{"id":"https://openalex.org/W1965985288","doi":"https://doi.org/10.1006/excr.1997.3890","title":"The Expression of Desmoglein Isoforms in Cultured Human Keratinocytes Is Regulated by Calcium, Serum, and Protein Kinase C","display_name":"The Expression of Desmoglein Isoforms in Cultured Human Keratinocytes Is Regulated by Calcium, Serum, and Protein Kinase C","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W1965985288","doi":"https://doi.org/10.1006/excr.1997.3890","mag":"1965985288","pmid":"https://pubmed.ncbi.nlm.nih.gov/9511724"},"language":"en","primary_location":{"id":"doi:10.1006/excr.1997.3890","doi":"https://doi.org/10.1006/excr.1997.3890","is_oa":true,"landing_page_url":"https://doi.org/10.1006/excr.1997.3890","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1006/excr.1997.3890","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070562109","display_name":"Mitchell F. Denning","orcid":"https://orcid.org/0000-0001-6165-6925","observed_orcids":["https://orcid.org/0000-0001-6165-6925"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell F. Denning","raw_affiliation_strings":["Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080661843","display_name":"Sandra G. Guy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra G. Guy","raw_affiliation_strings":["Departments of Pathology and Dermatology, Robert H. Lurie Cancer Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611-3008","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Dermatology, Robert H. Lurie Cancer Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611-3008","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033217089","display_name":"Shawn M. Ellerbroek","orcid":"https://orcid.org/0009-0009-7361-4621","observed_orcids":["https://orcid.org/0009-0009-7361-4621"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn M. Ellerbroek","raw_affiliation_strings":["Departments of Pathology and Dermatology, Robert H. Lurie Cancer Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611-3008","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Dermatology, Robert H. Lurie Cancer Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611-3008","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073796163","display_name":"Suzanne M. Norvell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne M. Norvell","raw_affiliation_strings":["Departments of Pathology and Dermatology, Robert H. Lurie Cancer Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611-3008","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Dermatology, Robert H. Lurie Cancer Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611-3008","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058739417","display_name":"Andrew P. Kowalczyk","orcid":"https://orcid.org/0000-0001-6438-7863","observed_orcids":["https://orcid.org/0000-0001-6438-7863"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew P. Kowalczyk","raw_affiliation_strings":["Departments of Pathology and Dermatology, Robert H. Lurie Cancer Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611-3008"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Dermatology, Robert H. Lurie Cancer Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611-3008","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088574888","display_name":"Kathleen Janee Green","orcid":"https://orcid.org/0000-0001-7332-5867","observed_orcids":["https://orcid.org/0000-0001-7332-5867"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathleen J. Green","raw_affiliation_strings":["Departments of Pathology and Dermatology, Robert H. Lurie Cancer Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611-3008"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Dermatology, Robert H. Lurie Cancer Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois, 60611-3008","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088574888"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"],"apc_list":{"value":3270,"currency":"USD","value_usd":3270},"apc_paid":{"value":3270,"currency":"USD","value_usd":3270},"fwci":1.4318,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.79942945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"239","issue":"1","first_page":"50","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases","score":0.20980000495910645,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/desmoglein-1","display_name":"desmoglein 1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/desmoglein-2","display_name":"desmoglein 2","score":0.996999979019165},{"id":"https://openalex.org/keywords/desmoglein-3","display_name":"desmoglein 3","score":1.0},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/desmosomal-cadherins","display_name":"desmosomal cadherins","score":0.8159999847412109},{"id":"https://openalex.org/keywords/calcium-regulation","display_name":"calcium regulation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/serum-regulation","display_name":"serum regulation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9900000095367432},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9539999961853027},{"id":"https://openalex.org/keywords/bryostatin-1","display_name":"bryostatin 1","score":0.996999979019165},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.847000002861023},{"id":"https://openalex.org/keywords/normal-human-epidermal-keratinocytes","display_name":"normal human epidermal keratinocytes","score":0.8870000243186951},{"id":"https://openalex.org/keywords/desmosomes","display_name":"desmosomes","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.895865797996521},{"id":"https://openalex.org/C67326383","wikidata":"https://www.wikidata.org/wiki/Q24768941","display_name":"Desmoglein","level":4,"score":0.7123533487319946},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.708088219165802},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.7052730321884155},{"id":"https://openalex.org/C2909223747","wikidata":"https://www.wikidata.org/wiki/Q3011469","display_name":"Desmoglein 3","level":4,"score":0.666762113571167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6489479541778564},{"id":"https://openalex.org/C2779084600","wikidata":"https://www.wikidata.org/wiki/Q5957181","display_name":"Staurosporine","level":4,"score":0.557461142539978},{"id":"https://openalex.org/C2781313415","wikidata":"https://www.wikidata.org/wiki/Q3899001","display_name":"Pemphigus vulgaris","level":2,"score":0.5483798980712891},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5394834280014038},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4669308066368103},{"id":"https://openalex.org/C2909761558","wikidata":"https://www.wikidata.org/wiki/Q416716","display_name":"Tetradecanoylphorbol Acetate","level":4,"score":0.4187396168708801},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36287641525268555},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.31183111667633057},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3016195297241211},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23148801922798157},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15896859765052795},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0850892961025238},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.0817531943321228},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06328609585762024},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003896","descriptor_name":"Desmosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003896","descriptor_name":"Desmosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051180","descriptor_name":"Desmoplakins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051182","descriptor_name":"Desmogleins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051183","descriptor_name":"Desmoglein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051301","descriptor_name":"Desmoglein 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054713","descriptor_name":"Bryostatins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/excr.1997.3890","doi":"https://doi.org/10.1006/excr.1997.3890","is_oa":true,"landing_page_url":"https://doi.org/10.1006/excr.1997.3890","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},{"id":"pmid:9511724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9511724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental cell research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1006/excr.1997.3890","doi":"https://doi.org/10.1006/excr.1997.3890","is_oa":true,"landing_page_url":"https://doi.org/10.1006/excr.1997.3890","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4057398968","display_name":null,"funder_award_id":"AR07593","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4921650091","display_name":"POST GRADUATE PROGRAM IN CUTANEOUS BIOLOGY","funder_award_id":"T32AR007593","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7439648197","display_name":"Junctions, Cytoskeleton & Matrix of the Oral Epithelium","funder_award_id":"P01DE012328","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000907123","display_name":"Function of Desmoglein 1/Pemphigus Foliaceus Antigen","funder_award_id":"R01AR041836","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W615333092","https://openalex.org/W1531841738","https://openalex.org/W1590941475","https://openalex.org/W1688179917","https://openalex.org/W1868042911","https://openalex.org/W1949189176","https://openalex.org/W1965971614","https://openalex.org/W1966342654","https://openalex.org/W1968611248","https://openalex.org/W1970370248","https://openalex.org/W1973835651","https://openalex.org/W1973869185","https://openalex.org/W1978049780","https://openalex.org/W1978411073","https://openalex.org/W1983851236","https://openalex.org/W1985841350","https://openalex.org/W1997261857","https://openalex.org/W1997469925","https://openalex.org/W2001716659","https://openalex.org/W2005777684","https://openalex.org/W2007692110","https://openalex.org/W2015691162","https://openalex.org/W2016378268","https://openalex.org/W2017940362","https://openalex.org/W2018155538","https://openalex.org/W2018576877","https://openalex.org/W2021378262","https://openalex.org/W2033721503","https://openalex.org/W2035135968","https://openalex.org/W2035388701","https://openalex.org/W2039356805","https://openalex.org/W2045508596","https://openalex.org/W2049319080","https://openalex.org/W2050858342","https://openalex.org/W2053532688","https://openalex.org/W2056989689","https://openalex.org/W2069771076","https://openalex.org/W2073638852","https://openalex.org/W2077463637","https://openalex.org/W2085426403","https://openalex.org/W2090667517","https://openalex.org/W2092416679","https://openalex.org/W2094800200","https://openalex.org/W2094807512","https://openalex.org/W2115419170","https://openalex.org/W2122412289","https://openalex.org/W2124569991","https://openalex.org/W2132644765","https://openalex.org/W2133462524","https://openalex.org/W2143464311","https://openalex.org/W2144891441","https://openalex.org/W2150104849","https://openalex.org/W2150873537","https://openalex.org/W2159195088","https://openalex.org/W2187578080","https://openalex.org/W2398899958","https://openalex.org/W2412456341","https://openalex.org/W2466950925","https://openalex.org/W2474280584","https://openalex.org/W6631701270","https://openalex.org/W6637190555","https://openalex.org/W6720033622"],"related_works":["https://openalex.org/W2058671739","https://openalex.org/W3032075860","https://openalex.org/W1985841350","https://openalex.org/W2027469569","https://openalex.org/W1966190461","https://openalex.org/W1968547012","https://openalex.org/W2079940390","https://openalex.org/W7100495008","https://openalex.org/W2187578080","https://openalex.org/W2053532688"],"abstract_inverted_index":{"Three":[0],"desmoglein":[1],"(Dsg)":[2],"isoforms":[3],"are":[4],"expressed":[5,97,113],"in":[6,10,50,90,99,120,134,141,160,195,209,218,243],"a":[7,213],"differentiation-specific":[8,236],"fashion":[9],"the":[11,34,42,56,77,116,121,165,178,219,222,235,244],"epidermis,":[12],"with":[13,104,176],"Dsg2":[14,194],"being":[15],"basal,":[16],"Dsg3":[17,49,206],"(pemphigus":[18,26],"vulgaris":[19],"antigen)":[20,28],"basal":[21],"and":[22,24,48,62,72,86,110,146,190,197,205,225],"spinous,":[23],"Dsg1":[25,98,125,131,137,189,204,224],"foliaceus":[27],"predominantly":[29],"granular.":[30],"To":[31],"better":[32],"understand":[33],"mechanism(s)":[35],"regulating":[36],"Dsg":[37,81,171],"isoform":[38,172],"expression,":[39],"we":[40,163],"examined":[41],"expression":[43,220],"pattern":[44,237],"of":[45,79,118,153,167,188,221,238],"Dsg1,":[46],"Dsg2,":[47],"normal":[51,106],"human":[52],"epidermal":[53],"keratinocytes":[54],"(NHEKs),":[55],"immortalized,":[57],"nontumorigenic":[58],"HaCaT":[59,109,135,198],"cell":[60,65,67],"line,":[61],"several":[63,230],"squamous":[64],"carcinoma":[66],"lines":[68],"(SCC-9,":[69],"SCC-12F,":[70,145],"SCC-13,":[71],"SCC-25).":[73],"In":[74],"all":[75,100],"cells,":[76],"accumulation":[78],"high":[80],"protein":[82,126,154],"levels":[83,133,187,208],"required":[84],"calcium":[85,92],"was":[87,138],"not":[88,139,193],"observed":[89],"low":[91],"(0.05-0.07":[93],"mM)":[94],"media.":[95],"NHEKs":[96,196],"media":[101,122],"tested,":[102],"consistent":[103],"their":[105],"differentiation":[107],"capacity.":[108],"SCC-25":[111],"also":[112,129,202],"Dsg1;":[114],"however,":[115],"presence":[117],"serum":[119],"dramatically":[123],"decreased":[124,203],"levels.":[127],"Serum":[128],"inhibited":[130,186],"mRNA":[132,207],"cells.":[136,199],"detected":[140],"extracts":[142],"from":[143],"SCC-9,":[144],"SCC-13":[147],"under":[148],"any":[149],"conditions.":[150],"Since":[151],"activation":[152,217],"kinase":[155],"C":[156],"(PKC)":[157],"is":[158,241],"involved":[159],"keratinocyte":[161],"differentiation,":[162],"evaluated":[164],"effects":[166],"PKC":[168,216],"down-regulation":[169],"on":[170],"expression.":[173],"Long-term":[174],"treatment":[175],"either":[177],"phorbol":[179],"ester":[180],"12-O-tetradecanoylphorbol-13-acetate":[181],"(TPA)":[182],"or":[183],"bryostatin":[184],"1":[185],"Dsg3,":[191],"but":[192],"Chronic":[200],"TPA":[201],"NHEKs,":[210],"further":[211],"supporting":[212],"role":[214],"for":[215],"suprabasal":[223],"Dsg3.":[226],"These":[227],"results":[228],"identify":[229],"regulatory":[231],"mechanisms":[232],"by":[233],"which":[234],"desmosomal":[239],"cadherins":[240],"established":[242],"epidermis.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}