{"id":"https://openalex.org/W1966321990","doi":"https://doi.org/10.1371/journal.pone.0006175","title":"Evaluation of the Possible Transmission of BSE and Scrapie to Gilthead Sea Bream (Sparus aurata)","display_name":"Evaluation of the Possible Transmission of BSE and Scrapie to Gilthead Sea Bream (Sparus aurata)","publication_year":2009,"publication_date":"2009-07-27","ids":{"openalex":"https://openalex.org/W1966321990","doi":"https://doi.org/10.1371/journal.pone.0006175","mag":"1966321990","pmid":"https://pubmed.ncbi.nlm.nih.gov/19636413","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2712096"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0006175","doi":"https://doi.org/10.1371/journal.pone.0006175","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0006175","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006175&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006175&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076983634","display_name":"Evgenia Salta","orcid":"https://orcid.org/0000-0003-3151-9369","observed_orcids":["https://orcid.org/0000-0003-3151-9369"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evgenia Salta","raw_affiliation_strings":["Department of Pharmacology, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113623144","display_name":"Cynthia H. Panagiotidis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Cynthia Panagiotidis","raw_affiliation_strings":["Centre for Research and Technology-Hellas, Institute of Agrobiotechnology, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research and Technology-Hellas, Institute of Agrobiotechnology, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084009958","display_name":"Konstantinos Teliousis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos Teliousis","raw_affiliation_strings":["Laboratory of Pathology, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025718299","display_name":"Spyros Petrakis","orcid":"https://orcid.org/0000-0001-9094-3480","observed_orcids":["https://orcid.org/0000-0001-9094-3480"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["DE","GR"],"is_corresponding":false,"raw_author_name":"Spyros Petrakis","raw_affiliation_strings":["Department of Pharmacology, Aristotle University of Thessaloniki, Thessaloniki, Greece","Max Delbruck Center for Molecular Medicine, Department of Neuroproteomics, Berlin-Buch, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Max Delbruck Center for Molecular Medicine, Department of Neuroproteomics, Berlin-Buch, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024419245","display_name":"Eleftherios Eleftheriadis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147215","display_name":"National Agricultural Research Foundation","ror":"https://ror.org/04e0pwy27","country_code":"GR","type":"facility","lineage":["https://openalex.org/I2800057246","https://openalex.org/I4210147215"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleftherios Eleftheriadis","raw_affiliation_strings":["National Agricultural Research Foundation, Fisheries Research Institute, Nea Peramos, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Agricultural Research Foundation, Fisheries Research Institute, Nea Peramos, Greece","institution_ids":["https://openalex.org/I4210147215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029149694","display_name":"Fotios Arapoglou","orcid":"https://orcid.org/0009-0002-6125-8008","observed_orcids":["https://orcid.org/0009-0002-6125-8008"]},"institutions":[{"id":"https://openalex.org/I4210147215","display_name":"National Agricultural Research Foundation","ror":"https://ror.org/04e0pwy27","country_code":"GR","type":"facility","lineage":["https://openalex.org/I2800057246","https://openalex.org/I4210147215"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Fotis Arapoglou","raw_affiliation_strings":["National Agricultural Research Foundation, Fisheries Research Institute, Nea Peramos, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Agricultural Research Foundation, Fisheries Research Institute, Nea Peramos, Greece","institution_ids":["https://openalex.org/I4210147215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014403258","display_name":"Nikolaos Grigoriadis","orcid":"https://orcid.org/0000-0002-4278-3301","observed_orcids":["https://orcid.org/0000-0002-4278-3301"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Grigoriadis","raw_affiliation_strings":["B' Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B' Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anna Nicolaou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192756129","display_name":"University of Macedonia","ror":"https://ror.org/05fg6gr82","country_code":"GR","type":"education","lineage":["https://openalex.org/I192756129"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anna Nicolaou","raw_affiliation_strings":["Department of Business Administration, University of Macedonia, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Business Administration, University of Macedonia, Thessaloniki, Greece","institution_ids":["https://openalex.org/I192756129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033685828","display_name":"Eleni Kaldrymidou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Kaldrymidou","raw_affiliation_strings":["Laboratory of Pathology, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028706835","display_name":"Grigorios D. Krey","orcid":"https://orcid.org/0000-0002-2948-8252","observed_orcids":["https://orcid.org/0000-0002-2948-8252"]},"institutions":[{"id":"https://openalex.org/I4210147215","display_name":"National Agricultural Research Foundation","ror":"https://ror.org/04e0pwy27","country_code":"GR","type":"facility","lineage":["https://openalex.org/I2800057246","https://openalex.org/I4210147215"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Grigorios Krey","raw_affiliation_strings":["National Agricultural Research Foundation, Fisheries Research Institute, Nea Peramos, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Agricultural Research Foundation, Fisheries Research Institute, Nea Peramos, Greece","institution_ids":["https://openalex.org/I4210147215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071050099","display_name":"Theodoros Sklaviadis","orcid":"https://orcid.org/0000-0002-0246-3100","observed_orcids":["https://orcid.org/0000-0002-0246-3100"]},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Theodoros Sklaviadis","raw_affiliation_strings":["Centre for Research and Technology-Hellas, Institute of Agrobiotechnology, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Research and Technology-Hellas, Institute of Agrobiotechnology, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5071050099"],"corresponding_institution_ids":["https://openalex.org/I4210134249"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.0725,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.73469109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"7","first_page":"e6175","last_page":"e6175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9390000104904175},{"id":"https://openalex.org/keywords/prion-transmission","display_name":"prion transmission","score":0.578000009059906},{"id":"https://openalex.org/keywords/gilthead-seabream","display_name":"Sparus aurata","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bovine-spongiform-encephalopathy","display_name":"bovine spongiform encephalopathy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/scrapie","display_name":"scrapie","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prion-protein","display_name":"prion protein","score":0.5730000138282776},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8220000267028809},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7179999947547913},{"id":"https://openalex.org/keywords/fish-farming","display_name":"fish farming","score":0.7480000257492065},{"id":"https://openalex.org/keywords/public-health-risk","display_name":"public health risk","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.9318984746932983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7320964336395264},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.583250880241394},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5459354519844055},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5077949166297913},{"id":"https://openalex.org/C2781131914","wikidata":"https://www.wikidata.org/wiki/Q154666","display_name":"Bovine spongiform encephalopathy","level":4,"score":0.47353026270866394},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.35531407594680786},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33578526973724365},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19057786464691162},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1659279465675354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09729024767875671}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005393","descriptor_name":"Fish Diseases","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D012608","descriptor_name":"Scrapie","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D016643","descriptor_name":"Encephalopathy, Bovine Spongiform","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D021541","descriptor_name":"Sea Bream","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0006175","doi":"https://doi.org/10.1371/journal.pone.0006175","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0006175","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006175&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1502703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2712096","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2712096","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2712096","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:19636413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19636413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:13590","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/13590/1/13590oa.pdf","pdf_url":"http://edoc.mdc-berlin.de/13590/1/13590oa.pdf","source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:cb58a0df31424a588557db46f17f7820","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cb58a0df31424a588557db46f17f7820","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 7, p e6175 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/146988","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Evaluation_of_the_Possible_Transmission_of_BSE_and_Scrapie_to_Gilthead_Sea_Bream_Sparus_aurata_/146988","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0006175","doi":"https://doi.org/10.1371/journal.pone.0006175","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0006175","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006175&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7778000235557556,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"},{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G340216549","display_name":null,"funder_award_id":"FOOD-CT-2004-506579","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6942172151","display_name":null,"funder_award_id":"QLK5-2002-00866","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8974889193","display_name":null,"funder_award_id":"506579","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1966321990.pdf","grobid_xml":"https://content.openalex.org/works/W1966321990.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W18040525","https://openalex.org/W161678687","https://openalex.org/W1550397805","https://openalex.org/W1587073199","https://openalex.org/W1674114396","https://openalex.org/W1706576307","https://openalex.org/W1866385346","https://openalex.org/W1965421867","https://openalex.org/W1983292653","https://openalex.org/W1983514205","https://openalex.org/W1998949210","https://openalex.org/W2002292600","https://openalex.org/W2002365653","https://openalex.org/W2004457763","https://openalex.org/W2004850139","https://openalex.org/W2018407130","https://openalex.org/W2024710814","https://openalex.org/W2031985057","https://openalex.org/W2041288238","https://openalex.org/W2057418115","https://openalex.org/W2062076246","https://openalex.org/W2063561762","https://openalex.org/W2064301224","https://openalex.org/W2065514717","https://openalex.org/W2067264815","https://openalex.org/W2069586722","https://openalex.org/W2069879109","https://openalex.org/W2070223219","https://openalex.org/W2071010015","https://openalex.org/W2073769687","https://openalex.org/W2079738171","https://openalex.org/W2079843273","https://openalex.org/W2089603371","https://openalex.org/W2093091702","https://openalex.org/W2120864200","https://openalex.org/W2122191525","https://openalex.org/W2128781491","https://openalex.org/W2129777335","https://openalex.org/W2132479870","https://openalex.org/W2140559080","https://openalex.org/W2142696909","https://openalex.org/W2146246590","https://openalex.org/W2147227684","https://openalex.org/W2150151638","https://openalex.org/W2156464988","https://openalex.org/W2168129906","https://openalex.org/W2170250399","https://openalex.org/W2171420378","https://openalex.org/W2324660492","https://openalex.org/W2951251674","https://openalex.org/W4393301242"],"related_works":["https://openalex.org/W7095071892","https://openalex.org/W2139586760","https://openalex.org/W3161915406","https://openalex.org/W2057007072","https://openalex.org/W2145358794","https://openalex.org/W3215709531","https://openalex.org/W2150661914","https://openalex.org/W2238500155","https://openalex.org/W2031985057","https://openalex.org/W2915893340"],"abstract_inverted_index":{"In":[0],"transmissible":[1],"spongiform":[2],"encephalopathies":[3],"(TSEs),":[4],"a":[5,57,101,258],"group":[6],"of":[7,23,29,40,117,128,132,211,247,257],"fatal":[8],"neurodegenerative":[9],"disorders":[10],"affecting":[11],"many":[12,68],"species,":[13,74,244],"the":[14,21,30,37,41,115,158,174,178,209,221,245],"key":[15],"event":[16],"in":[17,72,81,166,173,195,208,262],"disease":[18,260],"pathogenesis":[19,80],"is":[20,46,50,56,76,230,265],"accumulation":[22,131],"an":[24,200,231],"abnormal":[25,206],"conformational":[26],"isoform":[27],"(PrP(Sc))":[28],"host-encoded":[31],"cellular":[32],"prion":[33,62,113,259],"protein":[34,237],"(PrP(C)).":[35],"While":[36],"precise":[38],"mechanism":[39],"PrP(C)":[42,54],"to":[43,224],"PrP(Sc)":[44],"conversion":[45],"not":[47],"understood,":[48],"it":[49],"clear":[51],"that":[52,86,134],"host":[53],"expression":[55],"prerequisite":[58],"for":[59,239],"effective":[60],"infectious":[61,253],"propagation.":[63],"Although":[64],"there":[65],"have":[66],"been":[67],"studies":[69],"on":[70],"TSEs":[71],"mammalian":[73,243,254],"little":[75],"known":[77],"about":[78,220],"TSE":[79],"fish.":[82],"Here":[83],"we":[84],"show":[85,126],"while":[87],"gilthead":[88],"sea":[89,141],"bream":[90,142],"(Sparus":[91],"aurata)":[92],"orally":[93],"challenged":[94,176,213],"with":[95,137,148,169,177,182,199,214,252],"brain":[96,180],"homogenates":[97],"prepared":[98],"either":[99],"from":[100,106,150],"BSE":[102],"infected":[103,108],"cow":[104],"or":[105,256],"scrapie":[107],"sheep":[109],"developed":[110,160],"no":[111,154],"clinical":[112],"disease,":[114],"brains":[116,149,210],"TSE-fed":[118],"fish":[119,167,212,228,249,264],"sampled":[120],"two":[121],"years":[122],"after":[123],"challenge":[124],"did":[125],"signs":[127],"neurodegeneration":[129,204],"and":[130,164,193,205,241,267],"deposits":[133,159,184],"reacted":[135],"positively":[136],"antibodies":[138],"raised":[139],"against":[140],"PrP.":[143],"The":[144,203],"control":[145],"groups,":[146],"fed":[147],"uninfected":[151],"animals,":[152],"showed":[153],"such":[155],"signs.":[156],"Remarkably,":[157],"much":[161],"more":[162],"rapidly":[163],"extensively":[165],"inoculated":[168],"BSE-infected":[170],"material":[171],"than":[172],"ones":[175],"scrapie-infected":[179],"homogenate,":[181],"numerous":[183],"being":[185,250],"proteinase":[186],"K-resistant.":[187],"These":[188],"plaque-like":[189],"aggregates":[190],"exhibited":[191],"congophilia":[192],"birefringence":[194],"polarized":[196],"light,":[197],"consistent":[198],"amyloid-like":[201],"component.":[202],"deposition":[207],"prion,":[215],"especially":[216],"BSE,":[217],"raises":[218],"concerns":[219],"potential":[222],"risk":[223],"public":[225],"health.":[226],"As":[227],"aquaculture":[229],"economically":[232],"important":[233],"industry":[234],"providing":[235],"high":[236],"nutrition":[238],"humans":[240],"other":[242],"prospect":[246],"farmed":[248,263],"contaminated":[251],"PrP(Sc),":[255],"developing":[261],"alarming":[266],"requires":[268],"further":[269],"evaluation.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}