{"id":"https://openalex.org/W1966100700","doi":"https://doi.org/10.1016/j.ejps.2013.12.017","title":"Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays","display_name":"Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays","publication_year":2014,"publication_date":"2014-01-04","ids":{"openalex":"https://openalex.org/W1966100700","doi":"https://doi.org/10.1016/j.ejps.2013.12.017","mag":"1966100700","pmid":"https://pubmed.ncbi.nlm.nih.gov/24398107"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejps.2013.12.017","doi":"https://doi.org/10.1016/j.ejps.2013.12.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejps.2013.12.017","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058490092","display_name":"Clara Pereira","orcid":"https://orcid.org/0000-0002-8167-6912","observed_orcids":["https://orcid.org/0000-0002-8167-6912"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Clara Pereira","raw_affiliation_strings":["REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal; Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal; Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"]},{"raw_affiliation_string":"Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010582984","display_name":"Vanessa Lopes-Rodrigues","orcid":"https://orcid.org/0000-0002-0084-943X","observed_orcids":["https://orcid.org/0000-0002-0084-943X"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4387153601","display_name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental","ror":"https://ror.org/05p7z7s64","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4387153601"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Vanessa Lopes-Rodrigues","raw_affiliation_strings":["Cancer Drug Resistance Group, IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","Cancer Drug Resistance Group, IPATIMUP \u2013 Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal","Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Drug Resistance Group, IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153601"]},{"raw_affiliation_string":"Cancer Drug Resistance Group, IPATIMUP \u2013 Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010302182","display_name":"Isabel Coutinho","orcid":"https://orcid.org/0000-0002-4198-9818","observed_orcids":["https://orcid.org/0000-0002-4198-9818"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Isabel Coutinho","raw_affiliation_strings":["REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal; Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal; Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"]},{"raw_affiliation_string":"Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102330891","display_name":"Marta Perro Neves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4387153601","display_name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental","ror":"https://ror.org/05p7z7s64","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4387153601"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Marta P. Neves","raw_affiliation_strings":["Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal; Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal","Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal; Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153601"]},{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153601"]},{"raw_affiliation_string":"Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056647844","display_name":"Raquel T. Lima","orcid":"https://orcid.org/0000-0002-5838-9659","observed_orcids":["https://orcid.org/0000-0002-5838-9659"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4387153601","display_name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental","ror":"https://ror.org/05p7z7s64","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4387153601"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Raquel T. Lima","raw_affiliation_strings":["Cancer Drug Resistance Group, IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","Cancer Drug Resistance Group, IPATIMUP \u2013 Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal","Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Drug Resistance Group, IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal; Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153601"]},{"raw_affiliation_string":"Cancer Drug Resistance Group, IPATIMUP \u2013 Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057756576","display_name":"Madalena M. M. Pinto","orcid":"https://orcid.org/0000-0002-4676-1409","observed_orcids":["https://orcid.org/0000-0002-4676-1409"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4387153601","display_name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental","ror":"https://ror.org/05p7z7s64","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4387153601"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Madalena Pinto","raw_affiliation_strings":["Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal; Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal","Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal; Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153601"]},{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153601"]},{"raw_affiliation_string":"Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011085640","display_name":"Honorina M. Cidade","orcid":"https://orcid.org/0000-0003-0715-1779","observed_orcids":["https://orcid.org/0000-0003-0715-1779"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4387153601","display_name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental","ror":"https://ror.org/05p7z7s64","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4387153601"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Honorina Cidade","raw_affiliation_strings":["Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal; Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal","Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal; Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153601"]},{"raw_affiliation_string":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas n\u00b0 289, 4050-123 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153601"]},{"raw_affiliation_string":"Centro de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), and Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua Jorge Viterbo Ferreira n\u00b0 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040669857","display_name":"M. Helena Vasconcelos","orcid":"https://orcid.org/0000-0002-7801-4643","observed_orcids":["https://orcid.org/0000-0002-7801-4643"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"M. Helena Vasconcelos","raw_affiliation_strings":["Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal; Cancer Drug Resistance Group, IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal","Cancer Drug Resistance Group, IPATIMUP \u2013 Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal","Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal; Cancer Drug Resistance Group, IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Cancer Drug Resistance Group, IPATIMUP \u2013 Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Doutor Roberto Frias, 4200 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062260507","display_name":"Luc\u0131\u0301lia Saraiva","orcid":"https://orcid.org/0000-0002-9531-4939","observed_orcids":["https://orcid.org/0000-0002-9531-4939"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210138594","display_name":"Rede de Qu\u00edmica e Tecnologia","ror":"https://ror.org/04j14t006","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210138594"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Luc\u00edlia Saraiva","raw_affiliation_strings":["REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal; Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal. Electronic address: lucilia.saraiva@ff.up.pt","Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal; Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal. Electronic address: lucilia.saraiva@ff.up.pt","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"]},{"raw_affiliation_string":"Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"REQUIMTE, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062260507"],"corresponding_institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210138594"],"apc_list":{"value":3070,"currency":"USD","value_usd":3070},"apc_paid":null,"fwci":0.4406,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.55823214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"54","issue":null,"first_page":"8","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.3122999966144562,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caspase-7","display_name":"caspase-7","score":0.902999997138977},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9869999885559082},{"id":"https://openalex.org/keywords/yeast-based-screening","display_name":"yeast-based screening","score":0.7160000205039978},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.875},{"id":"https://openalex.org/keywords/pac-1","display_name":"PAC-1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6729999780654907},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/target-based-screening","display_name":"target-based screening","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.8191438913345337},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6088656783103943},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5117628574371338},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4768863022327423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4631224572658539},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.453390896320343},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.4409509301185608},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4358227252960205},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.43505188822746277},{"id":"https://openalex.org/C91096171","wikidata":"https://www.wikidata.org/wiki/Q17855901","display_name":"Caspase 7","level":5,"score":0.42966750264167786},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41593384742736816},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27523720264434814},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.1988186538219452},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06333690881729126}],"mesh":[{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047309","descriptor_name":"Flavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047309","descriptor_name":"Flavones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053179","descriptor_name":"Caspase 7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053179","descriptor_name":"Caspase 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejps.2013.12.017","doi":"https://doi.org/10.1016/j.ejps.2013.12.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejps.2013.12.017","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:24398107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24398107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W250541543","https://openalex.org/W1534237904","https://openalex.org/W1870460044","https://openalex.org/W1969825737","https://openalex.org/W1973839771","https://openalex.org/W1984341140","https://openalex.org/W1985732595","https://openalex.org/W1991762770","https://openalex.org/W1998274672","https://openalex.org/W2003436246","https://openalex.org/W2022126473","https://openalex.org/W2027542963","https://openalex.org/W2032097457","https://openalex.org/W2034891521","https://openalex.org/W2035504192","https://openalex.org/W2035835337","https://openalex.org/W2044499234","https://openalex.org/W2064495417","https://openalex.org/W2076198051","https://openalex.org/W2087638306","https://openalex.org/W2091511759","https://openalex.org/W2102602516","https://openalex.org/W2117692326","https://openalex.org/W2127595954","https://openalex.org/W2127697225","https://openalex.org/W2155208683","https://openalex.org/W2176592108","https://openalex.org/W2189626465","https://openalex.org/W2323711779","https://openalex.org/W6679239047"],"related_works":["https://openalex.org/W2323056684","https://openalex.org/W2907615645","https://openalex.org/W4415854919","https://openalex.org/W3040887595","https://openalex.org/W2590829335","https://openalex.org/W2008881547","https://openalex.org/W2035835337","https://openalex.org/W4250063029","https://openalex.org/W2942813810","https://openalex.org/W417849109"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
