{"id":"https://openalex.org/W1966000037","doi":"https://doi.org/10.1038/sj.mp.4000876","title":"Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity","display_name":"Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity","publication_year":2001,"publication_date":"2001-08-29","ids":{"openalex":"https://openalex.org/W1966000037","doi":"https://doi.org/10.1038/sj.mp.4000876","mag":"1966000037","pmid":"https://pubmed.ncbi.nlm.nih.gov/11526473"},"language":"en","primary_location":{"id":"doi:10.1038/sj.mp.4000876","doi":"https://doi.org/10.1038/sj.mp.4000876","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.mp.4000876","pdf_url":null,"source":{"id":"https://openalex.org/S71149355","display_name":"Molecular Psychiatry","issn_l":"1359-4184","issn":["1359-4184","1476-5578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062596209","display_name":"Alessandro Serretti","orcid":"https://orcid.org/0000-0003-4363-3759","observed_orcids":["https://orcid.org/0000-0003-4363-3759"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"A Serretti","raw_affiliation_strings":["Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy. serretti.alessandro@hsr.it","Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy. serretti.alessandro@hsr.it","institution_ids":["https://openalex.org/I154387261"]},{"raw_affiliation_string":"Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020986794","display_name":"Raffaella Zanardi","orcid":"https://orcid.org/0000-0001-5941-5663","observed_orcids":["https://orcid.org/0000-0001-5941-5663"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"R Zanardi","raw_affiliation_strings":["Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112034959","display_name":"D. Rossini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Rossini","raw_affiliation_strings":["Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046621609","display_name":"Cristina Cusin","orcid":"https://orcid.org/0000-0002-6334-9918","observed_orcids":["https://orcid.org/0000-0002-6334-9918"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Cusin","raw_affiliation_strings":["Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031798051","display_name":"Roberta Lilli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Lilli","raw_affiliation_strings":["Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048742568","display_name":"Enrico Smeraldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Smeraldi","raw_affiliation_strings":["Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020986794","https://openalex.org/A5062596209"],"corresponding_institution_ids":["https://openalex.org/I154387261"],"apc_list":{"value":5490,"currency":"USD","value_usd":5490},"apc_paid":null,"fwci":5.1522,"has_fulltext":false,"cited_by_count":162,"citation_normalized_percentile":{"value":0.96630452,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"5","first_page":"586","last_page":"592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7660999894142151,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7660999894142151,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.19120000302791595,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophan-hydroxylase","display_name":"tryptophan hydroxylase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fluvoxamine","display_name":"fluvoxamine","score":0.9120000004768372},{"id":"https://openalex.org/keywords/antidepressant-response","display_name":"antidepressant response","score":0.8740000128746033},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.7379999756813049},{"id":"https://openalex.org/keywords/5-httlpr","display_name":"5-HTTLPR","score":0.9259999990463257},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.6549999713897705},{"id":"https://openalex.org/keywords/bipolar-depression","display_name":"bipolar depression","score":0.9860000014305115},{"id":"https://openalex.org/keywords/psychotic-depression","display_name":"psychotic depression","score":0.8360000252723694},{"id":"https://openalex.org/keywords/pindolol","display_name":"pindolol","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8379999995231628},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2779910183","wikidata":"https://www.wikidata.org/wiki/Q409236","display_name":"Fluvoxamine","level":5,"score":0.9496122598648071},{"id":"https://openalex.org/C2778499207","wikidata":"https://www.wikidata.org/wiki/Q418101","display_name":"Pindolol","level":3,"score":0.8053092956542969},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.6601405143737793},{"id":"https://openalex.org/C2775951788","wikidata":"https://www.wikidata.org/wiki/Q418293","display_name":"Tryptophan hydroxylase","level":5,"score":0.6464288234710693},{"id":"https://openalex.org/C2776466505","wikidata":"https://www.wikidata.org/wiki/Q385555","display_name":"Hamilton Rating Scale for Depression","level":4,"score":0.6286953091621399},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.6284859776496887},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5499550104141235},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.46080684661865234},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4559219479560852},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4335797429084778},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4202568531036377},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.32429203391075134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28763318061828613},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.2752346992492676},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.2093190848827362},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.15853798389434814},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.09864795207977295},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08448001742362976},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.07399508357048035},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003702","descriptor_name":"Delusions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010869","descriptor_name":"Pindolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016666","descriptor_name":"Fluvoxamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.mp.4000876","doi":"https://doi.org/10.1038/sj.mp.4000876","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.mp.4000876","pdf_url":null,"source":{"id":"https://openalex.org/S71149355","display_name":"Molecular Psychiatry","issn_l":"1359-4184","issn":["1359-4184","1476-5578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Psychiatry","raw_type":"journal-article"},{"id":"pmid:11526473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11526473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular psychiatry","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W48750798","https://openalex.org/W75719538","https://openalex.org/W160287770","https://openalex.org/W588687509","https://openalex.org/W1596146531","https://openalex.org/W1941967701","https://openalex.org/W1965260540","https://openalex.org/W1972704616","https://openalex.org/W1977277134","https://openalex.org/W1980424969","https://openalex.org/W1980751469","https://openalex.org/W1982952880","https://openalex.org/W1993598570","https://openalex.org/W1994555315","https://openalex.org/W1996717544","https://openalex.org/W2004424937","https://openalex.org/W2004967282","https://openalex.org/W2005534453","https://openalex.org/W2014813076","https://openalex.org/W2020361307","https://openalex.org/W2023812173","https://openalex.org/W2025773780","https://openalex.org/W2032318019","https://openalex.org/W2038797348","https://openalex.org/W2039230966","https://openalex.org/W2039262765","https://openalex.org/W2043557429","https://openalex.org/W2044494092","https://openalex.org/W2045020364","https://openalex.org/W2046694660","https://openalex.org/W2054416059","https://openalex.org/W2056459965","https://openalex.org/W2061378977","https://openalex.org/W2063473805","https://openalex.org/W2065592421","https://openalex.org/W2065974729","https://openalex.org/W2067523962","https://openalex.org/W2070200621","https://openalex.org/W2070403918","https://openalex.org/W2070413556","https://openalex.org/W2070861572","https://openalex.org/W2071952197","https://openalex.org/W2077287189","https://openalex.org/W2078497034","https://openalex.org/W2082981647","https://openalex.org/W2091597565","https://openalex.org/W2094070014","https://openalex.org/W2094445259","https://openalex.org/W2103940746","https://openalex.org/W2106095564","https://openalex.org/W2107031757","https://openalex.org/W2111424618","https://openalex.org/W2128815213","https://openalex.org/W2133700875","https://openalex.org/W2136681439","https://openalex.org/W2136749432","https://openalex.org/W2147017267","https://openalex.org/W2154035477","https://openalex.org/W2159011576","https://openalex.org/W2324186045","https://openalex.org/W2329661970","https://openalex.org/W2410025091","https://openalex.org/W2413773969","https://openalex.org/W4234565373","https://openalex.org/W4300870773","https://openalex.org/W4301231228"],"related_works":["https://openalex.org/W2008709814","https://openalex.org/W2045020364","https://openalex.org/W2014249114","https://openalex.org/W2043175890","https://openalex.org/W2070861572","https://openalex.org/W1994516975","https://openalex.org/W2036421780","https://openalex.org/W2005524713","https://openalex.org/W1977160269","https://openalex.org/W2093414962"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
