{"id":"https://openalex.org/W1966262123","doi":"https://doi.org/10.1042/bst0340351","title":"Moving Ca2+ from the endoplasmic reticulum to mitochondria: is spatial intimacy enough?","display_name":"Moving Ca2+ from the endoplasmic reticulum to mitochondria: is spatial intimacy enough?","publication_year":2006,"publication_date":"2006-05-22","ids":{"openalex":"https://openalex.org/W1966262123","doi":"https://doi.org/10.1042/bst0340351","mag":"1966262123","pmid":"https://pubmed.ncbi.nlm.nih.gov/16709159"},"language":"en","primary_location":{"id":"doi:10.1042/bst0340351","doi":"https://doi.org/10.1042/bst0340351","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst0340351","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015737554","display_name":"Guy A. Rutter","orcid":"https://orcid.org/0000-0001-6360-0343","observed_orcids":["https://orcid.org/0000-0001-6360-0343"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"G.A. Rutter","raw_affiliation_strings":["Department of Biochemistry, School of Medical Sciences, University Walk University of Bristol, Bristol BS81TD, U.K","Department of Cell Biology, Division of Medicine, Imperial College, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medical Sciences, University Walk University of Bristol, Bristol BS81TD, U.K","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Department of Cell Biology, Division of Medicine, Imperial College, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, U.K","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015737554"],"corresponding_institution_ids":["https://openalex.org/I36234482","https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":0.318,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.25183374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"34","issue":"3","first_page":"351","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.07320000231266022,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-transfer","display_name":"calcium transfer","score":0.6269999742507935},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.9990000128746033},{"id":"https://openalex.org/keywords/er-mitochondria-contact-sites","display_name":"ER-mitochondria contact sites","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mitochondrial-calcium-uptake","display_name":"mitochondrial calcium uptake","score":0.6539999842643738},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.968999981880188},{"id":"https://openalex.org/keywords/voltage-dependent-anion-channel","display_name":"voltage-dependent anion channel","score":0.949999988079071},{"id":"https://openalex.org/keywords/outer-mitochondrial-membrane","display_name":"mitochondrial outer membrane","score":0.6430000066757202},{"id":"https://openalex.org/keywords/organelle-communication","display_name":"organelle communication","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8912912607192993},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7830138206481934},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.7618191242218018},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6835170388221741},{"id":"https://openalex.org/C200784783","wikidata":"https://www.wikidata.org/wiki/Q7940725","display_name":"Voltage-dependent anion channel","level":5,"score":0.6143754720687866},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.566204309463501},{"id":"https://openalex.org/C152624196","wikidata":"https://www.wikidata.org/wiki/Q418917","display_name":"Inositol trisphosphate receptor","level":4,"score":0.5452320575714111},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.48145145177841187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4025301933288574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3705240786075592},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.2825576066970825},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2738952040672302},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2080555558204651},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002413","descriptor_name":"Cations, Divalent","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002413","descriptor_name":"Cations, Divalent","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/bst0340351","doi":"https://doi.org/10.1042/bst0340351","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst0340351","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},{"id":"pmid:16709159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16709159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society transactions","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W618527793","https://openalex.org/W1516899109","https://openalex.org/W1963791094","https://openalex.org/W1975551623","https://openalex.org/W1978372269","https://openalex.org/W1992499283","https://openalex.org/W1995863161","https://openalex.org/W2002357266","https://openalex.org/W2010572143","https://openalex.org/W2014229034","https://openalex.org/W2015594876","https://openalex.org/W2018510333","https://openalex.org/W2030845275","https://openalex.org/W2031583642","https://openalex.org/W2039103199","https://openalex.org/W2042138321","https://openalex.org/W2046353863","https://openalex.org/W2089748426","https://openalex.org/W2091697443","https://openalex.org/W2107846158","https://openalex.org/W2109692759","https://openalex.org/W2114228694","https://openalex.org/W2122636937","https://openalex.org/W2124872060","https://openalex.org/W2126094269","https://openalex.org/W2132579877","https://openalex.org/W2135853075","https://openalex.org/W2138760035","https://openalex.org/W2144924187","https://openalex.org/W2163529058","https://openalex.org/W2165601218"],"related_works":["https://openalex.org/W2161687969","https://openalex.org/W2101300328","https://openalex.org/W2039255874","https://openalex.org/W2046353863","https://openalex.org/W2015536770","https://openalex.org/W7028300212","https://openalex.org/W3082944416","https://openalex.org/W2121330845","https://openalex.org/W4311969592","https://openalex.org/W2202728057"],"abstract_inverted_index":{"A":[0],"number":[1],"of":[2,94,100],"studies":[3],"in":[4],"recent":[5],"years":[6],"have":[7],"demonstrated":[8],"that":[9,36,61],"the":[10,19,47,70,76,86,92],"ER":[11,48],"(endoplasmic":[12],"reticulum)":[13],"makes":[14],"intimate":[15],"contacts":[16],"with":[17],"mitochondria,":[18],"latter":[20],"organelles":[21,26],"existing":[22],"both":[23],"as":[24,29,55],"individual":[25],"and":[27,80],"occasionally":[28],"a":[30,56,62],"more":[31,41,109],"extensive":[32],"interconnected":[33],"network.":[34],"Demonstrations":[35],"mitochondria":[37],"take":[38],"up":[39],"Ca(2+)":[40,66,103],"avidly":[42],"upon":[43],"its":[44],"mobilization":[45],"from":[46],"than":[49],"when":[50],"delivered":[51],"to":[52,114],"permeabilized":[53],"cells":[54],"buffered":[57],"solution":[58],"also":[59],"indicate":[60],"shielded":[63],"conduit":[64],"for":[65],"may":[67],"exist":[68],"between":[69],"two":[71],"organelle":[72],"types,":[73],"perhaps":[74],"comprising":[75],"inositol":[77],"1,4,5-trisphosphate":[78],"receptor":[79],"mitochondrial":[81],"outer":[82],"membrane":[83],"proteins":[84],"including":[85],"VDAC":[87],"(voltage-dependent":[88],"anion":[89],"channel).":[90],"Although":[91],"existence":[93],"such":[95],"intracellular":[96],"ER-mitochondria":[97,102],"'synapses',":[98],"or":[99],"an":[101,106],"'translocon',":[104],"is":[105],"exciting":[107],"idea,":[108],"definitive":[110],"experiments":[111],"are":[112],"needed":[113],"test":[115],"this":[116],"possibility.":[117]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}