{"id":"https://openalex.org/W1966238459","doi":"https://doi.org/10.1210/jcem-65-2-227","title":"Morning Salivary 17-Hydroxyprogesterone Is a Useful Screening Test for Nonclassical 21-Hydroxylase Deficiency*","display_name":"Morning Salivary 17-Hydroxyprogesterone Is a Useful Screening Test for Nonclassical 21-Hydroxylase Deficiency*","publication_year":1987,"publication_date":"1987-08-01","ids":{"openalex":"https://openalex.org/W1966238459","doi":"https://doi.org/10.1210/jcem-65-2-227","mag":"1966238459","pmid":"https://pubmed.ncbi.nlm.nih.gov/3496350"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-65-2-227","doi":"https://doi.org/10.1210/jcem-65-2-227","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-65-2-227","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066584780","display_name":"Michele Zerah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHELE ZERAH","raw_affiliation_strings":["Division of Pediatric Endocrinology, The New York Hospital-Cornell Medical Center, New York, New York, 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Endocrinology, The New York Hospital-Cornell Medical Center, New York, New York, 10021","institution_ids":["https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110179021","display_name":"Songya Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SONGYA PANG","raw_affiliation_strings":["Division of Pediatric Endocrinology, The New York Hospital-Cornell Medical Center, New York, New York, 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Endocrinology, The New York Hospital-Cornell Medical Center, New York, New York, 10021","institution_ids":["https://openalex.org/I4405272987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109148756","display_name":"Maria I. New","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARIA I. NEW","raw_affiliation_strings":["Division of Pediatric Endocrinology, The New York Hospital-Cornell Medical Center, New York, New York, 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Endocrinology, The New York Hospital-Cornell Medical Center, New York, New York, 10021","institution_ids":["https://openalex.org/I4405272987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405272987"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.9641,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.73649743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"65","issue":"2","first_page":"227","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/17-hydroxyprogesterone","display_name":"17-hydroxyprogesterone","score":0.9269999861717224},{"id":"https://openalex.org/keywords/screening-test","display_name":"screening test","score":0.7689999938011169},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.7289999723434448},{"id":"https://openalex.org/keywords/congenital-adrenal-hyperplasia","display_name":"congenital adrenal hyperplasia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mass-screening","display_name":"mass screening","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2909158248","wikidata":"https://www.wikidata.org/wiki/Q175901","display_name":"Hydroxyprogesterone","level":4,"score":0.6489831209182739},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.6297825574874878},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.41536960005760193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41040271520614624},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3814281225204468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34339553117752075},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.10104933381080627},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000312","descriptor_name":"Adrenal Hyperplasia, Congenital","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006908","descriptor_name":"Hydroxyprogesterones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006908","descriptor_name":"Hydroxyprogesterones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D019326","descriptor_name":"17-alpha-Hydroxyprogesterone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-65-2-227","doi":"https://doi.org/10.1210/jcem-65-2-227","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-65-2-227","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:3496350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3496350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3017589361","display_name":null,"funder_award_id":"HD 00072","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4275366277","display_name":null,"funder_award_id":"HL-07129-02","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5106835982","display_name":null,"funder_award_id":"RR 47","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W204815092","https://openalex.org/W1587204552","https://openalex.org/W1646507492","https://openalex.org/W1906758352","https://openalex.org/W1944901341","https://openalex.org/W1968890965","https://openalex.org/W1978109351","https://openalex.org/W1983561070","https://openalex.org/W1983819630","https://openalex.org/W2006346558","https://openalex.org/W2010208043","https://openalex.org/W2022370481","https://openalex.org/W2035814223","https://openalex.org/W2041214980","https://openalex.org/W2043136056","https://openalex.org/W2043263446","https://openalex.org/W2044011679","https://openalex.org/W2058214620","https://openalex.org/W2061492254","https://openalex.org/W2066410117","https://openalex.org/W2115832156","https://openalex.org/W2141061065","https://openalex.org/W2145641065","https://openalex.org/W2169787829","https://openalex.org/W2325389201"],"related_works":["https://openalex.org/W2035495272","https://openalex.org/W2035442019","https://openalex.org/W2022486615","https://openalex.org/W2058867339","https://openalex.org/W7053928842","https://openalex.org/W2943940139","https://openalex.org/W2083478966","https://openalex.org/W2472351844","https://openalex.org/W2054459763","https://openalex.org/W2081202116"],"abstract_inverted_index":{"A":[0],"screening":[1,172,204],"test":[2,173],"for":[3,174,206],"nonclassical":[4],"21-hydroxylase":[5],"deficiency":[6],"(NC":[7],"21-OHD)":[8],"has":[9],"been":[10],"established":[11],"based":[12],"on":[13],"early":[14,164],"morning":[15,165],"salivary":[16,55,130,149,166,197],"17-hydroxyprogesterone":[17],"(17-OHP)":[18],"measurements.":[19],"Saliva":[20],"and":[21,29,38,41,48,63,139,150,157,187,192],"serum":[22,64,137,151,184],"samples":[23],"were":[24,75,102],"collected":[25],"simultaneously":[26],"between":[27,148],"0700":[28],"1100":[30],"h":[31,107,115],"from":[32,42],"57":[33],"normal":[34,82,127,155],"subjects":[35,83,156],"(37":[36],"women":[37,47],"20":[39],"men)":[40,50],"15":[43,73],"untreated":[44],"patients":[45,74,98,158],"(6":[46],"9":[49],"with":[51,99,159],"NC":[52,100,160,178,207],"21-OHD.":[53,161],"The":[54,129],"(mean":[56],"+/-":[57,60,66,86,91,109,117],"SD,":[58],"524":[59],"508":[61],"pg/mL)":[62,68,111],"(10,548":[65],"5,998":[67],"17-OHP":[69,95,131,167,185,198],"concentrations":[70],"in":[71,81,97,126,153,202],"all":[72],"unequivocally":[76],"higher":[77,104],"than":[78,112],"the":[79,175,211],"levels":[80,96],"(saliva,":[84],"51":[85],"24":[87],"pg/mL;":[88],"serum,":[89],"1,564":[90],"787":[92],"pg/mL).":[93],"Salivary":[94],"21-OHD":[101,208],"significantly":[103],"at":[105,113],"0700-0900":[106],"(828":[108],"653":[110],"0900-1100":[114],"(314":[116],"227":[118],"pg/mL),":[119],"while":[120],"no":[121],"such":[122],"change":[123],"was":[124,133,141],"found":[125],"subjects.":[128],"concentration":[132,152],"1.3-6.9%":[134],"of":[135,177,214],"its":[136],"concentration,":[138],"there":[140],"an":[142,170],"excellent":[143,171],"correlation":[144],"(r":[145],"=":[146],"0.93)":[147],"both":[154],"In":[162],"conclusion,":[163],"measurement":[168],"is":[169,190],"diagnosis":[176],"21-OHD,":[179],"since":[180],"it":[181],"accurately":[182],"reflects":[183],"levels,":[186],"sample":[188],"collection":[189],"easy":[191],"noninvasive.":[193],"We":[194],"propose":[195],"that":[196],"determination":[199],"be":[200],"used":[201],"population":[203],"programs":[205],"to":[209],"establish":[210],"true":[212],"frequency":[213],"this":[215],"disease.":[216]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
