{"id":"https://openalex.org/W1966280408","doi":"https://doi.org/10.2165/00063030-199707010-00005","title":"Acute Lymphoblastic Leukaemia","display_name":"Acute Lymphoblastic Leukaemia","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W1966280408","doi":"https://doi.org/10.2165/00063030-199707010-00005","mag":"1966280408","pmid":"https://pubmed.ncbi.nlm.nih.gov/18031078"},"language":"en","primary_location":{"id":"doi:10.2165/00063030-199707010-00005","doi":"https://doi.org/10.2165/00063030-199707010-00005","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00063030-199707010-00005","pdf_url":null,"source":{"id":"https://openalex.org/S143194599","display_name":"BioDrugs","issn_l":"1172-7039","issn":["1172-7039","1173-8804","1179-190X","2195-8351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioDrugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030658031","display_name":"Lawrence J. Ettinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lawrence J. Ettinger","raw_affiliation_strings":["Division of Paediatric Hematology-Oncology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA","Division of Paediatric Hematology-Oncology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, The Institute for Children with Cancer and Blood Disorders, The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey, 08901, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Paediatric Hematology-Oncology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA","institution_ids":["https://openalex.org/I4405286694"]},{"raw_affiliation_string":"Division of Paediatric Hematology-Oncology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, The Institute for Children with Cancer and Blood Disorders, The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey, 08901, USA","institution_ids":["https://openalex.org/I4390039325","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045542802","display_name":"Alice G. Ettinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]},{"id":"https://openalex.org/I4405286694","display_name":"University of Medicine and Dentistry of New Jersey","ror":"https://ror.org/02tvvmk84","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4405286694"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice G. Ettinger","raw_affiliation_strings":["Children\u2019s Cancer Group, University of Southern California School of Medicine, Arcadia, California, USA","Division of Paediatric Hematology-Oncology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, The Institute for Children with Cancer and Blood Disorders, The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey, 08901, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Group, University of Southern California School of Medicine, Arcadia, California, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Division of Paediatric Hematology-Oncology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, The Institute for Children with Cancer and Blood Disorders, The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey, 08901, USA","institution_ids":["https://openalex.org/I4390039325","https://openalex.org/I4405286694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112259557","display_name":"Vassilios I. Avramis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vassilios I. Avramis","raw_affiliation_strings":["Division of Hematology-Oncology, Childrens Hospital Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Childrens Hospital Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069797568","display_name":"Paul S. Gaynon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2799905417","display_name":"UW Health University Hospital","ror":"https://ror.org/02mqqhj42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul S. Gaynon","raw_affiliation_strings":["Children\u2019s Cancer Group, University of Southern California School of Medicine, Arcadia, California, USA","Department of Paediatrics, University of Wisconsin Medical Center, Madison, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Group, University of Southern California School of Medicine, Arcadia, California, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Paediatrics, University of Wisconsin Medical Center, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2799905417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5030658031"],"corresponding_institution_ids":["https://openalex.org/I4390039325","https://openalex.org/I4405286694"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.8265,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.70369071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"30","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/l-asparaginase","display_name":"L-asparaginase","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pegaspargase","display_name":"pegaspargase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/escherichia-coli-asparaginase","display_name":"Escherichia coli asparaginase","score":0.8619999885559082},{"id":"https://openalex.org/keywords/asparagine-depletion","display_name":"asparagine depletion","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hypersensitivity","display_name":"hypersensitivity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.7770000100135803},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7760000228881836},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5649999976158142},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.35499998927116394},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.777999997138977},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2778904437","wikidata":"https://www.wikidata.org/wiki/Q105296036","display_name":"Asparaginase","level":4,"score":0.8545541763305664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6225417852401733},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5296654105186462},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44594234228134155},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4407682716846466},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4362425208091736},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3756966292858124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3156939446926117},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.23615187406539917},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.1589784324169159}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2165/00063030-199707010-00005","doi":"https://doi.org/10.2165/00063030-199707010-00005","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00063030-199707010-00005","pdf_url":null,"source":{"id":"https://openalex.org/S143194599","display_name":"BioDrugs","issn_l":"1172-7039","issn":["1172-7039","1173-8804","1179-190X","2195-8351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioDrugs","raw_type":"journal-article"},{"id":"pmid:18031078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18031078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W198182894","https://openalex.org/W1517546599","https://openalex.org/W1526681768","https://openalex.org/W1536189216","https://openalex.org/W1558897882","https://openalex.org/W1852365161","https://openalex.org/W1887374752","https://openalex.org/W1940732706","https://openalex.org/W1953387859","https://openalex.org/W1964852034","https://openalex.org/W1990294422","https://openalex.org/W1995905554","https://openalex.org/W1998762015","https://openalex.org/W2005753411","https://openalex.org/W2014405408","https://openalex.org/W2020373022","https://openalex.org/W2024777863","https://openalex.org/W2028579560","https://openalex.org/W2042542087","https://openalex.org/W2044192234","https://openalex.org/W2056562985","https://openalex.org/W2058767848","https://openalex.org/W2066178485","https://openalex.org/W2078714432","https://openalex.org/W2080525555","https://openalex.org/W2084612827","https://openalex.org/W2114064238","https://openalex.org/W2126336202","https://openalex.org/W2131669897","https://openalex.org/W2190350017","https://openalex.org/W2336096370","https://openalex.org/W2396050130","https://openalex.org/W2396441758","https://openalex.org/W2408379417","https://openalex.org/W2409047274","https://openalex.org/W4234454654"],"related_works":["https://openalex.org/W4412099903","https://openalex.org/W4387336535","https://openalex.org/W4283716548","https://openalex.org/W3155294922","https://openalex.org/W2471256249","https://openalex.org/W2156945455","https://openalex.org/W2005725119","https://openalex.org/W1965542498","https://openalex.org/W2588354438","https://openalex.org/W4320480672"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}