{"id":"https://openalex.org/W1965997385","doi":"https://doi.org/10.1016/j.brainres.2007.01.118","title":"Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells","display_name":"Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells","publication_year":2007,"publication_date":"2007-02-05","ids":{"openalex":"https://openalex.org/W1965997385","doi":"https://doi.org/10.1016/j.brainres.2007.01.118","mag":"1965997385","pmid":"https://pubmed.ncbi.nlm.nih.gov/17328872"},"language":"en","primary_location":{"id":"doi:10.1016/j.brainres.2007.01.118","doi":"https://doi.org/10.1016/j.brainres.2007.01.118","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.brainres.2007.01.118","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108370817","display_name":"Rola Barhoumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rola Barhoumi","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA. rmouneimne@cvm.tamu.edu","Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843-4458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA. rmouneimne@cvm.tamu.edu","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843-4458, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064099505","display_name":"Robert C. Burghardt","orcid":"https://orcid.org/0000-0003-1021-8444","observed_orcids":["https://orcid.org/0000-0003-1021-8444"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Burghardt","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103611706","display_name":"Yongchang Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongchang Qian","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041614695","display_name":"Evelyn Tiffany\u2010Castiglioni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evelyn Tiffany-Castiglioni","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108370817"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.5779,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.60837887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"1145","issue":null,"first_page":"11","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.8130000233650208,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.10819999873638153,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":1.0},{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.972000002861023},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mitochondrial-calcium","display_name":"mitochondrial calcium","score":0.6320000290870667},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9020000100135803},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.7950000166893005},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.8669999837875366},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.7850000262260437},{"id":"https://openalex.org/keywords/diazoxide","display_name":"diazoxide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitochondrial-calcium-uniporter","display_name":"mitochondrial calcium uniporter","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.5509999990463257},{"id":"https://openalex.org/keywords/general-anesthetics","display_name":"general anesthetics","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.8154412508010864},{"id":"https://openalex.org/C2779872217","wikidata":"https://www.wikidata.org/wiki/Q420009","display_name":"Diazoxide","level":3,"score":0.7424867749214172},{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.5949900150299072},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5682941675186157},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5569185018539429},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5292924046516418},{"id":"https://openalex.org/C153461711","wikidata":"https://www.wikidata.org/wiki/Q5072487","display_name":"Channel blocker","level":3,"score":0.46985307335853577},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.44924280047416687},{"id":"https://openalex.org/C35341161","wikidata":"https://www.wikidata.org/wiki/Q289992","display_name":"Uniporter","level":4,"score":0.44427230954170227},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41991090774536133},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3951113820075989},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3824159801006317},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.33778417110443115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3233442008495331},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27212733030319214},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.2507692575454712},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2029390037059784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18639826774597168},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002120","descriptor_name":"Calcium Channel Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.brainres.2007.01.118","doi":"https://doi.org/10.1016/j.brainres.2007.01.118","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.brainres.2007.01.118","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:17328872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17328872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2663047892","display_name":"Center for Rural and Environmental Health","funder_award_id":"P30ES009106","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320307808","display_name":"Colgate-Palmolive Company","ror":"https://ror.org/03q50jp21"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1544964229","https://openalex.org/W1593385535","https://openalex.org/W1920479129","https://openalex.org/W1946447667","https://openalex.org/W1964322029","https://openalex.org/W1970687880","https://openalex.org/W1971068325","https://openalex.org/W1971746260","https://openalex.org/W1980166477","https://openalex.org/W1981996617","https://openalex.org/W1985002988","https://openalex.org/W1987855345","https://openalex.org/W1989773668","https://openalex.org/W1992673892","https://openalex.org/W1992726458","https://openalex.org/W1997891245","https://openalex.org/W2027724167","https://openalex.org/W2030402917","https://openalex.org/W2034263248","https://openalex.org/W2035989294","https://openalex.org/W2038118202","https://openalex.org/W2039831117","https://openalex.org/W2055418337","https://openalex.org/W2067760166","https://openalex.org/W2068097240","https://openalex.org/W2071877413","https://openalex.org/W2073706613","https://openalex.org/W2080231375","https://openalex.org/W2101750224","https://openalex.org/W2103516867","https://openalex.org/W2107149602","https://openalex.org/W2110161211","https://openalex.org/W2120364576","https://openalex.org/W2149456573","https://openalex.org/W2196849795","https://openalex.org/W2335299375","https://openalex.org/W2440550660"],"related_works":["https://openalex.org/W70924435","https://openalex.org/W7134841324","https://openalex.org/W2032387398","https://openalex.org/W2032084773","https://openalex.org/W2041692149","https://openalex.org/W2060077879","https://openalex.org/W2321867209","https://openalex.org/W2329028117","https://openalex.org/W2381753263","https://openalex.org/W1971068325"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}