{"id":"https://openalex.org/W1966081131","doi":"https://doi.org/10.1212/wnl.25.3.259","title":"The effect of alcohol on essential tremor","display_name":"The effect of alcohol on essential tremor","publication_year":1975,"publication_date":"1975-03-01","ids":{"openalex":"https://openalex.org/W1966081131","doi":"https://doi.org/10.1212/wnl.25.3.259","mag":"1966081131","pmid":"https://pubmed.ncbi.nlm.nih.gov/1167633"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.25.3.259","doi":"https://doi.org/10.1212/wnl.25.3.259","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.25.3.259","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111694111","display_name":"John H. Growdon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN H. GROWDON","raw_affiliation_strings":["Department of Neurology and the Laboratory of Clinical Neurophysiology, Harvard Medical School and Massachusetts General Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and the Laboratory of Clinical Neurophysiology, Harvard Medical School and Massachusetts General Hospital, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013174230","display_name":"Bhagwan T. Shahani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BHAGWAN T. SHAHANI","raw_affiliation_strings":["Department of Neurology and the Laboratory of Clinical Neurophysiology, Harvard Medical School and Massachusetts General Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and the Laboratory of Clinical Neurophysiology, Harvard Medical School and Massachusetts General Hospital, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091600678","display_name":"Robert R. Young","orcid":"https://orcid.org/0000-0002-3783-782X","observed_orcids":["https://orcid.org/0000-0002-3783-782X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT R. YOUNG","raw_affiliation_strings":["Department of Neurology and the Laboratory of Clinical Neurophysiology, Harvard Medical School and Massachusetts General Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and the Laboratory of Clinical Neurophysiology, Harvard Medical School and Massachusetts General Hospital, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5419,"has_fulltext":false,"cited_by_count":147,"citation_normalized_percentile":{"value":0.95427729,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"3","first_page":"259","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10982","display_name":"Motor Control and Adaptation","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/essential-tremor","display_name":"essential tremor","score":1.0},{"id":"https://openalex.org/keywords/alcohol","display_name":"alcohol","score":0.7720000147819519},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.968999981880188},{"id":"https://openalex.org/keywords/tremor-amplitude","display_name":"tremor amplitude","score":0.8799999952316284},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.8389999866485596},{"id":"https://openalex.org/keywords/brachial-artery-infusion","display_name":"brachial artery infusion","score":0.796999990940094},{"id":"https://openalex.org/keywords/tremor-pathogenesis","display_name":"tremor pathogenesis","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2780112193","wikidata":"https://www.wikidata.org/wiki/Q693519","display_name":"Essential tremor","level":2,"score":0.7851884365081787},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.7788897156715393},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.6474636793136597},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5793157815933228},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5430334210395813},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4273115396499634},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.2342899739742279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22449645400047302},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1795068383216858},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001916","descriptor_name":"Brachial Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004576","descriptor_name":"Electromyography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007269","descriptor_name":"Injections, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014202","descriptor_name":"Tremor","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.25.3.259","doi":"https://doi.org/10.1212/wnl.25.3.259","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.25.3.259","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:1167633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1167633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2086400721","https://openalex.org/W1966813576","https://openalex.org/W2134371645","https://openalex.org/W2014807758","https://openalex.org/W4389682054","https://openalex.org/W2050202370","https://openalex.org/W1985805006","https://openalex.org/W2144527197","https://openalex.org/W4240972558","https://openalex.org/W2130111807"],"abstract_inverted_index":{"Five":[0],"patients":[1,24,54],"with":[2,55],"essential":[3,56,89],"tremor":[4,10,43],"had":[5],"a":[6,34,61,85],"dramatic":[7],"diminution":[8],"in":[9,42,45,53,60,88,100],"amplitude":[11,44],"within":[12,67],"15":[13],"minutes":[14],"of":[15,19,29],"ingesting":[16],"small":[17],"doses":[18],"ethyl":[20,30],"alcohol.":[21],"The":[22],"same":[23],"were":[25],"given":[26],"equivalent":[27],"amounts":[28],"alcohol":[31],"infused":[32],"into":[33],"brachial":[35],"artery,":[36],"and":[37,72],"there":[38],"was":[39],"no":[40,74],"decrease":[41],"the":[46,68],"perfused":[47],"limb.":[48],"It":[49],"is":[50],"concluded":[51],"that,":[52],"tremor,":[57,90],"ethanol":[58],"acts":[59],"specific":[62],"fashion":[63],"on":[64,76],"sensitive":[65],"structures":[66],"central":[69,86],"nervous":[70],"system":[71],"has":[73],"effect":[75],"peripheral":[77,101],"tremorogenic":[78],"mechanisms.":[79],"This":[80],"provides":[81],"additional":[82],"evidence":[83],"for":[84],"mechanism":[87],"distinguishing":[91],"it":[92],"from":[93,98],"other":[94],"tremors":[95],"arising":[96],"primarily":[97],"oscillation":[99],"servo-loops.":[102]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}