{"id":"https://openalex.org/W1966352180","doi":"https://doi.org/10.1046/j.1440-1746.2000.02205.x","title":"Branched\u2010chain amino acids","display_name":"Branched\u2010chain amino acids","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W1966352180","doi":"https://doi.org/10.1046/j.1440-1746.2000.02205.x","mag":"1966352180","pmid":"https://pubmed.ncbi.nlm.nih.gov/10937674"},"language":"en","primary_location":{"id":"doi:10.1046/j.1440-1746.2000.02205.x","doi":"https://doi.org/10.1046/j.1440-1746.2000.02205.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1440-1746.2000.02205.x","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025612986","display_name":"Cameron F E Platell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802692842","display_name":"Fremantle Hospital","ror":"https://ror.org/03yxgmm62","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800882159","https://openalex.org/I2802692842","https://openalex.org/I4388446375","https://openalex.org/I4388482742"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Cameron Platell","raw_affiliation_strings":["University Department of Surgery at Fremantle Hospital, Perth, Western Australia, Australia","Fremantle Hospital, Perth, Western Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Surgery at Fremantle Hospital, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I2802692842"]},{"raw_affiliation_string":"Fremantle Hospital, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I2802692842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111795215","display_name":"Sung\u2010Eun Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sung\u2010Eun Kong","raw_affiliation_strings":["University Departments of Surgery at Royal Perth Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Departments of Surgery at Royal Perth Hospital and","institution_ids":["https://openalex.org/I2799740997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047604051","display_name":"Rosalie McCauley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosalie McCauley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103468694","display_name":"John C. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John C Hall","raw_affiliation_strings":["University Departments of Surgery at Royal Perth Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Departments of Surgery at Royal Perth Hospital and","institution_ids":["https://openalex.org/I2799740997"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":0.3485,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.28346457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"15","issue":"7","first_page":"706","last_page":"717"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.07460000365972519,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":1.0},{"id":"https://openalex.org/keywords/isoleucine","display_name":"isoleucine","score":0.9139999747276306},{"id":"https://openalex.org/keywords/leucine","display_name":"leucine","score":1.0},{"id":"https://openalex.org/keywords/valine","display_name":"valine","score":1.0},{"id":"https://openalex.org/keywords/extrahepatic-metabolism","display_name":"extrahepatic metabolism","score":0.796999990940094},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9750000238418579},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.9539999961853027},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/nitrogen-retention","display_name":"nitrogen retention","score":0.9879999756813049},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.921999990940094},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.9449999928474426}],"concepts":[{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.7715422511100769},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.7598884105682373},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.7577345371246338},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7380979657173157},{"id":"https://openalex.org/C2777305461","wikidata":"https://www.wikidata.org/wiki/Q484940","display_name":"Isoleucine","level":4,"score":0.7182963490486145},{"id":"https://openalex.org/C2780677274","wikidata":"https://www.wikidata.org/wiki/Q420726","display_name":"Branched-chain amino acid","level":4,"score":0.6347100138664246},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6063646078109741},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.57993483543396},{"id":"https://openalex.org/C8101879","wikidata":"https://www.wikidata.org/wiki/Q175343","display_name":"Nitrogen balance","level":3,"score":0.47802647948265076},{"id":"https://openalex.org/C197683979","wikidata":"https://www.wikidata.org/wiki/Q14876077","display_name":"Protein catabolism","level":3,"score":0.4460827708244324},{"id":"https://openalex.org/C142796444","wikidata":"https://www.wikidata.org/wiki/Q181394","display_name":"Nutrient","level":2,"score":0.41515517234802246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3919319808483124},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3642021119594574},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3599163293838501},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3413580060005188},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3280472159385681},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3120153546333313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2223416268825531},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13272938132286072},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10532209277153015},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.09173482656478882},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000597","descriptor_name":"Amino Acids, Branched-Chain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002331","descriptor_name":"Carnitine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1440-1746.2000.02205.x","doi":"https://doi.org/10.1046/j.1440-1746.2000.02205.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1440-1746.2000.02205.x","pdf_url":null,"source":{"id":"https://openalex.org/S131037608","display_name":"Journal of Gastroenterology and Hepatology","issn_l":"0815-9319","issn":["0815-9319","1440-1746"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:10937674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10937674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology and hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/3e82acfe-b24f-4998-ac66-062326d8cff2","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/branchedchain-amino-acids(3e82acfe-b24f-4998-ac66-062326d8cff2).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Platell, C, Kong, S E, Mccauley, R & Hall, J 2000, 'Branched-chain amino acids', Journal of Gastroenterology and Hepatology, vol. 15, no. 7, pp. 706-717.","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W22755995","https://openalex.org/W121821925","https://openalex.org/W123269136","https://openalex.org/W139666696","https://openalex.org/W157675920","https://openalex.org/W256701750","https://openalex.org/W314960756","https://openalex.org/W347346825","https://openalex.org/W348642612","https://openalex.org/W1493493476","https://openalex.org/W1716232538","https://openalex.org/W1758964666","https://openalex.org/W1922448404","https://openalex.org/W1925778491","https://openalex.org/W1964327442","https://openalex.org/W1966610069","https://openalex.org/W1967508597","https://openalex.org/W1970110269","https://openalex.org/W1970293894","https://openalex.org/W1971226635","https://openalex.org/W1972095163","https://openalex.org/W1973435688","https://openalex.org/W1974209312","https://openalex.org/W1976991699","https://openalex.org/W1977870779","https://openalex.org/W1978054795","https://openalex.org/W1981410254","https://openalex.org/W1989000394","https://openalex.org/W1989606241","https://openalex.org/W1993469517","https://openalex.org/W1994020779","https://openalex.org/W1997496606","https://openalex.org/W1998177319","https://openalex.org/W1999655968","https://openalex.org/W1999929037","https://openalex.org/W2002111026","https://openalex.org/W2002287253","https://openalex.org/W2004055858","https://openalex.org/W2005918993","https://openalex.org/W2006100879","https://openalex.org/W2009127385","https://openalex.org/W2009526789","https://openalex.org/W2012105106","https://openalex.org/W2012835655","https://openalex.org/W2019422172","https://openalex.org/W2024813061","https://openalex.org/W2030229746","https://openalex.org/W2033529075","https://openalex.org/W2034733607","https://openalex.org/W2044305133","https://openalex.org/W2045766940","https://openalex.org/W2045788598","https://openalex.org/W2045830082","https://openalex.org/W2045864787","https://openalex.org/W2046298163","https://openalex.org/W2046956654","https://openalex.org/W2050000763","https://openalex.org/W2054411296","https://openalex.org/W2055120611","https://openalex.org/W2055219130","https://openalex.org/W2056166762","https://openalex.org/W2057888544","https://openalex.org/W2059540346","https://openalex.org/W2059612921","https://openalex.org/W2063841862","https://openalex.org/W2064029319","https://openalex.org/W2067193049","https://openalex.org/W2069185567","https://openalex.org/W2075173271","https://openalex.org/W2079212581","https://openalex.org/W2079486812","https://openalex.org/W2080345544","https://openalex.org/W2080370244","https://openalex.org/W2080805392","https://openalex.org/W2082878801","https://openalex.org/W2087118908","https://openalex.org/W2091316697","https://openalex.org/W2092033643","https://openalex.org/W2092904564","https://openalex.org/W2103841867","https://openalex.org/W2106561035","https://openalex.org/W2110752151","https://openalex.org/W2137889612","https://openalex.org/W2140553840","https://openalex.org/W2154403203","https://openalex.org/W2160628227","https://openalex.org/W2205678622","https://openalex.org/W2222831213","https://openalex.org/W2273913886","https://openalex.org/W2274678106","https://openalex.org/W2277541261","https://openalex.org/W2311790557","https://openalex.org/W2317402978","https://openalex.org/W2327974042","https://openalex.org/W2337242376","https://openalex.org/W2398392154","https://openalex.org/W2406423778","https://openalex.org/W2407344817","https://openalex.org/W2409407697","https://openalex.org/W2409734320","https://openalex.org/W2410288827","https://openalex.org/W2411505379","https://openalex.org/W2415221289","https://openalex.org/W2416030633","https://openalex.org/W2416543614","https://openalex.org/W2418570153","https://openalex.org/W2426478908","https://openalex.org/W2435571228","https://openalex.org/W2435609786","https://openalex.org/W2472397926","https://openalex.org/W2690927714","https://openalex.org/W4242638755","https://openalex.org/W4254785927","https://openalex.org/W6694257572"],"related_works":["https://openalex.org/W1991182707","https://openalex.org/W7036290636","https://openalex.org/W2114681089","https://openalex.org/W2807586373","https://openalex.org/W2015388529","https://openalex.org/W2073305348","https://openalex.org/W1987582842","https://openalex.org/W2008180932","https://openalex.org/W2016728810","https://openalex.org/W2165688472"],"abstract_inverted_index":{"The":[0,111],"branched-chain":[1],"amino":[2],"acids":[3],"(BCAA),":[4],"isoleucine,":[5],"leucine":[6],"and":[7,85,116],"valine,":[8],"are":[9,14,113],"unique":[10],"in":[11,18,31,48,55,98,158],"that":[12,119],"they":[13],"principally":[15],"metabolized":[16],"extrahepatically":[17],"the":[19,26,39,60,79,135,146],"skeletal":[20],"muscle.":[21],"This":[22],"observation":[23],"led":[24],"to":[25],"investigation":[27],"of":[28,34,134,141,148],"these":[29],"nutrients":[30],"a":[32,66,131],"number":[33],"clinical":[35,68],"scenarios.":[36],"By":[37],"far":[38],"most":[40],"intensively":[41],"studied":[42],"applications":[43],"for":[44,70],"BCAA":[45,71,80,103,112,149],"have":[46,63],"been":[47],"patients":[49,54,75,160],"with":[50,76,124,151,161],"liver":[51,77],"failure":[52],"and/or":[53],"catabolic":[56,162],"disease":[57,163],"states.":[58,164],"However,":[59],"resulting":[61],"studies":[62],"not":[64,105],"demonstrated":[65],"clear":[67],"benefit":[69],"nutritional":[72],"supplements.":[73],"In":[74],"failure,":[78],"did":[81,104],"improve":[82,106],"nitrogen":[83],"retention":[84],"protein":[86],"synthesis,":[87],"but":[88],"their":[89,125],"effect":[90],"on":[91],"patient":[92],"outcome":[93],"was":[94],"less":[95],"clear.":[96],"Similarly,":[97],"critically":[99],"ill":[100],"septic":[101],"patients,":[102],"either":[107],"survival":[108],"or":[109],"morbidity.":[110],"important":[114],"nutrients,":[115],"it":[117],"seems":[118],"any":[120],"specific":[121],"benefits":[122],"associated":[123],"use":[126],"will":[127],"be":[128],"based":[129],"upon":[130],"greater":[132],"understanding":[133],"underlying":[136],"cellular":[137],"biology.":[138],"Potential":[139],"areas":[140],"further":[142],"research":[143],"may":[144],"include":[145],"combination":[147],"supplements":[150],"other":[152],"anabolic":[153],"factors":[154],"(e.g.":[155],"growth":[156],"hormone)":[157],"managing":[159]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}