{"id":"https://openalex.org/W1966234453","doi":"https://doi.org/10.1046/j.1460-9568.1998.00278.x","title":"Induction of long\u2010term potentiation at spinal synapses by noxious stimulation or nerve injury","display_name":"Induction of long\u2010term potentiation at spinal synapses by noxious stimulation or nerve injury","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W1966234453","doi":"https://doi.org/10.1046/j.1460-9568.1998.00278.x","mag":"1966234453","pmid":"https://pubmed.ncbi.nlm.nih.gov/9749775"},"language":"en","primary_location":{"id":"doi:10.1046/j.1460-9568.1998.00278.x","doi":"https://doi.org/10.1046/j.1460-9568.1998.00278.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1460-9568.1998.00278.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1460-9568.1998.00278.x","source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1460-9568.1998.00278.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080591591","display_name":"J\u00fcrgen Sandk\u00fchler","orcid":"https://orcid.org/0000-0002-5209-485X","observed_orcids":["https://orcid.org/0000-0002-5209-485X"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Sandk\u00fchler","raw_affiliation_strings":["II. Physiologisches Institut, Universit\u00e4t Heidelberg, Germany. AF8@ix.urz.uni-heidelberg.de","II. Physiologisches Institut, Im Neuenheimer Feld 326, Universit\u00e4t Heidelberg, D\u201069120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"II. Physiologisches Institut, Universit\u00e4t Heidelberg, Germany. AF8@ix.urz.uni-heidelberg.de","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"II. Physiologisches Institut, Im Neuenheimer Feld 326, Universit\u00e4t Heidelberg, D\u201069120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078940852","display_name":"Xian\u2010Guo Liu","orcid":"https://orcid.org/0000-0002-4352-8687","observed_orcids":["https://orcid.org/0000-0002-4352-8687"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Xianguo Liu","raw_affiliation_strings":["II. Physiologisches Institut, Im Neuenheimer Feld 326, Universita\u0308t Heidelberg, D-69120 Heidelberg, Germany","II. Physiologisches Institut, Im Neuenheimer Feld 326, Universit\u00e4t Heidelberg, D\u201069120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"II. Physiologisches Institut, Im Neuenheimer Feld 326, Universita\u0308t Heidelberg, D-69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"II. Physiologisches Institut, Im Neuenheimer Feld 326, Universit\u00e4t Heidelberg, D\u201069120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":7.4606,"has_fulltext":true,"cited_by_count":322,"citation_normalized_percentile":{"value":0.98167419,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"10","issue":"7","first_page":"2476","last_page":"2480"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nociceptors","display_name":"nociceptors","score":0.7519999742507935},{"id":"https://openalex.org/keywords/c-fibers","display_name":"C-fibers","score":0.9359999895095825},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.8539999723434448},{"id":"https://openalex.org/keywords/noxious-stimulation","display_name":"noxious stimulation","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.8975681662559509},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7427651286125183},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6318973898887634},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.6197302341461182},{"id":"https://openalex.org/C104211972","wikidata":"https://www.wikidata.org/wiki/Q7067309","display_name":"Noxious stimulus","level":4,"score":0.6116934418678284},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5996662378311157},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.525482714176178},{"id":"https://openalex.org/C2776328245","wikidata":"https://www.wikidata.org/wiki/Q6460191","display_name":"LTP induction","level":4,"score":0.5067785382270813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4386341869831085},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.41590675711631775},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.4125266969203949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20865723490715027},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.15093550086021423},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.059077173471450806},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003714","descriptor_name":"Denervation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005071","descriptor_name":"Evoked Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008465","descriptor_name":"Mechanoreceptors","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010812","descriptor_name":"Physical Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013497","descriptor_name":"Sural Nerve","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017774","descriptor_name":"Long-Term Potentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1460-9568.1998.00278.x","doi":"https://doi.org/10.1046/j.1460-9568.1998.00278.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1460-9568.1998.00278.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1460-9568.1998.00278.x","source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:9749775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9749775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Journal Article"},{"id":"mag:2183585863","doi":null,"is_oa":false,"landing_page_url":"http://cbr.meduniwien.ac.at/fileadmin/db_files/pub_art_51.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1046/j.1460-9568.1998.00278.x","doi":"https://doi.org/10.1046/j.1460-9568.1998.00278.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1460-9568.1998.00278.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1460-9568.1998.00278.x","source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1966234453.pdf","grobid_xml":"https://content.openalex.org/works/W1966234453.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W103811464","https://openalex.org/W586567853","https://openalex.org/W1483867462","https://openalex.org/W1501996610","https://openalex.org/W1520027060","https://openalex.org/W1544320664","https://openalex.org/W1628708546","https://openalex.org/W1703928766","https://openalex.org/W1879737809","https://openalex.org/W1965281982","https://openalex.org/W1971055918","https://openalex.org/W1983956991","https://openalex.org/W1985333845","https://openalex.org/W1999576398","https://openalex.org/W2001751903","https://openalex.org/W2002735902","https://openalex.org/W2006154289","https://openalex.org/W2007962505","https://openalex.org/W2017213222","https://openalex.org/W2020994883","https://openalex.org/W2025267803","https://openalex.org/W2025794287","https://openalex.org/W2035880579","https://openalex.org/W2048030440","https://openalex.org/W2049511526","https://openalex.org/W2059010387","https://openalex.org/W2060138687","https://openalex.org/W2068775907","https://openalex.org/W2070094949","https://openalex.org/W2079840847","https://openalex.org/W2081094382","https://openalex.org/W2082660315","https://openalex.org/W2083560398","https://openalex.org/W2083956045","https://openalex.org/W2085580985","https://openalex.org/W2090501101","https://openalex.org/W2094013335","https://openalex.org/W2101341122","https://openalex.org/W2123811496","https://openalex.org/W2147122909","https://openalex.org/W2167230283","https://openalex.org/W2169325955","https://openalex.org/W2170651949","https://openalex.org/W2330080589","https://openalex.org/W4214891130","https://openalex.org/W4313634981","https://openalex.org/W7214220836"],"related_works":["https://openalex.org/W2183585863","https://openalex.org/W1483867462","https://openalex.org/W2007156132","https://openalex.org/W2016371773","https://openalex.org/W1581054228","https://openalex.org/W127868658","https://openalex.org/W2081861166","https://openalex.org/W2047431298","https://openalex.org/W2101341122","https://openalex.org/W1905139199"],"abstract_inverted_index":{"Use-dependent":[0],"long-term":[1],"potentiation":[2],"of":[3,19,27,70,79,105,113,128,174,206,213],"synaptic":[4,72],"strength":[5],"(LTP)":[6],"is":[7,153,176],"an":[8,149,210],"intensively":[9],"studied":[10],"model":[11],"for":[12,94],"learning":[13],"and":[14,54,83,201],"memory":[15],"in":[16,61,85,119,161,169],"vertebrates.":[17],"Induction":[18],"LTP":[20,53,56,69,91,129,160,175,200,207],"critically":[21],"depends":[22],"on":[23],"the":[24,68,120,187],"stimulation":[25,104,112,197],"parameters":[26],"presynaptic":[28],"fibres":[29],"with":[30],"synchronous":[31],"high-frequency":[32],"bursts":[33],"being":[34],"most":[35],"effective":[36],"at":[37],"many":[38,78],"central":[39],"synapses.":[40],"It":[41],"is,":[42],"however,":[43],"not":[44,98,131,154],"known":[45],"whether":[46,55],"naturally":[47],"occurring":[48],"discharge":[49,190],"patterns":[50,191],"may":[51,198,208],"induce":[52,199],"has":[57],"any":[58],"biological":[59],"function":[60],"sensory":[62],"systems.":[63,183],"Here":[64],"we":[65],"have":[66],"investigated":[67],"excitatory":[71],"transmission":[73],"between":[74],"primary":[75],"afferent":[76,134,151,214],"C-fibres,":[77],"which":[80,163],"are":[81,193],"nociceptors,":[82],"neurons":[84],"rat":[86],"superficial":[87],"spinal":[88],"dorsal":[89],"horn.":[90],"that":[92,148,186,192,202],"lasted":[93],"4-6":[95],"h":[96,139],"could":[97],"only":[99],"be":[100,209],"induced":[101,159,215],"by":[102,110,123,178,195],"electrical":[103],"sural":[106],"nerve":[107,125],"but":[108,166],"also":[109],"natural":[111,188],"heat-,":[114],"mechano-":[115],"or":[116,122,140],"chemosensitive":[117],"nociceptors":[118],"skin":[121,145],"acute":[124],"injury.":[126],"Maintenance":[127],"was":[130],"affected":[132],"when":[133],"nerves":[135],"were":[136,164,167],"cut":[137],"1":[138],"5":[141],"min":[142],"after":[143],"noxious":[144,157,196],"stimulation,":[146],"indicating":[147],"ongoing":[150],"barrage":[152],"required.":[155],"Natural":[156],"stimuli":[158],"animals":[162],"spinalized":[165],"ineffective":[168],"intact":[170],"animals.":[171],"Thus,":[172],"induction":[173],"suppressed":[177],"tonically":[179],"active":[180],"supraspinal":[181],"descending":[182],"We":[184],"conclude":[185],"non-synchronized":[189],"evoked":[194],"this":[203],"new":[204],"form":[205],"underlying":[211],"mechanism":[212],"hyperalgesia.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}