{"id":"https://openalex.org/W1966322307","doi":"https://doi.org/10.1097/cji.0b013e3181a00068","title":"Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients","display_name":"Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients","publication_year":2009,"publication_date":"2009-05-21","ids":{"openalex":"https://openalex.org/W1966322307","doi":"https://doi.org/10.1097/cji.0b013e3181a00068","mag":"1966322307","pmid":"https://pubmed.ncbi.nlm.nih.gov/19609242"},"language":"en","primary_location":{"id":"doi:10.1097/cji.0b013e3181a00068","doi":"https://doi.org/10.1097/cji.0b013e3181a00068","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cji.0b013e3181a00068","pdf_url":null,"source":{"id":"https://openalex.org/S177451610","display_name":"Journal of Immunotherapy","issn_l":"1524-9557","issn":["1524-9557","1537-4513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103122140","display_name":"Benjamin Weide","orcid":"https://orcid.org/0000-0002-7941-223X","observed_orcids":["https://orcid.org/0000-0002-7941-223X"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Benjamin Weide","raw_affiliation_strings":["Department of Dermatology, Division of Dermatooncology, University of T\u00fcbingen, T\u00fcbingen, Germany. benjamin.weide@med.uni-tuebingen.de","Department of Dermatology, Division of Dermatooncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Division of Dermatooncology, University of T\u00fcbingen, T\u00fcbingen, Germany. benjamin.weide@med.uni-tuebingen.de","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Department of Dermatology, Division of Dermatooncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087903302","display_name":"Steve Pascolo","orcid":"https://orcid.org/0000-0003-2946-5576","observed_orcids":["https://orcid.org/0000-0003-2946-5576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Pascolo","raw_affiliation_strings":["Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112453456","display_name":"Birgit Scheel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123470","display_name":"CureVac (Germany)","ror":"https://ror.org/02q3n2241","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210123470"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birgit Scheel","raw_affiliation_strings":["CureVac GmbH, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CureVac GmbH, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210123470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063812788","display_name":"Evelyna Derhovanessian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Evelyna Derhovanessian","raw_affiliation_strings":["Department of Internal Medicine II, Section for Transplantation Immunology and Immunohaematology, University of T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Section for Transplantation Immunology and Immunohaematology, University of T\u00fcbingen","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044487752","display_name":"Annette Pflugfelder","orcid":"https://orcid.org/0000-0001-7858-0453","observed_orcids":["https://orcid.org/0000-0001-7858-0453"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Annette Pflugfelder","raw_affiliation_strings":["Department of Dermatology, Division of Dermatooncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Division of Dermatooncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056227404","display_name":"Thomas Eigentler","orcid":"https://orcid.org/0000-0003-0019-2770","observed_orcids":["https://orcid.org/0000-0003-0019-2770"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas K. Eigentler","raw_affiliation_strings":["Department of Dermatology, Division of Dermatooncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Division of Dermatooncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027331206","display_name":"Graham Pawelec","orcid":"https://orcid.org/0000-0002-3600-0163","observed_orcids":["https://orcid.org/0000-0002-3600-0163"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Graham Pawelec","raw_affiliation_strings":["Department of Internal Medicine II, Section for Transplantation Immunology and Immunohaematology, University of T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Section for Transplantation Immunology and Immunohaematology, University of T\u00fcbingen","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036714567","display_name":"Ingmar Hoerr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123470","display_name":"CureVac (Germany)","ror":"https://ror.org/02q3n2241","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210123470"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingmar Hoerr","raw_affiliation_strings":["CureVac GmbH, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CureVac GmbH, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210123470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090153362","display_name":"Hans\u2010Georg Rammensee","orcid":"https://orcid.org/0000-0003-1614-2647","observed_orcids":["https://orcid.org/0000-0003-1614-2647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans-Georg Rammensee","raw_affiliation_strings":["Department of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001548963","display_name":"Claus Garbe","orcid":"https://orcid.org/0000-0001-8530-780X","observed_orcids":["https://orcid.org/0000-0001-8530-780X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Claus Garbe","raw_affiliation_strings":["Department of Dermatology, Division of Dermatooncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Division of Dermatooncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001548963","https://openalex.org/A5044487752","https://openalex.org/A5056227404","https://openalex.org/A5103122140"],"corresponding_institution_ids":["https://openalex.org/I8087733"],"apc_list":null,"apc_paid":null,"fwci":6.2013,"has_fulltext":false,"cited_by_count":388,"citation_normalized_percentile":{"value":0.97041088,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"32","issue":"5","first_page":"498","last_page":"507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrna-vaccination","display_name":"mRNA vaccination","score":0.7089999914169312},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.878000020980835},{"id":"https://openalex.org/keywords/melan-a","display_name":"Melan-A","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/gp100","display_name":"gp100","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mage-a1","display_name":"MAGE-1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mage-a3","display_name":"MAGE-A3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/keyhole-limpet-hemocyanin","display_name":"keyhole limpet hemocyanin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9100000262260437},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7910000085830688},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.5130000114440918},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6775875687599182},{"id":"https://openalex.org/C2776727803","wikidata":"https://www.wikidata.org/wiki/Q1496686","display_name":"Keyhole limpet hemocyanin","level":3,"score":0.6688912510871887},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.59342360496521},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5911620855331421},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5573089122772217},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5409643650054932},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5397170186042786},{"id":"https://openalex.org/C2780835560","wikidata":"https://www.wikidata.org/wiki/Q5449573","display_name":"Protamine","level":3,"score":0.5034903883934021},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.4500024914741516},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42939478158950806},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32440781593322754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25489258766174316},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.220747709274292},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006433","descriptor_name":"Hemocyanins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011479","descriptor_name":"Protamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016233","descriptor_name":"Immunotherapy, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D039481","descriptor_name":"CD11b Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058950","descriptor_name":"Melanoma-Specific Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/cji.0b013e3181a00068","doi":"https://doi.org/10.1097/cji.0b013e3181a00068","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cji.0b013e3181a00068","pdf_url":null,"source":{"id":"https://openalex.org/S177451610","display_name":"Journal of Immunotherapy","issn_l":"1524-9557","issn":["1524-9557","1537-4513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotherapy","raw_type":"journal-article"},{"id":"pmid:19609242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19609242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunotherapy (Hagerstown, Md. : 1997)","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1530044612","https://openalex.org/W1981816112","https://openalex.org/W1991064719","https://openalex.org/W1995202011","https://openalex.org/W1997849135","https://openalex.org/W2014495927","https://openalex.org/W2026364942","https://openalex.org/W2037813830","https://openalex.org/W2038715317","https://openalex.org/W2041778510","https://openalex.org/W2043063663","https://openalex.org/W2050933039","https://openalex.org/W2063287711","https://openalex.org/W2066847748","https://openalex.org/W2072994153","https://openalex.org/W2077523827","https://openalex.org/W2086050574","https://openalex.org/W2095475784","https://openalex.org/W2117273583","https://openalex.org/W2119077297","https://openalex.org/W2133205326","https://openalex.org/W2138002048","https://openalex.org/W2148373543","https://openalex.org/W2150678612","https://openalex.org/W2167614869","https://openalex.org/W2168071482","https://openalex.org/W2410313936","https://openalex.org/W6679827509"],"related_works":["https://openalex.org/W2066847748","https://openalex.org/W4415924719","https://openalex.org/W2587240151","https://openalex.org/W4407425344","https://openalex.org/W1994310269","https://openalex.org/W2093003099","https://openalex.org/W2536529113","https://openalex.org/W2001740055","https://openalex.org/W4324054820","https://openalex.org/W7148719578"],"abstract_inverted_index":{"In":[0,43,147],"mice,":[1],"injection":[2,154],"of":[3,84,98,123,131,137,155,165,171,176,185,191,200],"messenger":[4],"RNA":[5],"(mRNA)":[6],"coding":[7,29],"for":[8,30],"tumor-associated":[9],"antigens":[10],"can":[11],"induce":[12],"antitumor":[13],"immune":[14,68],"responses":[15],"and":[16,36,67,160],"therefore":[17],"offers":[18],"a":[19,144,183,192],"broadly":[20],"applicable":[21],"immunotherapy":[22],"approach.":[23],"We":[24],"injected":[25],"intradermally":[26],"protamine-stabilized":[27],"mRNAs":[28],"Melan-A,":[31],"Tyrosinase,":[32],"gp100,":[33],"Mage-A1,":[34],"Mage-A3,":[35],"Survivin":[37],"in":[38,95,101,114,129,182],"21":[39],"metastatic":[40],"melanoma":[41],"patients.":[42,135],"10":[44],"patients":[45,100,116,139,186],"keyhole":[46],"limpet":[47],"hemocyanin":[48],"(KLH)":[49],"was":[50,59,89,127],"added":[51],"to":[52],"the":[53,82,99,102,115,166,169,174,189,201],"vaccine.":[54,203],"Granulocyte":[55],"macrophage":[56],"colony-stimulating":[57],"factor":[58],"applied":[60],"as":[61],"an":[62],"adjuvant.":[63],"Endpoints":[64],"were":[65,112],"toxicity":[66],"responses.":[69],"No":[70],"adverse":[71],"events":[72],"more":[73],"than":[74],"grade":[75],"II":[76],"have":[77],"been":[78],"observed.":[79],"During":[80],"treatment":[81,167,181],"frequency":[83,170],"Foxp3+/CD4+":[85],"regulatory":[86],"T":[87,125,178],"cells":[88,108,126,179],"significantly":[90],"decreased":[91],"upon":[92,180],"mRNA":[93,157],"vaccination":[94],"peripheral":[96],"blood":[97],"KLH":[103],"arm,":[104],"whereas":[105],"myeloid":[106],"suppressor":[107],"(CD11b+HLA-DR":[109],"lo":[110],"monocytes)":[111],"reduced":[113],"not":[117],"receiving":[118],"KLH.":[119],"A":[120],"reproducible":[121],"increase":[122,175],"vaccine-directed":[124,177],"observed":[128],"2":[130],"4":[132],"immunologically":[133],"evaluable":[134],"One":[136],"7":[138],"with":[140,188],"measurable":[141],"disease":[142],"showed":[143],"complete":[145,193],"response.":[146],"conclusion,":[148],"we":[149],"show":[150],"here":[151],"that":[152],"direct":[153],"protamine-protected":[156],"is":[158],"feasible":[159],"safe.":[161],"The":[162],"significant":[163],"influence":[164],"on":[168],"immunosuppressive":[172],"cells,":[173],"subset":[184],"together":[187],"demonstration":[190],"clinical":[194,198],"response":[195],"encourage":[196],"further":[197],"investigation":[199],"protamine-mRNA":[202]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":45},{"year":2022,"cited_by_count":46},{"year":2021,"cited_by_count":41},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}