{"id":"https://openalex.org/W1966089805","doi":"https://doi.org/10.1021/jm100102v","title":"3\u2032-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity","display_name":"3\u2032-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity","publication_year":2010,"publication_date":"2010-08-27","ids":{"openalex":"https://openalex.org/W1966089805","doi":"https://doi.org/10.1021/jm100102v","mag":"1966089805","pmid":"https://pubmed.ncbi.nlm.nih.gov/20799693"},"language":"en","primary_location":{"id":"doi:10.1021/jm100102v","doi":"https://doi.org/10.1021/jm100102v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm100102v","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080215094","display_name":"St\u00e9phane Priet","orcid":"https://orcid.org/0000-0001-7102-3654","observed_orcids":["https://orcid.org/0000-0001-7102-3654"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stephane Priet","raw_affiliation_strings":["Department of Structural Virology, AFMB UMR 6098, CNRS Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 932, 163 Avenue de Luminy, 13288 Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Virology, AFMB UMR 6098, CNRS Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 932, 163 Avenue de Luminy, 13288 Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079933148","display_name":"Ivan Zlatev","orcid":"https://orcid.org/0000-0003-2797-3032","observed_orcids":["https://orcid.org/0000-0003-2797-3032"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210145258","display_name":"Institut des Biomol\u00e9cules Max Mousseron","ror":"https://ror.org/05d1e6v30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I11935315","https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210128300","https://openalex.org/I4210145258"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ivan Zlatev","raw_affiliation_strings":["Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS\u2014Universit\u00e9 Montpellier 1\u2014Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, CC1704, 34095 Montpellier Cedex 5, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS\u2014Universit\u00e9 Montpellier 1\u2014Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, CC1704, 34095 Montpellier Cedex 5, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210145258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041325691","display_name":"Ivan Barv\u0131\u0301k","orcid":"https://orcid.org/0000-0002-0802-1346","observed_orcids":["https://orcid.org/0000-0002-0802-1346"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ivan Barvik","raw_affiliation_strings":["Institute of Physics, Faculty of Mathematics and Physics, Charles University, Ke Karlovu 5, Prague 2 121 16, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physics, Faculty of Mathematics and Physics, Charles University, Ke Karlovu 5, Prague 2 121 16, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081322373","display_name":"Katrien Geerts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Katrien Geerts","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036860979","display_name":"Pieter Leyssen","orcid":"https://orcid.org/0000-0002-7537-1688","observed_orcids":["https://orcid.org/0000-0002-7537-1688"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Pieter Leyssen","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Johan Neyts","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017581321","display_name":"H\u00e9l\u00e8ne Dutartre","orcid":"https://orcid.org/0000-0002-2682-4302","observed_orcids":["https://orcid.org/0000-0002-2682-4302"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Helene Dutartre","raw_affiliation_strings":["Department of Structural Virology, AFMB UMR 6098, CNRS Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 932, 163 Avenue de Luminy, 13288 Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Virology, AFMB UMR 6098, CNRS Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 932, 163 Avenue de Luminy, 13288 Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039783946","display_name":"Bruno Canard","orcid":"https://orcid.org/0000-0003-4924-1991","observed_orcids":["https://orcid.org/0000-0003-4924-1991"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Canard","raw_affiliation_strings":["Department of Structural Virology, AFMB UMR 6098, CNRS Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 932, 163 Avenue de Luminy, 13288 Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Virology, AFMB UMR 6098, CNRS Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 932, 163 Avenue de Luminy, 13288 Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024525017","display_name":"Jean\u2010Jacques Vasseur","orcid":"https://orcid.org/0000-0002-4379-6139","observed_orcids":["https://orcid.org/0000-0002-4379-6139"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210145258","display_name":"Institut des Biomol\u00e9cules Max Mousseron","ror":"https://ror.org/05d1e6v30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I11935315","https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210128300","https://openalex.org/I4210145258"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Jacques Vasseur","raw_affiliation_strings":["Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS\u2014Universit\u00e9 Montpellier 1\u2014Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, CC1704, 34095 Montpellier Cedex 5, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS\u2014Universit\u00e9 Montpellier 1\u2014Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, CC1704, 34095 Montpellier Cedex 5, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210145258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076236363","display_name":"F. Morvan","orcid":"https://orcid.org/0000-0001-5077-0028","observed_orcids":["https://orcid.org/0000-0001-5077-0028"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210145258","display_name":"Institut des Biomol\u00e9cules Max Mousseron","ror":"https://ror.org/05d1e6v30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I11935315","https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210128300","https://openalex.org/I4210145258"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fran\u00e7ois Morvan","raw_affiliation_strings":["Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS\u2014Universit\u00e9 Montpellier 1\u2014Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, CC1704, 34095 Montpellier Cedex 5, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS\u2014Universit\u00e9 Montpellier 1\u2014Universit\u00e9 Montpellier 2, Place Eug\u00e8ne Bataillon, CC1704, 34095 Montpellier Cedex 5, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210145258"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050379278","display_name":"Karine Alvarez","orcid":"https://orcid.org/0000-0002-6108-6966","observed_orcids":["https://orcid.org/0000-0002-6108-6966"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Karine Alvarez","raw_affiliation_strings":["Department of Structural Virology, AFMB UMR 6098, CNRS Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 932, 163 Avenue de Luminy, 13288 Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural Virology, AFMB UMR 6098, CNRS Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 932, 163 Avenue de Luminy, 13288 Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210146787"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5050379278","https://openalex.org/A5076236363"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210145258","https://openalex.org/I4210146787"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8388,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.76394937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"53","issue":"18","first_page":"6608","last_page":"6617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ns5b-polymerase-inhibitors","display_name":"NS5B polymerase inhibitors","score":0.8420000076293945},{"id":"https://openalex.org/keywords/subgenomic-replicon","display_name":"subgenomic replicon","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chain-terminators","display_name":"chain terminators","score":0.890999972820282},{"id":"https://openalex.org/keywords/antiviral-nucleoside-analogues","display_name":"antiviral nucleosides","score":0.6970000267028809},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2780880337","wikidata":"https://www.wikidata.org/wiki/Q7187542","display_name":"Phosphoramidate","level":2,"score":0.9842841625213623},{"id":"https://openalex.org/C189819185","wikidata":"https://www.wikidata.org/wiki/Q384283","display_name":"Subgenomic mRNA","level":4,"score":0.8688234090805054},{"id":"https://openalex.org/C18103114","wikidata":"https://www.wikidata.org/wiki/Q1720369","display_name":"Replicon","level":4,"score":0.8326778411865234},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7971018552780151},{"id":"https://openalex.org/C2781426373","wikidata":"https://www.wikidata.org/wiki/Q24766653","display_name":"NS5B","level":5,"score":0.7115052938461304},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5766288042068481},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.560187816619873},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4336863160133362},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3703639507293701},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3283706307411194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32374143600463867},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2297607660293579},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1609380543231964},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.1459122896194458},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09892210364341736},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.09388762712478638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.061341822147369385},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012093","descriptor_name":"Replicon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/jm100102v","doi":"https://doi.org/10.1021/jm100102v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm100102v","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:20799693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20799693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00533933v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00533933","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medicinal Chemistry, 2010, 53, pp.6608-6617. ⟨10.1021/jm100102v⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/298408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20799693","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medicinal Chemistry, vol. 53 (18), (6608-6617)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321519","display_name":"Centre National d\u2019Etudes Spatiales","ror":"https://ror.org/04h1h0y33"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1581048386","https://openalex.org/W1975402226","https://openalex.org/W1976499671","https://openalex.org/W1984304262","https://openalex.org/W1990568874","https://openalex.org/W2004585892","https://openalex.org/W2004721925","https://openalex.org/W2006309458","https://openalex.org/W2020849085","https://openalex.org/W2021199098","https://openalex.org/W2023049085","https://openalex.org/W2028194374","https://openalex.org/W2029667189","https://openalex.org/W2037427168","https://openalex.org/W2041961923","https://openalex.org/W2044318670","https://openalex.org/W2053061988","https://openalex.org/W2054896136","https://openalex.org/W2058479011","https://openalex.org/W2062153657","https://openalex.org/W2063235805","https://openalex.org/W2066124462","https://openalex.org/W2068430448","https://openalex.org/W2070919781","https://openalex.org/W2076348665","https://openalex.org/W2078948957","https://openalex.org/W2091795018","https://openalex.org/W2093381148","https://openalex.org/W2097641909","https://openalex.org/W2102030104","https://openalex.org/W2107713887","https://openalex.org/W2116442049","https://openalex.org/W2127577355","https://openalex.org/W2127685726","https://openalex.org/W2129802492","https://openalex.org/W2138788149","https://openalex.org/W2150340227","https://openalex.org/W2150981663","https://openalex.org/W2168912424","https://openalex.org/W2317428995","https://openalex.org/W2953350388"],"related_works":["https://openalex.org/W1990568874","https://openalex.org/W1971896683","https://openalex.org/W7024814201","https://openalex.org/W645652221","https://openalex.org/W2116442049","https://openalex.org/W2009444278","https://openalex.org/W2071546427","https://openalex.org/W2077064549","https://openalex.org/W2168586962","https://openalex.org/W2007468850"],"abstract_inverted_index":{"Phosphoramidate":[0],"dinucleosides":[1],"named":[2],"\"GC":[3,31],"3'-OH\"":[4],"series,":[5],"carrying":[6],"various":[7],"phosphoramidate":[8,56],"linkages":[9],"have":[10],"been":[11],"previously":[12],"reported":[13],"as":[14,34],"hepatitis":[15],"C":[16],"virus":[17],"(HCV)":[18],"inhibitors.":[19],"To":[20],"enhance":[21],"the":[22,48,125,141,145],"efficacy":[23],"of":[24,50,113,121,140,146],"these":[25],"dinucleotides,":[26],"we":[27],"synthesized":[28],"a":[29,98,102],"novel":[30,51],"3'-H\"":[32],"series":[33],"potential":[35],"chain":[36,107],"terminators.":[37],"We":[38],"showed":[39],"that":[40],"their":[41,86],"inhibition":[42],"potency":[43],"is":[44,134],"strongly":[45],"increased":[46],"by":[47,144],"introduction":[49],"neutral":[52],"and":[53,70,118],"bis-negatively":[54,103],"charged":[55,104],"side":[57,106],"chains.":[58],"Their":[59],"inhibitory":[60],"effect":[61],"on":[62],"HCV":[63,72,91,126],"NS5B":[64],"polymerase":[65,92],"was":[66],"evaluated":[67],"in":[68,71,116,124],"vitro":[69,117],"subgenomic":[73,127],"replicon":[74,128],"containing":[75],"Huh-6":[76],"cells.":[77],"As":[78],"expected,":[79],"3'-H":[80],"compounds":[81],"are":[82],"more":[83],"potent":[84,96],"than":[85],"3'-OH":[87],"counterparts":[88],"to":[89,136],"inhibit":[90],"activity.":[93],"The":[94],"most":[95],"inhibitor,":[97],"5'-phosphorylated":[99],"dinucleotide":[100],"bearing":[101],"amino":[105],"(7),":[108],"exhibits":[109],"an":[110,138],"IC(50)":[111],"value":[112,120],"8":[114],"\u03bcM":[115,123],"EC(50)":[119],"2.6":[122],"system.":[129],"A":[130],"molecular":[131],"structure":[132],"model":[133],"presented":[135],"propose":[137],"interpretation":[139],"gain":[142],"afforded":[143],"3'-H-cytidine":[147],"modification.":[148]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}