{"id":"https://openalex.org/W1965950628","doi":"https://doi.org/10.1002/1099-1166(200006)15:6<506::aid-gps146>3.0.co;2-v","title":"A long-term, multicenter, open-label study of risperidone in elderly patients with psychosis","display_name":"A long-term, multicenter, open-label study of risperidone in elderly patients with psychosis","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1965950628","doi":"https://doi.org/10.1002/1099-1166(200006)15:6<506::aid-gps146>3.0.co;2-v","mag":"1965950628","pmid":"https://pubmed.ncbi.nlm.nih.gov/10861916"},"language":"en","primary_location":{"id":"doi:10.1002/1099-1166(200006)15:6<506::aid-gps146>3.0.co;2-v","doi":"https://doi.org/10.1002/1099-1166(200006)15:6<506::aid-gps146>3.0.co;2-v","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1099-1166(200006)15:6<506::aid-gps146>3.0.co;2-v","pdf_url":null,"source":{"id":"https://openalex.org/S77085303","display_name":"International Journal of Geriatric Psychiatry","issn_l":"0885-6230","issn":["0885-6230","1099-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Geriatric Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076875466","display_name":"Michael Davidson","orcid":"https://orcid.org/0000-0002-0020-4578","observed_orcids":["https://orcid.org/0000-0002-0020-4578"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"M. Davidson","raw_affiliation_strings":["Sheba Medical Center, Tel Aviv, Israel. davidson@netvision.net.il","Sheba Medical Center, Tel Aviv, ISRAEL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheba Medical Center, Tel Aviv, Israel. davidson@netvision.net.il","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Sheba Medical Center, Tel Aviv, ISRAEL,","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029742430","display_name":"Philip D. Harvey","orcid":"https://orcid.org/0000-0002-9501-9366","observed_orcids":["https://orcid.org/0000-0002-9501-9366","https://orcid.org/0000-0001-7813-4701"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. D. Harvey","raw_affiliation_strings":["Mt. Sinai School of Medicine, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mt. Sinai School of Medicine, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080669341","display_name":"J. Vervarcke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Vervarcke","raw_affiliation_strings":["P.Z. O.L. Vrouw, Brugge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P.Z. O.L. Vrouw, Brugge, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110892097","display_name":"Carlo A Gagiano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26999989","display_name":"University of the Free State","ror":"https://ror.org/009xwd568","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26999989"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"C. A. Gagiano","raw_affiliation_strings":["Oranje Hospital, University of Orange Free State, Bloemfontein, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oranje Hospital, University of Orange Free State, Bloemfontein, South Africa","institution_ids":["https://openalex.org/I26999989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020026015","display_name":"J. D. De Hooge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. D. De Hooge","raw_affiliation_strings":["Delta Psychiatrisch Zkh, Poortugaal, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delta Psychiatrisch Zkh, Poortugaal, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"G. Bray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Bray","raw_affiliation_strings":["Winterton Hospital, Sedgefield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winterton Hospital, Sedgefield, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064851753","display_name":"Matthias Dose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Dose","raw_affiliation_strings":["Bezirkskrankenhaus Gabersee, Wasserburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bezirkskrankenhaus Gabersee, Wasserburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034327788","display_name":"Yoram Barak","orcid":"https://orcid.org/0000-0002-8271-4255","observed_orcids":["https://orcid.org/0000-0002-8271-4255"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Y. Barak","raw_affiliation_strings":["Sheba Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheba Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028928603","display_name":"Manfred Haushofer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Haushofer","raw_affiliation_strings":["Psychiatrisches Krankenhaus der Stadt Wien, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatrisches Krankenhaus der Stadt Wien, Vienna, Austria","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076875466"],"corresponding_institution_ids":["https://openalex.org/I2799810450"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":6.7231,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.97045802,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"6","first_page":"506","last_page":"514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12666","display_name":"Historical Psychiatry and Medical Practices","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":1.0},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8849999904632568},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/long-term-antipsychotic-treatment","display_name":"long-term antipsychotic treatment","score":0.9259999990463257},{"id":"https://openalex.org/keywords/extrapyramidal-symptoms","display_name":"extrapyramidal symptoms","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tardive-dyskinesia","display_name":"tardive dyskinesia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antiparkinsonian-drugs","display_name":"antiparkinsonian drugs","score":0.8980000019073486},{"id":"https://openalex.org/keywords/positive-and-negative-syndrome-scale","display_name":"PANSS","score":0.7459999918937683},{"id":"https://openalex.org/keywords/symptom-improvement","display_name":"symptom improvement","score":0.6359999775886536},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.8692923784255981},{"id":"https://openalex.org/C2780616385","wikidata":"https://www.wikidata.org/wiki/Q1385411","display_name":"Extrapyramidal symptoms","level":4,"score":0.7167567610740662},{"id":"https://openalex.org/C2779158372","wikidata":"https://www.wikidata.org/wiki/Q1546328","display_name":"Tardive dyskinesia","level":3,"score":0.7021697759628296},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.6324207186698914},{"id":"https://openalex.org/C2780135775","wikidata":"https://www.wikidata.org/wiki/Q7233251","display_name":"Positive and Negative Syndrome Scale","level":3,"score":0.5873170495033264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5809272527694702},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5504069924354553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5436749458312988},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.5227858424186707},{"id":"https://openalex.org/C123273963","wikidata":"https://www.wikidata.org/wiki/Q624758","display_name":"Psychopathology","level":2,"score":0.50855553150177},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4550013542175293},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4548152685165405},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.416594535112381},{"id":"https://openalex.org/C2776619155","wikidata":"https://www.wikidata.org/wiki/Q201872","display_name":"Olanzapine","level":3,"score":0.4148314893245697},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3944355845451355},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.33752909302711487},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.07655397057533264},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003702","descriptor_name":"Delusions","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003702","descriptor_name":"Delusions","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003702","descriptor_name":"Delusions","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004409","descriptor_name":"Dyskinesia, Drug-Induced","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004409","descriptor_name":"Dyskinesia, Drug-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008134","descriptor_name":"Long-Term Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012565","descriptor_name":"Schizophrenic Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/1099-1166(200006)15:6<506::aid-gps146>3.0.co;2-v","doi":"https://doi.org/10.1002/1099-1166(200006)15:6<506::aid-gps146>3.0.co;2-v","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1099-1166(200006)15:6<506::aid-gps146>3.0.co;2-v","pdf_url":null,"source":{"id":"https://openalex.org/S77085303","display_name":"International Journal of Geriatric Psychiatry","issn_l":"0885-6230","issn":["0885-6230","1099-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Geriatric Psychiatry","raw_type":"journal-article"},{"id":"pmid:10861916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10861916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of geriatric psychiatry","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W150190670","https://openalex.org/W153750880","https://openalex.org/W585785247","https://openalex.org/W1656430147","https://openalex.org/W1657694742","https://openalex.org/W1979300931","https://openalex.org/W1979700184","https://openalex.org/W1985474440","https://openalex.org/W1989004477","https://openalex.org/W1991864608","https://openalex.org/W1993818042","https://openalex.org/W2002664886","https://openalex.org/W2020676501","https://openalex.org/W2035560842","https://openalex.org/W2040538157","https://openalex.org/W2054706899","https://openalex.org/W2067790056","https://openalex.org/W2092303165","https://openalex.org/W2094953531","https://openalex.org/W2112764261","https://openalex.org/W2125738714","https://openalex.org/W2125993125","https://openalex.org/W2140606211","https://openalex.org/W2146438680","https://openalex.org/W2159011576","https://openalex.org/W2159562025","https://openalex.org/W2170280946","https://openalex.org/W2200688976","https://openalex.org/W2321785219","https://openalex.org/W2329599448","https://openalex.org/W2345907171","https://openalex.org/W2403689664","https://openalex.org/W2417984090","https://openalex.org/W3041047318","https://openalex.org/W3090293687","https://openalex.org/W3144372880","https://openalex.org/W4210957923","https://openalex.org/W4302197575"],"related_works":["https://openalex.org/W2077263618","https://openalex.org/W1656430147","https://openalex.org/W2078866502","https://openalex.org/W1990673580","https://openalex.org/W2159562025","https://openalex.org/W2017034803","https://openalex.org/W2067790056","https://openalex.org/W2045765028","https://openalex.org/W4230212367","https://openalex.org/W114906256"],"abstract_inverted_index":{"RATIONALE:":[0],"Studies":[1],"have":[2],"shown":[3],"that":[4],"risperidone":[5,51,87,185,252],"is":[6],"safe":[7],"and":[8,12,100,125,128,193,221,238,267],"efficacious":[9],"in":[10,52,98,119,181,229,236,261,273],"young":[11],"middle-aged":[13,237],"adults":[14],"with":[15,30,184,251,255],"chronic":[16],"schizophrenia,":[17],"but":[18],"considerably":[19],"fewer":[20],"data":[21,152],"are":[22],"available":[23],"on":[24],"the":[25,48,78,83,194,205,210,222,232,262],"treatment":[26,172,250],"of":[27,50,75,86,111,139,159,176,196,202,217,224,264,271],"elderly":[28,239,274],"patients":[29,67,112,160,182,203,240],"schizophrenia":[31],"or":[32,95],"other":[33],"psychotic":[34,56,66,275],"disorders,":[35],"particularly":[36],"long-term":[37],"outcomes.":[38],"OBJECTIVE:":[39],"A":[40],"12-month,":[41],"open-label":[42],"study":[43,60],"was":[44,88,107,227,253],"conducted":[45],"to":[46,190,207,231],"assess":[47],"effects":[49],"elderly,":[53,63],"chronically":[54,64],"ill,":[55,65],"patients.":[57,276],"METHODS:":[58],"This":[59],"enrolled":[61],"180":[62],"(median":[68],"age,":[69],"72":[70],"years":[71],"[range":[72],"54-89]),":[73],"97":[74],"whom":[76],"completed":[77],"12-month":[79,171],"study.":[80],"At":[81],"endpoint,":[82],"mean":[84],"dose":[85],"3.7":[89],"mg/day.":[90],"RESULTS:":[91],"Clinical":[92,135],"improvement":[93,144,168],"(>":[94],"=20%":[96],"reduction":[97],"Positive":[99],"Negative":[101],"Syndrome":[102],"Score":[103],"[PANSS]":[104],"total":[105],"score)":[106],"achieved":[108],"by":[109],"54%":[110],"at":[113,132],"endpoint.":[114],"There":[115,212],"were":[116,213],"significant":[117],"reductions":[118],"PANSS":[120,151],"total,":[121],"subscale":[122],"(positive,":[123],"negative,":[124],"general":[126],"psychopathology),":[127],"cognition":[129],"cluster":[130],"scores":[131,141],"endpoint":[133,191],"(p<0.001).":[134,148],"Global":[136],"Impressions":[137],"severity":[138,175,263],"illness":[140],"showed":[142,165],"continued":[143,256],"through":[145],"month":[146],"12":[147],"In":[149],"contrast,":[150],"from":[153,188,200],"a":[154,170,259,268],"historical":[155],"comparable":[156],"control":[157],"group":[158],"receiving":[161,241],"conventional":[162,242],"antipsychotic":[163,243],"agents":[164,244],"no":[166,214],"symptom":[167,257],"over":[169],"period.":[173],"The":[174],"preexisting":[177],"extrapyramidal":[178],"symptoms":[179],"(EPS)":[180],"treated":[183],"decreased":[186,199],"significantly":[187],"baseline":[189],"(p<0.001),":[192],"use":[195],"antiparkinsonian":[197],"medication":[198],"41.1%":[201],"before":[204],"trial":[206],"25.6%":[208],"during":[209],"trial.":[211],"spontaneous":[215],"reports":[216],"tardive":[218],"dyskinesia":[219],"(TD)":[220],"incidence":[223,270],"assessed":[225],"TD":[226,272],"4.3%":[228],"contrast":[230],"expected":[233],"26%":[234],"reported":[235],"for":[245],"1":[246],"year.":[247],"CONCLUSIONS:":[248],"Long-term":[249],"associated":[254],"improvement,":[258],"decrease":[260],"preexising":[265],"EPS,":[266],"low":[269]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
