{"id":"https://openalex.org/W1966245225","doi":"https://doi.org/10.1007/bf00431272","title":"Dopamine and mania: Behavioral and biochemical effects of the dopamine receptor blocker pimozide","display_name":"Dopamine and mania: Behavioral and biochemical effects of the dopamine receptor blocker pimozide","publication_year":1980,"publication_date":"1980-03-01","ids":{"openalex":"https://openalex.org/W1966245225","doi":"https://doi.org/10.1007/bf00431272","mag":"1966245225","pmid":"https://pubmed.ncbi.nlm.nih.gov/6155678"},"language":"en","primary_location":{"id":"doi:10.1007/bf00431272","doi":"https://doi.org/10.1007/bf00431272","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00431272","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053329398","display_name":"Robert M. Post","orcid":"https://orcid.org/0000-0002-4246-524X","observed_orcids":["https://orcid.org/0000-0002-4246-524X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Post","raw_affiliation_strings":["Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, 20205, Bethesda, MD, USA","Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, 20205, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111824054","display_name":"David C. Jimerson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Jimerson","raw_affiliation_strings":["Biological Psychiatry Branch, National Institute of Mental Health, 20205, Bethesda, MD, USA","Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Psychiatry Branch, National Institute of Mental Health, 20205, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, USA","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054827230","display_name":"William E. Bunney","orcid":"https://orcid.org/0000-0002-4166-0836","observed_orcids":["https://orcid.org/0000-0002-4166-0836"]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Bunney","raw_affiliation_strings":["Biological Psychiatry Branch, National Institute of Mental Health, 20205, Bethesda, MD, USA","Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Psychiatry Branch, National Institute of Mental Health, 20205, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, USA","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108570838","display_name":"Frederick K. Goodwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick K. Goodwin","raw_affiliation_strings":["Laboratory of Clinical Psychobiology, National Institute of Mental Health, 20205, Bethesda, MD, USA","Laboratory of Clinical Psychobiology, National Institute of Mental Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Psychobiology, National Institute of Mental Health, 20205, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Laboratory of Clinical Psychobiology, National Institute of Mental Health, Bethesda, USA","institution_ids":["https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":12.4901,"has_fulltext":false,"cited_by_count":136,"citation_normalized_percentile":{"value":0.98906279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"67","issue":"3","first_page":"297","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pimozide","display_name":"pimozide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mania","display_name":"mania","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dopamine-receptors","display_name":"dopamine receptors","score":0.7580000162124634},{"id":"https://openalex.org/keywords/homovanillic-acid","display_name":"homovanillic acid","score":0.9300000071525574},{"id":"https://openalex.org/keywords/probenecid","display_name":"probenecid","score":0.8529999852180481},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.753000020980835},{"id":"https://openalex.org/keywords/phenothiazines","display_name":"phenothiazines","score":0.8429999947547913},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/thioridazine","display_name":"thioridazine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/manic-syndrome","display_name":"manic syndrome","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C2777845345","wikidata":"https://www.wikidata.org/wiki/Q144085","display_name":"Pimozide","level":4,"score":0.9706028699874878},{"id":"https://openalex.org/C2775841634","wikidata":"https://www.wikidata.org/wiki/Q903566","display_name":"Homovanillic acid","level":4,"score":0.747219443321228},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7470530271530151},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6473650932312012},{"id":"https://openalex.org/C2778775820","wikidata":"https://www.wikidata.org/wiki/Q407972","display_name":"Chlorpromazine","level":2,"score":0.5697799324989319},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.5524085760116577},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5378334522247314},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.5147850513458252},{"id":"https://openalex.org/C2781353949","wikidata":"https://www.wikidata.org/wiki/Q3271533","display_name":"Dopamine antagonist","level":4,"score":0.49107885360717773},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.467398464679718},{"id":"https://openalex.org/C2780688371","wikidata":"https://www.wikidata.org/wiki/Q58375","display_name":"Thioridazine","level":3,"score":0.42583000659942627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38020482659339905},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3516691029071808},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3241317868232727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27177250385284424},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2425495684146881},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.22489586472511292},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.13905444741249084},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.12227079272270203},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.07836192846298218}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001519","descriptor_name":"Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010868","descriptor_name":"Pimozide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011339","descriptor_name":"Probenecid","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00431272","doi":"https://doi.org/10.1007/bf00431272","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00431272","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:6155678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6155678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W22043311","https://openalex.org/W33652345","https://openalex.org/W186646570","https://openalex.org/W1795726959","https://openalex.org/W1965256322","https://openalex.org/W1966998460","https://openalex.org/W1973593783","https://openalex.org/W1975520016","https://openalex.org/W1978618811","https://openalex.org/W1979749661","https://openalex.org/W1981234468","https://openalex.org/W1981740808","https://openalex.org/W1989900998","https://openalex.org/W1990501910","https://openalex.org/W1996571600","https://openalex.org/W2000589316","https://openalex.org/W2001202400","https://openalex.org/W2002622375","https://openalex.org/W2004055859","https://openalex.org/W2005595168","https://openalex.org/W2009447429","https://openalex.org/W2013718093","https://openalex.org/W2014367145","https://openalex.org/W2014405902","https://openalex.org/W2017744422","https://openalex.org/W2017773830","https://openalex.org/W2019628818","https://openalex.org/W2022845718","https://openalex.org/W2026363217","https://openalex.org/W2026812180","https://openalex.org/W2028570930","https://openalex.org/W2030020962","https://openalex.org/W2031148523","https://openalex.org/W2032103464","https://openalex.org/W2034103754","https://openalex.org/W2035469067","https://openalex.org/W2036633796","https://openalex.org/W2040246569","https://openalex.org/W2047313211","https://openalex.org/W2047415716","https://openalex.org/W2049893239","https://openalex.org/W2051663860","https://openalex.org/W2059660265","https://openalex.org/W2062506524","https://openalex.org/W2066061318","https://openalex.org/W2067944324","https://openalex.org/W2073968491","https://openalex.org/W2074585051","https://openalex.org/W2075105194","https://openalex.org/W2077001644","https://openalex.org/W2080700416","https://openalex.org/W2086340893","https://openalex.org/W2087980220","https://openalex.org/W2090610111","https://openalex.org/W2092416470","https://openalex.org/W2093492423","https://openalex.org/W2096629452","https://openalex.org/W2097978353","https://openalex.org/W2106926455","https://openalex.org/W2120194850","https://openalex.org/W2121843306","https://openalex.org/W2129132384","https://openalex.org/W2139547537","https://openalex.org/W2159996636","https://openalex.org/W2170417799","https://openalex.org/W2182363772","https://openalex.org/W2274117830","https://openalex.org/W2297247113","https://openalex.org/W2313858558","https://openalex.org/W2399989504","https://openalex.org/W2401884941","https://openalex.org/W2402530170","https://openalex.org/W2403004248","https://openalex.org/W2405321108","https://openalex.org/W2409394421","https://openalex.org/W2410827374","https://openalex.org/W2411746851","https://openalex.org/W2415699971","https://openalex.org/W2415922766","https://openalex.org/W2418608948","https://openalex.org/W2435270021","https://openalex.org/W2437900319","https://openalex.org/W2443820293","https://openalex.org/W2522973505","https://openalex.org/W2615376826","https://openalex.org/W2744135635","https://openalex.org/W2752150190","https://openalex.org/W4246595593","https://openalex.org/W4253763218","https://openalex.org/W6694083070"],"related_works":["https://openalex.org/W1594608696","https://openalex.org/W2409394421","https://openalex.org/W2306003069","https://openalex.org/W2017528176","https://openalex.org/W2038347696","https://openalex.org/W1553286395","https://openalex.org/W2030020962","https://openalex.org/W2006658212","https://openalex.org/W2061207728","https://openalex.org/W2048774477"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}