{"id":"https://openalex.org/W1966201557","doi":"https://doi.org/10.1021/bi00417a024","title":"Structure of a hydroxyl radical induced cross-link of thymine and tyrosine","display_name":"Structure of a hydroxyl radical induced cross-link of thymine and tyrosine","publication_year":1988,"publication_date":"1988-08-23","ids":{"openalex":"https://openalex.org/W1966201557","doi":"https://doi.org/10.1021/bi00417a024","mag":"1966201557","pmid":"https://pubmed.ncbi.nlm.nih.gov/2851321"},"language":"en","primary_location":{"id":"doi:10.1021/bi00417a024","doi":"https://doi.org/10.1021/bi00417a024","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00417a024","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111502497","display_name":"Sam A. Margolis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321296531","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416","country_code":"US","type":"government","lineage":["https://openalex.org/I1321296531","https://openalex.org/I1343035065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sam A. Margolis","raw_affiliation_strings":["Center for Analytical Chemistry, National Bureau of Standards, Gaithersburg, Maryland 20899"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Analytical Chemistry, National Bureau of Standards, Gaithersburg, Maryland 20899","institution_ids":["https://openalex.org/I1321296531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087250707","display_name":"Bruce Coxon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce Coxon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062847097","display_name":"Ewa Gajewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewa Gajewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012088953","display_name":"Miral Dizdaro\u011flu","orcid":"https://orcid.org/0000-0003-0283-1695","observed_orcids":["https://orcid.org/0000-0003-0283-1695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miral Dizdaroglu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.2397,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.88810606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"27","issue":"17","first_page":"6353","last_page":"6359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.29589998722076416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.29589998722076416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.17990000545978546,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.16920000314712524,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-protein-cross-links","display_name":"DNA-protein crosslinks","score":0.8989999890327454},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/covalent-cross-links","display_name":"covalent cross-links","score":0.7310000061988831},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2776858809","wikidata":"https://www.wikidata.org/wiki/Q171973","display_name":"Thymine","level":3,"score":0.8020371198654175},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7928147315979004},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.6861221790313721},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.6818152666091919},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.5656813979148865},{"id":"https://openalex.org/C142708767","wikidata":"https://www.wikidata.org/wiki/Q898597","display_name":"Cross-link","level":3,"score":0.5282543897628784},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5236713290214539},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.5049439072608948},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.49039125442504883},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.36179119348526},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3296253979206085},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24318107962608337},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18315601348876953},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.15426793694496155},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.07090345025062561}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004295","descriptor_name":"Dihydroxyphenylalanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006878","descriptor_name":"Hydroxides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017665","descriptor_name":"Hydroxyl Radical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00417a024","doi":"https://doi.org/10.1021/bi00417a024","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00417a024","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:2851321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2851321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1523652295","https://openalex.org/W1981891299","https://openalex.org/W1988551491","https://openalex.org/W1992583244","https://openalex.org/W1993688305","https://openalex.org/W2004276705","https://openalex.org/W2008684671","https://openalex.org/W2030829537","https://openalex.org/W2041358433","https://openalex.org/W2077519189","https://openalex.org/W2201804044","https://openalex.org/W2342704820","https://openalex.org/W2411543007"],"related_works":["https://openalex.org/W2077519189","https://openalex.org/W2031412848","https://openalex.org/W1550507502","https://openalex.org/W2075183429","https://openalex.org/W2001559087","https://openalex.org/W2075479169","https://openalex.org/W2008684671","https://openalex.org/W1973589943","https://openalex.org/W2048163833","https://openalex.org/W2090791200"],"abstract_inverted_index":{"DNA-protein":[0],"cross-links":[1],"are":[2],"formed":[3],"when":[4],"living":[5],"cells":[6],"or":[7],"isolated":[8,42,71,131],"chromatin":[9],"is":[10,16,142],"exposed":[11,62],"to":[12,63],"ionizing":[13,68],"radiation.":[14,69],"Little":[15],"known":[17],"about":[18],"the":[19,94,101,104,111,115,121,126,137,147],"actual":[20],"cross-linked":[21],"products":[22],"of":[23,36,52,55,93,106,114,120,136,139,152],"DNA":[24,157],"and":[25,38,57,83,85,117,132],"proteins.":[26],"In":[27,124],"this":[28],"work,":[29],"a":[30,45,107,153],"novel":[31],"hydroxyl":[32,64,154],"radical":[33,155],"induced":[34,156],"cross-link":[35,96],"thymine":[37,58,116],"tyrosine":[39,46,56,122,128],"has":[40,97],"been":[41,61,74,98],"along":[43],"with":[44],"dimer":[47,129],"by":[48,67,76],"high-performance":[49],"liquid":[50],"chromatography":[51],"aqueous":[53],"mixtures":[54],"that":[59],"had":[60],"radicals":[65],"generated":[66],"The":[70,91,134],"compounds":[72,141],"have":[73],"examined":[75],"gas":[77],"chromatography-mass":[78],"spectrometry,":[79,82],"high-resolution":[80],"mass":[81],"1H":[84],"13C":[86],"nuclear":[87],"magnetic":[88],"resonance":[89],"spectroscopy.":[90],"structure":[92],"thymine-tyrosine":[95],"identified":[99],"as":[100],"product":[102],"from":[103],"formation":[105,138],"covalent":[108],"bond":[109],"between":[110],"methyl":[112],"group":[113],"carbon":[118],"3":[119],"ring.":[123],"addition,":[125],"3,3'":[127],"was":[130],"characterized.":[133],"mechanism":[135],"these":[140],"discussed.":[143],"This":[144],"work":[145],"presents":[146],"first":[148],"complete":[149],"chemical":[150],"characterization":[151],"base-amino":[158],"acid":[159],"cross-link.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
