{"id":"https://openalex.org/W1966011370","doi":"https://doi.org/10.1093/molehr/4.3.207","title":"Ovarian transforming growth factor-beta (TGF-beta) receptors: in-vitro effects of follicle stimulating hormone, epidermal growth factor and TGF-beta on receptor expression in human preantral follicles","display_name":"Ovarian transforming growth factor-beta (TGF-beta) receptors: in-vitro effects of follicle stimulating hormone, epidermal growth factor and TGF-beta on receptor expression in human preantral follicles","publication_year":1998,"publication_date":"1998-03-01","ids":{"openalex":"https://openalex.org/W1966011370","doi":"https://doi.org/10.1093/molehr/4.3.207","mag":"1966011370","pmid":"https://pubmed.ncbi.nlm.nih.gov/9570266"},"language":"en","primary_location":{"id":"doi:10.1093/molehr/4.3.207","doi":"https://doi.org/10.1093/molehr/4.3.207","is_oa":false,"landing_page_url":"https://doi.org/10.1093/molehr/4.3.207","pdf_url":null,"source":{"id":"https://openalex.org/S4210190516","display_name":"Molecular Human Reproduction","issn_l":"1360-9947","issn":["1360-9947","1460-2407"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043667168","display_name":"Shyamal K. Roy","orcid":"https://orcid.org/0000-0002-4746-9602","observed_orcids":["https://orcid.org/0000-0002-4746-9602"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. Roy","raw_affiliation_strings":["Leland J. and Dorothy H. Olson Center for Women's Health, Department of OB/GYN, University of Nebraska Medical Center, Omaha 68198-4515, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leland J. and Dorothy H. Olson Center for Women's Health, Department of OB/GYN, University of Nebraska Medical Center, Omaha 68198-4515, USA","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043667168"],"corresponding_institution_ids":["https://openalex.org/I59130452"],"apc_list":{"value":3973,"currency":"EUR","value_usd":4490},"apc_paid":null,"fwci":2.8778,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.89379968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"4","issue":"3","first_page":"207","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.6068999767303467,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.3109999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-receptor","display_name":"TGF-beta receptor","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tgf-beta-type-i-receptor","display_name":"TGF-beta type I receptor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":1.0},{"id":"https://openalex.org/keywords/preantral-follicles","display_name":"preantral follicles","score":0.949999988079071},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9679999947547913},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":1.0},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/theca-cells","display_name":"theca cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.7609999775886536},{"id":"https://openalex.org/keywords/follicular-development","display_name":"folliculogenesis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/human-ovary","display_name":"human ovary","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7628726959228516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7570466995239258},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7442214488983154},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5854911804199219},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4854191243648529},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.47651445865631104},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.46280473470687866},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.461984246969223},{"id":"https://openalex.org/C2780536345","wikidata":"https://www.wikidata.org/wiki/Q953556","display_name":"Ovarian follicle","level":3,"score":0.4607348144054413},{"id":"https://openalex.org/C2777203538","wikidata":"https://www.wikidata.org/wiki/Q1543282","display_name":"Granulosa cell","level":3,"score":0.4486334025859833},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.4101805090904236},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.40516623854637146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09080609679222107},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077294","descriptor_name":"Receptor, Transforming Growth Factor-beta Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005498","descriptor_name":"Follicular Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017697","descriptor_name":"Premenopause","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D030201","descriptor_name":"Activin Receptors, Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/molehr/4.3.207","doi":"https://doi.org/10.1093/molehr/4.3.207","is_oa":false,"landing_page_url":"https://doi.org/10.1093/molehr/4.3.207","pdf_url":null,"source":{"id":"https://openalex.org/S4210190516","display_name":"Molecular Human Reproduction","issn_l":"1360-9947","issn":["1360-9947","1460-2407"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Human Reproduction","raw_type":"journal-article"},{"id":"pmid:9570266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9570266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular human reproduction","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.327.4676","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.4676","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://molehr.oxfordjournals.org/content/4/3/207.full.pdf","raw_type":"text"},{"id":"mag:2291524921","doi":null,"is_oa":false,"landing_page_url":"http://molehr.oxfordjournals.org/content/4/3/207.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3284946082","display_name":null,"funder_award_id":"HD-28165","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W30147252","https://openalex.org/W56968267","https://openalex.org/W1494055834","https://openalex.org/W1551944091","https://openalex.org/W1601394191","https://openalex.org/W1968538228","https://openalex.org/W1978585028","https://openalex.org/W1985271747","https://openalex.org/W1985672833","https://openalex.org/W1991766569","https://openalex.org/W1997241192","https://openalex.org/W2009588677","https://openalex.org/W2013931420","https://openalex.org/W2019050177","https://openalex.org/W2020977918","https://openalex.org/W2038303018","https://openalex.org/W2041823687","https://openalex.org/W2067602961","https://openalex.org/W2075086587","https://openalex.org/W2079251901","https://openalex.org/W2080079821","https://openalex.org/W2090136483","https://openalex.org/W2113787725","https://openalex.org/W2113992117","https://openalex.org/W2117901334","https://openalex.org/W2131211068","https://openalex.org/W2136819827","https://openalex.org/W2145198061","https://openalex.org/W2245883552","https://openalex.org/W2273323818","https://openalex.org/W4295554713"],"related_works":["https://openalex.org/W2291524921","https://openalex.org/W7098252550","https://openalex.org/W2063252223","https://openalex.org/W2074160114","https://openalex.org/W1985271747","https://openalex.org/W2033457392","https://openalex.org/W2159913632","https://openalex.org/W2047683813","https://openalex.org/W2002572737","https://openalex.org/W2168398734"],"abstract_inverted_index":{"The":[0,194],"expression":[1,41,103,144],"patterns":[2],"of":[3,25,53,168,229,243],"transforming":[4,35],"growth":[5,31,36,137,154,173,253],"factor":[6,32],"(TGF)-beta":[7],"receptor":[8,40,54,156,219],"type":[9],"I":[10],"(TbetaRI)":[11],"and":[12,17,21,34,49,60,81,101,108,126,133,138,180,198,232,245,252],"-II":[13,199],"(TbetaRII)":[14],"in":[15,42,57,86,92,99,104,111,117,123,129,142,145,163,185,190,196,221],"pre-":[16],"post-menopausal":[18,119],"human":[19,186],"ovaries,":[20],"the":[22,87,93,105,112,118,191,209,214,222,226],"in-vitro":[23],"effects":[24],"follicle":[26],"stimulating":[27],"hormone":[28],"(FSH),":[29],"epidermal":[30],"(EGF)":[33],"factor-beta1":[37],"(TGF-beta1)":[38],"on":[39],"preantral":[43,234,256],"follicles":[44,122],"were":[45,55,70,84,115],"evaluated":[46],"using":[47],"immunohistochemistry":[48],"immunoblotting.":[50],"Both":[51],"types":[52],"present":[56],"granulosa,":[58],"theca":[59],"interstitial":[61],"cells;":[62,147],"however,":[63,148],"more":[64,74],"mural":[65],"than":[66,78],"antral":[67],"granulosa":[68,146,192,215],"cells":[69,75,216],"TbetaRII":[71,82,100,143,181,244],"positive.":[72],"Overall,":[73],"expressed":[76,183],"TbetaRI":[77,80,102,165,179],"TbetaRII.":[79],"expressions":[83],"detected":[85],"membrane":[88,113,223],"as":[89,91],"well":[90],"soluble":[94,106,203],"fractions.":[95],"However,":[96],"marked":[97],"increases":[98],"fraction":[107,114,204],"corresponding":[109,140],"decreases":[110],"noted":[116],"ovary.":[120],"Preantral":[121],"class":[124],"1":[125],"2":[127],"responded":[128],"vitro":[130],"to":[131,202],"FSH":[132],"EGF":[134],"with":[135,239],"increased":[136],"a":[139,240,248],"increase":[141],"TGF-beta":[149],"did":[150],"not":[151],"influence":[152],"follicular":[153,164,172,235],"or":[155,171],"expression.":[157],"There":[158],"was":[159],"no":[160],"apparent":[161],"change":[162],"immunoreactivity":[166],"regardless":[167],"test":[169],"factors":[170],"status.":[174],"These":[175],"results":[176],"suggest":[177],"that":[178,208],"are":[182],"differentially":[184],"ovarian":[187],"cells,":[188],"particularly":[189],"cells.":[193],"shift":[195],"TbetaR-I":[197],"from":[200],"transmembrane":[201],"after":[205],"menopause":[206],"indicates":[207],"endocrine":[210],"milieu":[211],"provided":[212],"by":[213],"positively":[217],"influences":[218],"induction":[220,242],"and,":[224],"hence,":[225],"biological":[227],"action":[228],"TGF-beta.":[230],"FSH-":[231],"EGF-induced":[233],"development":[236],"is":[237],"associated":[238],"selective":[241],"may":[246],"indicate":[247],"mechanism":[249],"whereby":[250],"gonadotrophins":[251],"factor(s)":[254],"regulate":[255],"folliculogenesis.":[257]},"counts_by_year":[{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
