{"id":"https://openalex.org/W1966105378","doi":"https://doi.org/10.1097/00000542-200701000-00024","title":"Determination of the Full Dose\u2013Response Relation of Intrathecal Bupivacaine, Levobupivacaine, and Ropivacaine, Combined with Sufentanil, for Labor Analgesia","display_name":"Determination of the Full Dose\u2013Response Relation of Intrathecal Bupivacaine, Levobupivacaine, and Ropivacaine, Combined with Sufentanil, for Labor Analgesia","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1966105378","doi":"https://doi.org/10.1097/00000542-200701000-00024","mag":"1966105378","pmid":"https://pubmed.ncbi.nlm.nih.gov/17197857"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-200701000-00024","doi":"https://doi.org/10.1097/00000542-200701000-00024","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-200701000-00024","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/106/1/149/362539/0000542-200701000-00024.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/106/1/149/362539/0000542-200701000-00024.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089485062","display_name":"Marc Van de Velde","orcid":"https://orcid.org/0000-0001-8638-5287","observed_orcids":["https://orcid.org/0000-0001-8638-5287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Van de Velde","raw_affiliation_strings":["Professor of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Anesthesiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033136967","display_name":"Rebekka Dreelinck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebekka Dreelinck","raw_affiliation_strings":["Consultant Obstetrician"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Obstetrician","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040427276","display_name":"Jasperina Dubois","orcid":"https://orcid.org/0000-0002-8076-9279","observed_orcids":["https://orcid.org/0000-0002-8076-9279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jasperina Dubois","raw_affiliation_strings":["Consultant Obstetrician"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Obstetrician","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088683807","display_name":"Ariane Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ariane Kumar","raw_affiliation_strings":["Consultant Obstetrician"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Obstetrician","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079918230","display_name":"Jan A. Deprest","orcid":"https://orcid.org/0000-0002-4920-945X","observed_orcids":["https://orcid.org/0000-0002-4920-945X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Deprest","raw_affiliation_strings":["Professor of Obstetrics and Gynecology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Obstetrics and Gynecology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091409871","display_name":"Liesbeth Lewi","orcid":"https://orcid.org/0000-0002-9884-5778","observed_orcids":["https://orcid.org/0000-0002-9884-5778"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Liesbeth Lewi","raw_affiliation_strings":["Consultant Obstetrician, Department of Obstetrics and Gynecology, University Hospitals Leuven, Katholieke Universiteit Leuven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Obstetrician, Department of Obstetrics and Gynecology, University Hospitals Leuven, Katholieke Universiteit Leuven","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006925508","display_name":"Eug\u00e8ne Vandermeersch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugene Vandermeersch","raw_affiliation_strings":["Professor of Anesthesiology and Chairman, Department of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Anesthesiology and Chairman, Department of Anesthesiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.3449,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.98342847,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"106","issue":"1","first_page":"149","last_page":"156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bupivacaine","display_name":"bupivacaine","score":0.8849999904632568},{"id":"https://openalex.org/keywords/levobupivacaine","display_name":"levobupivacaine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ropivacaine","display_name":"ropivacaine","score":1.0},{"id":"https://openalex.org/keywords/sufentanil","display_name":"sufentanil","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.8659999966621399},{"id":"https://openalex.org/keywords/ed95","display_name":"ED95","score":0.777999997138977},{"id":"https://openalex.org/keywords/local-anesthetic-potency","display_name":"local anesthetic potency","score":0.8510000109672546},{"id":"https://openalex.org/keywords/combined-spinal-epidural-anesthesia","display_name":"combined spinal-epidural anesthesia","score":0.843999981880188},{"id":"https://openalex.org/keywords/active-phase-of-labor","display_name":"active phase of labor","score":0.6290000081062317},{"id":"https://openalex.org/keywords/obstetric-analgesia","display_name":"obstetric analgesia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/probit-analysis","display_name":"probit model","score":0.6380000114440918},{"id":"https://openalex.org/keywords/engine-block","display_name":"motor block","score":0.6240000128746033},{"id":"https://openalex.org/keywords/sensory-and-motor-block","display_name":"sensory and motor block","score":0.7559999823570251},{"id":"https://openalex.org/keywords/term-parturients","display_name":"term parturients","score":0.699999988079071},{"id":"https://openalex.org/keywords/neonatal-outcomes","display_name":"neonatal outcomes","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2776572635","wikidata":"https://www.wikidata.org/wiki/Q3272027","display_name":"Levobupivacaine","level":3,"score":0.9812136292457581},{"id":"https://openalex.org/C2780269707","wikidata":"https://www.wikidata.org/wiki/Q279504","display_name":"Ropivacaine","level":2,"score":0.9472043514251709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9452579617500305},{"id":"https://openalex.org/C2777019824","wikidata":"https://www.wikidata.org/wiki/Q417915","display_name":"Sufentanil","level":2,"score":0.8788215517997742},{"id":"https://openalex.org/C2781328992","wikidata":"https://www.wikidata.org/wiki/Q422806","display_name":"Bupivacaine","level":2,"score":0.8272866010665894},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7889063954353333},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.598375678062439},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.47242605686187744},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.43264150619506836},{"id":"https://openalex.org/C2778994108","wikidata":"https://www.wikidata.org/wiki/Q1868462","display_name":"Local anesthetic","level":2,"score":0.42368412017822266},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09539946913719177}],"mesh":[{"descriptor_ui":"D000077212","descriptor_name":"Ropivacaine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077554","descriptor_name":"Levobupivacaine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002045","descriptor_name":"Bupivacaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002045","descriptor_name":"Bupivacaine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007278","descriptor_name":"Injections, Spinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015360","descriptor_name":"Analgesia, Epidural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016362","descriptor_name":"Analgesia, Obstetrical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017409","descriptor_name":"Sufentanil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-200701000-00024","doi":"https://doi.org/10.1097/00000542-200701000-00024","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-200701000-00024","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/106/1/149/362539/0000542-200701000-00024.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:17197857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17197857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/00000542-200701000-00024","doi":"https://doi.org/10.1097/00000542-200701000-00024","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-200701000-00024","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/106/1/149/362539/0000542-200701000-00024.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1966105378.pdf","grobid_xml":"https://content.openalex.org/works/W1966105378.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2397487518"],"related_works":["https://openalex.org/W2761250663","https://openalex.org/W2051899112","https://openalex.org/W1986428716","https://openalex.org/W1492608894","https://openalex.org/W2900816102","https://openalex.org/W2100970178","https://openalex.org/W1978422217","https://openalex.org/W2054248950","https://openalex.org/W2057811852","https://openalex.org/W2015514443"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ropivacaine":[1,219],"and":[2,12,55,87,136,157,159,190,199,216,220,235],"levobupivacaine":[3,191,217,221,236],"are":[4,33,237],"local":[5,26],"anesthetics":[6],"that":[7,31,233],"produce":[8],"less":[9,34,129,143],"motor":[10],"block":[11],"greater":[13],"sensory-motor":[14],"separation":[15],"when":[16,60],"compared":[17],"with":[18,58,109],"equal":[19],"milligram":[20],"doses":[21],"of":[22,52,98,177,188,223,238],"bupivacaine.":[23],"Although":[24],"minimum":[25],"analgesic":[27],"concentration":[28],"studies":[29,40],"suggested":[30],"they":[32],"potent":[35,212,245],"than":[36,130,144,213,246],"bupivacaine,":[37,56],"full":[38,229],"dose-response":[39,50,165,230],"have":[41],"not":[42],"been":[43],"performed.":[44],"The":[45,175,186],"current":[46],"trial":[47],"describes":[48],"the":[49,121,137],"relation":[51],"levobupivacaine,":[53,89],"ropivacaine,":[54,88],"combined":[57,108],"sufentanil,":[59],"used":[61],"for":[62,126,147],"intrathecal":[63],"labor":[64,74],"analgesia.":[65],"METHODS:":[66],"Four":[67],"hundred":[68],"fifty":[69],"term":[70],"parturients":[71],"in":[72,77,95],"active":[73],"were":[75,114,162,167,192,222],"included":[76],"this":[78],"double-blind,":[79],"randomized":[80],"trial.":[81],"Combined":[82],"spinal-epidural":[83],"anesthesia":[84],"was":[85,92,128,179,209],"performed,":[86],"or":[90,104],"bupivacaine":[91,178,208,242],"intrathecally":[93],"administered":[94],"a":[96,170],"dose":[97],"1.0,":[99],"1.5,":[100],"2.0,":[101],"2.5,":[102],"3.0,":[103],"3.5":[105],"mg,":[106],"always":[107],"1.5":[110],"microg":[111],"sufentanil.":[112],"Patients":[113],"considered":[115],"responders":[116],"to":[117],"spinal":[118],"analgesia":[119],"if":[120],"visual":[122,138],"analog":[123,139],"scale":[124,140],"score":[125,141],"pain":[127],"25":[131,145],"mm":[132,146],"within":[133],"15":[134],"min":[135],"remained":[142],"45":[148],"min.":[149],"Patient":[150],"demographics,":[151],"obstetric":[152],"data,":[153],"maternal":[154],"side":[155],"effects,":[156],"fetal":[158],"neonatal":[160],"well-being":[161],"noted.":[163],"Group-specific":[164],"curves":[166],"constructed":[168],"using":[169],"probit":[171],"regression":[172],"model.":[173],"RESULTS:":[174],"ED95":[176],"3.3":[180],"mg":[181,194,201],"(95%":[182,195,202],"confidence":[183,196,203],"interval,":[184,197,204],"2.9-4.1).":[185],"ED95s":[187],"ropivacaine":[189,214,234],"4.8":[193],"4.0-6.7)":[198],"5.0":[200],"4.1-7.0),":[205],"respectively.":[206],"Racemic":[207],"significantly":[210],"more":[211,244],"(P=0.0027)":[215],"(P=0.0006).":[218],"similar":[224,239],"potency":[225],"(P=0.91).":[226],"CONCLUSIONS:":[227],"This":[228],"study":[231],"suggests":[232],"potency,":[240],"whereas":[241],"is":[243],"both":[247],"other":[248],"drugs.":[249]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
