{"id":"https://openalex.org/W1966291272","doi":"https://doi.org/10.1111/j.1399-0004.1998.tb03702.x","title":"Infectious complications of propionic acidemia in Saudia Arabia","display_name":"Infectious complications of propionic acidemia in Saudia Arabia","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W1966291272","doi":"https://doi.org/10.1111/j.1399-0004.1998.tb03702.x","mag":"1966291272","pmid":"https://pubmed.ncbi.nlm.nih.gov/9727749"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-0004.1998.tb03702.x","doi":"https://doi.org/10.1111/j.1399-0004.1998.tb03702.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-0004.1998.tb03702.x","pdf_url":null,"source":{"id":"https://openalex.org/S4954800","display_name":"Clinical Genetics","issn_l":"0009-9163","issn":["0009-9163","1399-0004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109556059","display_name":"M. Al Essa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"M. Al. Essa","raw_affiliation_strings":["Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia","Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]},{"raw_affiliation_string":"Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059260901","display_name":"Zuhair Abdalla Rahbeeni","orcid":"https://orcid.org/0000-0002-6890-1652","observed_orcids":["https://orcid.org/0000-0002-6890-1652"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Z. Rahbeeni","raw_affiliation_strings":["Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065345233","display_name":"Suliman Aljumaah","orcid":"https://orcid.org/0000-0002-5526-1174","observed_orcids":["https://orcid.org/0000-0002-5526-1174"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"S. Jumaah","raw_affiliation_strings":["Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109362232","display_name":"S. Joshi","orcid":"https://orcid.org/0009-0002-2893-3331","observed_orcids":["https://orcid.org/0009-0002-2893-3331"]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"S. Joshi","raw_affiliation_strings":["Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Al. Jishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"E. Al. Jishi","raw_affiliation_strings":["Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110036909","display_name":"M. S. Rashed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"M. S. Rashed","raw_affiliation_strings":["Departments of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Al. Amoudi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"M. Al. Amoudi","raw_affiliation_strings":["Departments of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103387682","display_name":"Pinar T. Ozand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800965796","display_name":"King Faisal Specialist Hospital & Research Centre","ror":"https://ror.org/05n0wgt02","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2800965796"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"P. T. Ozand","raw_affiliation_strings":["Departments of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia","Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]},{"raw_affiliation_string":"Departments of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia","institution_ids":["https://openalex.org/I2800965796"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109556059"],"corresponding_institution_ids":["https://openalex.org/I2800965796"],"apc_list":{"value":4980,"currency":"USD","value_usd":4980},"apc_paid":null,"fwci":0.1903,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.43224461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"54","issue":"1","first_page":"90","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propionic-acidemia","display_name":"propionic acidemia","score":1.0},{"id":"https://openalex.org/keywords/infectious-complications","display_name":"infectious complications","score":0.9800000190734863},{"id":"https://openalex.org/keywords/consanguinity","display_name":"consanguinity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.7039999961853027},{"id":"https://openalex.org/keywords/metabolic-decompensation","display_name":"metabolic decompensation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":0.8610000014305115},{"id":"https://openalex.org/keywords/carnitine-therapy","display_name":"carnitine therapy","score":0.878000020980835},{"id":"https://openalex.org/keywords/t-and-b-lymphocytes","display_name":"T and B lymphocytes","score":0.8050000071525574},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.7889999747276306},{"id":"https://openalex.org/keywords/saudi-patients","display_name":"Saudi patients","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2779488543","wikidata":"https://www.wikidata.org/wiki/Q7250337","display_name":"Propionic acidemia","level":2,"score":0.8642936944961548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6476558446884155},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5275970101356506},{"id":"https://openalex.org/C2778721985","wikidata":"https://www.wikidata.org/wiki/Q1183680","display_name":"Decompensation","level":2,"score":0.516707181930542},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48418334126472473},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4826691448688507},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4201841354370117},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37764936685562134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32535475492477417},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007532","descriptor_name":"Isoleucine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012529","descriptor_name":"Saudi Arabia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1399-0004.1998.tb03702.x","doi":"https://doi.org/10.1111/j.1399-0004.1998.tb03702.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-0004.1998.tb03702.x","pdf_url":null,"source":{"id":"https://openalex.org/S4954800","display_name":"Clinical Genetics","issn_l":"0009-9163","issn":["0009-9163","1399-0004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Genetics","raw_type":"journal-article"},{"id":"pmid:9727749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9727749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321144","display_name":"King Faisal Specialist Hospital and Research Centre","ror":"https://ror.org/05n0wgt02"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1845886872","https://openalex.org/W1965515166","https://openalex.org/W1972509889","https://openalex.org/W1973746136","https://openalex.org/W1978350104","https://openalex.org/W1989649079","https://openalex.org/W1992285776","https://openalex.org/W1995595546","https://openalex.org/W2000441830","https://openalex.org/W2000448133","https://openalex.org/W2000862897","https://openalex.org/W2015089164","https://openalex.org/W2016988342","https://openalex.org/W2017371255","https://openalex.org/W2018662129","https://openalex.org/W2034443422","https://openalex.org/W2038068164","https://openalex.org/W2049654057","https://openalex.org/W2054289355","https://openalex.org/W2056813079","https://openalex.org/W2058784608","https://openalex.org/W2067483328","https://openalex.org/W2069952630","https://openalex.org/W2082057773","https://openalex.org/W2084636813","https://openalex.org/W2096115705","https://openalex.org/W2144073146","https://openalex.org/W2334285530","https://openalex.org/W2340979936","https://openalex.org/W2395073859","https://openalex.org/W2921459128"],"related_works":["https://openalex.org/W2015089164","https://openalex.org/W2026030998","https://openalex.org/W2972251184","https://openalex.org/W4396738952","https://openalex.org/W2087373722","https://openalex.org/W2107398247","https://openalex.org/W2312746738","https://openalex.org/W2149089031","https://openalex.org/W2130955724","https://openalex.org/W1973746136"],"abstract_inverted_index":{"A":[0],"retrospective":[1],"study":[2],"of":[3,13,17,28,63,73],"38":[4],"patients":[5],"with":[6,33,55,66,91,105],"propionic":[7,92],"acidemia":[8,93],"indicates":[9],"a":[10,26,34,70],"high":[11],"frequency":[12],"infections;":[14],"affecting":[15],"80%":[16],"such":[18],"patients.":[19],"The":[20],"Saudi":[21],"Arabian":[22],"population":[23],"studied":[24],"is":[25],"product":[27],"consanguineous":[29],"marriages,":[30],"and":[31,59,78],"presents":[32],"severe":[35],"phenotype.":[36],"Most":[37],"microorganisms":[38],"implicated":[39],"are":[40],"unusual,":[41],"which":[42,68],"suggests":[43,69],"an":[44,100],"underlying":[45],"immune":[46],"deficiency.":[47],"These":[48],"frequent":[49],"infections":[50],"occur":[51],"despite":[52],"aggressive":[53],"treatment":[54],"appropriate":[56],"diets,":[57],"carnitine":[58],"during":[60],"acute":[61,106],"episodes":[62],"the":[64,74,85],"disease":[65,75],"metronidazole,":[67],"global":[71],"effect":[72],"on":[76,84],"T":[77],"B":[79],"lymphocytes":[80],"as":[81,83],"well":[82],"bone":[86],"marrow":[87],"cells.":[88],"Any":[89],"patient":[90],"should":[94],"be":[95],"closely":[96],"followed":[97],"up":[98],"for":[99],"intercurrent":[101],"infection":[102],"in":[103],"association":[104],"metabolic":[107],"decompensation.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
