{"id":"https://openalex.org/W1966038367","doi":"https://doi.org/10.1160/th06-09-0498","title":"Coagulation and endothelial dysfunction during longterm hyperdynamic porcine bacteremia \u2013 effects of selective inducible nitric oxide synthase inhibition","display_name":"Coagulation and endothelial dysfunction during longterm hyperdynamic porcine bacteremia \u2013 effects of selective inducible nitric oxide synthase inhibition","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1966038367","doi":"https://doi.org/10.1160/th06-09-0498","mag":"1966038367","pmid":"https://pubmed.ncbi.nlm.nih.gov/17264961"},"language":"en","primary_location":{"id":"doi:10.1160/th06-09-0498","doi":"https://doi.org/10.1160/th06-09-0498","is_oa":false,"landing_page_url":"https://doi.org/10.1160/th06-09-0498","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077467750","display_name":"Ale\u0161 Krou\u017eeck\u00fd","orcid":"https://orcid.org/0009-0008-6743-4256","observed_orcids":["https://orcid.org/0009-0008-6743-4256"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ales Krouzecky","raw_affiliation_strings":["Intensive Care Unit, 1 st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic","ICU, 1st Medical Deptartment, Charles University Medical School and Teaching Hospital, Alej svobody 80, 304 60 Plzen, Czech Republic. matejovic@fnplzen.cz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, 1 st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"ICU, 1st Medical Deptartment, Charles University Medical School and Teaching Hospital, Alej svobody 80, 304 60 Plzen, Czech Republic. matejovic@fnplzen.cz","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072298203","display_name":"Jaroslav Rad\u011bj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jaroslav Radej","raw_affiliation_strings":["Intensive Care Unit, 1 st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, 1 st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061514923","display_name":"Richard Rokyta","orcid":"https://orcid.org/0000-0003-2273-2766","observed_orcids":["https://orcid.org/0000-0003-2273-2766"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Richard Rokyta","raw_affiliation_strings":["Intensive Care Unit, 1 st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, 1 st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013821694","display_name":"Hana Kralova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210113757","display_name":"University Hospital Plzen","ror":"https://ror.org/02c1tfz23","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I21250087","https://openalex.org/I4210113757"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Hana Kralova","raw_affiliation_strings":["Institute of Clinical Biochemistry and Hematology, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Biochemistry and Hematology, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210113757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113488715","display_name":"Peter Radermacher","orcid":"https://orcid.org/0000-0002-5913-3102","observed_orcids":["https://orcid.org/0000-0002-5913-3102"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Radermacher","raw_affiliation_strings":["Sektion An\u00e4sthesiologische Pathophysiologie und Verfahrensentwicklung, Universit\u00e4tsklinikum Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sektion An\u00e4sthesiologische Pathophysiologie und Verfahrensentwicklung, Universit\u00e4tsklinikum Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102990796","display_name":"Ivan Nov\u00e1k","orcid":"https://orcid.org/0000-0002-6481-288X","observed_orcids":["https://orcid.org/0000-0002-6481-288X"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ivan Novak","raw_affiliation_strings":["Intensive Care Unit, 1 st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, 1 st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086130645","display_name":"Martin Mat\u011bjovi\u010d","orcid":"https://orcid.org/0000-0001-9814-5256","observed_orcids":["https://orcid.org/0000-0001-9814-5256"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Martin Matejovic","raw_affiliation_strings":["Intensive Care Unit, 1 st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic","ICU, 1st Medical Deptartment, Charles University Medical School and Teaching Hospital, Alej svobody 80, 304 60 Plzen, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, 1 st Medical Department, Charles University Medical School and Teaching Hospital Plzen, Plzen, Czech Republic","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"ICU, 1st Medical Deptartment, Charles University Medical School and Teaching Hospital, Alej svobody 80, 304 60 Plzen, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086130645"],"corresponding_institution_ids":["https://openalex.org/I21250087"],"apc_list":null,"apc_paid":null,"fwci":3.1488,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90868325,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"97","issue":"02","first_page":"304","last_page":"309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.2273000031709671,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/bacteremia","display_name":"bacteremia","score":0.718999981880188},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase-inhibition","display_name":"inducible nitric oxide synthase inhibition","score":0.8889999985694885},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9120000004768372},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9150000214576721},{"id":"https://openalex.org/keywords/l-nil","display_name":"L-NIL","score":0.8309999704360962},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/thrombin-antithrombin-complex","display_name":"thrombin-antithrombin complex","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9829999804496765},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.8389999866485596},{"id":"https://openalex.org/keywords/isoprostanes","display_name":"isoprostanes","score":0.9440000057220459},{"id":"https://openalex.org/keywords/nitrate-nitrite","display_name":"nitrite/nitrate","score":0.9010000228881836},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.6740000247955322},{"id":"https://openalex.org/keywords/pig-model","display_name":"porcine model","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7241572141647339},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6440069079399109},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6217739582061768},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.5978580713272095},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.5469955205917358},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5407521724700928},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.5085252523422241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5058550834655762},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.4868725836277008},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4712505638599396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45381706953048706},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.45200034976005554},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.4475996494293213},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.43154653906822205},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40547290444374084},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3627912998199463},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35534289479255676}],"mesh":[{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1160/th06-09-0498","doi":"https://doi.org/10.1160/th06-09-0498","is_oa":false,"landing_page_url":"https://doi.org/10.1160/th06-09-0498","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:17264961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17264961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995573824","https://openalex.org/W1567723240","https://openalex.org/W2027497569","https://openalex.org/W2572966853","https://openalex.org/W2052593869","https://openalex.org/W1548077599","https://openalex.org/W2070782834","https://openalex.org/W1971808890","https://openalex.org/W6893122009","https://openalex.org/W2155791167"],"abstract_inverted_index":{"Coagulation":[0],"abnormalities":[1,47],"have":[2],"been":[3],"implicated":[4],"in":[5,48,66,171,186,194],"the":[6,53,213,231,248],"pathogenesis":[7],"of":[8,22,55,61,71,85,92,103,150,224,235,242],"sepsis":[9],"and":[10,45,63,75,115,158,174,179,189,205,227,238],"organ":[11],"dysfunction.":[12],"Nitric":[13],"oxide":[14],"(NO)":[15],"is":[16,31],"regarded":[17],"as":[18,110,112],"a":[19,35,67,82],"critical":[20],"mediator":[21],"many":[23],"vascular":[24,236],"pathologies,":[25],"including":[26],"sepsis.":[27,49],"However,":[28],"limited":[29],"evidence":[30],"available":[32],"to":[33,125,247],"document":[34],"relationship":[36],"between":[37,233],"NO":[38,42],"generated":[39],"by":[40,199,212,252],"inducible":[41],"synthase":[43],"(iNOS)":[44],"hemostatic":[46,239],"Therefore,":[50],"we":[51],"evaluated":[52],"effects":[54,250],"selective":[56,104,217],"iNOS":[57,105,200,218,253],"inhibition":[58,219],"on":[59],"markers":[60],"endothelial":[62,127,228],"coagulation":[64,139,226],"homeostasis":[65],"clinically":[68],"relevant":[69],"model":[70],"porcine":[72],"bacteremia":[73],"induced":[74],"maintained":[76],"for":[77],"24":[78,116],"hours":[79],"(h)":[80],"with":[81,222],"continuous":[83,101],"infusion":[84,102],"live":[86],"P.":[87,120,191],"aeruginosa.":[88],"After":[89],"12":[90],"h":[91,117],"sepsis,":[93],"animals":[94],"received":[95],"either":[96],"vehicle":[97],"(Control,":[98],"n=7)":[99],"or":[100],"inhibitor":[106,153],"L-NIL":[107,167,181],"(n=7).":[108],"Before":[109],"well":[111],"12,":[113],"18":[114],"after":[118],"starting":[119],"aeruginosa":[121],"following":[122],"variables":[123],"related":[124],"i)":[126],"dysfunction":[128,229],"(von":[129],"Willebrand":[130],"factor":[131],"[vWf];":[132],"tissue":[133],"plasminogen":[134,151],"activator":[135,152],"activity":[136,149,196],"[t-PA];":[137],"ii)":[138],"(thrombin-antithrombin":[140],"complexes":[141],"[TAT];":[142],"platelet":[143,207],"count);":[144],"iii)":[145],"fibrinolysis":[146],"(t-PA":[147],"activity,":[148],"type":[154],"1":[155],"(PAI-1":[156],"act);":[157],"iv)":[159],"oxidative/nitrosative":[160],"stress":[161,244],"(isoprostanes,":[162],"nitrate/nitrite":[163,173],"levels)":[164],"were":[165,209],"measured.":[166],"inhibited":[168],"sepsis-induced":[169,184,225],"increase":[170],"plasma":[172,187],"isoprostanes":[175],"concentrations,":[176],"prevented":[177],"hypotension":[178],"acidosis.":[180],"significantly":[182],"attenuated":[183],"rise":[185],"vWF":[188],"TAT.":[190],"aeruginosa-induced":[192],"drop":[193],"t-PA":[195],"was":[197,220],"blunted":[198],"inhibition,":[201],"while":[202],"increased":[203],"PAI-1":[204],"reduced":[206],"count":[208],"not":[210],"reversed":[211],"treatment.":[214],"In":[215],"conclusion,":[216],"associated":[221],"attenuation":[223],"suggesting":[230],"interplay":[232],"mediators":[234],"system":[237],"balance.":[240],"Reduction":[241],"oxidative":[243],"probably":[245],"contributes":[246],"beneficial":[249],"afforded":[251],"blockade.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
