{"id":"https://openalex.org/W1966029043","doi":"https://doi.org/10.3389/fonc.2012.00012","title":"Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations","display_name":"Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1966029043","doi":"https://doi.org/10.3389/fonc.2012.00012","mag":"1966029043","pmid":"https://pubmed.ncbi.nlm.nih.gov/22655260","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3356053"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2012.00012","doi":"https://doi.org/10.3389/fonc.2012.00012","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2012.00012","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2012.00012/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2012.00012/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085014608","display_name":"Krishna R. Kalari","orcid":"https://orcid.org/0000-0001-8944-8378","observed_orcids":["https://orcid.org/0000-0001-8944-8378"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna R. Kalari","raw_affiliation_strings":["Division of Biostatistics and Bioinformatics, Department of Health Sciences Research, Mayo Clinic Rochester, MN, USA","Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics and Bioinformatics, Department of Health Sciences Research, Mayo Clinic Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]},{"raw_affiliation_string":"Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063900043","display_name":"David Rossell","orcid":"https://orcid.org/0000-0002-7104-5789","observed_orcids":["https://orcid.org/0000-0002-7104-5789"]},"institutions":[{"id":"https://openalex.org/I4210122345","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/01z1gye03","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122345","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Rossell","raw_affiliation_strings":["Institute for Research in Biomedicine of Barcelona, Bioinformatics and Biostatistics, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine of Barcelona, Bioinformatics and Biostatistics, Barcelona, Spain","institution_ids":["https://openalex.org/I4210122345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038191637","display_name":"Brian M. Necela","orcid":"https://orcid.org/0000-0002-4409-1245","observed_orcids":["https://orcid.org/0000-0002-4409-1245"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian M. Necela","raw_affiliation_strings":["Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022178171","display_name":"Yan W. Asmann","orcid":"https://orcid.org/0000-0002-8896-2647","observed_orcids":["https://orcid.org/0000-0002-8896-2647"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan W. Asmann","raw_affiliation_strings":["Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111532472","display_name":"Asha Nair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asha Nair","raw_affiliation_strings":["Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111996562","display_name":"Saurabh Baheti","orcid":"https://orcid.org/0000-0002-3564-7627","observed_orcids":["https://orcid.org/0000-0002-3564-7627"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saurabh Baheti","raw_affiliation_strings":["Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072734589","display_name":"Jennifer M. Kachergus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Kachergus","raw_affiliation_strings":["Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010157023","display_name":"Curtis S. Younkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curtis S. Younkin","raw_affiliation_strings":["Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005595463","display_name":"Tiffany R. Baker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany Baker","raw_affiliation_strings":["Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072948023","display_name":"Jennifer M. Carr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Carr","raw_affiliation_strings":["Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076441673","display_name":"Xiaojia Tang","orcid":"https://orcid.org/0000-0003-2457-9953","observed_orcids":["https://orcid.org/0000-0003-2457-9953"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaojia Tang","raw_affiliation_strings":["Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101703176","display_name":"Michael P. Walsh","orcid":"https://orcid.org/0000-0002-1387-7173","observed_orcids":["https://orcid.org/0000-0002-1387-7173"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Walsh","raw_affiliation_strings":["Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111731909","display_name":"High Seng Chai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"High-Seng Chai","raw_affiliation_strings":["Division of Biostatistics and Bioinformatics , Department of Health Sciences Research , Mayo Clinic , Rochester , MN , USA","Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics and Bioinformatics , Department of Health Sciences Research , Mayo Clinic , Rochester , MN , USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067865294","display_name":"Zhifu Sun","orcid":"https://orcid.org/0000-0001-8461-7523","observed_orcids":["https://orcid.org/0000-0001-8461-7523"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhifu Sun","raw_affiliation_strings":["Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085507659","display_name":"Steven N. Hart","orcid":"https://orcid.org/0000-0001-7714-2734","observed_orcids":["https://orcid.org/0000-0001-7714-2734"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven N. Hart","raw_affiliation_strings":["Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085479273","display_name":"Alexey A. Leontovich","orcid":"https://orcid.org/0009-0002-2014-8996","observed_orcids":["https://orcid.org/0009-0002-2014-8996"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexey A. Leontovich","raw_affiliation_strings":["Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041593601","display_name":"Asif Hossain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asif Hossain","raw_affiliation_strings":["Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110176668","display_name":"Jean-Pierre A. Kocher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Kocher","raw_affiliation_strings":["Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Health Sciences Research, Rochester, Minnesota, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065306642","display_name":"Edith A. Perez","orcid":"https://orcid.org/0000-0002-5037-6677","observed_orcids":["https://orcid.org/0000-0002-5037-6677","https://orcid.org/0000-0001-7009-7467"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edith A. Perez","raw_affiliation_strings":["Mayo Clinic, Department of Internal Medicine, Jacksonville, 32224, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Department of Internal Medicine, Jacksonville, 32224, Florida, United States","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087205210","display_name":"David Reisman","orcid":"https://orcid.org/0000-0002-7028-8500","observed_orcids":["https://orcid.org/0000-0002-7028-8500"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David N. Reisman","raw_affiliation_strings":["University of Florida, Department of Hematology and Oncology, Gainesville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, Department of Hematology and Oncology, Gainesville, Florida, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081306238","display_name":"Alan P. Fields","orcid":"https://orcid.org/0000-0001-9529-0888","observed_orcids":["https://orcid.org/0000-0001-9529-0888"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan P. Fields","raw_affiliation_strings":["Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026692399","display_name":"E. Aubrey Thompson","orcid":"https://orcid.org/0000-0002-9001-4240","observed_orcids":["https://orcid.org/0000-0002-9001-4240"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E. Aubrey Thompson","raw_affiliation_strings":["Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic comprehensive cancer center, Cancer Biology, Jacksonville, Florida, United States","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5026692399"],"corresponding_institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":7.4819,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.97581359,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":null,"first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.972000002861023},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/oncogenic-kras","display_name":"oncogenic KRAS","score":0.8669999837875366},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.843999981880188},{"id":"https://openalex.org/keywords/single-nucleotide-variants","display_name":"single nucleotide variants","score":0.925000011920929},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.6850000023841858},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ppargamma-signaling","display_name":"PPAR\u03b3 signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/druggable-targets","display_name":"druggable targets","score":0.8299999833106995},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.40700000524520874},{"id":"https://openalex.org/keywords/genomic-landscape","display_name":"genomic landscape","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7224459648132324},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6814365983009338},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6214455366134644},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5982024073600769},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5762760639190674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5523607134819031},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5179352164268494},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4880586862564087},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.481836199760437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46229952573776245},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.45902806520462036},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4584265947341919},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.44989532232284546},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.40545058250427246},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37657657265663147},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35348379611968994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.317212849855423},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2209731936454773},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2177235186100006},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.19672942161560059}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fonc.2012.00012","doi":"https://doi.org/10.3389/fonc.2012.00012","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2012.00012","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2012.00012/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3356053","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3356053","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:22655260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22655260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:wrap.warwick.ac.uk:64252","doi":null,"is_oa":false,"landing_page_url":"http://wrap.warwick.ac.uk/64252/1/WRAP_Rossell_fonc-02-00012.pdf","pdf_url":"http://wrap.warwick.ac.uk/64252/1/WRAP_Rossell_fonc-02-00012.pdf","source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:131a3715ba6d4f08a6790b57ec719bed","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/131a3715ba6d4f08a6790b57ec719bed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 2 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2012.00012","doi":"https://doi.org/10.3389/fonc.2012.00012","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2012.00012","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2012.00012/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1185147035","display_name":"Protein Kinase C Signaling Mechanisms in Cancer","funder_award_id":"R01CA081436","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1828094709","display_name":null,"funder_award_id":"N01 CA015083","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6667116099","display_name":null,"funder_award_id":"CA081436","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G844520391","display_name":null,"funder_award_id":"CA 15083","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000866180","display_name":"Mayo Clinic Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA015083","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320309360","display_name":"Florida Department of Health","ror":"https://ror.org/03e1xkn26"},{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1966029043.pdf","grobid_xml":"https://content.openalex.org/works/W1966029043.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W101590649","https://openalex.org/W1981634943","https://openalex.org/W1984068087","https://openalex.org/W1999441881","https://openalex.org/W2000771269","https://openalex.org/W2002937040","https://openalex.org/W2006533331","https://openalex.org/W2006559366","https://openalex.org/W2009235369","https://openalex.org/W2014782775","https://openalex.org/W2029446677","https://openalex.org/W2049633694","https://openalex.org/W2058451329","https://openalex.org/W2062983115","https://openalex.org/W2074364115","https://openalex.org/W2103441770","https://openalex.org/W2103611039","https://openalex.org/W2108234281","https://openalex.org/W2118004874","https://openalex.org/W2121389354","https://openalex.org/W2124985265","https://openalex.org/W2127045236","https://openalex.org/W2127640118","https://openalex.org/W2132377490","https://openalex.org/W2141458291","https://openalex.org/W2142850084","https://openalex.org/W2144656637","https://openalex.org/W2144708319","https://openalex.org/W2155142785","https://openalex.org/W2161724277","https://openalex.org/W2164034599","https://openalex.org/W2184417913","https://openalex.org/W2783677708","https://openalex.org/W4238680552","https://openalex.org/W6679229923","https://openalex.org/W7073539852"],"related_works":["https://openalex.org/W2335541778","https://openalex.org/W2547499110","https://openalex.org/W2898254503","https://openalex.org/W4412756437","https://openalex.org/W2016536401","https://openalex.org/W4295817483","https://openalex.org/W7118255472","https://openalex.org/W3002487670","https://openalex.org/W4406330938","https://openalex.org/W4200378798"],"abstract_inverted_index":{"KRAS":[0,41,54,90,124,190,221,246,279],"mutations":[1,15],"are":[2,33],"highly":[3],"prevalent":[4],"in":[5,36,119],"non-small":[6],"cell":[7],"lung":[8,37,48,134,247],"cancer":[9],"(NSCLC),":[10],"and":[11,20,55,69,79,88,114,158,178,196,199,222,225,234,263],"tumors":[12,38,50,86,121,191,276],"harboring":[13,39,52,122],"these":[14,208],"tend":[16],"to":[17,22,29,65,139,204,254,264,275],"be":[18,201,238],"aggressive":[19],"resistant":[21],"chemotherapy.":[23],"We":[24],"used":[25,138],"next-generation":[26],"sequencing":[27],"technology":[28],"identify":[30],"pathways":[31,149,198],"that":[32,188,230,272],"specifically":[34],"altered":[35],"a":[40,93,123,266],"mutation.":[42,125],"Paired-end":[43],"RNA-sequencing":[44],"of":[45,95,244],"15":[46],"primary":[47],"adenocarcinoma":[49,135],"(8":[51],"mutant":[53,164,189,220,245],"7":[56],"with":[57,87,277],"wild-type":[58],"KRAS)":[59],"were":[60,63,83,137,154],"performed.":[61],"Sequences":[62],"mapped":[64],"the":[66,133,155,175,223,252],"human":[67],"genome,":[68],"genomic":[70,256,269],"features,":[71],"including":[72],"differentially":[73],"expressed":[74],"genes,":[75],"alternate":[76,110],"splicing":[77,111],"isoforms":[78],"single":[80],"nucleotide":[81],"variants,":[82],"determined":[84],"for":[85,180,242],"without":[89],"mutation":[91],"using":[92],"variety":[94],"computational":[96],"methods.":[97],"Network":[98],"analysis":[99,153,213],"was":[100,168],"carried":[101],"out":[102,141],"on":[103,171],"genes":[104],"showing":[105],"differential":[106],"expression":[107],"(374":[108],"genes),":[109,113],"(259":[112],"SNV-related":[115],"changes":[116],"(65":[117],"genes)":[118],"NSCLC":[120,262],"Genes":[126],"exhibiting":[127],"two":[128],"or":[129],"more":[130],"connections":[131,173],"from":[132,174,258,261],"network":[136,167],"carry":[140],"integrated":[142,176],"pathway":[143],"analysis.":[144],"The":[145],"most":[146],"significant":[147],"signaling":[148,227],"identified":[150],"through":[151],"this":[152],"NF\u03baB,":[156,194],"ERK1/2,":[157,195],"AKT":[159,197],"pathways.":[160,209],"A":[161],"27":[162],"gene":[163],"KRAS-specific":[165],"sub":[166],"extracted":[169],"based":[170],"gene-gene":[172],"network,":[177],"interrogated":[179],"druggable":[181],"targets.":[182],"Our":[183,249],"results":[184],"confirm":[185],"previous":[186],"evidence":[187],"exhibit":[192],"activated":[193],"may":[200,237],"preferentially":[202],"sensitive":[203],"target":[205],"therapeutics":[206],"toward":[207],"In":[210],"addition,":[211],"our":[212],"indicates":[214],"novel,":[215],"previously":[216],"unappreciated":[217],"links":[218],"between":[219],"TNFR":[224,235],"PPAR\u03b3":[226,232],"pathways,":[228],"suggesting":[229],"targeted":[231],"antagonists":[233],"inhibitors":[236],"useful":[239],"therapeutic":[240],"strategies":[241],"treatment":[243],"tumors.":[248],"study":[250],"is":[251,273],"first":[253,267],"integrate":[255],"features":[257],"RNA-Seq":[259],"data":[260],"define":[265],"draft":[268],"landscape":[270],"model":[271],"unique":[274],"oncogenic":[278],"mutations.":[280]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
