{"id":"https://openalex.org/W1966240406","doi":"https://doi.org/10.1126/science.3983641","title":"Location of Gene for \u03b2 Subunit of Human T-Cell Receptor at Band 7q35, a Region Prone to Rearrangements in T Cells","display_name":"Location of Gene for \u03b2 Subunit of Human T-Cell Receptor at Band 7q35, a Region Prone to Rearrangements in T Cells","publication_year":1985,"publication_date":"1985-05-03","ids":{"openalex":"https://openalex.org/W1966240406","doi":"https://doi.org/10.1126/science.3983641","mag":"1966240406","pmid":"https://pubmed.ncbi.nlm.nih.gov/3983641"},"language":"en","primary_location":{"id":"doi:10.1126/science.3983641","doi":"https://doi.org/10.1126/science.3983641","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3983641","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019149598","display_name":"Masaharu Isobe","orcid":"https://orcid.org/0000-0003-1864-9273","observed_orcids":["https://orcid.org/0000-0003-1864-9273"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaharu Isobe","raw_affiliation_strings":["Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048644594","display_name":"Jan Erikson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Erikson","raw_affiliation_strings":["Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023255205","display_name":"Beverly S. Emanuel","orcid":"https://orcid.org/0000-0002-9207-6955","observed_orcids":["https://orcid.org/0000-0002-9207-6955"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beverly S. Emanuel","raw_affiliation_strings":["Departments of Human Genetics, Pediatrics, and Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Human Genetics, Pediatrics, and Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111814791","display_name":"Peter C. Nowell\u0300","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter C. Nowell","raw_affiliation_strings":["Departments of Human Genetics, Pediatrics, and Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Human Genetics, Pediatrics, and Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079700663","display_name":"Carlo Maria Croce","orcid":"https://orcid.org/0000-0003-3788-1457","observed_orcids":["https://orcid.org/0000-0003-3788-1457"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo M. Croce","raw_affiliation_strings":["Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I102322052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.0795,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.98442654,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"228","issue":"4699","first_page":"580","last_page":"582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tcr-beta-chain","display_name":"T cell receptor beta chain","score":0.9259999990463257},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.6940000057220459},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.6230000257492065},{"id":"https://openalex.org/keywords/somatic-rearrangements","display_name":"somatic rearrangements","score":0.722000002861023},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/in-situ-hybridization","display_name":"in situ hybridization","score":0.6470000147819519},{"id":"https://openalex.org/keywords/chromosome-breakage","display_name":"chromosome breakage","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6175506711006165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5995070934295654},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5857691168785095},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48346003890037537},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4637184143066406},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.4390113651752472},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.42603519558906555},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.42027565836906433},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4104975461959839},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3900437653064728}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001260","descriptor_name":"Ataxia Telangiectasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002901","descriptor_name":"Chromosomes, Human, 13-15","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002906","descriptor_name":"Chromosomes, Human, 6-12 and X","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025063","descriptor_name":"Chromosome Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.3983641","doi":"https://doi.org/10.1126/science.3983641","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3983641","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:3983641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3983641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3905917545","display_name":"MAPPING OF TUMOR VIRUS GENOMES IN TRANSFORMED CELLS","funder_award_id":"R01CA016685","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5829924076","display_name":"IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTES","funder_award_id":"P01CA015822","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7692713811","display_name":"ENZYME MARKERS IN THE MAPPING OF HUMAN GENES","funder_award_id":"R01GM020700","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W110182977","https://openalex.org/W1575334374","https://openalex.org/W1587765371","https://openalex.org/W1990319128","https://openalex.org/W1991756452","https://openalex.org/W1995089109","https://openalex.org/W1996533462","https://openalex.org/W2001509055","https://openalex.org/W2002649342","https://openalex.org/W2017963255","https://openalex.org/W2018404376","https://openalex.org/W2036160208","https://openalex.org/W2036509722","https://openalex.org/W2045217835","https://openalex.org/W2046425132","https://openalex.org/W2049867388","https://openalex.org/W2056236326","https://openalex.org/W2061323376","https://openalex.org/W2061624786","https://openalex.org/W2062927712","https://openalex.org/W2063436574","https://openalex.org/W2069970568","https://openalex.org/W2074189042","https://openalex.org/W2089368550","https://openalex.org/W2092116302","https://openalex.org/W2106719152","https://openalex.org/W2161402720","https://openalex.org/W4246462458","https://openalex.org/W4254501086"],"related_works":["https://openalex.org/W2010946778","https://openalex.org/W1559824655","https://openalex.org/W103115847","https://openalex.org/W1575334374","https://openalex.org/W2046425132","https://openalex.org/W2161402720","https://openalex.org/W1981856998","https://openalex.org/W2038744586","https://openalex.org/W2052774560","https://openalex.org/W7097292762"],"abstract_inverted_index":{"The":[0],"T-cell":[1,30,71],"receptor":[2,31,72],"is":[3,55],"formed":[4],"by":[5,43,67],"two":[6],"chains,":[7],"alpha":[8],"and":[9],"beta,":[10],"for":[11,23],"which":[12],"specific":[13],"clones":[14],"were":[15],"recently":[16],"obtained.":[17],"In":[18],"this":[19,78],"report":[20],"the":[21,24,28,35],"gene":[22],"beta":[25],"chain":[26],"of":[27,38,45,70],"human":[29],"was":[32],"located":[33],"on":[34],"long":[36],"arm":[37],"chromosome":[39,50],"7,":[40],"band":[41],"q35,":[42],"means":[44],"in":[46,52,61,77],"situ":[47],"hybridization.":[48],"This":[49],"region":[51],"T":[53],"cells":[54],"unusually":[56],"prone":[57],"to":[58],"develop":[59],"breaks":[60],"vivo,":[62],"perhaps":[63],"reflecting":[64],"instability":[65],"generated":[66],"somatic":[68],"rearrangement":[69],"genes":[73],"during":[74],"normal":[75],"differentiation":[76],"cell":[79],"lineage.":[80]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
