{"id":"https://openalex.org/W1966274656","doi":"https://doi.org/10.1097/00007890-200205150-00008","title":"Induction of donor-specific tolerance by adenovirus-mediated cd40ig gene therapy in rat liver transplantation1","display_name":"Induction of donor-specific tolerance by adenovirus-mediated cd40ig gene therapy in rat liver transplantation1","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W1966274656","doi":"https://doi.org/10.1097/00007890-200205150-00008","mag":"1966274656","pmid":"https://pubmed.ncbi.nlm.nih.gov/12023617"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-200205150-00008","doi":"https://doi.org/10.1097/00007890-200205150-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200205150-00008","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Masaru Nomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Nomura","raw_affiliation_strings":["First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan","First Department of Surgery, Hokkaido University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4210141669"]},{"raw_affiliation_string":"First Department of Surgery, Hokkaido University School of Medicine","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103013571","display_name":"Kenichiro Yamashita","orcid":"https://orcid.org/0000-0002-1409-6504","observed_orcids":["https://orcid.org/0000-0002-1409-6504"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichiro Yamashita","raw_affiliation_strings":["First Department of Surgery, Hokkaido University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hokkaido University School of Medicine","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068093589","display_name":"Masaaki Murakami","orcid":"https://orcid.org/0000-0001-7159-7279","observed_orcids":["https://orcid.org/0000-0001-7159-7279","https://orcid.org/0000-0001-7544-9791"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Murakami","raw_affiliation_strings":["Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084474011","display_name":"Megumi Takehara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Megumi Takehara","raw_affiliation_strings":["Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University","First Department of Surgery, Hokkaido University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]},{"raw_affiliation_string":"First Department of Surgery, Hokkaido University School of Medicine","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037442604","display_name":"Hayato Echizenya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hayato Echizenya","raw_affiliation_strings":["First Department of Surgery, Hokkaido University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hokkaido University School of Medicine","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033566866","display_name":"Masao Sunahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Sunahara","raw_affiliation_strings":["First Department of Surgery, Hokkaido University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hokkaido University School of Medicine","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104124967","display_name":"Norihiko Kitagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norihiko Kitagawa","raw_affiliation_strings":["First Department of Surgery, Hokkaido University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hokkaido University School of Medicine","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113609246","display_name":"Miri Fujita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miri Fujita","raw_affiliation_strings":["Division of Pathology, Shinnittetu Muroran General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, Shinnittetu Muroran General Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109970717","display_name":"Hiroyuki Furukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Furukawa","raw_affiliation_strings":["First Department of Surgery, Hokkaido University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hokkaido University School of Medicine","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109866901","display_name":"T Uede","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshimistu Uede","raw_affiliation_strings":["Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043443062","display_name":"Satoru Todo","orcid":"https://orcid.org/0000-0002-1277-4594","observed_orcids":["https://orcid.org/0000-0002-1277-4594"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoru Todo","raw_affiliation_strings":["First Department of Surgery, Hokkaido University School of Medicine","Satoru Todo, M.D., Professor and Chairman, First Department of Surgery, Hokkaido University School of Medicine, N-15, W-7, Kita-ku, Sapporo 060-8638, Japan. E-mail"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Hokkaido University School of Medicine","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Satoru Todo, M.D., Professor and Chairman, First Department of Surgery, Hokkaido University School of Medicine, N-15, W-7, Kita-ku, Sapporo 060-8638, Japan. E-mail","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043443062"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":null,"apc_paid":null,"fwci":4.7609,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.94766912,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"73","issue":"9","first_page":"1403","last_page":"1410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.2777999937534332,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.07540000230073929,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.8169999718666077},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/donor-specific-tolerance","display_name":"donor-specific tolerance","score":0.8140000104904175},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.8100000023841858},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7570000290870667},{"id":"https://openalex.org/keywords/skin-graft-acceptance","display_name":"skin graft acceptance","score":0.6399999856948853},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C2779234475","wikidata":"https://www.wikidata.org/wiki/Q14897851","display_name":"CD154","level":5,"score":0.8605287075042725},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.7015190124511719},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.639724850654602},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.633833110332489},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5973789691925049},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5347050428390503},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.45783448219299316},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4467405676841736},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.43739283084869385},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39683079719543457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2606722116470337},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.221603125333786},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.1533195972442627},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.14774909615516663},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011912","descriptor_name":"Rats, Inbred ACI","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-200205150-00008","doi":"https://doi.org/10.1097/00007890-200205150-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200205150-00008","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:12023617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12023617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W213499032","https://openalex.org/W1485526722","https://openalex.org/W1512736148","https://openalex.org/W1517873264","https://openalex.org/W1581554632","https://openalex.org/W1599588446","https://openalex.org/W1964997094","https://openalex.org/W1965062403","https://openalex.org/W1969382126","https://openalex.org/W1969797237","https://openalex.org/W1973323884","https://openalex.org/W1973957725","https://openalex.org/W1976595206","https://openalex.org/W1977635226","https://openalex.org/W1983082877","https://openalex.org/W1993786781","https://openalex.org/W1995407332","https://openalex.org/W1999481925","https://openalex.org/W2009262301","https://openalex.org/W2010401156","https://openalex.org/W2016200465","https://openalex.org/W2016808992","https://openalex.org/W2019291297","https://openalex.org/W2019899829","https://openalex.org/W2023492750","https://openalex.org/W2033067722","https://openalex.org/W2035455050","https://openalex.org/W2037626742","https://openalex.org/W2039028985","https://openalex.org/W2040386532","https://openalex.org/W2042043269","https://openalex.org/W2046703284","https://openalex.org/W2046993540","https://openalex.org/W2054083392","https://openalex.org/W2067567916","https://openalex.org/W2067701958","https://openalex.org/W2068225706","https://openalex.org/W2068269731","https://openalex.org/W2078321284","https://openalex.org/W2084407937","https://openalex.org/W2085083824","https://openalex.org/W2100215924","https://openalex.org/W2109044040","https://openalex.org/W2111215982","https://openalex.org/W2118061894","https://openalex.org/W2132243512","https://openalex.org/W2137099568","https://openalex.org/W2141681336","https://openalex.org/W2151902657","https://openalex.org/W2160229740","https://openalex.org/W2164491088","https://openalex.org/W2171021135","https://openalex.org/W2172658766","https://openalex.org/W2215489080","https://openalex.org/W4248034314","https://openalex.org/W4295201567"],"related_works":["https://openalex.org/W2067093572","https://openalex.org/W2335193164","https://openalex.org/W2287686476","https://openalex.org/W1968132638","https://openalex.org/W2099713229","https://openalex.org/W2370846640","https://openalex.org/W1995407332","https://openalex.org/W2022422022","https://openalex.org/W1516736393","https://openalex.org/W1980059478"],"abstract_inverted_index":{"BACKGROUND:":[0],"Blockade":[1,167],"of":[2,92,101,150,163,168,185],"CD40-CD40":[3],"ligand":[4],"(CD154)":[5],"costimulatory":[6],"pathway":[7,170],"with":[8,82,160],"anti-CD154":[9],"antibody":[10],"(Ab)":[11],"prolongs":[12],"allograft":[13,96,187],"survival":[14],"in":[15,104,158,195],"experimental":[16],"organ":[17],"transplantations;":[18],"however,":[19],"repeated":[20],"agent":[21],"administration":[22],"is":[23,175],"needed":[24],"to":[25,36,68,181],"provide":[26],"an":[27],"adequate":[28],"immunosuppression.":[29],"Seeking":[30],"for":[31],"simple":[32],"and":[33,64,107,188],"effective":[34],"approach":[35],"interfere":[37],"this":[38],"signaling,":[39],"we":[40],"applied":[41],"adenovirus-mediated":[42],"gene":[43,48,94,173],"therapy":[44,174],"by":[45,171],"encoding":[46],"CD40Ig":[47,93,172],"(AdCD40Ig).":[49],"METHODS:":[50],"Liver":[51],"graft":[52,110,134],"from":[53,135],"ACI":[54,125],"(RT1av1)":[55],"rat":[56],"was":[57,66,155],"transplanted":[58],"orthotopically":[59],"into":[60],"LEW":[61,113],"(RT1l)":[62],"rat,":[63],"AdCD40Ig":[65,83],"given":[67,115],"animals":[69,154],"via":[70],"the":[71,102,105,136,141,151],"penile":[72],"vein":[73],"immediately":[74],"after":[75],"grafting":[76],"(n=6).":[77],"RESULTS:":[78],"A":[79],"single":[80],"treatment":[81,117],"at":[84],"1x10(9)":[85],"plaque":[86],"forming":[87],"units":[88],"induced":[89],"specific":[90],"expression":[91],"on":[95],"liver,":[97],"produced":[98],"substantial":[99],"amount":[100],"protein":[103],"sera,":[106],"allowed":[108],"indefinite":[109],"survival.":[111],"Whereas,":[112],"recipients":[114],"no":[116,161],"or":[118],"control":[119],"adenovirus":[120],"vector":[121],"(AdLacZ)":[122],"promptly":[123],"rejected":[124],"liver.":[126],"In":[127],"addition,":[128],"AdCD40Ig-treated,":[129],"long-term":[130,152],"survivors":[131],"accepted":[132],"skin":[133],"donor":[137],"strain":[138],"but":[139],"not":[140],"third":[142],"party":[143],"graft.":[144],"Histopathology":[145],"revealed":[146],"that":[147],"liver":[148,186,198],"structure":[149],"surviving":[153],"completely":[156],"preserved":[157],"normal":[159],"infiltration":[162],"mononuclear":[164],"cells.":[165],"CONCLUSION:":[166],"CD40-CD154":[169],"a":[176,191,196],"potent":[177],"alloantigen-specific":[178],"immunosuppressive":[179],"strategy":[180],"induce":[182],"permanent":[183],"acceptance":[184],"would":[189],"be":[190],"new":[192],"therapeutic":[193],"candidate":[194],"clinical":[197],"transplantation.":[199]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}