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38539814949035645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35870927572250366},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08150175213813782}],"mesh":[{"descriptor_ui":"D000073718","descriptor_name":"Pancreatitis-Associated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099209","descriptor_name":"Sodium-Iodide Symporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/hum.2007.153","doi":"https://doi.org/10.1089/hum.2007.153","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2007.153","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"doi:10.1089/hgt.2007.153","doi":"https://doi.org/10.1089/hgt.2007.153","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hgt.2007.153","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmid:18759560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18759560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03268571v1","doi":null,"is_oa":false,"landing_page_url":"https://univ-angers.hal.science/hal-03268571","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Gene Therapy, 2008, 19 (9), pp.915 - 926. ⟨10.1089/hum.2007.153⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1491403843","https://openalex.org/W1500162811","https://openalex.org/W1540542144","https://openalex.org/W1567981986","https://openalex.org/W1570718650","https://openalex.org/W1578866008","https://openalex.org/W1594977639","https://openalex.org/W1608151297","https://openalex.org/W1752683265","https://openalex.org/W1964811394","https://openalex.org/W1971042261","https://openalex.org/W1975987942","https://openalex.org/W1983156626","https://openalex.org/W1983205679","https://openalex.org/W1985738702","https://openalex.org/W1992076816","https://openalex.org/W1993376394","https://openalex.org/W1995443632","https://openalex.org/W2006485937","https://openalex.org/W2007787939","https://openalex.org/W2015416035","https://openalex.org/W2018858097","https://openalex.org/W2019961689","https://openalex.org/W2022138851","https://openalex.org/W2024936954","https://openalex.org/W2028683300","https://openalex.org/W2029265061","https://openalex.org/W2036671075","https://openalex.org/W2044697485","https://openalex.org/W2046061197","https://openalex.org/W2046470280","https://openalex.org/W2047138020","https://openalex.org/W2053504588","https://openalex.org/W2057159037","https://openalex.org/W2059485540","https://openalex.org/W2059486127","https://openalex.org/W2066022830","https://openalex.org/W2074282817","https://openalex.org/W2079109836","https://openalex.org/W2082832566","https://openalex.org/W2084122261","https://openalex.org/W2090966017","https://openalex.org/W2093780636","https://openalex.org/W2107051524","https://openalex.org/W2110278157","https://openalex.org/W2123782548","https://openalex.org/W2123814970","https://openalex.org/W2130862103","https://openalex.org/W2133916339","https://openalex.org/W2139009820","https://openalex.org/W2140528724","https://openalex.org/W2147943356","https://openalex.org/W2210213852","https://openalex.org/W4253422011"],"related_works":["https://openalex.org/W2051431996","https://openalex.org/W2077068563","https://openalex.org/W2187730762","https://openalex.org/W2090039505","https://openalex.org/W2125632509","https://openalex.org/W2057572740","https://openalex.org/W2074898369","https://openalex.org/W2110278157","https://openalex.org/W7097329893","https://openalex.org/W2159563520"],"abstract_inverted_index":{"The":[0,47],"hepatocarcinoma-intestine-pancreas":[1],"(HIP)":[2],"gene,":[3],"also":[4],"called":[5],"pancreatitis-associated":[6],"protein-1":[7],"(PAP1)":[8],"or":[9,138,170],"Reg":[10],"IIIalpha,":[11],"is":[12,60],"activated":[13],"in":[14,22,44,73,98,110,128,154,166,187,197],"most":[15],"human":[16],"hepatocellular":[17],"carcinomas":[18],"(HCCs)":[19],"but":[20],"not":[21],"normal":[23,129,168],"liver,":[24],"which":[25,52],"suggests":[26],"that":[27,184],"HIP":[28,71],"regulatory":[29,209],"sequence":[30,210],"could":[31],"be":[32],"used":[33],"as":[34,91,153,211,227],"efficient":[35],"liver":[36,45,214],"tumor-specific":[37,215],"promoters":[38],"to":[39,62],"express":[40],"a":[41,80,92,158,212,228],"therapeutic":[42,55,221],"polynucleotide":[43],"cancer.":[46],"sodium":[48],"iodide":[49,105],"symporter":[50],"(NIS),":[51],"has":[53,205],"recognized":[54],"and":[56,67,87,104,114,117,124,130,223],"reporter":[57],"gene":[58],"properties,":[59],"appropriate":[61],"evaluate":[63],"the":[64,70,140,198,207,218,232],"transcriptional":[65],"strength":[66],"specificity":[68],"of":[69,94,191,194,200,220,234],"promoter":[72,216],"HCC.":[74,236],"For":[75],"this":[76],"purpose,":[77],"we":[78],"constructed":[79],"recombinant":[81],"rat":[82],"HIP-NIS":[83],"adenoviral":[84],"vector":[85],"(AdrHIP-NIS),":[86],"evaluated":[88],"its":[89],"performance":[90],"mediator":[93],"selective":[95],"radioiodide":[96],"uptake":[97,106],"tumor":[99,188],"hepatocytes.":[100,189],"Western":[101],"blot,":[102],"immunofluorescence,":[103],"assays":[107],"were":[108,126],"performed":[109,127],"AdrHIP-NIS-infected":[111,144,167],"primary":[112],"hepatocytes":[113,169],"transformed":[115,145,171],"hepatic":[116,141,146],"nonhepatic":[118,172],"cells.":[119,173],"Nuclear":[120],"imaging,":[121],"tissue":[122],"counting":[123],"immunohistochemistry":[125],"HCC-bearing":[131],"Wistar":[132],"rats":[133,175],"infected":[134,156],"with":[135,157],"AdrHIP-NIS":[136,179],"intratumorally":[137],"via":[139],"artery.":[142],"In":[143,174],"cells,":[147],"functional":[148,181],"NIS":[149,162,182],"was":[150,164,185],"strongly":[151],"expressed,":[152],"cells":[155],"cytomegalovirus-NIS":[159],"vector.":[160],"No":[161],"expression":[163,183],"found":[165],"bearing":[176],"multinodular":[177,235],"HCC,":[178],"triggered":[180],"preferential":[186],"Administration":[190],"18":[192],"mCi":[193],"(131)I":[195,225],"resulted":[196],"destruction":[199],"AdrHIP-NIS-injected":[201],"nodules.":[202],"This":[203],"study":[204],"identified":[206],"rHIP":[208],"potent":[213],"for":[217,231],"transfer":[219],"genes,":[222],"AdrHIP-NIS-mediated":[224],"therapy":[226],"valuable":[229],"option":[230],"treatment":[233]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}