{"id":"https://openalex.org/W1965977597","doi":"https://doi.org/10.2165/11592550-000000000-00000","title":"Topical Therapies for Osteoarthritis","display_name":"Topical Therapies for Osteoarthritis","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W1965977597","doi":"https://doi.org/10.2165/11592550-000000000-00000","mag":"1965977597","pmid":"https://pubmed.ncbi.nlm.nih.gov/21770475"},"language":"en","primary_location":{"id":"doi:10.2165/11592550-000000000-00000","doi":"https://doi.org/10.2165/11592550-000000000-00000","is_oa":false,"landing_page_url":"https://doi.org/10.2165/11592550-000000000-00000","pdf_url":null,"source":{"id":"https://openalex.org/S4436492","display_name":"Drugs","issn_l":"0012-6667","issn":["0012-6667","1179-1950"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031970656","display_name":"Roy Davis Altman","orcid":"https://orcid.org/0000-0002-9427-8577","observed_orcids":["https://orcid.org/0000-0002-9427-8577"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roy D. Altman","raw_affiliation_strings":["David Geffen School of Medicine, Department of Rheumatology and Immunology, University of California, Los Angeles, 90024, USA. Journals@royaltman.com","David Geffen School of Medicine, Department of Rheumatology and Immunology, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Geffen School of Medicine, Department of Rheumatology and Immunology, University of California, Los Angeles, 90024, USA. Journals@royaltman.com","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"David Geffen School of Medicine, Department of Rheumatology and Immunology, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026346646","display_name":"Hans Richard Barthel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Richard Barthel","raw_affiliation_strings":["Private Practice, Santa Barbara, CA, USA","Private Practice"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private Practice, Santa Barbara, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Private Practice","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031970656"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":1.7324,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.85340314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"71","issue":"10","first_page":"1259","last_page":"1279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topical-nsaids","display_name":"topical NSAIDs","score":0.9470000267028809},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/osteoarthritis-pain-management","display_name":"osteoarthritis pain management","score":0.8709999918937683},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ketoprofen","display_name":"ketoprofen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/piroxicam","display_name":"piroxicam","score":0.9139999747276306},{"id":"https://openalex.org/keywords/analgesic-efficacy","display_name":"analgesic efficacy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.5170000195503235},{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.75},{"id":"https://openalex.org/keywords/hand-osteoarthritis","display_name":"hand osteoarthritis","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9732221364974976},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7334311008453369},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6786885261535645},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.600488543510437},{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.5905133485794067},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5594590306282043},{"id":"https://openalex.org/C2777489490","wikidata":"https://www.wikidata.org/wiki/Q684924","display_name":"Rheumatism","level":2,"score":0.5408353209495544},{"id":"https://openalex.org/C2779777798","wikidata":"https://www.wikidata.org/wiki/Q407592","display_name":"Tramadol","level":3,"score":0.43411126732826233},{"id":"https://openalex.org/C2776467144","wikidata":"https://www.wikidata.org/wiki/Q408801","display_name":"Celecoxib","level":2,"score":0.4102204144001007},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.30718082189559937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2832753658294678},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1824985146522522},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012459","descriptor_name":"Salicylates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012459","descriptor_name":"Salicylates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012459","descriptor_name":"Salicylates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018689","descriptor_name":"Sensory System Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018689","descriptor_name":"Sensory System Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018689","descriptor_name":"Sensory System Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2165/11592550-000000000-00000","doi":"https://doi.org/10.2165/11592550-000000000-00000","is_oa":false,"landing_page_url":"https://doi.org/10.2165/11592550-000000000-00000","pdf_url":null,"source":{"id":"https://openalex.org/S4436492","display_name":"Drugs","issn_l":"0012-6667","issn":["0012-6667","1179-1950"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs","raw_type":"journal-article"},{"id":"pmid:21770475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21770475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W43261232","https://openalex.org/W61849817","https://openalex.org/W80966816","https://openalex.org/W107715711","https://openalex.org/W138164548","https://openalex.org/W146984140","https://openalex.org/W149973811","https://openalex.org/W162379374","https://openalex.org/W198917344","https://openalex.org/W1480874656","https://openalex.org/W1494229485","https://openalex.org/W1495326015","https://openalex.org/W1792815882","https://openalex.org/W1812033507","https://openalex.org/W1833951622","https://openalex.org/W1877154941","https://openalex.org/W1890512155","https://openalex.org/W1890739221","https://openalex.org/W1894018457","https://openalex.org/W1963763533","https://openalex.org/W1964860289","https://openalex.org/W1965869386","https://openalex.org/W1970890037","https://openalex.org/W1974982280","https://openalex.org/W1977061321","https://openalex.org/W1982515380","https://openalex.org/W1986877549","https://openalex.org/W1997412490","https://openalex.org/W1998232267","https://openalex.org/W1999759770","https://openalex.org/W2004081931","https://openalex.org/W2004641692","https://openalex.org/W2007789292","https://openalex.org/W2008923536","https://openalex.org/W2009768290","https://openalex.org/W2010860405","https://openalex.org/W2011941025","https://openalex.org/W2022869703","https://openalex.org/W2023183853","https://openalex.org/W2023243818","https://openalex.org/W2023377426","https://openalex.org/W2023752710","https://openalex.org/W2025647645","https://openalex.org/W2025982670","https://openalex.org/W2032345563","https://openalex.org/W2032731780","https://openalex.org/W2034167816","https://openalex.org/W2038932922","https://openalex.org/W2047762257","https://openalex.org/W2049978602","https://openalex.org/W2052744840","https://openalex.org/W2055336840","https://openalex.org/W2055932738","https://openalex.org/W2057122829","https://openalex.org/W2057878174","https://openalex.org/W2059107498","https://openalex.org/W2060437287","https://openalex.org/W2065569567","https://openalex.org/W2066820702","https://openalex.org/W2073917243","https://openalex.org/W2076748018","https://openalex.org/W2080195990","https://openalex.org/W2084289720","https://openalex.org/W2089903081","https://openalex.org/W2091050054","https://openalex.org/W2095127972","https://openalex.org/W2099003995","https://openalex.org/W2102043593","https://openalex.org/W2103481781","https://openalex.org/W2103936693","https://openalex.org/W2105722936","https://openalex.org/W2109399977","https://openalex.org/W2110746182","https://openalex.org/W2113010000","https://openalex.org/W2113079259","https://openalex.org/W2113737049","https://openalex.org/W2116143759","https://openalex.org/W2120551915","https://openalex.org/W2124298870","https://openalex.org/W2124433729","https://openalex.org/W2125205359","https://openalex.org/W2125327054","https://openalex.org/W2129208878","https://openalex.org/W2132552005","https://openalex.org/W2138004638","https://openalex.org/W2139124406","https://openalex.org/W2143566744","https://openalex.org/W2143777566","https://openalex.org/W2146766861","https://openalex.org/W2156175487","https://openalex.org/W2157537680","https://openalex.org/W2159278278","https://openalex.org/W2161895091","https://openalex.org/W2167792025","https://openalex.org/W2168209429","https://openalex.org/W2196165191","https://openalex.org/W2200166616","https://openalex.org/W2230785318","https://openalex.org/W2261853236","https://openalex.org/W2395709878","https://openalex.org/W2405887519","https://openalex.org/W2615043561","https://openalex.org/W4234691377","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1978415294","https://openalex.org/W4230160441","https://openalex.org/W2889151630","https://openalex.org/W2068020172","https://openalex.org/W2007748187","https://openalex.org/W2185291866","https://openalex.org/W1932619275","https://openalex.org/W2110477419","https://openalex.org/W2078454905","https://openalex.org/W2944049329"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}