{"id":"https://openalex.org/W1966042629","doi":"https://doi.org/10.1089/cap.2012.0020","title":"Additive Effects of 5-HTTLPR (Serotonin Transporter) and Tryptophan Hydroxylase 2 G-703T Gene Polymorphisms on the Clinical Response to Citalopram among Children and Adolescents with Depression and Anxiety Disorders","display_name":"Additive Effects of 5-HTTLPR (Serotonin Transporter) and Tryptophan Hydroxylase 2 G-703T Gene Polymorphisms on the Clinical Response to Citalopram among Children and Adolescents with Depression and Anxiety Disorders","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W1966042629","doi":"https://doi.org/10.1089/cap.2012.0020","mag":"1966042629","pmid":"https://pubmed.ncbi.nlm.nih.gov/23510446"},"language":"en","primary_location":{"id":"doi:10.1089/cap.2012.0020","doi":"https://doi.org/10.1089/cap.2012.0020","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cap.2012.0020","pdf_url":null,"source":{"id":"https://openalex.org/S198272637","display_name":"Journal of Child and Adolescent Psychopharmacology","issn_l":"1044-5463","issn":["1044-5463","1557-8992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Child and Adolescent Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112526128","display_name":"Benyamin Rotberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210143993","display_name":"Geha Mental Health Center","ror":"https://ror.org/03tp0ty93","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210143993","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Benyamin Rotberg","raw_affiliation_strings":["Geha Mental Health Center","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","Department of Child and Adolescent Psychiatry, Geha Mental Health Center, Petach Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geha Mental Health Center","institution_ids":["https://openalex.org/I4210143993"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, Geha Mental Health Center, Petach Tikva, Israel","institution_ids":["https://openalex.org/I4210143993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029281080","display_name":"Sefi Kronenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sefi Kronenberg","raw_affiliation_strings":["Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","Schneider's Children's Medical Center of Israel","Feinberg Child Study Center, Schneider's Children's Medical Center of Israel, Petach Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Schneider's Children's Medical Center of Israel","institution_ids":["https://openalex.org/I4210109312"]},{"raw_affiliation_string":"Feinberg Child Study Center, Schneider's Children's Medical Center of Israel, Petach Tikva, Israel","institution_ids":["https://openalex.org/I4210109312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111593694","display_name":"Miri Carmel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Miri Carmel","raw_affiliation_strings":["Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013209204","display_name":"Amos Frisch","orcid":"https://orcid.org/0009-0003-6769-6989","observed_orcids":["https://orcid.org/0009-0003-6769-6989"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Amos Frisch","raw_affiliation_strings":["Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082847636","display_name":"David A. Brent","orcid":"https://orcid.org/0000-0002-5756-2157","observed_orcids":["https://orcid.org/0000-0002-5756-2157"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Brent","raw_affiliation_strings":["Western Psychiatric Institute and Clinic","Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western Psychiatric Institute and Clinic","institution_ids":[]},{"raw_affiliation_string":"Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055832192","display_name":"Gil Zalsman","orcid":"https://orcid.org/0000-0003-2269-2928","observed_orcids":["https://orcid.org/0000-0003-2269-2928"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210143993","display_name":"Geha Mental Health Center","ror":"https://ror.org/03tp0ty93","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210143993","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gil Zalsman","raw_affiliation_strings":["Geha Mental Health Center","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","Department of Child and Adolescent Psychiatry, Geha Mental Health Center, Petach Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geha Mental Health Center","institution_ids":["https://openalex.org/I4210143993"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Child and Adolescent Psychiatry, Geha Mental Health Center, Petach Tikva, Israel","institution_ids":["https://openalex.org/I4210143993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080388880","display_name":"Alan Apter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Alan Apter","raw_affiliation_strings":["Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","Schneider's Children's Medical Center of Israel","Feinberg Child Study Center, Schneider's Children's Medical Center of Israel, Petach Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Schneider's Children's Medical Center of Israel","institution_ids":["https://openalex.org/I4210109312"]},{"raw_affiliation_string":"Feinberg Child Study Center, Schneider's Children's Medical Center of Israel, Petach Tikva, Israel","institution_ids":["https://openalex.org/I4210109312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063898483","display_name":"Abraham Weizman","orcid":"https://orcid.org/0000-0002-9765-8938","observed_orcids":["https://orcid.org/0000-0002-9765-8938"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210143993","display_name":"Geha Mental Health Center","ror":"https://ror.org/03tp0ty93","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210143993","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Abraham Weizman","raw_affiliation_strings":["Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel","Research Unit, Geha Mental Health Center, Petah Tikva, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Research Unit, Geha Mental Health Center, Petah Tikva, Israel","institution_ids":["https://openalex.org/I4210143993"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112526128"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I4210143993"],"apc_list":null,"apc_paid":null,"fwci":1.7507,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81154699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"2","first_page":"117","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.05469999834895134,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-httlpr","display_name":"5-HTTLPR","score":0.968999981880188},{"id":"https://openalex.org/keywords/tryptophan-hydroxylase-2","display_name":"tryptophan hydroxylase 2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/citalopram","display_name":"citalopram","score":0.8050000071525574},{"id":"https://openalex.org/keywords/antidepressant-response","display_name":"antidepressant response","score":0.8859999775886536},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.7149999737739563},{"id":"https://openalex.org/keywords/childhood-depression","display_name":"childhood depression","score":0.7400000095367432},{"id":"https://openalex.org/keywords/adolescent-depression","display_name":"adolescent depression","score":0.8379999995231628},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.625}],"concepts":[{"id":"https://openalex.org/C2779999352","wikidata":"https://www.wikidata.org/wiki/Q18049432","display_name":"TPH2","level":5,"score":0.9891445636749268},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.8704303503036499},{"id":"https://openalex.org/C2777490545","wikidata":"https://www.wikidata.org/wiki/Q409672","display_name":"Citalopram","level":4,"score":0.8519289493560791},{"id":"https://openalex.org/C5284366","wikidata":"https://www.wikidata.org/wiki/Q3299516","display_name":"5-HTTLPR","level":5,"score":0.5964129567146301},{"id":"https://openalex.org/C2775951788","wikidata":"https://www.wikidata.org/wiki/Q418293","display_name":"Tryptophan hydroxylase","level":5,"score":0.5744854211807251},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5379214286804199},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5325542688369751},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.506020724773407},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4673381745815277},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.46291688084602356},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.41593965888023376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4093407094478607},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.39975422620773315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3293302357196808},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3221295475959778},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31809014081954956},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.294716477394104},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.2724606692790985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24614205956459045},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.18413099646568298},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.060973018407821655},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.053854674100875854},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/cap.2012.0020","doi":"https://doi.org/10.1089/cap.2012.0020","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cap.2012.0020","pdf_url":null,"source":{"id":"https://openalex.org/S198272637","display_name":"Journal of Child and Adolescent Psychopharmacology","issn_l":"1044-5463","issn":["1044-5463","1557-8992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Child and Adolescent Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:23510446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23510446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of child and adolescent psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1972177155","https://openalex.org/W1975353296","https://openalex.org/W1977949510","https://openalex.org/W1981725027","https://openalex.org/W1982886582","https://openalex.org/W1991638980","https://openalex.org/W1993607324","https://openalex.org/W1998149933","https://openalex.org/W2000389963","https://openalex.org/W2021490346","https://openalex.org/W2035090322","https://openalex.org/W2054014670","https://openalex.org/W2054702712","https://openalex.org/W2060944416","https://openalex.org/W2063959960","https://openalex.org/W2065514195","https://openalex.org/W2069683199","https://openalex.org/W2077254617","https://openalex.org/W2078124330","https://openalex.org/W2082179080","https://openalex.org/W2082569011","https://openalex.org/W2087270747","https://openalex.org/W2095651162","https://openalex.org/W2096991502","https://openalex.org/W2103606283","https://openalex.org/W2103748523","https://openalex.org/W2105938068","https://openalex.org/W2106095564","https://openalex.org/W2111686081","https://openalex.org/W2118826874","https://openalex.org/W2125322498","https://openalex.org/W2127523994","https://openalex.org/W2131873172","https://openalex.org/W2142351553","https://openalex.org/W2158533153","https://openalex.org/W2162176738","https://openalex.org/W2170524922","https://openalex.org/W2183950985","https://openalex.org/W2254051562","https://openalex.org/W3197972117","https://openalex.org/W4413981323"],"related_works":["https://openalex.org/W2021490346","https://openalex.org/W2025709826","https://openalex.org/W2356629914","https://openalex.org/W2473812671","https://openalex.org/W2043432295","https://openalex.org/W2084965184","https://openalex.org/W7212204547","https://openalex.org/W2164949086","https://openalex.org/W2158533153","https://openalex.org/W191982317"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,71,166],"purpose":[2],"of":[3,84,99,117,131,152],"this":[4],"study":[5],"was":[6],"to":[7,22,57,125,143,163,193,198],"evaluate":[8],"the":[9,19,52,55,62,67,79,85,89,100,118,122,129,135,140,150,156,195],"association":[10,53],"between":[11,54],"polymorphisms":[12,60,72,76],"in":[13,61,78,191],"two":[14,119],"serotonin":[15,68,90],"pathway":[16],"genes":[17,120,188],"and":[18,26,36,59,66,88,134,155,172,186,202],"clinical":[20,123,196],"response":[21,56,105,124,178,197],"citalopram":[23,46,58,199],"among":[24,200],"children":[25,35,201],"adolescents":[27,37,203],"with":[28,38,45,204],"depression":[29,39,205],"and/or":[30,40,206],"anxiety":[31,41,207],"disorders.":[32,208],"METHODS:":[33],"Eighty-three":[34],"disorders":[42],"were":[43,139,160],"treated":[44],"for":[47],"8":[48],"weeks.":[49],"We":[50,112],"assessed":[51],"tryptophan":[63],"hydroxylase-2":[64],"(TPH2)":[65],"transporter":[69,91],"gene.":[70],"included":[73],"single":[74],"nucleotide":[75],"(SNPs)":[77],"transcriptional":[80],"control":[81],"region":[82,94],"(G-703T)":[83],"TPH2":[86,132,153,187],"gene":[87],"gene-linked":[92],"promoter":[93],"(5-HTTLPR).":[95],"RESULTS:":[96],"Fifty":[97],"patients":[98,148,168],"83":[101],"(60.2%)":[102],"achieved":[103],"satisfactory":[104],"(Clinical":[106],"Global":[107],"Impressions":[108],"-":[109],"Improvement":[110],"\u22642).":[111],"observed":[113],"an":[114],"additive":[115],"effect":[116],"on":[121],"citalopram.":[126],"Patients":[127],"carrying":[128,149],"combination":[130,151],"-703G":[133],"5-HTTLPR":[136,157,185],"L":[137,174],"alleles":[138,159],"most":[141],"likely":[142,162],"respond":[144,164],"(80%).":[145],"In":[146],"contrast,":[147],"-703T":[154],"S":[158,171],"least":[161],"(31%).":[165],"other":[167],"(with":[169],"-703G/5-HTTLPR":[170],"-703T/5-HTTLPR":[173],"alleles)":[175],"showed":[176],"intermediate":[177],"(67%).":[179],"CONCLUSIONS:":[180],"This":[181],"finding":[182],"suggests":[183],"that":[184],"may":[189],"act":[190],"concert":[192],"modulate":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
