{"id":"https://openalex.org/W1966053383","doi":"https://doi.org/10.1002/art.22030","title":"Relationship between serum NR2a antibodies and cognitive dysfunction in systemic lupus erythematosus","display_name":"Relationship between serum NR2a antibodies and cognitive dysfunction in systemic lupus erythematosus","publication_year":2006,"publication_date":"2006-07-25","ids":{"openalex":"https://openalex.org/W1966053383","doi":"https://doi.org/10.1002/art.22030","mag":"1966053383","pmid":"https://pubmed.ncbi.nlm.nih.gov/16868972"},"language":"en","primary_location":{"id":"doi:10.1002/art.22030","doi":"https://doi.org/10.1002/art.22030","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.22030","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113543045","display_name":"Melanie J. Harrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie J. Harrison","raw_affiliation_strings":["Hospital for Special Surgery and Weill Medical College of Cornell University, New York, New York 10021, USA. HarrisonM@hss.edu","Hospital for Special Surgery and Weill Medical College of Cornell University; New York New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Special Surgery and Weill Medical College of Cornell University, New York, New York 10021, USA. HarrisonM@hss.edu","institution_ids":["https://openalex.org/I1281539108","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Hospital for Special Surgery and Weill Medical College of Cornell University; New York New York","institution_ids":["https://openalex.org/I1281539108","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068089474","display_name":"Lisa Ravdin","orcid":"https://orcid.org/0000-0003-3959-9682","observed_orcids":["https://orcid.org/0000-0003-3959-9682"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa D. Ravdin","raw_affiliation_strings":["New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031470088","display_name":"Michael D. Lockshin","orcid":"https://orcid.org/0000-0003-1034-0351","observed_orcids":["https://orcid.org/0000-0003-1034-0351"]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Lockshin","raw_affiliation_strings":["Hospital for Special Surgery and Weill Medical College of Cornell University; New York New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Special Surgery and Weill Medical College of Cornell University; New York New York","institution_ids":["https://openalex.org/I1281539108","https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5874,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.94757725,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"54","issue":"8","first_page":"2515","last_page":"2522"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7390000224113464},{"id":"https://openalex.org/keywords/neuropsychological-impairment","display_name":"neuropsychological deficits","score":0.8410000205039978},{"id":"https://openalex.org/keywords/neuropsychiatric-symptoms","display_name":"neuropsychiatric symptoms","score":0.6200000047683716},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7620000243186951},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.9879999756813049},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6728854775428772},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6484948396682739},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5333195924758911},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.5201883316040039},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.5054051876068115},{"id":"https://openalex.org/C2778355293","wikidata":"https://www.wikidata.org/wiki/Q3997285","display_name":"Trail Making Test","level":4,"score":0.475511372089386},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.46976280212402344},{"id":"https://openalex.org/C2776811091","wikidata":"https://www.wikidata.org/wiki/Q3818443","display_name":"Neuropsychological test","level":4,"score":0.4669075608253479},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.4354035258293152},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3770013749599457},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3593696355819702},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.30792438983917236},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2583789825439453},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.22030","doi":"https://doi.org/10.1002/art.22030","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.22030","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"pmid:16868972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16868972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G409595495","display_name":null,"funder_award_id":"AR-049165-01","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G457965300","display_name":"Cognitive dysfunction in neuropsychiatric-SLE","funder_award_id":"R55AR049165","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W50998637","https://openalex.org/W1605213317","https://openalex.org/W1607171655","https://openalex.org/W1971708952","https://openalex.org/W2000445173","https://openalex.org/W2008392867","https://openalex.org/W2013309566","https://openalex.org/W2026169138","https://openalex.org/W2028734026","https://openalex.org/W2040236551","https://openalex.org/W2043046139","https://openalex.org/W2053180905","https://openalex.org/W2058470282","https://openalex.org/W2060069980","https://openalex.org/W2064999867","https://openalex.org/W2086939928","https://openalex.org/W2087728801","https://openalex.org/W2103982494","https://openalex.org/W2104673530","https://openalex.org/W2108905161","https://openalex.org/W2112778345","https://openalex.org/W2137640241","https://openalex.org/W2146203649","https://openalex.org/W2159482351","https://openalex.org/W2162887450","https://openalex.org/W2174668858","https://openalex.org/W2275231661","https://openalex.org/W2561536790"],"related_works":["https://openalex.org/W1883960381","https://openalex.org/W1983203217","https://openalex.org/W2065262547","https://openalex.org/W3031010712","https://openalex.org/W2036223015","https://openalex.org/W1979117688","https://openalex.org/W2060069980","https://openalex.org/W1570190630","https://openalex.org/W1968396227","https://openalex.org/W2150514406"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,44,62,68,70,78,92,128,139,172,193,219,267],"association":[4,228,249],"between":[5,121,231,252],"serum":[6,40],"NR2a":[7,109,136,154,232,253],"antibodies":[8,110,271],"and":[9,35,51,54,59,77,123,221,235,256],"cognitive":[10,257,280],"dysfunction":[11],"in":[12,43,192],"systemic":[13],"lupus":[14],"erythematosus":[15],"(SLE).":[16],"METHODS:":[17],"The":[18],"study":[19],"population":[20],"consisted":[21],"of":[22,29,94,159,177,269,287],"English-speaking":[23],"adults":[24],"who":[25,142,161],"met":[26],"American":[27],"College":[28],"Rheumatology":[30],"(ACR)":[31],"criteria":[32],"for":[33,46,72,108,135,153],"SLE":[34],"had":[36],"at":[37,100],"least":[38,101],"1":[39],"sample":[41],"stored":[42],"Hospital":[45],"Special":[47],"Surgery":[48],"Autoimmune":[49],"Registry":[50],"Repository.":[52],"Demographic":[53],"clinical":[55,225],"information":[56],"was":[57,85,119,183,206,229,250],"obtained,":[58],"patients":[60,141],"completed":[61],"neuropsychological":[63,103,117,178],"test":[64,148,214],"battery":[65],"recommended":[66],"by":[67,111],"ACR,":[69],"Center":[71],"Epidemiologic":[73],"Studies":[74],"Depression":[75],"Scale,":[76],"Spielberger":[79],"State-Trait":[80],"Anxiety":[81],"Inventory.":[82],"Cognitive":[83],"impairment":[84,205],"defined":[86,207],"as":[87],"scores":[88,215],">1.5":[89],"SD":[90,175,217],"below":[91,218],"mean":[93,173],"age-matched":[95],"published":[96],"normative":[97],"data":[98],"on":[99,116,147,279],"2":[102],"tests.":[104],"Sera":[105],"were":[106,133,143,151,162,202],"tested":[107],"enzyme-linked":[112],"immunosorbent":[113],"assay.":[114],"Performance":[115],"tests":[118,179],"compared":[120,156,187],"NR2a-positive":[122],"NR2a-negative":[124],"patients.":[125],"RESULTS:":[126],"Of":[127,138],"93":[129],"patients,":[130,171],"24":[131],"(25.8%)":[132],"positive":[134,152],"antibodies.":[137],"48":[140],"cognitively":[144,164],"impaired":[145,165],"based":[146],"results,":[149],"31%":[150],"antibodies,":[155],"with":[157,180,188],"20%":[158],"those":[160],"not":[163,274],"(P":[166,196,238,243],"=":[167,197,239,244],"0.24).":[168],"Among":[169],"antibody-positive":[170],"+/-":[174,185,190],"number":[176],"abnormal":[181],"results":[182,264],"2.3":[184],"2.2,":[186],"2.0":[189],"1.8":[191],"antibody-negative":[194],"group":[195],"0.59).":[198],"Similar":[199],"nonsignificant":[200],"differences":[201],"found":[203,251],"when":[204],"using":[208,222],"a":[209,223,276],"more":[210],"stringent":[211],"definition":[212],"(i.e.,":[213],">2.0":[216],"mean)":[220],"neuropsychologist's":[224],"ratings.":[226],"No":[227,247],"detected":[230],"antibody":[233,254],"positivity":[234,255],"depressive":[236,259],"symptoms":[237],"0.73)":[240],"or":[241,261,282],"anxiety":[242],"0.42).":[245],"CONCLUSION:":[246],"significant":[248],"dysfunction,":[258],"symptoms,":[260],"anxiety.":[262],"These":[263],"indicate":[265],"that":[266],"presence":[268],"these":[270],"alone":[272],"does":[273],"have":[275],"direct":[277],"effect":[278],"functioning":[281],"any":[283],"other":[284],"neuropsychiatric":[285],"manifestation":[286],"SLE.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
