{"id":"https://openalex.org/W1966323697","doi":"https://doi.org/10.1002/jps.21742","title":"Metronidazole loaded pectin microspheres for colon targeting","display_name":"Metronidazole loaded pectin microspheres for colon targeting","publication_year":2009,"publication_date":"2009-06-02","ids":{"openalex":"https://openalex.org/W1966323697","doi":"https://doi.org/10.1002/jps.21742","mag":"1966323697","pmid":"https://pubmed.ncbi.nlm.nih.gov/19492406"},"language":"en","primary_location":{"id":"doi:10.1002/jps.21742","doi":"https://doi.org/10.1002/jps.21742","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.21742","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085257615","display_name":"Ankur Vaidya","orcid":"https://orcid.org/0000-0002-6693-6085","observed_orcids":["https://orcid.org/0000-0002-6693-6085"]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ankur vaidya","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India","institution_ids":["https://openalex.org/I8977528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023023732","display_name":"Aviral Jain","orcid":"https://orcid.org/0000-0001-7808-6180","observed_orcids":["https://orcid.org/0000-0001-7808-6180"]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aviral Jain","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India","institution_ids":["https://openalex.org/I8977528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057205406","display_name":"Piush Khare","orcid":"https://orcid.org/0000-0002-3245-9225","observed_orcids":["https://orcid.org/0000-0002-3245-9225"]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Piush Khare","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India","institution_ids":["https://openalex.org/I8977528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111574063","display_name":"Ram Kishor Agrawal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ram K. Agrawal","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India","institution_ids":["https://openalex.org/I8977528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073264497","display_name":"Sanjay Jain","orcid":"https://orcid.org/0000-0002-9241-3114","observed_orcids":["https://orcid.org/0000-0002-9241-3114"]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sanjay K. Jain","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar 470 003, Madhya Pradesh, India","institution_ids":["https://openalex.org/I8977528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073264497"],"corresponding_institution_ids":["https://openalex.org/I8977528"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":2.8835,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.88659218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"98","issue":"11","first_page":"4229","last_page":"4236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":0.9850000143051147},{"id":"https://openalex.org/keywords/colon-specific-drug-delivery","display_name":"colon-targeted drug delivery","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ph-responsive-drug-release","display_name":"pH-responsive drug release","score":0.8100000023841858},{"id":"https://openalex.org/keywords/multiparticulate-formulation","display_name":"multiparticulate formulation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/caecal-contents","display_name":"caecal contents","score":0.6880000233650208},{"id":"https://openalex.org/keywords/gastrointestinal-drug-release","display_name":"gastrointestinal drug release","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2780756937","wikidata":"https://www.wikidata.org/wiki/Q188154","display_name":"Pectin","level":2,"score":0.8334438800811768},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6456587910652161},{"id":"https://openalex.org/C189942447","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microsphere","level":2,"score":0.6438273787498474},{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.6238384246826172},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5910807251930237},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5777950286865234},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5149300694465637},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.5046769380569458},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.48727428913116455},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44176238775253296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2353578507900238},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.13522371649742126},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10773038864135742},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.10767611861228943},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10385793447494507},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06251892447471619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002432","descriptor_name":"Cecum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002432","descriptor_name":"Cecum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005766","descriptor_name":"Gastrointestinal Contents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010368","descriptor_name":"Pectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jps.21742","doi":"https://doi.org/10.1002/jps.21742","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.21742","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:19492406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19492406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W126201954","https://openalex.org/W261761568","https://openalex.org/W1549826455","https://openalex.org/W1672660987","https://openalex.org/W1995263937","https://openalex.org/W2008279842","https://openalex.org/W2012419970","https://openalex.org/W2013980387","https://openalex.org/W2021909277","https://openalex.org/W2029103483","https://openalex.org/W2044231361","https://openalex.org/W2051884496","https://openalex.org/W2068686072","https://openalex.org/W2071850776","https://openalex.org/W2104046482","https://openalex.org/W2106195128","https://openalex.org/W2112321307","https://openalex.org/W2112336067","https://openalex.org/W2145817077","https://openalex.org/W2155650356","https://openalex.org/W2282147439","https://openalex.org/W4249253434"],"related_works":["https://openalex.org/W2071850776","https://openalex.org/W2013980387","https://openalex.org/W2071857931","https://openalex.org/W4251769538","https://openalex.org/W2182862444","https://openalex.org/W7100877478","https://openalex.org/W7095806896","https://openalex.org/W2012419970","https://openalex.org/W7143375911","https://openalex.org/W2038924037"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}