{"id":"https://openalex.org/W1966035009","doi":"https://doi.org/10.4155/tde.11.65","title":"Decreased blood\u2013brain Barrier Expression of P-glycoprotein in Alzheimer\u2018s Disease: Impact on Pathogenesis and Brain Access of Therapeutic Agents","display_name":"Decreased blood\u2013brain Barrier Expression of P-glycoprotein in Alzheimer\u2018s Disease: Impact on Pathogenesis and Brain Access of Therapeutic Agents","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W1966035009","doi":"https://doi.org/10.4155/tde.11.65","mag":"1966035009","pmid":"https://pubmed.ncbi.nlm.nih.gov/22833898"},"language":"en","primary_location":{"id":"doi:10.4155/tde.11.65","doi":"https://doi.org/10.4155/tde.11.65","is_oa":false,"landing_page_url":"https://doi.org/10.4155/tde.11.65","pdf_url":null,"source":{"id":"https://openalex.org/S89829989","display_name":"Therapeutic Delivery","issn_l":"2041-5990","issn":["2041-5990","2041-6008"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Delivery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077971641","display_name":"Joseph A. Nicolazzo","orcid":"https://orcid.org/0000-0002-0983-7152","observed_orcids":["https://orcid.org/0000-0002-0983-7152"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Joseph A Nicolazzo","raw_affiliation_strings":["Drug Delivery Disposition &amp; Dynamics Monash Institute of Pharmaceutical Sciences Monash University\r          381 Royal Parade\r          Parkville\r          VIC\r          3052\r          Australia","Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Delivery Disposition &amp; Dynamics Monash Institute of Pharmaceutical Sciences Monash University\r          381 Royal Parade\r          Parkville\r          VIC\r          3052\r          Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054959155","display_name":"William A. Banks","orcid":"https://orcid.org/0000-0002-0496-3619","observed_orcids":["https://orcid.org/0000-0002-0496-3619"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A Banks","raw_affiliation_strings":["Geriatrics Research Education &amp; Clinical Center (GRECC) Veterans Affairs Puget Sound Health Care System\r          WA\r          USA Division of Gerontology &amp; Geriatric Medicine Department of Internal Medicine University of Washington School of Medicine\r          WA\r          USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatrics Research Education &amp; Clinical Center (GRECC) Veterans Affairs Puget Sound Health Care System\r          WA\r          USA Division of Gerontology &amp; Geriatric Medicine Department of Internal Medicine University of Washington School of Medicine\r          WA\r          USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210094549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.10788774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"7","first_page":"841","last_page":"844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.06610000133514404,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8949999809265137},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9739999771118164},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.4779999852180481},{"id":"https://openalex.org/keywords/alzheimer-s-disease-pathogenesis","display_name":"Alzheimer's disease pathogenesis","score":0.781000018119812},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8193149566650391},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.806390106678009},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.6120941042900085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5200609564781189},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5147028565406799},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5078476071357727},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.48062700033187866},{"id":"https://openalex.org/C2991673738","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Brain disease","level":3,"score":0.4101712703704834},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3686866760253906},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3504146933555603},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33222663402557373},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2465657889842987},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2299230396747589},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2126532793045044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1937541961669922},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.07038316130638123},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07023429870605469},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4155/tde.11.65","doi":"https://doi.org/10.4155/tde.11.65","is_oa":false,"landing_page_url":"https://doi.org/10.4155/tde.11.65","pdf_url":null,"source":{"id":"https://openalex.org/S89829989","display_name":"Therapeutic Delivery","issn_l":"2041-5990","issn":["2041-5990","2041-6008"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Delivery","raw_type":"journal-article"},{"id":"pmid:22833898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22833898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic delivery","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1512719559","https://openalex.org/W1744830941","https://openalex.org/W1967546408","https://openalex.org/W1977940746","https://openalex.org/W1989005947","https://openalex.org/W1992758695","https://openalex.org/W2014426079","https://openalex.org/W2024865604","https://openalex.org/W2025944561","https://openalex.org/W2026935710","https://openalex.org/W2041140779","https://openalex.org/W2046003362","https://openalex.org/W2046826638","https://openalex.org/W2047853787","https://openalex.org/W2052958637","https://openalex.org/W2058243804","https://openalex.org/W2059841300","https://openalex.org/W2067956029","https://openalex.org/W2072093696","https://openalex.org/W2090097368","https://openalex.org/W2095568016","https://openalex.org/W2100258988","https://openalex.org/W2104290477","https://openalex.org/W2111962751","https://openalex.org/W2115609442","https://openalex.org/W2127377575","https://openalex.org/W2142878553","https://openalex.org/W2163209521","https://openalex.org/W2167527439","https://openalex.org/W2169152986","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4362457781","https://openalex.org/W2019520545","https://openalex.org/W2052958637","https://openalex.org/W2961083150","https://openalex.org/W746799169","https://openalex.org/W3083082591","https://openalex.org/W4385554483","https://openalex.org/W6889695362","https://openalex.org/W2167527439","https://openalex.org/W2271636521"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
